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United States Patent | 6,217,852 |
Gildenberg ,   et al. | April 17, 2001 |
A composition for use as a sunscreen applied during washing includes photoprotective agents of the organic type (e.g., octylmethoxy cinnamate and oxybenzone), the inorganic type (e.g., titanium dioxide and zinc oxide), or combinations of the organic and inorganic agents. Additional components include skin penetration enhancers, emollients and surfactants. Additional sunscreen combinations include a sunscreen cleanser based upon triethanolamine (TEA).
Inventors: | Gildenberg; Stuart R. (West Bloomfield, MI); Siegel; Michael T. (Orchard Lake, MI); Salentine; Christopher G. (San Rafael, CA); Durrani; Manzer J. (Hudson, OH); Dow; Debra A. (Petaluma, CA) |
Assignee: | Skinnovative Dermatologic Concepts, L.L.C. (Waterford, MI) |
Appl. No.: | 134882 |
Filed: | August 15, 1998 |
Current U.S. Class: | 424/59; 424/60; 424/70.9; 424/401; 510/130; 514/844; 514/846; 514/937; 514/947; 977/DIG.1 |
Intern'l Class: | A61K 007/42; A61K 007/44; A61K 007/06; A61K 007/00; A61K 007/50 |
Field of Search: | 424/401,59,60,70.9 514/844,846,937,947 510/130 |
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COMPONENT 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Sodium Laureth Sulfate 10.00 10.00 10.00 20.00 20.00 20.00 20.00 20.00 10.00 10.00 10.00 10.00 10.00 10.00 10.00 Cocamidopropyl Betaine 5.00 5.00 5.00 10.00 10.00 10.00 10.00 10.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 Transcutol 10.00 5.00 10.00 Octylmethoxy Cinnamate 7.50 1.50 7.50 7.50 7.50 7.50 7.50 7.50 7.50 7.50 7.50 3.50 7.50 7.50 7.50 Oxybenzone 6.00 1.00 6.00 6.00 6.00 6.00 6.00 6.00 6.00 6.00 3.00 6.00 6.00 6.00 Propylene Glycol 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Span 20 2.40 2.40 2.40 2.40 2.40 2.40 2.40 2.40 2.40 2.40 2.40 2.40 2.40 Tween 20 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 Carbomer 1382 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 Methylparaben 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 Disodium EDTA 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 10% KOH 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 Sodium Laureth Sulfosuccinate 12.00 Isopropyl Myristate 2.00 2.00 2.00 Velsan D8P3 2.00 2.00 2.00 5.00 10.00 Velsan D8P16 2.00 Purified H.sub.2 O 51.50 61.50 55.50 55.50 49.50 43.50 43.50 43.50 58.50 46.50 58.50 65.50 55.50 50.50 50.50 Glycerin 10.00 FINAL SPF RESULTS: Subject 1 3.7 3.7 3.7 3.7 3.7 3.7 3.7 3.0 3.0 3.7 3.0 3.0 3.7 3.0 4.7 Subject 2 3.0 3.0 3.0 3.0 3.0 3.0 3.7 3.0 3.8 3.0 3.8 3.0 4.7 3.8 3.7 Subject 3 3.7 3.0 3.7 3.7 3.7 2.9 3.7 4.7 4.7 4.7 3.8 4.7 3.8 4.7 4.7 Average 3.47 3.23 3.47 3.47 3.47 3.20 3.70 3.57 3.83 3.80 3.53 3.57 4.7 3.83 4.37 Standard Deviation 0.40 0.40 0.94 0.40 0.40 0.44 0.00 0.98 0.85 0.85 0.46 0.98 0.55 0.85 0.58
COMPONENT 16 17 18 19 20 21 22 23 24 Sodium Laureth Sulfate 10.00 10.00 10.00 10.00 10.00 10.00 10.00 10.00 10.00 Cocamidopropyl Betaine 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 Titanium Dioxide 10.00 10.00 5.00 5.00 10.00 5.00 5.00 Methylparaben 0.10 0.10 0.10 0.10 Disodium EDTA 0.10 0.10 0.10 0.10 Hydroxyethyl Cellulose 0.80 0.80 0.80 0.80 0.80 Glycerin 30.00 30.00 30.00 30.00 30.00 Silsoft 900 1.00 3.00 Sun Caps 664 25.00 Cyclomethicone 345 5.00 Z Cote HPI 5.00 White Petroleum 10.00 10.00 10.00 Stearyl Alcohol 2.00 2.00 2.00 BRIJ 72 2.40 2.40 2.40 BRIJ 721 1.60 1.60 1.60 Pemulen TR-2 0.30 0.30 0.30 Cyclomethicone 345 15.00 15.00 10% KOH 0.50 0.30 0.30 Propylene Glycol 7.50 20% NaCl 10.00 Purified H.sub.2 O 43.20 41.20 29.20 53.00 47.30 49.20 44.20 48.20 43.20 Finsolv EMG-20 5.00 FINAL SPF RESULTS: Subject 1 3.0 3.0 2.4 2.4 3.0 3.0 3.7 3.3 2.4 Subject 2 3.8 3.8 3.8 2.4 2.4 3.0 3.0 3.7 3.0 Subject 3 3.7 3.0 3.0 2.4 3.0 3.0 3.8 3.8 3.0 Average 3.50 3.27 3.07 2.40 2.80 3.00 3.50 3.73 2.80 Standard Deviation 0.44 0.46 0.70 0.00 0.35 0.00 0.44 0.06 0.35
COMPONENT 25 26 27 28 29 30 31 Octylmethoxy 7.50 7.50 7.50 7.50 7.50 7.50 7.50 Cinnamate Oxybenzone 6.00 6.00 6.00 6.00 6.00 6.00 Titanium Dioxide 10.00 (M212) Tioveil IPM 17.00 17.00 Tioveil TG 17.00 17.00 Tioveil TGOP 17.00 Spectraveil IPM 9.00 Zinc Oxide 5.00 (Z-Cote HPI) Sodium Lauryl Ether 10.00 10.00 10.00 10.00 10.00 10.00 10.00 Sulfate Cocamidopropyl 5.00 5.00 5.00 5.00 5.00 5.00 5.00 Betaine Transcutol 5.00 5.00 5.00 5.00 Methylparaben 0.10 0.10 0.10 0.10 0.10 0.10 Disodium EDTA 0.10 0.10 0.10 0.10 0.10 0.10 10% KOH 0.20 0.20 0.20 0.20 0.20 0.20 Hydroxyethyl 0.50 Cellulose Glycerin 5.00 5.00 20.00 Silsoft 900 1.00 Brij 72 2.40 2.40 2.40 2.40 2.40 2.40 Brij 721 1.60 1.60 1.60 1.60 1.60 1.60 Pemulen TR2 0.10 0.10 0.10 0.10 0.10 0.10 Stearyl Alcohol 2.00 2.00 2.00 2.00 2.00 2.00 White Petrolatum 5.00 5.00 5.00 5.00 5.00 5.00 Purified Water 38.00 38.00 38.00 44.00 46.00 33.00 40.00 SPF RESULTS: Subject 1 3.0 3.0 3.0 2.4 3.0 4.7 4.7 Subject 2 3.0 3.0 2.4 2.4 3.0 4.7 4.7 Subject 3 3.0 3.0 3.0 2.4 3.0 4.7 4.7 Average 3.00 3.00 2.80 2.40 3.00 4.70 4.70
TIME DELAYED SPF RESULTS Composition SPF Results - Irradiated 8 Hours After Application Example 13 Subject 1 - 3.0 Subject 2 - 4.7 Subject 3 - 3.0 Average: 3.57 Standard Deviation - 0.98 Example 15 Subject 1 - 3.7 Subject 2 - 3.0 Subject 3 - 4.7 Average: 3.80 Standard Deviation - 0.85 Example 22 Subject 1 - 1.9 Subject 2 - 3.0 Subject 3 - 3.8 Average: <2.90 Standard Deviation: <0.95
MULTIPLE APPLICATIONS SPF Results - Day One Composition (Initial Application) SPF Results - Day Five Example 13 Subject 4 - 3.0 Subject 4 - 3.0 Subject 5 - 4.7 Subject 5 - <1.9 Subject 6 - 2.4 Subject 6 - 2.4 Average: 3.37 Average: <2.43 Example 15 Subject 4 - 3.0 Subject 4 - 3.7 Subject 5 - 4.7 Subject 5 - <1.9 Subject 6 - 2.4 Subject 6 - 2.4 Average: 3.37 Average: <2.67 Example 30 Subject 4 - 4.7 Subject 4 - >4.7* Subject 5 - 2.4 Subject 5 - 4.7 Subject 6 - 4.7 Subject 6 - >4.7* Average: 3.93 Average: >4.70 Example 30 Subject 7 - 3.7 Subject 7 - 12.5 Subject 8 - >4.7* Subject 8 - 12.5 Subject 9 - >4.7* Subject 9 - 10.0 Average: >4.37 Average: 11.67 *Testing was not done to identify SPF results over 4.7 in this instance.
Hard Paraffin 25.0 Soft Paraffin 11.75 Liquid Paraffin 3.50 Cetostearyl Alcohol 5.00 Triethanolamine 0.70 Stearic Acid 0.20 Sunscreen As needed QS DI Water 100.00