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United States Patent | 6,203,758 |
Marks ,   et al. | March 20, 2001 |
A micro-circuit for performing analyses of multimolecular interactions and for performing molecular syntheses, comprising: (a) a support; (b) at least one micro-electrode attached to the support, the micro-electrode being selectively electronically activated and the micro-electrode having a protective layer which is removable; (c) a binding entity for attachment to the at least one micro-electrode, the binding entity being capable of attachment to at least one micro-electrode when the protective layer has been removed; and (d) a power source being operatively connected to at least one micro-electrode for electronically activating at least one micro-electrode. The micro-circuit of the present invention also includes embodiments featuring a micro-circuit reader for detecting the interaction of the binding entity to a complementary probe, as well as methods for making and using the micro-circuit of the present invention.
Inventors: | Marks; Robert (Beersheva, IL); Lellouche; Jean-Paul (Ashdod, IL) |
Assignee: | Bio-Pixel Ltd. (Beer-Sheva, IL) |
Appl. No.: | 966618 |
Filed: | November 10, 1997 |
Current U.S. Class: | 422/68.1; 204/403.01; 204/418; 204/419; 204/434; 205/687; 250/461.1; 250/461.2; 422/82.01; 422/82.02; 422/82.03; 422/101; 427/2.11; 427/2.13; 427/455; 427/470; 435/6; 435/7.1; 435/16; 435/970; 435/973; 436/518; 436/525; 549/223 |
Intern'l Class: | C25C 001/14; G01N 015/06; G01N 021/64; G01N 033/543; C12Q 001/68; B01D 017/06; C07D 311/82; A61L 051/103 |
Field of Search: | 204/112,22,403,418,419,434 422/68.1,101,82.01,82.02,82.03 250/461.1,461.2,687 435/6,16,5,7.1,970,973 549/223 427/2.11,2.13,455,470 436/518,525 205/687 |
4512855 | Apr., 1985 | Mazur | 204/22. |
5532128 | Jul., 1996 | Eggers et al. | 435/16. |
5605662 | Feb., 1997 | Heller | 422/68. |
5607646 | Mar., 1997 | Okano et al. | 422/101. |
5632957 | May., 1997 | Heller et al. | 422/68. |
5641630 | Jun., 1997 | Snitman et al. | 435/6. |
5667667 | Sep., 1997 | Southern | 205/687. |
Foreign Patent Documents | |||
WO 95/12808 | Oct., 1994 | WO | . |
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