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United States Patent | 6,177,078 |
Lopez | January 23, 2001 |
Anti IL-3 Receptor alpha chain monoclonal antibody (MoAb) is the product of a hybridoma cell line designated 7G3. The MoAb acts as an antagonist to IL-3 in vitro activity. The MoAb binds to the N terminal domain of the IL-3 receptor alpha chain and does so competitively with IL-3 which indicates that this is, at least in part, involved in IL-3 binding. Treatment with the MoAb or fragment thereof, whether recombinant or otherwise, may be suitable for the treatment of one or more of the following conditions: myeloid leukemias, lymphomas such as follicular B cell lymphoma, or the alleviation of allergies.
Inventors: | Lopez; Angel F (Adelaide, AU) |
Assignee: | Medvet Science Pty Limited (AU) |
Appl. No.: | 101162 |
Filed: | June 29, 1998 |
PCT Filed: | December 24, 1996 |
PCT NO: | PCT/AU96/00840 |
371 Date: | June 29, 1998 |
102(e) Date: | June 29, 1998 |
PCT PUB.NO.: | WO97/24373 |
PCT PUB. Date: | July 10, 1997 |
Dec 29, 1995[AU] | PN 7368 | |
Jan 04, 1996[AU] | PN 7418 |
Current U.S. Class: | 424/143.1; 424/130.1; 424/139.1; 424/141.1; 424/142.1; 435/326; 435/334; 530/388.1; 530/388.22 |
Intern'l Class: | A61K 039/00; A61K 039/395; A61K 039/44; C07K 016/28 |
Field of Search: | 424/130.1,131.1,141.1,142.1,143.1 435/326,334 530/388.22,388.1 |
5747032 | May., 1998 | Metcalf et al. | 424/133. |
Foreign Patent Documents | |||
WO 94/091-49 | Apr., 1994 | WO. |
Sato et al, Blood vol. 82 No. 3, pp. 752-761, Aug. 1993. Callard and Gearing, Cytokine Facts Book, Academic Press, pp. 48-49 and 141-142, 1994. Devos, R et al. 1995. "Interleukin-5 and its receptor:a drug target for eosinophilia associated with chronic allergic disease," Journal of Leukocyte Biology 57:813-819. Korpelainen, E.I. et al., 1995. "Interferon-.gamma. upregulates Interleukin -3 (IL-3) Receptor expression in Human Endothelial Cells and synergizes with IL-3 in stimulating Major Histocompatibility Complex Class II Expression and Cytokine Production," Blood 86: 176-182. Palacios, R. et al., 1986. "Monoclonal Antibodies Specific for Interleukin 3-Sensitive Murine Cells," Journal of Experimental Medicine 163:369-382. Sun Q, et al., 1996. "Monoclonal Antibody 7G3 Recognizes the N-terminal domain of the Human Interleukin-3 (IL-3) Receptor .alpha. chain and functions as a specific IL-3 Receptor Antagonist," Blood 87:83-92. Van der Hyden, J et al., 1991. "Characterization of the Murine IL-5 receptor complex with the use of a panel of monoclonal antibodies; relationship to the Murine IL-3 Receptor," The Journal of Immunology 147:3416-3417. |