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United States Patent | 6,174,698 |
Miller | January 16, 2001 |
A micro lysis and analysis process applying precise quantities of focused energy, such as light energy, to a precise microscopic area of a very small cell sample to activate an energy sensitive agent, such as a fluorescing agent, which permits measurement of cell fragility providing a means for determining the sensitivity of cells to particular chemicals, drugs, and/or diseases and the susceptibility and/or exposure of the cells to same.
Inventors: | Miller; Frederick N. (Louisville, KY) |
Assignee: | Micro-Med, Inc. (Louisville, KY) |
Appl. No.: | 196464 |
Filed: | November 19, 1998 |
Current U.S. Class: | 435/29; 435/4; 435/7.2 |
Intern'l Class: | C12Q 001/02 |
Field of Search: | 435/4,29,7.2,6,34,70 356/39 436/10,63,172,902,17,164,165,519 422/55,73,82.05,82.07 324/71.4,71.1 |
5532139 | Jul., 1996 | Miller | 435/29. |
5610027 | Mar., 1997 | Miller | 435/29. |
5955295 | Sep., 1999 | Miller | 435/29. |
ND POWER (mw) ED (Joules/cm.sup.2) 0.0 0.40 137.14 .times. exposure mins 0.1 0.32 109.71 .times. exposure mins 0.3 0.20 68.57 .times. exposure mins 0.6 0.10 34.29 .times. exposure mins