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United States Patent | 6,156,908 |
Drauz ,   et al. | December 5, 2000 |
The invention is directed to a process for the preparation of lactams of Formula I. It is further directed to new advantageous intermediates of Formula II and the use thereof. By the cyclization of compounds of Formula II, compounds of Formula I are obtained.
Inventors: | Drauz; Karlheinz (Freigericht, DE); Klement; Ingo (Pohlheim, DE); Knaup; Gunter (Bruchkobel, DE) |
Assignee: | Rohm Gesellschaft, GmbH (Dartmstadt, DE) |
Appl. No.: | 393874 |
Filed: | September 10, 1999 |
Sep 11, 1998[DE] | 198 41 895 |
Current U.S. Class: | 548/546; 562/556; 562/559 |
Intern'l Class: | C07D 207/40; C07D 315/00; C07D 321/00 |
Field of Search: | 548/546 562/559,556 |
5484946 | Jan., 1996 | Abood et al. | |
Foreign Patent Documents | |||
94/22820 | Oct., 1994 | WO. |
German Patent Office communication dated Sep. 15, 1998. "Protected Lactam-Bridged Dipeptides for Use as Conformational Constraints in Peptides", 1982 Amer. Chem. Soc., pp. 104-198, vol. 47, No. 1. "Decrease of a-Helix Potential and Biological Activity of b-Endorphin in Response to Modifications of MET.sup.5 ", Neuropeptides : 47-51, 1980. Methiomine Studies VII, May, 1945, pp. 849-851,Toennies, et al, 1945. "Preparation of D-,DL, and L-Homoserine Lactone from Methionine", Microchem. Journal, 40, 226-232 (1989). "The Reaction of Idoacetate with Methionine", Journal of Biol. Chem. vol. 234, No. 7, Jul. 1959, pp. 1761-1765. |