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United States Patent | 6,156,551 |
Neel ,   et al. | December 5, 2000 |
The invention relates to novel mutant SH2 domain containing protein tyrosine phosphatases wherein the phosphatase is partially or constitutively active; and whose ability to regulate biological processes are different from the wildtype protein tyrosine phosphatases. The invention also relates to methods of use of the novel mutants, for example, in in vitro assays to screen for binding partners and inhibitors of protein tyrosine phosphatases and in the treatment of protein tyrosine phosphatase mediated diseases or conditions.
Inventors: | Neel; Benjamin G. (Wayland, MA); O'Reilly; Alana M. (Watertown, MA); Shoelson; Steven (Natick, MA); Pluskey; Scott (Allston, MA) |
Assignee: | Beth Israel Deaconess Medical Center (Boston, MA); Joslin Diabetes Center (Boston, MA) |
Appl. No.: | 092443 |
Filed: | June 5, 1998 |
Current U.S. Class: | 435/196 |
Intern'l Class: | C12N 009/16 |
Field of Search: | 435/196 |
5536636 | Jul., 1996 | Freeman, Jr. et al. | 435/6. |
5589375 | Dec., 1996 | Ullrich et al. | 435/240. |
5659012 | Aug., 1997 | Klingmuller et al. | 530/327. |
Foreign Patent Documents | |||
WO 98/04712 | Feb., 1998 | EP. | |
WO 98/14596 | Apr., 1998 | EP. |
Rudinger, p. of Peptide Hormones, Parsons, Ed., University Park Press, Jun. 1976. Matthews et al., "Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences," Mol. Cell. Bi, 1992. Bastien et al., "Cloning, expression and mutational analysis of SH-PTP2, human protein-tyrosine phosphatase," Biochem. Biophys. Res. Commun. 196, 124-133, 1993. Thornton et al., "Protein engineering," Cur. Opinion Biotech., vol. 6, No. 4, pp. 367-369, Aug. 1995. Aoki et al., EMBL accession No. P81718, submitted Nov. 1996. Neel, B. G. et al., "Protein tyrosine phosphatases in signal transduction," Current Opinion in Cell Biology, 9:193-204 (1997). Freeman, R. M. et al., "Indentification of a human src homology 2-containing protein-tyrosine-phosphatase: A putative homolog of Drosophila corkscrew," Proc. Natl. Acad. Sci. USA, 89:11239-11243 (1992). Tang, T. L. et al., "The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development," Cell, 80:473-483 (1995). O'Reilly, A. M. et al., "Structural determinants of SHP-2 function and specificity in Xenopus mesoderm induction," Molecular and Cellular Biology, 18:161-177 (1998). Hof, P. et al., "Crystal structure of the tyrosine phosphatase SHP-2," Cell, 92:441-450 (1998). Schlessinger, J. et al., "Growth factor signaling by receptor tyrosine kinases," Neuron, 9:383-391 (1992). Denu, J. M. et al., "Form and function in protein dephosphorylation," Cell, 87:361-364 (1996). Lorenz, U. et al., "Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1," J. Exp. Med., 184:1111-1126 (1996). Paulson, R. F. et al., "Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shpl," Nature Genetics, 13:309-315 (1996). Neel, B. G., "Structure and function of SH2-domain containing tyrosine phosphatases," Seminars in Cell Biology, 4:419-432 (1993). Flint, A. J. et al., "Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases," Proc. Natl. Acad. Sci. USA, 94:1680-1685 (1997). Feng, G. S. et al., "Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction," TIG, 10:54-58 (1994). Lechleider, R. J. et al., "Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor .beta.*," J. Biol. Chem., 268:21478-21481 (1993). Garton, A. J. et al., "Identification of P130.sup.cas as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST," Molecular and Cellular Biology, 16:6408-6418 (1996). Barford, D. et al., "Revealing mechanisms for SH2 domain-mediated regulation of the protein tyrosine phosphatase SHP-2," Structure, 6:249-254 (1998). Amaya, E. et al., "Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos," Cell, 66:257-270 (1991). Lamb, T. M. et al., "Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern," Development 121:3627-3636 (1995). Nieuwkoop, P. D., "Inductive interactions in early amphibian development and their general nature," J. Embryol. Exp. Morph. Suppl. 89:333-347 (1985). Amaya, E. et al., "FGF signalling in the early specification of mesoderm in Xenopus," Development 118:477-487 (1993). Klein, P. S. et al., "Hormonal regulation of embryogenesis: The formation of mesoderm in Xenopus laevis," Endocrine Reviews 15:326-341 (1994). Smith, J. C. et al., "Mesoderm-inducing factors and mesodermal patterning," Current Opinion in Cell Biology, 7:856-861 (1995). Isaacs, H. V., "New perspectives on the role of the fibroblast growth factor family in amphibian development," Cell. Mol. Life Sci. 53: 350-361 (1997). Kroll, K. L. et al., "Transgenic Xenopus embryos from sperm nuclear transplantations reveal FGF signalling requirements during gastrulation," Development, 122:3173-3183 (1996). Kengaku, M. et al., "bFGF as a possible morphogen for the anteroposterior axis of the central nervous system in Xenopus," Development 121:3121-3130 (1996). |
__________________________________________________________________________ # SEQUENCE LISTING - - - - (1) GENERAL INFORMATION: - - (iii) NUMBER OF SEQUENCES: 70 - - - - (2) INFORMATION FOR SEQ ID NO:1: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1782 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1779 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1: - - ATG ACA TCG CGG AGA TGG TTT CAC CCA AAT AT - #C ACT GGT GTG GAG GCA 48 Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - GAA AAC CTA CTG TTG ACA AGA GGA GTT GAT GG - #C AGT TTT TTG GCA AGG 96 Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Arg 20 - # 25 - # 30 - - CCT AGT AAA AGT AAC CCT GGA GAC TTC ACA CT - #T TCC GTT AGA AGA AAT 144 Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - GGA GCT GTC ACC CAC ATC AAG ATT CAG AAC AC - #T GGT GAT TAC TAT GAC 192 Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Asp Tyr Tyr Asp 50 - # 55 - # 60 - - CTG TAT GGA GGG GAG AAA TTT GCC ACT TTG GC - #T GCG TTG GTC CAG TAT 240 Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Ala Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - TAC ATG GAA CAT CAC GGG CAA TTA AAA GAG AA - #G AAT GGA GAT GTC ATT 288 Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - GAG CTT AAA TAT CCT CTG AAC TGT GCA GAT CC - #T ACC TCT GAA AGG TGG 336 Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - TTT CAT GGA CAT CTC TCT GGG AAA GAA GCA GA - #G AAA TTA TTA ACT GAA 384 Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - AAA GGA AAA CAT GGT AGT TTT CTT GTA CGA GA - #G AGC CAG AGC CAC CCT 432 Lys Gly Lys His Gly Ser Phe Leu Val Arg Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - GGA GAT TTT GTT CTT TCT GTG CGC ACT GGT GA - #T GAC AAA GGG GAG AGC 480 Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - AAT GAC GGC AAG TCT AAA GTG ACC CAT GTT AT - #G ATT CGC TGT CAG GAA 528 Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - CTG AAA TAC GAC GTT GGT GGA GGA GAA CGG TT - #T GAT TCT TTG ACA GAT 576 Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - CTT GTG GAA CAT TAT AAG AAG AAT CCT ATG GT - #G GAA ACA TTG GGT ACA 624 Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - GTA CTA CAA CTC AAG CAG CCC CTT AAC ACG AC - #T CGT ATA AAT GCT GCT 672 Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - GAA ATA GAA AGC AGA GTT CGA GAA CTA AGC AA - #A TTA GCT GAG ACC ACA 720 Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - GAT AAA GTC AAA CAA GGC TTT TGG GAA GAA TT - #T GAG ACA CTA CAA CAA 768 Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - CAG GAG TGC AAA CTT CTC TAC AGC CGA AAA GA - #G GGT CAA AGG CAA GAA 816 Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - AAC AAA AAC AAA AAT AGA TAT AAA AAC ATC CT - #G CCC TTT GAT CAT ACC 864 Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - AGG GTT GTC CTA CAC GAT GGT GAT CCC AAT GA - #G CCT GTT TCA GAT TAC 912 Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - ATC AAT GCA AAT ATC ATC ATG CCT GAA TTT GA - #A ACC AAG TGC AAC AAT 960 Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - TCA AAG CCC AAA AAG AGT TAC ATT GCC ACA CA - #A GGC TGC CTG CAA AAC 1008 Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - ACG GTG AAT GAC TTT TGG CGG ATG GTG TTC CA - #A GAA AAC TCC CGA GTG 1056 Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - ATT GTC ATG ACA ACG AAA GAA GTG GAG AGA GG - #A AAG AGT AAA TGT GTC 1104 Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - AAA TAC TGG CCT GAT GAG TAT GCT CTA AAA GA - #A TAT GGC GTC ATG CGT 1152 Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - GTT AGG AAC GTC AAA GAA AGC GCC GCT CAT GA - #C TAT ACG CTA AGA GAA 1200 Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - CTT AAA CTT TCA AAG GTT GGA CAA GGG AAT AC - #G GAG AGA ACG GTC TGG 1248 Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - CAA TAC CAC TTT CGG ACC TGG CCG GAC CAC GG - #C GTG CCC AGC GAC CCT 1296 Gln Tyr His Phe Arg Thr Trp Pro Asp His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - GGG GGC GTG CTG GAC TTC CTG GAG GAG GTG CA - #C CAT AAG CAG GAG AGC 1344 Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - ATC ATG GAT GCA GGG CCG GTC GTG GTG CAC TG - #C AGT GCT GGA ATT GGC 1392 Ile Met Asp Ala Gly Pro Val Val Val His Cy - #s Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - CGG ACA GGG ACG TTC ATT GTG ATT GAT ATT CT - #T ATT GAC ATC ATC AGA 1440 Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - GAG AAA GGT GTT GAC TGC GAT ATT GAC GTT CC - #C AAA ACC ATC CAG ATG 1488 Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - GTG CGG TCT CAG AGG TCA GGG ATG GTC CAG AC - #A GAA GCA CAG TAC CGA 1536 Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - TTT ATC TAT ATG GCG GTC CAG CAT TAT ATT GA - #A ACA CTA CAG CGC AGG 1584 Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - ATT GAA GAA GAG CAG AAA AGC AAG AGG AAA GG - #G CAC GAA TAT ACA AAT 1632 Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - ATT AAG TAT TCT CTA GCG GAC CAG ACG AGT GG - #A GAT CAG AGC CCT CTC 1680 Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - CCG CCT TGT ACT CCA ACG CCA CCC TGT GCA GA - #A ATG AGA GAA GAC AGT 1728 Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - GCT AGA GTC TAT GAA AAC GTG GGC CTG ATG CA - #A CAG CAG AAA AGT TTC 1776 Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - AGA TGA - # - # - # 1782 Arg - - - - (2) INFORMATION FOR SEQ ID NO:2: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 593 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2: - - Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Arg 20 - # 25 - # 30 - - Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Asp Tyr Tyr Asp 50 - # 55 - # 60 - - Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Ala Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - Lys Gly Lys His Gly Ser Phe Leu Val Arg Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - Gln Tyr His Phe Arg Thr Trp Pro Asp His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - Ile Met Asp Ala Gly Pro Val Val Val His Cy - #s Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525
- - Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - Arg - - - - (2) INFORMATION FOR SEQ ID NO:3: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1782 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1779 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:3: - - ATG ACA TCG CGG AGA TGG TTT CAC CCA AAT AT - #C ACT GGT GTG GAG GCA 48 Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - GAA AAC CTA CTG TTG ACA AGA GGA GTT GAT GG - #C AGT TTT TTG GCA AGG 96 Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Arg 20 - # 25 - # 30 - - CCT AGT AAA AGT AAC CCT GGA GAC TTC ACA CT - #T TCC GTT AGA AGA AAT 144 Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - GGA GCT GTC ACC CAC ATC AAG ATT CAG AAC AC - #T GGT GAT TAC TAT GAC 192 Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Asp Tyr Tyr Asp 50 - # 55 - # 60 - - CTG TAT GGA GGG GAG AAA TTT GCC ACT TTG GC - #T GCG TTG GTC CAG TAT 240 Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Ala Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - TAC ATG GAA CAT CAC GGG CAA TTA AAA GAG AA - #G AAT GGA GAT GTC ATT 288 Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - GAG CTT AAA TAT CCT CTG AAC TGT GCA GAT CC - #T ACC TCT GAA AGG TGG 336 Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - TTT CAT GGA CAT CTC TCT GGG AAA GAA GCA GA - #G AAA TTA TTA ACT GAA 384 Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - AAA GGA AAA CAT GGT AGT TTT CTT GTA CGA GA - #G AGC CAG AGC CAC CCT 432 Lys Gly Lys His Gly Ser Phe Leu Val Arg Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - GGA GAT TTT GTT CTT TCT GTG CGC ACT GGT GA - #T GAC AAA GGG GAG AGC 480 Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - AAT GAC GGC AAG TCT AAA GTG ACC CAT GTT AT - #G ATT CGC TGT CAG GAA 528 Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - CTG AAA TAC GAC GTT GGT GGA GGA GAA CGG TT - #T GAT TCT TTG ACA GAT 576 Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - CTT GTG GAA CAT TAT AAG AAG AAT CCT ATG GT - #G GAA ACA TTG GGT ACA 624 Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - GTA CTA CAA CTC AAG CAG CCC CTT AAC ACG AC - #T CGT ATA AAT GCT GCT 672 Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - GAA ATA GAA AGC AGA GTT CGA GAA CTA AGC AA - #A TTA GCT GAG ACC ACA 720 Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - GAT AAA GTC AAA CAA GGC TTT TGG GAA GAA TT - #T GAG ACA CTA CAA CAA 768 Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - CAG GAG TGC AAA CTT CTC TAC AGC CGA AAA GA - #G GGT CAA AGG CAA GAA 816 Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - AAC AAA AAC AAA AAT AGA TAT AAA AAC ATC CT - #G CCC TTT GAT CAT ACC 864 Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - AGG GTT GTC CTA CAC GAT GGT GAT CCC AAT GA - #G CCT GTT TCA GAT TAC 912 Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - ATC AAT GCA AAT ATC ATC ATG CCT GAA TTT GA - #A ACC AAG TGC AAC AAT 960 Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - TCA AAG CCC AAA AAG AGT TAC ATT GCC ACA CA - #A GGC TGC CTG CAA AAC 1008 Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - ACG GTG AAT GAC TTT TGG CGG ATG GTG TTC CA - #A GAA AAC TCC CGA GTG 1056 Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - ATT GTC ATG ACA ACG AAA GAA GTG GAG AGA GG - #A AAG AGT AAA TGT GTC 1104 Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - AAA TAC TGG CCT GAT GAG TAT GCT CTA AAA GA - #A TAT GGC GTC ATG CGT 1152 Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - GTT AGG AAC GTC AAA GAA AGC GCC GCT CAT GA - #C TAT ACG CTA AGA GAA 1200 Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - CTT AAA CTT TCA AAG GTT GGA CAA GGG AAT AC - #G GAG AGA ACG GTC TGG 1248 Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - CAA TAC CAC TTT CGG ACC TGG CCG GAC CAC GG - #C GTG CCC AGC GAC CCT 1296 Gln Tyr His Phe Arg Thr Trp Pro Asp His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - GGG GGC GTG CTG GAC TTC CTG GAG GAG GTG CA - #C CAT AAG CAG GAG AGC 1344 Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - ATC ATG GAT GCA GGG CCG GTC GTG GTG CAC TG - #C AGT GCT GGA ATT GGC 1392 Ile Met Asp Ala Gly Pro Val Val Val His Cy - #s Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - CGG ACA GGG ACG TTC ATT GTG ATT GAT ATT CT - #T ATT GAC ATC ATC AGA 1440 Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - GAG AAA GGT GTT GAC TGC GAT ATT GAC GTT CC - #C AAA ACC ATC CAG ATG 1488 Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - GTG CGG TCT CAG AGG TCA GGG ATG GTC CAG AC - #A GAA GCA CAG TAC CGA 1536 Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - TTT ATC TAT ATG GCG GTC CAG CAT TAT ATT GA - #A ACA CTA CAG CGC AGG 1584 Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - ATT GAA GAA GAG CAG AAA AGC AAG AGG AAA GG - #G CAC GAA TAT ACA AAT 1632 Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - ATT AAG TAT TCT CTA GCG GAC CAG ACG AGT GG - #A GAT CAG AGC CCT CTC 1680 Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - CCG CCT TGT ACT CCA ACG CCA CCC TGT GCA GA - #A ATG AGA GAA GAC AGT 1728 Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - GCT AGA GTC TAT GAA AAC GTG GGC CTG ATG CA - #A CAG CAG AAA AGT TTC 1776 Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - AGA TGA - # - # - # 1782 Arg - - - - (2) INFORMATION FOR SEQ ID NO:4: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 593 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:4: - - Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Arg 20 - # 25 - # 30 - - Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Asp Tyr Tyr Asp 50 - # 55 - # 60 - - Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Ala Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - Lys Gly Lys His Gly Ser Phe Leu Val Arg Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - Gln Tyr His Phe Arg Thr Trp Pro Asp His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - Ile Met Asp Ala Gly Pro Val Val Val His Cy - #s Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80
- - Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - Arg - - - - (2) INFORMATION FOR SEQ ID NO:5: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1782 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1779 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:5: - - ATG ACA TCG CGG AGA TGG TTT CAC CCA AAT AT - #C ACT GGT GTG GAG GCA 48 Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - GAA AAC CTA CTG TTG ACA AGA GGA GTT GAT GG - #C AGT TTT TTG GCA AGG 96 Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Arg 20 - # 25 - # 30 - - CCT AGT AAA AGT AAC CCT GGA GAC TTC ACA CT - #T TCC GTT AGA AGA AAT 144 Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - GGA GCT GTC ACC CAC ATC AAG ATT CAG AAC AC - #T GGT GAT TAC TAT GAC 192 Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Asp Tyr Tyr Asp 50 - # 55 - # 60 - - CTG TAT GGA GGG GAG AAA TTT GCC ACT TTG GC - #T GAG TTG GTC CAG TAT 240 Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Glu Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - TAC ATG GAA CAT CAC GGG CAA TTA AAA GAG AA - #G AAT GGA GAT GTC ATT 288 Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - GAG CTT AAA TAT CCT CTG AAC TGT GCA GAT CC - #T ACC TCT GAA AGG TGG 336 Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - TTT CAT GGA CAT CTC TCT GGG AAA GAA GCA GA - #G AAA TTA TTA ACT GAA 384 Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - AAA GGA AAA CAT GGT AGT TTT CTT GTA CGA GA - #G AGC CAG AGC CAC CCT 432 Lys Gly Lys His Gly Ser Phe Leu Val Arg Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - GGA GAT TTT GTT CTT TCT GTG CGC ACT GGT GA - #T GAC AAA GGG GAG AGC 480 Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - AAT GAC GGC AAG TCT AAA GTG ACC CAT GTT AT - #G ATT CGC TGT CAG GAA 528 Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - CTG AAA TAC GAC GTT GGT GGA GGA GAA CGG TT - #T GAT TCT TTG ACA GAT 576 Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - CTT GTG GAA CAT TAT AAG AAG AAT CCT ATG GT - #G GAA ACA TTG GGT ACA 624 Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - GTA CTA CAA CTC AAG CAG CCC CTT AAC ACG AC - #T CGT ATA AAT GCT GCT 672 Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - GAA ATA GAA AGC AGA GTT CGA GAA CTA AGC AA - #A TTA GCT GAG ACC ACA 720 Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - GAT AAA GTC AAA CAA GGC TTT TGG GAA GAA TT - #T GAG ACA CTA CAA CAA 768 Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - CAG GAG TGC AAA CTT CTC TAC AGC CGA AAA GA - #G GGT CAA AGG CAA GAA 816 Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - AAC AAA AAC AAA AAT AGA TAT AAA AAC ATC CT - #G CCC TTT GAT CAT ACC 864 Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - AGG GTT GTC CTA CAC GAT GGT GAT CCC AAT GA - #G CCT GTT TCA GAT TAC 912 Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - ATC AAT GCA AAT ATC ATC ATG CCT GAA TTT GA - #A ACC AAG TGC AAC AAT 960 Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - TCA AAG CCC AAA AAG AGT TAC ATT GCC ACA CA - #A GGC TGC CTG CAA AAC 1008 Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - ACG GTG AAT GAC TTT TGG CGG ATG GTG TTC CA - #A GAA AAC TCC CGA GTG 1056 Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - ATT GTC ATG ACA ACG AAA GAA GTG GAG AGA GG - #A AAG AGT AAA TGT GTC 1104 Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - AAA TAC TGG CCT GAT GAG TAT GCT CTA AAA GA - #A TAT GGC GTC ATG CGT 1152 Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - GTT AGG AAC GTC AAA GAA AGC GCC GCT CAT GA - #C TAT ACG CTA AGA GAA 1200 Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - CTT AAA CTT TCA AAG GTT GGA CAA GGG AAT AC - #G GAG AGA ACG GTC TGG 1248 Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - CAA TAC CAC TTT CGG ACC TGG CCG GAC CAC GG - #C GTG CCC AGC GAC CCT 1296 Gln Tyr His Phe Arg Thr Trp Pro Asp His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - GGG GGC GTG CTG GAC TTC CTG GAG GAG GTG CA - #C CAT AAG CAG GAG AGC 1344 Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - ATC ATG GAT GCA GGG CCG GTC GTG GTG CAC TG - #C AGT GCT GGA ATT GGC 1392 Ile Met Asp Ala Gly Pro Val Val Val His Cy - #s Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - CGG ACA GGG ACG TTC ATT GTG ATT GAT ATT CT - #T ATT GAC ATC ATC AGA 1440 Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - GAG AAA GGT GTT GAC TGC GAT ATT GAC GTT CC - #C AAA ACC ATC CAG ATG 1488 Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - GTG CGG TCT CAG AGG TCA GGG ATG GTC CAG AC - #A GAA GCA CAG TAC CGA 1536 Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - TTT ATC TAT ATG GCG GTC CAG CAT TAT ATT GA - #A ACA CTA CAG CGC AGG 1584 Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - ATT GAA GAA GAG CAG AAA AGC AAG AGG AAA GG - #G CAC GAA TAT ACA AAT 1632 Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - ATT AAG TAT TCT CTA GCG GAC CAG ACG AGT GG - #A GAT CAG AGC CCT CTC 1680 Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - CCG CCT TGT ACT CCA ACG CCA CCC TGT GCA GA - #A ATG AGA GAA GAC AGT 1728 Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - GCT AGA GTC TAT GAA AAC GTG GGC CTG ATG CA - #A CAG CAG AAA AGT TTC 1776 Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - AGA TGA - # - # - # 1782 Arg - - - - (2) INFORMATION FOR SEQ ID NO:6: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 593 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:6: - - Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Arg 20 - # 25 - # 30 - - Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Asp Tyr Tyr Asp 50 - # 55 - # 60 - - Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Glu Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - Lys Gly Lys His Gly Ser Phe Leu Val Arg Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - Gln Tyr His Phe Arg Thr Trp Pro Asp His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430
- - Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - Ile Met Asp Ala Gly Pro Val Val Val His Cy - #s Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - Arg - - - - (2) INFORMATION FOR SEQ ID NO:7: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1788 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1785 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:7: - - ATG GTG AGG TGG TTT CAC CGA GAC CTC AGT GG - #G CTG GAT GCA GAG ACC 48 Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - CTG CTC AAG GGC CGA GGT GTC CAC GGT AGC TT - #C CTG GCT CGG CCC AGT 96 Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Arg Pro Ser 20 - # 25 - # 30 - - CGC AAG AAC CAG GGT GAC TTC TCG CTC TCC GT - #C AGG GTG GGG GAT CAG 144 Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - GTG ACC CAT ATT CGG ATC CAG AAC TCA GGG GA - #T TTC TAT GAC CTG TAT 192 Val Thr His Ile Arg Ile Gln Asn Ser Gly As - #p Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - GGA GGG GAG AAG TTT GCG ACT CTG ACA GAG CT - #G GTG GAG TAC TAC ACT 240 Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - CAG CAG CAG GGT GTG GTG CAG GAC CGC GAC GG - #C ACC ATC ATC CAC CTC 288 Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - AAG TAC CCG CTG AAC TGC TCC GAT CCC ACT AG - #T GAG AGG TGG TAC CAT 336 Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - GGC CAC ATG TCT GGC GGG CAG GCA GAG ACG CT - #G CTG CAG GCC AAG GGC 384 Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - GAG CCC TGG ACG TTT CTT GTG CGT GAG AGC CT - #C AGC CAG CCT GGA GAC 432 Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - TTC GTG CTT TCT GTG CTC AGT GAC CAG CCC AA - #G GCT GGC CCA GGC TCC 480 Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - CCG CTC AGG GTC ACC CAC ATC AAG GTC ATG TG - #C GAG GGT GGA CGC TAC 528 Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - ACA GTG GGT GGT TTG GAG ACC TTC GAC AGC CT - #C ACG GAC CTG GTG GAG 576 Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - CAT TTC AAG AAG ACG GGG ATT GAG GAG GCC TC - #A GGC GCC TTT GTC TAC 624 His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - CTG CGG CAG CCG TAC TAT GCC ACG AGG GTG AA - #T GCG GCT GAC ATT GAG 672 Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - AAC CGA GTG TTG GAA CTG AAC AAG AAG CAG GA - #G TCC GAG GAT ACA GCC 720 Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - AAG GCT GGC TTC TGG GAG GAG TTT GAG AGT TT - #G CAG AAG CAG GAG GTG 768 Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - AAG AAC TTG CAC CAG CGT CTG GAA GGG CAA CG - #G CCA GAG AAC AAG GGC 816 Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - AAG AAC CGC TAC AAG AAC ATT CTC CCC TTT GA - #C CAC AGC CGA GTG ATC 864 Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - CTG CAG GGA CGG GAC AGT AAC ATC CCC GGG TC - #C GAC TAC ATC AAT GCC 912 Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - AAC TAC ATC AAG AAC CAG CTG CTA GGC CCT GA - #T GAG AAC GCT AAG ACC 960 Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - TAC ATC GCC AGC CAG GGC TGT CTG GAG GCC AC - #G GTC AAT GAC TTC TGG 1008 Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - CAG ATG GCG TGG CAG GAG AAC AGC CGT GTC AT - #C GTC ATG ACC ACC CGA 1056 Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - GAG GTG GAG AAA GGC CGG AAC AAA TGC GTC CC - #A TAC TGG CCC GAG GTG 1104 Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - GGC ATG CAG CGT GCT TAT GGG CCC TAC TCT GT - #G ACC AAC TGC GGG GAG 1152 Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - CAT GAC ACA ACC GAA TAC AAA CTC CGT ACC TT - #A CAG GTC TCC CCG CTG 1200 His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - GAC AAT GGA GAC CTG ATT CGG GAG ATC TGG CA - #T TAC CAG TAC CTG AGC 1248 Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - TGG CCC GAC CAT GGG GTC CCC AGT GAG CCT GG - #G GGT GTC CTC AGC TTC 1296 Trp Pro Asp His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - CTG GAC CAG ATC AAC CAG CGG CAG GAA AGT CT - #G CCT CAC GCA GGG CCC 1344 Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - ATC ATC GTG CAC TGC AGC GCC GGC ATC GGC CG - #C ACA GGC ACC ATC ATT 1392 Ile Ile Val His Cys Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - GTC ATC GAC ATG CTC ATG GAG AAC ATC TCC AC - #C AAG GGC CTG GAC TGT 1440 Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - GAC ATT GAC ATC CAG AAG ACC ATC CAG ATG GT - #G CGG GCG CAG CGC TCG 1488 Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - GGC ATG GTG CAG ACG GAG GCG CAG TAC AAG TT - #C ATC TAC GTG GCC ATC 1536 Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - GCC CAG TTC ATT GAA ACC ACT AAG AAG AAG CT - #G GAG GTC CTG CAG TCG 1584 Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - CAG AAG GGC CAG GAG TCG GAG TAC GGG AAC AT - #C ACC TAT CCC CCA GCC 1632 Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - ATG AAG AAT GCC CAT GCC AAG GCC TCC CGC AC - #C TCG TCC AAA CAC AAG 1680 Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - GAG GAT GTG TAT GAG AAC CTG CAC ACT AAG AA - #C AAG AGG GAG GAG AAA 1728 Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - GTG AAG AAG CAG CGG TCA GCA GAC AAG GAG AA - #G AGC AAG GGT TCC CTC 1776 Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - AAG AGG AAG TGA - # - # - # 1788 Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:8: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 595 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:8: - - Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Arg Pro Ser 20 - # 25 - # 30 - - Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - Val Thr His Ile Arg Ile Gln Asn Ser Gly As - #p Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu
385 3 - #90 3 - #95 4 - #00 - - Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - Trp Pro Asp His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - Ile Ile Val His Cys Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:9: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2526 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..2523 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:9: - - ATG TCA TCG CGA AGA TGG TTC CAC CCA ACG AT - #A TCT GGC ATC GAA GCT 48 Met Ser Ser Arg Arg Trp Phe His Pro Thr Il - #e Ser Gly Ile Glu Ala 1 5 - # 10 - # 15 - - GAG AAA CTG CTG CAG GAG CAG GGA TTC GAC GG - #C TCC TTC CTC GCC CGC 96 Glu Lys Leu Leu Gln Glu Gln Gly Phe Asp Gl - #y Ser Phe Leu Ala Arg 20 - # 25 - # 30 - - CTC TCC TCC TCG AAT CCG GGC GCC TTC ACG CT - #C TCC GTG CGC CGC GGC 144 Leu Ser Ser Ser Asn Pro Gly Ala Phe Thr Le - #u Ser Val Arg Arg Gly 35 - # 40 - # 45 - - AAC GAG GTG ACC CAC ATC AAA ATC CAA AAC AA - #T GGC GAC TTC TTT GAT 192 Asn Glu Val Thr His Ile Lys Ile Gln Asn As - #n Gly Asp Phe Phe Asp 50 - # 55 - # 60 - - CTC TAC GGT GGT GAA AAG TTC GCC ACA CTG CC - #G GAA CTG GTA CAA TAC 240 Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Pr - #o Glu Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - TAC ATG GAG AAT GGC GAG CTA AAG GAG AAG AA - #C GGC CAG GCC ATC GAA 288 Tyr Met Glu Asn Gly Glu Leu Lys Glu Lys As - #n Gly Gln Ala Ile Glu 85 - # 90 - # 95 - - CTC AAG CAG CCG CTG ATC TGC GCC GAG CCC AC - #C ACG GAA AGA TGG TTT 336 Leu Lys Gln Pro Leu Ile Cys Ala Glu Pro Th - #r Thr Glu Arg Trp Phe 100 - # 105 - # 110 - - CAT GGC AAT CTT TCC GGA AAG GAA GCG GAA AA - #A TTG ATC CTG GAG CGG 384 His Gly Asn Leu Ser Gly Lys Glu Ala Glu Ly - #s Leu Ile Leu Glu Arg 115 - # 120 - # 125 - - GGC AAG AAT GGT TCG TTT CTC GTC CGT GAA TC - #T CAG AGC AAG CCT GGC 432 Gly Lys Asn Gly Ser Phe Leu Val Arg Glu Se - #r Gln Ser Lys Pro Gly 130 - # 135 - # 140 - - GAC TTC GTC CTT TCC GTG CGC ACG GAC GAC AA - #A GTA ACG CAT GTC ATG 480 Asp Phe Val Leu Ser Val Arg Thr Asp Asp Ly - #s Val Thr His Val Met 145 1 - #50 1 - #55 1 - #60 - - ATT CGA TGG CAG GAC AAG AAG TAC GAC GTC GG - #C GGC GGG GAA TCC TTT 528 Ile Arg Trp Gln Asp Lys Lys Tyr Asp Val Gl - #y Gly Gly Glu Ser Phe 165 - # 170 - # 175 - - GGC ACC TTG TCG GAA CTG ATC GAT CAC TAC AA - #G CGT AAT CCC ATG GTG 576 Gly Thr Leu Ser Glu Leu Ile Asp His Tyr Ly - #s Arg Asn Pro Met Val 180 - # 185 - # 190 - - GAG ACG TGC GGA ACC GTG GTG CAT CTG CGA CA - #G CCA TTC AAC GCC ACA 624 Glu Thr Cys Gly Thr Val Val His Leu Arg Gl - #n Pro Phe Asn Ala Thr 195 - # 200 - # 205 - - CGA ATC ACG GCG GCC GGC ATC AAT GCC CGG GT - #G GAA CAG CTG GTC AAG 672 Arg Ile Thr Ala Ala Gly Ile Asn Ala Arg Va - #l Glu Gln Leu Val Lys 210 - # 215 - # 220 - - GGA GGT TTC TGG GAG GAA TTC GAA TCG CTG CA - #A CAG GAC AGT CGG GAC 720 Gly Gly Phe Trp Glu Glu Phe Glu Ser Leu Gl - #n Gln Asp Ser Arg Asp 225 2 - #30 2 - #35 2 - #40 - - ACA TTC TCG CGC AAC GAG GGC TAC AAA CAG GA - #G AAC CGC CTC AAG AAT 768 Thr Phe Ser Arg Asn Glu Gly Tyr Lys Gln Gl - #u Asn Arg Leu Lys Asn 245 - # 250 - # 255 - - CGC TAC CGC AAC ATA TTG CCA TAC GAC CAC AC - #G CGC GTC AAG CTG CTG 816 Arg Tyr Arg Asn Ile Leu Pro Tyr Asp His Th - #r Arg Val Lys Leu Leu 260 - # 265 - # 270 - - GAC GTG GAG CAT AGC GTG GCC GGA GCC GAG TA - #C ATC AAT GCC AAC TAC 864 Asp Val Glu His Ser Val Ala Gly Ala Glu Ty - #r Ile Asn Ala Asn Tyr 275 - # 280 - # 285 - - ATA CGG CTG CCC ACC GAC GGC GAC CTG TAC AA - #C ATG AGC AGC TCG TCG 912 Ile Arg Leu Pro Thr Asp Gly Asp Leu Tyr As - #n Met Ser Ser Ser Ser 290 - # 295 - # 300 - - GAG AGC CTG AAC AGC TCG GTG CCC TCG TGC CC - #C GCC TGC ACG GCT GCC 960 Glu Ser Leu Asn Ser Ser Val Pro Ser Cys Pr - #o Ala Cys Thr Ala Ala 305 3 - #10 3 - #15 3 - #20 - - CAG ACA CAG CGG AAC TGC TCC AAC TGC CAG CT - #G CAA AAC AAG ACG TGC 1008 Gln Thr Gln Arg Asn Cys Ser Asn Cys Gln Le - #u Gln Asn Lys Thr Cys 325 - # 330 - # 335 - - GTG CAG TGC GCC GTG AAG AGC GCC ATT CTG CC - #G TAT AGC AAC TGT GCC 1056 Val Gln Cys Ala Val Lys Ser Ala Ile Leu Pr - #o Tyr Ser Asn Cys Ala 340 - # 345 - # 350 - - ACC TGC AGC CGC AAG TCA GAC TCC CTG AGC AA - #G CAC AAG CGG AGC GAA 1104 Thr Cys Ser Arg Lys Ser Asp Ser Leu Ser Ly - #s His Lys Arg Ser Glu 355 - # 360 - # 365 - - TCC TCG GCC TCT TCA TCG CCC TCC TCC GGC TC - #T GGG TCC GGA CCA GGA 1152 Ser Ser Ala Ser Ser Ser Pro Ser Ser Gly Se - #r Gly Ser Gly Pro Gly 370 - # 375 - # 380 - - TCG TCG GGC ACC AGC GGA GTG AGC AGC GTC AA - #T GGA CCC GGC ACA CCC 1200 Ser Ser Gly Thr Ser Gly Val Ser Ser Val As - #n Gly Pro Gly Thr Pro 385 3 - #90 3 - #95 4 - #00 - - ACC AAT CTC ACG AGC GGC ACA GCC GGA TGT CT - #G GTC GGC CTG CTG AAG 1248 Thr Asn Leu Thr Ser Gly Thr Ala Gly Cys Le - #u Val Gly Leu Leu Lys 405 - # 410 - # 415 - - AGA CAC TCG AAC GAC TCG TCC GGA GCT GTT TC - #T ATA TCG ATG GCC GAA 1296 Arg His Ser Asn Asp Ser Ser Gly Ala Val Se - #r Ile Ser Met Ala Glu 420 - # 425 - # 430 - - CGG GAA CGC GAG AGG GAG CGC GAG ATG TTT AA - #G ACC TAC ATC GCC ACC 1344 Arg Glu Arg Glu Arg Glu Arg Glu Met Phe Ly - #s Thr Tyr Ile Ala Thr 435 - # 440 - # 445 - - CAG GGC TGT CTG CTC ACC CAG CAA GTG AAC AC - #G GTG ACG GAC TTC TGG 1392 Gln Gly Cys Leu Leu Thr Gln Gln Val Asn Th - #r Val Thr Asp Phe Trp 450 - # 455 - # 460 - - AAC ATG GTC TGG CAG GAG AAC ACG CGG GTG AT - #C GTC ATG ACC ACC AAG 1440 Asn Met Val Trp Gln Glu Asn Thr Arg Val Il - #e Val Met Thr Thr Lys 465 4 - #70 4 - #75 4 - #80 - - GAG TAC GAG CGC GGC AAA GAA AAG TGC GCC CG - #C TAC TGG CCG GAC GAG 1488 Glu Tyr Glu Arg Gly Lys Glu Lys Cys Ala Ar - #g Tyr Trp Pro Asp Glu 485 - # 490 - # 495 - - GGT AGA TCG GAG CAG TTC GGC CAC GCG CGG AT - #A CAG TGC GTC TCG GAG 1536 Gly Arg Ser Glu Gln Phe Gly His Ala Arg Il - #e Gln Cys Val Ser Glu 500 - # 505 - # 510 - - AAC TCG ACC AGT GAC TAT ACG CTG CGC GAG TT - #C CTC GTC TCG TGG CGG 1584 Asn Ser Thr Ser Asp Tyr Thr Leu Arg Glu Ph - #e Leu Val Ser Trp Arg 515 - # 520 - # 525 - - GAT CAG CCG GCG CGC CGG ATC TTT CAC TAC CA - #T TTC CAG GTG TGG CCG 1632 Asp Gln Pro Ala Arg Arg Ile Phe His Tyr Hi - #s Phe Gln Val Trp Pro 530 - # 535 - # 540 - - GAT CAC GGA GTG CCC GCC GAT CCG GGC TGT GT - #G CTC AAC TTC CTG CAA 1680 Asp His Gly Val Pro Ala Asp Pro Gly Cys Va - #l Leu Asn Phe Leu Gln 545 5 - #50 5 - #55 5 - #60 - - GAT GTC AAC ACG CGT CAG AGT CAC CTG GCT CA - #A GCG GGC GAG AAG CCG 1728 Asp Val Asn Thr Arg Gln Ser His Leu Ala Gl - #n Ala Gly Glu Lys Pro 565 - # 570 - # 575 - - GGT CCG ATC TGC GTG CAC TGC TCT GCG GGC AT - #C GGT CGC ACT GGC ACC 1776 Gly Pro Ile Cys Val His Cys Ser Ala Gly Il - #e Gly Arg Thr Gly Thr 580 - # 585 - # 590 - - TTT ATT GTG ATC GAT ATG ATT CTC GAT CAG AT - #T GTG CGC AAT GGA TTG 1824 Phe Ile Val Ile Asp Met Ile Leu Asp Gln Il - #e Val Arg Asn Gly Leu 595 - # 600 - # 605 - - GAT ACT GAA ATC GAC ATC CAG CGC ACC ATT CA - #G ATG GTC CGA TCG CAG 1872 Asp Thr Glu Ile Asp Ile Gln Arg Thr Ile Gl - #n Met Val Arg Ser Gln 610 - # 615 - # 620 - - CGT TCC GGT CTT GTG CAA ACC GAG GCG CAA TA - #C AAG TTC GTC TAC TAT 1920 Arg Ser Gly Leu Val Gln Thr Glu Ala Gln Ty - #r Lys Phe Val Tyr Tyr 625 6 - #30 6 - #35 6 - #40 - - GCG GTG CAG CAC TAT ATA CAG ACC CTG ATC GC - #C CGG AAA CGA GCT GAG 1968 Ala Val Gln His Tyr Ile Gln Thr Leu Ile Al - #a Arg Lys Arg Ala Glu 645 - # 650 - # 655 - - GAG CAG AGC CTG CAG GTT GGC CGC GAG TAC AC - #C AAT ATA AAG TAC ACG 2016 Glu Gln Ser Leu Gln Val Gly Arg Glu Tyr Th - #r Asn Ile Lys Tyr Thr 660 - # 665 - # 670 - - GGC GAA ATT GGA AAC GAT TCA CAA AGA TCT CC - #A TTA CCA CCA GCA ATT 2064 Gly Glu Ile Gly Asn Asp Ser Gln Arg Ser Pr - #o Leu Pro Pro Ala Ile 675 - # 680 - # 685 - - TCT AGC ATA AGT TTA GTT CCG AGT AAG ACG CC - #A CTG ACG CCG ACA TCG 2112 Ser Ser Ile Ser Leu Val Pro Ser Lys Thr Pr - #o Leu Thr Pro Thr Ser 690 - # 695 - # 700 - - GCG GAT TTG GGC ACT GGG ATG GGC CTA AGC AT - #G GGC GTG GGC ATG GGC 2160 Ala Asp Leu Gly Thr Gly Met Gly Leu Ser Me - #t Gly Val Gly Met Gly 705 7 - #10 7 - #15 7 - #20 - - GTC GGC AAC AAG CAC GCA TCG AAG CAG CAG CC - #G CCG TTG CCG GTG GTC 2208 Val Gly Asn Lys His Ala Ser Lys Gln Gln Pr - #o Pro Leu Pro Val Val 725 - # 730 - # 735 - - AAC TGC AAC AAT AAT AAC AAC GGC ATT GGC AA - #T AGC GGC TGC AGC AAC 2256 Asn Cys Asn Asn Asn Asn Asn Gly Ile Gly As - #n Ser Gly Cys Ser Asn 740 - # 745 - # 750 - - GGC GGC GGG AGC AGC ACC ACC AGC AGC AGC AA - #C GGC AGC AGC AAC GGT 2304 Gly Gly Gly Ser Ser Thr Thr Ser Ser Ser As - #n Gly Ser Ser Asn Gly 755 - # 760 - # 765 - - AAC ATC AAC GCC CTA CTG GGC GGC ATC GGC TT - #G GGG CTG GGC GGC AAT 2352 Asn Ile Asn Ala Leu Leu Gly Gly Ile Gly Le - #u Gly Leu Gly Gly Asn 770 - # 775 - # 780 - - ATG CGC AAG TCG AAC TTT TAC AGC GAC TCG CT - #G AAG CAG CAA CAG CAG 2400 Met Arg Lys Ser Asn Phe Tyr Ser Asp Ser Le - #u Lys Gln Gln Gln Gln 785 7 - #90 7 - #95 8 - #00 - - CGC GAG GAG CAG GCT CCG GCG GGA GCA GCA AA - #A TTC AAA AAC ATT CCC 2448 Arg Glu Glu Gln Ala Pro Ala Gly Ala Ala Ly - #s Phe Lys Asn Ile Pro
805 - # 810 - # 815 - - AAA GAC ATG ATC GGC TTG CGA CCG CCA AGC CA - #T GCG CCT GCG TTG CCG 2496 Lys Asp Met Ile Gly Leu Arg Pro Pro Ser Hi - #s Ala Pro Ala Leu Pro 820 - # 825 - # 830 - - CCG CCA CCG ACA CCG CCG CGC AAA ACA TGA - # - # 2526 Pro Pro Pro Thr Pro Pro Arg Lys Thr 835 - # 840 - - - - (2) INFORMATION FOR SEQ ID NO:10: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 841 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:10: - - Met Ser Ser Arg Arg Trp Phe His Pro Thr Il - #e Ser Gly Ile Glu Ala 1 5 - # 10 - # 15 - - Glu Lys Leu Leu Gln Glu Gln Gly Phe Asp Gl - #y Ser Phe Leu Ala Arg 20 - # 25 - # 30 - - Leu Ser Ser Ser Asn Pro Gly Ala Phe Thr Le - #u Ser Val Arg Arg Gly 35 - # 40 - # 45 - - Asn Glu Val Thr His Ile Lys Ile Gln Asn As - #n Gly Asp Phe Phe Asp 50 - # 55 - # 60 - - Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Pr - #o Glu Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - Tyr Met Glu Asn Gly Glu Leu Lys Glu Lys As - #n Gly Gln Ala Ile Glu 85 - # 90 - # 95 - - Leu Lys Gln Pro Leu Ile Cys Ala Glu Pro Th - #r Thr Glu Arg Trp Phe 100 - # 105 - # 110 - - His Gly Asn Leu Ser Gly Lys Glu Ala Glu Ly - #s Leu Ile Leu Glu Arg 115 - # 120 - # 125 - - Gly Lys Asn Gly Ser Phe Leu Val Arg Glu Se - #r Gln Ser Lys Pro Gly 130 - # 135 - # 140 - - Asp Phe Val Leu Ser Val Arg Thr Asp Asp Ly - #s Val Thr His Val Met 145 1 - #50 1 - #55 1 - #60 - - Ile Arg Trp Gln Asp Lys Lys Tyr Asp Val Gl - #y Gly Gly Glu Ser Phe 165 - # 170 - # 175 - - Gly Thr Leu Ser Glu Leu Ile Asp His Tyr Ly - #s Arg Asn Pro Met Val 180 - # 185 - # 190 - - Glu Thr Cys Gly Thr Val Val His Leu Arg Gl - #n Pro Phe Asn Ala Thr 195 - # 200 - # 205 - - Arg Ile Thr Ala Ala Gly Ile Asn Ala Arg Va - #l Glu Gln Leu Val Lys 210 - # 215 - # 220 - - Gly Gly Phe Trp Glu Glu Phe Glu Ser Leu Gl - #n Gln Asp Ser Arg Asp 225 2 - #30 2 - #35 2 - #40 - - Thr Phe Ser Arg Asn Glu Gly Tyr Lys Gln Gl - #u Asn Arg Leu Lys Asn 245 - # 250 - # 255 - - Arg Tyr Arg Asn Ile Leu Pro Tyr Asp His Th - #r Arg Val Lys Leu Leu 260 - # 265 - # 270 - - Asp Val Glu His Ser Val Ala Gly Ala Glu Ty - #r Ile Asn Ala Asn Tyr 275 - # 280 - # 285 - - Ile Arg Leu Pro Thr Asp Gly Asp Leu Tyr As - #n Met Ser Ser Ser Ser 290 - # 295 - # 300 - - Glu Ser Leu Asn Ser Ser Val Pro Ser Cys Pr - #o Ala Cys Thr Ala Ala 305 3 - #10 3 - #15 3 - #20 - - Gln Thr Gln Arg Asn Cys Ser Asn Cys Gln Le - #u Gln Asn Lys Thr Cys 325 - # 330 - # 335 - - Val Gln Cys Ala Val Lys Ser Ala Ile Leu Pr - #o Tyr Ser Asn Cys Ala 340 - # 345 - # 350 - - Thr Cys Ser Arg Lys Ser Asp Ser Leu Ser Ly - #s His Lys Arg Ser Glu 355 - # 360 - # 365 - - Ser Ser Ala Ser Ser Ser Pro Ser Ser Gly Se - #r Gly Ser Gly Pro Gly 370 - # 375 - # 380 - - Ser Ser Gly Thr Ser Gly Val Ser Ser Val As - #n Gly Pro Gly Thr Pro 385 3 - #90 3 - #95 4 - #00 - - Thr Asn Leu Thr Ser Gly Thr Ala Gly Cys Le - #u Val Gly Leu Leu Lys 405 - # 410 - # 415 - - Arg His Ser Asn Asp Ser Ser Gly Ala Val Se - #r Ile Ser Met Ala Glu 420 - # 425 - # 430 - - Arg Glu Arg Glu Arg Glu Arg Glu Met Phe Ly - #s Thr Tyr Ile Ala Thr 435 - # 440 - # 445 - - Gln Gly Cys Leu Leu Thr Gln Gln Val Asn Th - #r Val Thr Asp Phe Trp 450 - # 455 - # 460 - - Asn Met Val Trp Gln Glu Asn Thr Arg Val Il - #e Val Met Thr Thr Lys 465 4 - #70 4 - #75 4 - #80 - - Glu Tyr Glu Arg Gly Lys Glu Lys Cys Ala Ar - #g Tyr Trp Pro Asp Glu 485 - # 490 - # 495 - - Gly Arg Ser Glu Gln Phe Gly His Ala Arg Il - #e Gln Cys Val Ser Glu 500 - # 505 - # 510 - - Asn Ser Thr Ser Asp Tyr Thr Leu Arg Glu Ph - #e Leu Val Ser Trp Arg 515 - # 520 - # 525 - - Asp Gln Pro Ala Arg Arg Ile Phe His Tyr Hi - #s Phe Gln Val Trp Pro 530 - # 535 - # 540 - - Asp His Gly Val Pro Ala Asp Pro Gly Cys Va - #l Leu Asn Phe Leu Gln 545 5 - #50 5 - #55 5 - #60 - - Asp Val Asn Thr Arg Gln Ser His Leu Ala Gl - #n Ala Gly Glu Lys Pro 565 - # 570 - # 575 - - Gly Pro Ile Cys Val His Cys Ser Ala Gly Il - #e Gly Arg Thr Gly Thr 580 - # 585 - # 590 - - Phe Ile Val Ile Asp Met Ile Leu Asp Gln Il - #e Val Arg Asn Gly Leu 595 - # 600 - # 605 - - Asp Thr Glu Ile Asp Ile Gln Arg Thr Ile Gl - #n Met Val Arg Ser Gln 610 - # 615 - # 620 - - Arg Ser Gly Leu Val Gln Thr Glu Ala Gln Ty - #r Lys Phe Val Tyr Tyr 625 6 - #30 6 - #35 6 - #40 - - Ala Val Gln His Tyr Ile Gln Thr Leu Ile Al - #a Arg Lys Arg Ala Glu 645 - # 650 - # 655 - - Glu Gln Ser Leu Gln Val Gly Arg Glu Tyr Th - #r Asn Ile Lys Tyr Thr 660 - # 665 - # 670 - - Gly Glu Ile Gly Asn Asp Ser Gln Arg Ser Pr - #o Leu Pro Pro Ala Ile 675 - # 680 - # 685 - - Ser Ser Ile Ser Leu Val Pro Ser Lys Thr Pr - #o Leu Thr Pro Thr Ser 690 - # 695 - # 700 - - Ala Asp Leu Gly Thr Gly Met Gly Leu Ser Me - #t Gly Val Gly Met Gly 705 7 - #10 7 - #15 7 - #20 - - Val Gly Asn Lys His Ala Ser Lys Gln Gln Pr - #o Pro Leu Pro Val Val 725 - # 730 - # 735 - - Asn Cys Asn Asn Asn Asn Asn Gly Ile Gly As - #n Ser Gly Cys Ser Asn 740 - # 745 - # 750 - - Gly Gly Gly Ser Ser Thr Thr Ser Ser Ser As - #n Gly Ser Ser Asn Gly 755 - # 760 - # 765 - - Asn Ile Asn Ala Leu Leu Gly Gly Ile Gly Le - #u Gly Leu Gly Gly Asn 770 - # 775 - # 780 - - Met Arg Lys Ser Asn Phe Tyr Ser Asp Ser Le - #u Lys Gln Gln Gln Gln 785 7 - #90 7 - #95 8 - #00 - - Arg Glu Glu Gln Ala Pro Ala Gly Ala Ala Ly - #s Phe Lys Asn Ile Pro 805 - # 810 - # 815 - - Lys Asp Met Ile Gly Leu Arg Pro Pro Ser Hi - #s Ala Pro Ala Leu Pro 820 - # 825 - # 830 - - Pro Pro Pro Thr Pro Pro Arg Lys Thr 835 - # 840 - - - - (2) INFORMATION FOR SEQ ID NO:11: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1782 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1779 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:11: - - ATG ACA TCG CGG AGA TGG TTT CAC CCA AAT AT - #C ACT GGT GTG GAG GCA 48 Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - GAA AAC CTA CTG TTG ACA AGA GGA GTT GAT GG - #C AGT TTT TTG GCA AGG 96 Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Arg 20 - # 25 - # 30 - - CCT AGT AAA AGT AAC CCT GGA GAC TTC ACA CT - #T TCC GTT AGA AGA AAT 144 Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - GGA GCT GTC ACC CAC ATC AAG ATT CAG AAC AC - #T GGT GCT TAC TAT GAC 192 Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Ala Tyr Tyr Asp 50 - # 55 - # 60 - - CTG TAT GGA GGG GAG AAA TTT GCC ACT TTG GC - #T GAG TTG GTC CAG TAT 240 Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Glu Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - TAC ATG GAA CAT CAC GGG CAA TTA AAA GAG AA - #G AAT GGA GAT GTC ATT 288 Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - GAG CTT AAA TAT CCT CTG AAC TGT GCA GAT CC - #T ACC TCT GAA AGG TGG 336 Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - TTT CAT GGA CAT CTC TCT GGG AAA GAA GCA GA - #G AAA TTA TTA ACT GAA 384 Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - AAA GGA AAA CAT GGT AGT TTT CTT GTA CGA GA - #G AGC CAG AGC CAC CCT 432 Lys Gly Lys His Gly Ser Phe Leu Val Arg Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - GGA GAT TTT GTT CTT TCT GTG CGC ACT GGT GA - #T GAC AAA GGG GAG AGC 480 Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - AAT GAC GGC AAG TCT AAA GTG ACC CAT GTT AT - #G ATT CGC TGT CAG GAA 528 Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - CTG AAA TAC GAC GTT GGT GGA GGA GAA CGG TT - #T GAT TCT TTG ACA GAT 576 Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - CTT GTG GAA CAT TAT AAG AAG AAT CCT ATG GT - #G GAA ACA TTG GGT ACA 624 Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - GTA CTA CAA CTC AAG CAG CCC CTT AAC ACG AC - #T CGT ATA AAT GCT GCT 672 Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - GAA ATA GAA AGC AGA GTT CGA GAA CTA AGC AA - #A TTA GCT GAG ACC ACA 720 Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - GAT AAA GTC AAA CAA GGC TTT TGG GAA GAA TT - #T GAG ACA CTA CAA CAA 768 Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - CAG GAG TGC AAA CTT CTC TAC AGC CGA AAA GA - #G GGT CAA AGG CAA GAA 816 Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - AAC AAA AAC AAA AAT AGA TAT AAA AAC ATC CT - #G CCC TTT GAT CAT ACC 864 Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - AGG GTT GTC CTA CAC GAT GGT GAT CCC AAT GA - #G CCT GTT TCA GAT TAC 912 Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - ATC AAT GCA AAT ATC ATC ATG CCT GAA TTT GA - #A ACC AAG TGC AAC AAT 960 Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - TCA AAG CCC AAA AAG AGT TAC ATT GCC ACA CA - #A GGC TGC CTG CAA AAC 1008 Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - ACG GTG AAT GAC TTT TGG CGG ATG GTG TTC CA - #A GAA AAC TCC CGA GTG 1056 Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - ATT GTC ATG ACA ACG AAA GAA GTG GAG AGA GG - #A AAG AGT AAA TGT GTC 1104 Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - AAA TAC TGG CCT GAT GAG TAT GCT CTA AAA GA - #A TAT GGC GTC ATG CGT 1152 Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - GTT AGG AAC GTC AAA GAA AGC GCC GCT CAT GA - #C TAT ACG CTA AGA GAA 1200 Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - CTT AAA CTT TCA AAG GTT GGA CAA GGG AAT AC - #G GAG AGA ACG GTC
TGG 1248 Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - CAA TAC CAC TTT CGG ACC TGG CCG GAC CAC GG - #C GTG CCC AGC GAC CCT 1296 Gln Tyr His Phe Arg Thr Trp Pro Asp His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - GGG GGC GTG CTG GAC TTC CTG GAG GAG GTG CA - #C CAT AAG CAG GAG AGC 1344 Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - ATC ATG GAT GCA GGG CCG GTC GTG GTG CAC TG - #C AGT GCT GGA ATT GGC 1392 Ile Met Asp Ala Gly Pro Val Val Val His Cy - #s Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - CGG ACA GGG ACG TTC ATT GTG ATT GAT ATT CT - #T ATT GAC ATC ATC AGA 1440 Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - GAG AAA GGT GTT GAC TGC GAT ATT GAC GTT CC - #C AAA ACC ATC CAG ATG 1488 Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - GTG CGG TCT CAG AGG TCA GGG ATG GTC CAG AC - #A GAA GCA CAG TAC CGA 1536 Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - TTT ATC TAT ATG GCG GTC CAG CAT TAT ATT GA - #A ACA CTA CAG CGC AGG 1584 Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - ATT GAA GAA GAG CAG AAA AGC AAG AGG AAA GG - #G CAC GAA TAT ACA AAT 1632 Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - ATT AAG TAT TCT CTA GCG GAC CAG ACG AGT GG - #A GAT CAG AGC CCT CTC 1680 Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - CCG CCT TGT ACT CCA ACG CCA CCC TGT GCA GA - #A ATG AGA GAA GAC AGT 1728 Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - GCT AGA GTC TAT GAA AAC GTG GGC CTG ATG CA - #A CAG CAG AAA AGT TTC 1776 Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - AGA TGA - # - # - # 1782 Arg - - - - (2) INFORMATION FOR SEQ ID NO:12: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 593 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:12: - - Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Arg 20 - # 25 - # 30 - - Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Ala Tyr Tyr Asp 50 - # 55 - # 60 - - Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Glu Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - Lys Gly Lys His Gly Ser Phe Leu Val Arg Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - Gln Tyr His Phe Arg Thr Trp Pro Asp His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - Ile Met Asp Ala Gly Pro Val Val Val His Cy - #s Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - Arg - - - - (2) INFORMATION FOR SEQ ID NO:13: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1782 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1779 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:13: - - ATG ACA TCG CGG AGA TGG TTT CAC CCA AAT AT - #C ACT GGT GTG GAG GCA 48 Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - GAA AAC CTA CTG TTG ACA AGA GGA GTT GAT GG - #C AGT TTT TTG GCA AGG 96 Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Arg 20 - # 25 - # 30 - - CCT AGT AAA AGT AAC CCT GGA GAC TTC ACA CT - #T TCC GTT AGA AGA AAT 144 Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - GGA GCT GTC ACC CAC ATC AAG ATT CAG AAC AC - #T GGT GCT TAC TAT GAC 192 Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Ala Tyr Tyr Asp 50 - # 55 - # 60 - - CTG TAT GGA GGG GAG AAA TTT GCC ACT TTG GC - #T GAG TTG GTC CAG TAT 240 Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Glu Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - TAC ATG GAA CAT CAC GGG CAA TTA AAA GAG AA - #G AAT GGA GAT GTC ATT 288 Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - GAG CTT AAA TAT CCT CTG AAC TGT GCA GAT CC - #T ACC TCT GAA AGG TGG 336 Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - TTT CAT GGA CAT CTC TCT GGG AAA GAA GCA GA - #G AAA TTA TTA ACT GAA 384 Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - AAA GGA AAA CAT GGT AGT TTT CTT GTA CGA GA - #G AGC CAG AGC CAC CCT 432 Lys Gly Lys His Gly Ser Phe Leu Val Arg Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - GGA GAT TTT GTT CTT TCT GTG CGC ACT GGT GA - #T GAC AAA GGG GAG AGC 480 Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - AAT GAC GGC AAG TCT AAA GTG ACC CAT GTT AT - #G ATT CGC TGT CAG GAA 528 Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - CTG AAA TAC GAC GTT GGT GGA GGA GAA CGG TT - #T GAT TCT TTG ACA GAT 576 Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - CTT GTG GAA CAT TAT AAG AAG AAT CCT ATG GT - #G GAA ACA TTG GGT ACA 624 Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - GTA CTA CAA CTC AAG CAG CCC CTT AAC ACG AC - #T CGT ATA AAT GCT GCT 672 Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - GAA ATA GAA AGC AGA GTT CGA GAA CTA AGC AA - #A TTA GCT GAG ACC ACA 720 Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - GAT AAA GTC AAA CAA GGC TTT TGG GAA GAA TT - #T GAG ACA CTA CAA CAA 768 Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - CAG GAG TGC AAA CTT CTC TAC AGC CGA AAA GA - #G GGT CAA AGG CAA GAA 816 Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - AAC AAA AAC AAA AAT AGA TAT AAA AAC ATC CT - #G CCC TTT GAT CAT ACC 864 Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - AGG GTT GTC CTA CAC GAT GGT GAT CCC AAT GA - #G CCT GTT TCA GAT TAC 912 Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - ATC AAT GCA AAT ATC ATC ATG CCT GAA TTT GA - #A ACC AAG TGC AAC AAT 960 Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - TCA AAG CCC AAA AAG AGT TAC ATT GCC ACA CA - #A GGC TGC CTG CAA AAC 1008 Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - ACG GTG AAT GAC TTT TGG CGG ATG GTG TTC CA - #A GAA AAC TCC CGA GTG 1056 Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - ATT GTC ATG ACA ACG AAA GAA GTG GAG AGA GG - #A AAG AGT AAA TGT GTC 1104 Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - AAA TAC TGG CCT GAT GAG TAT GCT CTA AAA GA - #A TAT GGC GTC ATG CGT 1152 Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg
370 - # 375 - # 380 - - GTT AGG AAC GTC AAA GAA AGC GCC GCT CAT GA - #C TAT ACG CTA AGA GAA 1200 Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - CTT AAA CTT TCA AAG GTT GGA CAA GGG AAT AC - #G GAG AGA ACG GTC TGG 1248 Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - CAA TAC CAC TTT CGG ACC TGG CCG GAC CAC GG - #C GTG CCC AGC GAC CCT 1296 Gln Tyr His Phe Arg Thr Trp Pro Asp His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - GGG GGC GTG CTG GAC TTC CTG GAG GAG GTG CA - #C CAT AAG CAG GAG AGC 1344 Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - ATC ATG GAT GCA GGG CCG GTC GTG GTG CAC TC - #G AGT GCT GGA ATT GGC 1392 Ile Met Asp Ala Gly Pro Val Val Val His Se - #r Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - CGG ACA GGG ACG TTC ATT GTG ATT GAT ATT CT - #T ATT GAC ATC ATC AGA 1440 Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - GAG AAA GGT GTT GAC TGC GAT ATT GAC GTT CC - #C AAA ACC ATC CAG ATG 1488 Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - GTG CGG TCT CAG AGG TCA GGG ATG GTC CAG AC - #A GAA GCA CAG TAC CGA 1536 Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - TTT ATC TAT ATG GCG GTC CAG CAT TAT ATT GA - #A ACA CTA CAG CGC AGG 1584 Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - ATT GAA GAA GAG CAG AAA AGC AAG AGG AAA GG - #G CAC GAA TAT ACA AAT 1632 Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - ATT AAG TAT TCT CTA GCG GAC CAG ACG AGT GG - #A GAT CAG AGC CCT CTC 1680 Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - CCG CCT TGT ACT CCA ACG CCA CCC TGT GCA GA - #A ATG AGA GAA GAC AGT 1728 Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - GCT AGA GTC TAT GAA AAC GTG GGC CTG ATG CA - #A CAG CAG AAA AGT TTC 1776 Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - AGA TGA - # - # - # 1782 Arg - - - - (2) INFORMATION FOR SEQ ID NO:14: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 593 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:14: - - Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Arg 20 - # 25 - # 30 - - Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Ala Tyr Tyr Asp 50 - # 55 - # 60 - - Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Glu Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - Lys Gly Lys His Gly Ser Phe Leu Val Arg Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - Gln Tyr His Phe Arg Thr Trp Pro Asp His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - Ile Met Asp Ala Gly Pro Val Val Val His Se - #r Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - Arg - - - - (2) INFORMATION FOR SEQ ID NO:15: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1782 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1779 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:15: - - ATG ACA TCG CGG AGA TGG TTT CAC CCA AAT AT - #C ACT GGT GTG GAG GCA 48 Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - GAA AAC CTA CTG TTG ACA AGA GGA GTT GAT GG - #C AGT TTT TTG GCA AGG 96 Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Arg 20 - # 25 - # 30 - - CCT AGT AAA AGT AAC CCT GGA GAC TTC ACA CT - #T TCC GTT AGA AGA AAT 144 Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - GGA GCT GTC ACC CAC ATC AAG ATT CAG AAC AC - #T GGT GAT TAC TAT GAC 192 Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Asp Tyr Tyr Asp 50 - # 55 - # 60 - - CTG TAT GGA GGG GAG AAA TTT GCC ACT TTG GC - #T GCG TTG GTC CAG TAT 240 Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Ala Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - TAC ATG GAA CAT CAC GGG CAA TTA AAA GAG AA - #G AAT GGA GAT GTC ATT 288 Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - GAG CTT AAA TAT CCT CTG AAC TGT GCA GAT CC - #T ACC TCT GAA AGG TGG 336 Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - TTT CAT GGA CAT CTC TCT GGG AAA GAA GCA GA - #G AAA TTA TTA ACT GAA 384 Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - AAA GGA AAA CAT GGT AGT TTT CTT GTA CGA GA - #G AGC CAG AGC CAC CCT 432 Lys Gly Lys His Gly Ser Phe Leu Val Arg Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - GGA GAT TTT GTT CTT TCT GTG CGC ACT GGT GA - #T GAC AAA GGG GAG AGC 480 Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - AAT GAC GGC AAG TCT AAA GTG ACC CAT GTT AT - #G ATT CGC TGT CAG GAA 528 Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - CTG AAA TAC GAC GTT GGT GGA GGA GAA CGG TT - #T GAT TCT TTG ACA GAT 576 Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - CTT GTG GAA CAT TAT AAG AAG AAT CCT ATG GT - #G GAA ACA TTG GGT ACA 624 Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - GTA CTA CAA CTC AAG CAG CCC CTT AAC ACG AC - #T CGT ATA AAT GCT GCT 672 Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - GAA ATA GAA AGC AGA GTT CGA GAA CTA AGC AA - #A TTA GCT GAG ACC ACA 720 Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - GAT AAA GTC AAA CAA GGC TTT TGG GAA GAA TT - #T GAG ACA CTA CAA CAA 768 Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - CAG GAG TGC AAA CTT CTC TAC AGC CGA AAA GA - #G GGT CAA AGG CAA GAA 816 Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - AAC AAA AAC AAA AAT AGA TAT AAA AAC ATC CT - #G CCC TTT GAT CAT ACC 864 Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - AGG GTT GTC CTA CAC GAT GGT GAT CCC AAT GA - #G CCT GTT TCA GAT TAC 912 Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - ATC AAT GCA AAT ATC ATC ATG CCT GAA TTT GA - #A ACC AAG TGC AAC AAT 960 Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - TCA AAG CCC AAA AAG AGT TAC ATT GCC ACA CA - #A GGC TGC CTG CAA AAC 1008 Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - ACG GTG AAT GAC TTT TGG CGG ATG GTG TTC CA - #A GAA AAC TCC CGA GTG 1056 Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350
- - ATT GTC ATG ACA ACG AAA GAA GTG GAG AGA GG - #A AAG AGT AAA TGT GTC 1104 Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - AAA TAC TGG CCT GAT GAG TAT GCT CTA AAA GA - #A TAT GGC GTC ATG CGT 1152 Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - GTT AGG AAC GTC AAA GAA AGC GCC GCT CAT GA - #C TAT ACG CTA AGA GAA 1200 Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - CTT AAA CTT TCA AAG GTT GGA CAA GGG AAT AC - #G GAG AGA ACG GTC TGG 1248 Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - CAA TAC CAC TTT CGG ACC TGG CCG GAC CAC GG - #C GTG CCC AGC GAC CCT 1296 Gln Tyr His Phe Arg Thr Trp Pro Asp His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - GGG GGC GTG CTG GAC TTC CTG GAG GAG GTG CA - #C CAT AAG CAG GAG AGC 1344 Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - ATC ATG GAT GCA GGG CCG GTC GTG GTG CAC TC - #G AGT GCT GGA ATT GGC 1392 Ile Met Asp Ala Gly Pro Val Val Val His Se - #r Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - CGG ACA GGG ACG TTC ATT GTG ATT GAT ATT CT - #T ATT GAC ATC ATC AGA 1440 Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - GAG AAA GGT GTT GAC TGC GAT ATT GAC GTT CC - #C AAA ACC ATC CAG ATG 1488 Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - GTG CGG TCT CAG AGG TCA GGG ATG GTC CAG AC - #A GAA GCA CAG TAC CGA 1536 Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - TTT ATC TAT ATG GCG GTC CAG CAT TAT ATT GA - #A ACA CTA CAG CGC AGG 1584 Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - ATT GAA GAA GAG CAG AAA AGC AAG AGG AAA GG - #G CAC GAA TAT ACA AAT 1632 Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - ATT AAG TAT TCT CTA GCG GAC CAG ACG AGT GG - #A GAT CAG AGC CCT CTC 1680 Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - CCG CCT TGT ACT CCA ACG CCA CCC TGT GCA GA - #A ATG AGA GAA GAC AGT 1728 Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - GCT AGA GTC TAT GAA AAC GTG GGC CTG ATG CA - #A CAG CAG AAA AGT TTC 1776 Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - AGA TGA - # - # - # 1782 Arg - - - - (2) INFORMATION FOR SEQ ID NO:16: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 593 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:16: - - Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Arg 20 - # 25 - # 30 - - Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Asp Tyr Tyr Asp 50 - # 55 - # 60 - - Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Ala Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - Lys Gly Lys His Gly Ser Phe Leu Val Arg Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - Gln Tyr His Phe Arg Thr Trp Pro Asp His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - Ile Met Asp Ala Gly Pro Val Val Val His Se - #r Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - Arg - - - - (2) INFORMATION FOR SEQ ID NO:17: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1782 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1779 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:17: - - ATG ACA TCG CGG AGA TGG TTT CAC CCA AAT AT - #C ACT GGT GTG GAG GCA 48 Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - GAA AAC CTA CTG TTG ACA AGA GGA GTT GAT GG - #C AGT TTT TTG GCA AGG 96 Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Arg 20 - # 25 - # 30 - - CCT AGT AAA AGT AAC CCT GGA GAC TTC ACA CT - #T TCC GTT AGA AGA AAT 144 Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - GGA GCT GTC ACC CAC ATC AAG ATT CAG AAC AC - #T GGT GAT TAC TAT GAC 192 Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Asp Tyr Tyr Asp 50 - # 55 - # 60 - - CTG TAT GGA GGG GAG AAA TTT GCC ACT TTG GC - #T GCG TTG GTC CAG TAT 240 Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Ala Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - TAC ATG GAA CAT CAC GGG CAA TTA AAA GAG AA - #G AAT GGA GAT GTC ATT 288 Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - GAG CTT AAA TAT CCT CTG AAC TGT GCA GAT CC - #T ACC TCT GAA AGG TGG 336 Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - TTT CAT GGA CAT CTC TCT GGG AAA GAA GCA GA - #G AAA TTA TTA ACT GAA 384 Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - AAA GGA AAA CAT GGT AGT TTT CTT GTA CGA GA - #G AGC CAG AGC CAC CCT 432 Lys Gly Lys His Gly Ser Phe Leu Val Arg Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - GGA GAT TTT GTT CTT TCT GTG CGC ACT GGT GA - #T GAC AAA GGG GAG AGC 480 Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - AAT GAC GGC AAG TCT AAA GTG ACC CAT GTT AT - #G ATT CGC TGT CAG GAA 528 Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - CTG AAA TAC GAC GTT GGT GGA GGA GAA CGG TT - #T GAT TCT TTG ACA GAT 576 Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - CTT GTG GAA CAT TAT AAG AAG AAT CCT ATG GT - #G GAA ACA TTG GGT ACA 624 Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - GTA CTA CAA CTC AAG CAG CCC CTT AAC ACG AC - #T CGT ATA AAT GCT GCT 672 Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - GAA ATA GAA AGC AGA GTT CGA GAA CTA AGC AA - #A TTA GCT GAG ACC ACA 720 Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - GAT AAA GTC AAA CAA GGC TTT TGG GAA GAA TT - #T GAG ACA CTA CAA CAA 768 Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - CAG GAG TGC AAA CTT CTC TAC AGC CGA AAA GA - #G GGT CAA AGG CAA GAA 816 Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - AAC AAA AAC AAA AAT AGA TAT AAA AAC ATC CT - #G CCC TTT GAT CAT ACC 864 Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - AGG GTT GTC CTA CAC GAT GGT GAT CCC AAT GA - #G CCT GTT TCA GAT TAC 912 Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - ATC AAT GCA AAT ATC ATC ATG CCT GAA TTT GA - #A ACC AAG TGC AAC AAT 960 Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - TCA AAG CCC AAA AAG AGT TAC ATT GCC ACA CA - #A GGC TGC CTG CAA
AAC 1008 Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - ACG GTG AAT GAC TTT TGG CGG ATG GTG TTC CA - #A GAA AAC TCC CGA GTG 1056 Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - ATT GTC ATG ACA ACG AAA GAA GTG GAG AGA GG - #A AAG AGT AAA TGT GTC 1104 Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - AAA TAC TGG CCT GAT GAG TAT GCT CTA AAA GA - #A TAT GGC GTC ATG CGT 1152 Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - GTT AGG AAC GTC AAA GAA AGC GCC GCT CAT GA - #C TAT ACG CTA AGA GAA 1200 Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - CTT AAA CTT TCA AAG GTT GGA CAA GGG AAT AC - #G GAG AGA ACG GTC TGG 1248 Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - CAA TAC CAC TTT CGG ACC TGG CCG GCC CAC GG - #C GTG CCC AGC GAC CCT 1296 Gln Tyr His Phe Arg Thr Trp Pro Ala His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - GGG GGC GTG CTG GAC TTC CTG GAG GAG GTG CA - #C CAT AAG CAG GAG AGC 1344 Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - ATC ATG GAT GCA GGG CCG GTC GTG GTG CAC TG - #C AGT GCT GGA ATT GGC 1392 Ile Met Asp Ala Gly Pro Val Val Val His Cy - #s Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - CGG ACA GGG ACG TTC ATT GTG ATT GAT ATT CT - #T ATT GAC ATC ATC AGA 1440 Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - GAG AAA GGT GTT GAC TGC GAT ATT GAC GTT CC - #C AAA ACC ATC CAG ATG 1488 Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - GTG CGG TCT CAG AGG TCA GGG ATG GTC CAG AC - #A GAA GCA CAG TAC CGA 1536 Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - TTT ATC TAT ATG GCG GTC CAG CAT TAT ATT GA - #A ACA CTA CAG CGC AGG 1584 Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - ATT GAA GAA GAG CAG AAA AGC AAG AGG AAA GG - #G CAC GAA TAT ACA AAT 1632 Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - ATT AAG TAT TCT CTA GCG GAC CAG ACG AGT GG - #A GAT CAG AGC CCT CTC 1680 Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - CCG CCT TGT ACT CCA ACG CCA CCC TGT GCA GA - #A ATG AGA GAA GAC AGT 1728 Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - GCT AGA GTC TAT GAA AAC GTG GGC CTG ATG CA - #A CAG CAG AAA AGT TTC 1776 Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - AGA TGA - # - # - # 1782 Arg - - - - (2) INFORMATION FOR SEQ ID NO:18: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 593 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:18: - - Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Arg 20 - # 25 - # 30 - - Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Asp Tyr Tyr Asp 50 - # 55 - # 60 - - Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Ala Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - Lys Gly Lys His Gly Ser Phe Leu Val Arg Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - Gln Tyr His Phe Arg Thr Trp Pro Ala His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - Ile Met Asp Ala Gly Pro Val Val Val His Cy - #s Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - Arg - - - - (2) INFORMATION FOR SEQ ID NO:19: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1782 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1779 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:19: - - ATG ACA TCG CGG AGA TGG TTT CAC CCA AAT AT - #C ACT GGT GTG GAG GCA 48 Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - GAA AAC CTA CTG TTG ACA AGA GGA GTT GAT GG - #C AGT TTT TTG GCA AAG 96 Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Lys 20 - # 25 - # 30 - - CCT AGT AAA AGT AAC CCT GGA GAC TTC ACA CT - #T TCC GTT AGA AGA AAT 144 Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - GGA GCT GTC ACC CAC ATC AAG ATT CAG AAC AC - #T GGT GCT TAC TAT GAC 192 Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Ala Tyr Tyr Asp 50 - # 55 - # 60 - - CTG TAT GGA GGG GAG AAA TTT GCC ACT TTG GC - #T GAG TTG GTC CAG TAT 240 Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Glu Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - TAC ATG GAA CAT CAC GGG CAA TTA AAA GAG AA - #G AAT GGA GAT GTC ATT 288 Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - GAG CTT AAA TAT CCT CTG AAC TGT GCA GAT CC - #T ACC TCT GAA AGG TGG 336 Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - TTT CAT GGA CAT CTC TCT GGG AAA GAA GCA GA - #G AAA TTA TTA ACT GAA 384 Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - AAA GGA AAA CAT GGT AGT TTT CTT GTA AAA GA - #G AGC CAG AGC CAC CCT 432 Lys Gly Lys His Gly Ser Phe Leu Val Lys Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - GGA GAT TTT GTT CTT TCT GTG CGC ACT GGT GA - #T GAC AAA GGG GAG AGC 480 Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - AAT GAC GGC AAG TCT AAA GTG ACC CAT GTT AT - #G ATT CGC TGT CAG GAA 528 Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - CTG AAA TAC GAC GTT GGT GGA GGA GAA CGG TT - #T GAT TCT TTG ACA GAT 576 Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - CTT GTG GAA CAT TAT AAG AAG AAT CCT ATG GT - #G GAA ACA TTG GGT ACA 624 Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - GTA CTA CAA CTC AAG CAG CCC CTT AAC ACG AC - #T CGT ATA AAT GCT GCT 672 Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - GAA ATA GAA AGC AGA GTT CGA GAA CTA AGC AA - #A TTA GCT GAG ACC ACA 720 Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - GAT AAA GTC AAA CAA GGC TTT TGG GAA GAA TT - #T GAG ACA CTA CAA CAA 768 Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - CAG GAG TGC AAA CTT CTC TAC AGC CGA AAA GA - #G GGT CAA AGG CAA GAA 816 Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - AAC AAA AAC AAA AAT AGA TAT AAA AAC ATC CT - #G CCC TTT GAT CAT ACC 864 Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - AGG GTT GTC CTA CAC GAT GGT GAT CCC AAT GA - #G CCT GTT TCA GAT TAC 912 Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr
290 - # 295 - # 300 - - ATC AAT GCA AAT ATC ATC ATG CCT GAA TTT GA - #A ACC AAG TGC AAC AAT 960 Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - TCA AAG CCC AAA AAG AGT TAC ATT GCC ACA CA - #A GGC TGC CTG CAA AAC 1008 Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - ACG GTG AAT GAC TTT TGG CGG ATG GTG TTC CA - #A GAA AAC TCC CGA GTG 1056 Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - ATT GTC ATG ACA ACG AAA GAA GTG GAG AGA GG - #A AAG AGT AAA TGT GTC 1104 Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - AAA TAC TGG CCT GAT GAG TAT GCT CTA AAA GA - #A TAT GGC GTC ATG CGT 1152 Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - GTT AGG AAC GTC AAA GAA AGC GCC GCT CAT GA - #C TAT ACG CTA AGA GAA 1200 Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - CTT AAA CTT TCA AAG GTT GGA CAA GGG AAT AC - #G GAG AGA ACG GTC TGG 1248 Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - CAA TAC CAC TTT CGG ACC TGG CCG GAC CAC GG - #C GTG CCC AGC GAC CCT 1296 Gln Tyr His Phe Arg Thr Trp Pro Asp His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - GGG GGC GTG CTG GAC TTC CTG GAG GAG GTG CA - #C CAT AAG CAG GAG AGC 1344 Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - ATC ATG GAT GCA GGG CCG GTC GTG GTG CAC TG - #C AGT GCT GGA ATT GGC 1392 Ile Met Asp Ala Gly Pro Val Val Val His Cy - #s Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - CGG ACA GGG ACG TTC ATT GTG ATT GAT ATT CT - #T ATT GAC ATC ATC AGA 1440 Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - GAG AAA GGT GTT GAC TGC GAT ATT GAC GTT CC - #C AAA ACC ATC CAG ATG 1488 Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - GTG CGG TCT CAG AGG TCA GGG ATG GTC CAG AC - #A GAA GCA CAG TAC CGA 1536 Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - TTT ATC TAT ATG GCG GTC CAG CAT TAT ATT GA - #A ACA CTA CAG CGC AGG 1584 Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - ATT GAA GAA GAG CAG AAA AGC AAG AGG AAA GG - #G CAC GAA TAT ACA AAT 1632 Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - ATT AAG TAT TCT CTA GCG GAC CAG ACG AGT GG - #A GAT CAG AGC CCT CTC 1680 Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - CCG CCT TGT ACT CCA ACG CCA CCC TGT GCA GA - #A ATG AGA GAA GAC AGT 1728 Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - GCT AGA GTC TAT GAA AAC GTG GGC CTG ATG CA - #A CAG CAG AAA AGT TTC 1776 Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - AGA TGA - # - # - # 1782 Arg - - - - (2) INFORMATION FOR SEQ ID NO:20: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 593 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:20: - - Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Lys 20 - # 25 - # 30 - - Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Ala Tyr Tyr Asp 50 - # 55 - # 60 - - Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Glu Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - Lys Gly Lys His Gly Ser Phe Leu Val Lys Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - Gln Tyr His Phe Arg Thr Trp Pro Asp His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - Ile Met Asp Ala Gly Pro Val Val Val His Cy - #s Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - Arg - - - - (2) INFORMATION FOR SEQ ID NO:21: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1782 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1779 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:21: - - ATG ACA TCG CGG AGA TGG TTT CAC CCA AAT AT - #C ACT GGT GTG GAG GCA 48 Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - GAA AAC CTA CTG TTG ACA AGA GGA GTT GAT GG - #C AGT TTT TTG GCA AAG 96 Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Lys 20 - # 25 - # 30 - - CCT AGT AAA AGT AAC CCT GGA GAC TTC ACA CT - #T TCC GTT AGA AGA AAT 144 Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - GGA GCT GTC ACC CAC ATC AAG ATT CAG AAC AC - #T GGT GAT TAC TAT GAC 192 Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Asp Tyr Tyr Asp 50 - # 55 - # 60 - - CTG TAT GGA GGG GAG AAA TTT GCC ACT TTG GC - #T GCG TTG GTC CAG TAT 240 Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Ala Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - TAC ATG GAA CAT CAC GGG CAA TTA AAA GAG AA - #G AAT GGA GAT GTC ATT 288 Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - GAG CTT AAA TAT CCT CTG AAC TGT GCA GAT CC - #T ACC TCT GAA AGG TGG 336 Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - TTT CAT GGA CAT CTC TCT GGG AAA GAA GCA GA - #G AAA TTA TTA ACT GAA 384 Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - AAA GGA AAA CAT GGT AGT TTT CTT GTA AAA GA - #G AGC CAG AGC CAC CCT 432 Lys Gly Lys His Gly Ser Phe Leu Val Lys Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - GGA GAT TTT GTT CTT TCT GTG CGC ACT GGT GA - #T GAC AAA GGG GAG AGC 480 Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - AAT GAC GGC AAG TCT AAA GTG ACC CAT GTT AT - #G ATT CGC TGT CAG GAA 528 Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - CTG AAA TAC GAC GTT GGT GGA GGA GAA CGG TT - #T GAT TCT TTG ACA GAT 576 Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - CTT GTG GAA CAT TAT AAG AAG AAT CCT ATG GT - #G GAA ACA TTG GGT ACA 624 Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - GTA CTA CAA CTC AAG CAG CCC CTT AAC ACG AC - #T CGT ATA AAT GCT GCT 672 Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - GAA ATA GAA AGC AGA GTT CGA GAA CTA AGC AA - #A TTA GCT GAG ACC ACA 720 Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - GAT AAA GTC AAA CAA GGC TTT TGG GAA GAA TT - #T GAG ACA CTA CAA CAA 768 Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - CAG GAG TGC AAA CTT CTC TAC AGC CGA AAA GA - #G GGT CAA AGG CAA GAA 816 Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270
- - AAC AAA AAC AAA AAT AGA TAT AAA AAC ATC CT - #G CCC TTT GAT CAT ACC 864 Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - AGG GTT GTC CTA CAC GAT GGT GAT CCC AAT GA - #G CCT GTT TCA GAT TAC 912 Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - ATC AAT GCA AAT ATC ATC ATG CCT GAA TTT GA - #A ACC AAG TGC AAC AAT 960 Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - TCA AAG CCC AAA AAG AGT TAC ATT GCC ACA CA - #A GGC TGC CTG CAA AAC 1008 Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - ACG GTG AAT GAC TTT TGG CGG ATG GTG TTC CA - #A GAA AAC TCC CGA GTG 1056 Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - ATT GTC ATG ACA ACG AAA GAA GTG GAG AGA GG - #A AAG AGT AAA TGT GTC 1104 Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - AAA TAC TGG CCT GAT GAG TAT GCT CTA AAA GA - #A TAT GGC GTC ATG CGT 1152 Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - GTT AGG AAC GTC AAA GAA AGC GCC GCT CAT GA - #C TAT ACG CTA AGA GAA 1200 Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - CTT AAA CTT TCA AAG GTT GGA CAA GGG AAT AC - #G GAG AGA ACG GTC TGG 1248 Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - CAA TAC CAC TTT CGG ACC TGG CCG GAC CAC GG - #C GTG CCC AGC GAC CCT 1296 Gln Tyr His Phe Arg Thr Trp Pro Asp His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - GGG GGC GTG CTG GAC TTC CTG GAG GAG GTG CA - #C CAT AAG CAG GAG AGC 1344 Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - ATC ATG GAT GCA GGG CCG GTC GTG GTG CAC TG - #C AGT GCT GGA ATT GGC 1392 Ile Met Asp Ala Gly Pro Val Val Val His Cy - #s Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - CGG ACA GGG ACG TTC ATT GTG ATT GAT ATT CT - #T ATT GAC ATC ATC AGA 1440 Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - GAG AAA GGT GTT GAC TGC GAT ATT GAC GTT CC - #C AAA ACC ATC CAG ATG 1488 Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - GTG CGG TCT CAG AGG TCA GGG ATG GTC CAG AC - #A GAA GCA CAG TAC CGA 1536 Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - TTT ATC TAT ATG GCG GTC CAG CAT TAT ATT GA - #A ACA CTA CAG CGC AGG 1584 Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - ATT GAA GAA GAG CAG AAA AGC AAG AGG AAA GG - #G CAC GAA TAT ACA AAT 1632 Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - ATT AAG TAT TCT CTA GCG GAC CAG ACG AGT GG - #A GAT CAG AGC CCT CTC 1680 Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - CCG CCT TGT ACT CCA ACG CCA CCC TGT GCA GA - #A ATG AGA GAA GAC AGT 1728 Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - GCT AGA GTC TAT GAA AAC GTG GGC CTG ATG CA - #A CAG CAG AAA AGT TTC 1776 Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - AGA TGA - # - # - # 1782 Arg - - - - (2) INFORMATION FOR SEQ ID NO:22: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 593 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:22: - - Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Lys 20 - # 25 - # 30 - - Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Asp Tyr Tyr Asp 50 - # 55 - # 60 - - Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Ala Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - Lys Gly Lys His Gly Ser Phe Leu Val Lys Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - Gln Tyr His Phe Arg Thr Trp Pro Asp His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - Ile Met Asp Ala Gly Pro Val Val Val His Cy - #s Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - Arg - - - - (2) INFORMATION FOR SEQ ID NO:23: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1782 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1779 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:23: - - ATG ACA TCG CGG AGA TGG TTT CAC CCA AAT AT - #C ACT GGT GTG GAG GCA 48 Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - GAA AAC CTA CTG TTG ACA AGA GGA GTT GAT GG - #C AGT TTT TTG GCA AAG 96 Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Lys 20 - # 25 - # 30 - - CCT AGT AAA AGT AAC CCT GGA GAC TTC ACA CT - #T TCC GTT AGA AGA AAT 144 Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - GGA GCT GTC ACC CAC ATC AAG ATT CAG AAC AC - #T GGT GCT TAC TAT GAC 192 Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Ala Tyr Tyr Asp 50 - # 55 - # 60 - - CTG TAT GGA GGG GAG AAA TTT GCC ACT TTG GC - #T GAG TTG GTC CAG TAT 240 Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Glu Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - TAC ATG GAA CAT CAC GGG CAA TTA AAA GAG AA - #G AAT GGA GAT GTC ATT 288 Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - GAG CTT AAA TAT CCT CTG AAC TGT GCA GAT CC - #T ACC TCT GAA AGG TGG 336 Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - TTT CAT GGA CAT CTC TCT GGG AAA GAA GCA GA - #G AAA TTA TTA ACT GAA 384 Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - AAA GGA AAA CAT GGT AGT TTT CTT GTA AAA GA - #G AGC CAG AGC CAC CCT 432 Lys Gly Lys His Gly Ser Phe Leu Val Lys Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - GGA GAT TTT GTT CTT TCT GTG CGC ACT GGT GA - #T GAC AAA GGG GAG AGC 480 Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - AAT GAC GGC AAG TCT AAA GTG ACC CAT GTT AT - #G ATT CGC TGT CAG GAA 528 Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - CTG AAA TAC GAC GTT GGT GGA GGA GAA CGG TT - #T GAT TCT TTG ACA GAT 576 Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - CTT GTG GAA CAT TAT AAG AAG AAT CCT ATG GT - #G GAA ACA TTG GGT ACA 624 Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - GTA CTA CAA CTC AAG CAG CCC CTT AAC ACG AC - #T CGT ATA AAT GCT GCT 672 Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - GAA ATA GAA AGC AGA GTT CGA GAA CTA AGC AA - #A TTA GCT GAG ACC ACA 720 Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - GAT AAA GTC AAA CAA GGC TTT TGG GAA GAA TT - #T GAG ACA CTA CAA
CAA 768 Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - CAG GAG TGC AAA CTT CTC TAC AGC CGA AAA GA - #G GGT CAA AGG CAA GAA 816 Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - AAC AAA AAC AAA AAT AGA TAT AAA AAC ATC CT - #G CCC TTT GAT CAT ACC 864 Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - AGG GTT GTC CTA CAC GAT GGT GAT CCC AAT GA - #G CCT GTT TCA GAT TAC 912 Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - ATC AAT GCA AAT ATC ATC ATG CCT GAA TTT GA - #A ACC AAG TGC AAC AAT 960 Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - TCA AAG CCC AAA AAG AGT TAC ATT GCC ACA CA - #A GGC TGC CTG CAA AAC 1008 Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - ACG GTG AAT GAC TTT TGG CGG ATG GTG TTC CA - #A GAA AAC TCC CGA GTG 1056 Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - ATT GTC ATG ACA ACG AAA GAA GTG GAG AGA GG - #A AAG AGT AAA TGT GTC 1104 Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - AAA TAC TGG CCT GAT GAG TAT GCT CTA AAA GA - #A TAT GGC GTC ATG CGT 1152 Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - GTT AGG AAC GTC AAA GAA AGC GCC GCT CAT GA - #C TAT ACG CTA AGA GAA 1200 Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - CTT AAA CTT TCA AAG GTT GGA CAA GGG AAT AC - #G GAG AGA ACG GTC TGG 1248 Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - CAA TAC CAC TTT CGG ACC TGG CCG GAC CAC GG - #C GTG CCC AGC GAC CCT 1296 Gln Tyr His Phe Arg Thr Trp Pro Asp His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - GGG GGC GTG CTG GAC TTC CTG GAG GAG GTG CA - #C CAT AAG CAG GAG AGC 1344 Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - ATC ATG GAT GCA GGG CCG GTC GTG GTG CAC TC - #G AGT GCT GGA ATT GGC 1392 Ile Met Asp Ala Gly Pro Val Val Val His Se - #r Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - CGG ACA GGG ACG TTC ATT GTG ATT GAT ATT CT - #T ATT GAC ATC ATC AGA 1440 Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - GAG AAA GGT GTT GAC TGC GAT ATT GAC GTT CC - #C AAA ACC ATC CAG ATG 1488 Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - GTG CGG TCT CAG AGG TCA GGG ATG GTC CAG AC - #A GAA GCA CAG TAC CGA 1536 Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - TTT ATC TAT ATG GCG GTC CAG CAT TAT ATT GA - #A ACA CTA CAG CGC AGG 1584 Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - ATT GAA GAA GAG CAG AAA AGC AAG AGG AAA GG - #G CAC GAA TAT ACA AAT 1632 Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - ATT AAG TAT TCT CTA GCG GAC CAG ACG AGT GG - #A GAT CAG AGC CCT CTC 1680 Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - CCG CCT TGT ACT CCA ACG CCA CCC TGT GCA GA - #A ATG AGA GAA GAC AGT 1728 Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - GCT AGA GTC TAT GAA AAC GTG GGC CTG ATG CA - #A CAG CAG AAA AGT TTC 1776 Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - AGA TGA - # - # - # 1782 Arg - - - - (2) INFORMATION FOR SEQ ID NO:24: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 593 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:24: - - Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Lys 20 - # 25 - # 30 - - Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Ala Tyr Tyr Asp 50 - # 55 - # 60 - - Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Glu Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - Lys Gly Lys His Gly Ser Phe Leu Val Lys Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - Gln Tyr His Phe Arg Thr Trp Pro Asp His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - Ile Met Asp Ala Gly Pro Val Val Val His Se - #r Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - Arg - - - - (2) INFORMATION FOR SEQ ID NO:25: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1782 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1779 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:25: - - ATG ACA TCG CGG AGA TGG TTT CAC CCA AAT AT - #C ACT GGT GTG GAG GCA 48 Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - GAA AAC CTA CTG TTG ACA AGA GGA GTT GAT GG - #C AGT TTT TTG GCA AAG 96 Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Lys 20 - # 25 - # 30 - - CCT AGT AAA AGT AAC CCT GGA GAC TTC ACA CT - #T TCC GTT AGA AGA AAT 144 Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - GGA GCT GTC ACC CAC ATC AAG ATT CAG AAC AC - #T GGT GCT TAC TAT GAC 192 Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Ala Tyr Tyr Asp 50 - # 55 - # 60 - - CTG TAT GGA GGG GAG AAA TTT GCC ACT TTG GC - #T GAG TTG GTC CAG TAT 240 Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Glu Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - TAC ATG GAA CAT CAC GGG CAA TTA AAA GAG AA - #G AAT GGA GAT GTC ATT 288 Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - GAG CTT AAA TAT CCT CTG AAC TGT GCA GAT CC - #T ACC TCT GAA AGG TGG 336 Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - TTT CAT GGA CAT CTC TCT GGG AAA GAA GCA GA - #G AAA TTA TTA ACT GAA 384 Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - AAA GGA AAA CAT GGT AGT TTT CTT GTA AAA GA - #G AGC CAG AGC CAC CCT 432 Lys Gly Lys His Gly Ser Phe Leu Val Lys Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - GGA GAT TTT GTT CTT TCT GTG CGC ACT GGT GA - #T GAC AAA GGG GAG AGC 480 Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - AAT GAC GGC AAG TCT AAA GTG ACC CAT GTT AT - #G ATT CGC TGT CAG GAA 528 Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - CTG AAA TAC GAC GTT GGT GGA GGA GAA CGG TT - #T GAT TCT TTG ACA GAT 576 Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - CTT GTG GAA CAT TAT AAG AAG AAT CCT ATG GT - #G GAA ACA TTG GGT ACA 624 Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - GTA CTA CAA CTC AAG CAG CCC CTT AAC ACG AC - #T CGT ATA AAT GCT GCT 672 Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala
210 - # 215 - # 220 - - GAA ATA GAA AGC AGA GTT CGA GAA CTA AGC AA - #A TTA GCT GAG ACC ACA 720 Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - GAT AAA GTC AAA CAA GGC TTT TGG GAA GAA TT - #T GAG ACA CTA CAA CAA 768 Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - CAG GAG TGC AAA CTT CTC TAC AGC CGA AAA GA - #G GGT CAA AGG CAA GAA 816 Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - AAC AAA AAC AAA AAT AGA TAT AAA AAC ATC CT - #G CCC TTT GAT CAT ACC 864 Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - AGG GTT GTC CTA CAC GAT GGT GAT CCC AAT GA - #G CCT GTT TCA GAT TAC 912 Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - ATC AAT GCA AAT ATC ATC ATG CCT GAA TTT GA - #A ACC AAG TGC AAC AAT 960 Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - TCA AAG CCC AAA AAG AGT TAC ATT GCC ACA CA - #A GGC TGC CTG CAA AAC 1008 Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - ACG GTG AAT GAC TTT TGG CGG ATG GTG TTC CA - #A GAA AAC TCC CGA GTG 1056 Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - ATT GTC ATG ACA ACG AAA GAA GTG GAG AGA GG - #A AAG AGT AAA TGT GTC 1104 Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - AAA TAC TGG CCT GAT GAG TAT GCT CTA AAA GA - #A TAT GGC GTC ATG CGT 1152 Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - GTT AGG AAC GTC AAA GAA AGC GCC GCT CAT GA - #C TAT ACG CTA AGA GAA 1200 Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - CTT AAA CTT TCA AAG GTT GGA CAA GGG AAT AC - #G GAG AGA ACG GTC TGG 1248 Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - CAA TAC CAC TTT CGG ACC TGG CCG GCC CAC GG - #C GTG CCC AGC GAC CCT 1296 Gln Tyr His Phe Arg Thr Trp Pro Ala His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - GGG GGC GTG CTG GAC TTC CTG GAG GAG GTG CA - #C CAT AAG CAG GAG AGC 1344 Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - ATC ATG GAT GCA GGG CCG GTC GTG GTG CAC TG - #C AGT GCT GGA ATT GGC 1392 Ile Met Asp Ala Gly Pro Val Val Val His Cy - #s Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - CGG ACA GGG ACG TTC ATT GTG ATT GAT ATT CT - #T ATT GAC ATC ATC AGA 1440 Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - GAG AAA GGT GTT GAC TGC GAT ATT GAC GTT CC - #C AAA ACC ATC CAG ATG 1488 Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - GTG CGG TCT CAG AGG TCA GGG ATG GTC CAG AC - #A GAA GCA CAG TAC CGA 1536 Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - TTT ATC TAT ATG GCG GTC CAG CAT TAT ATT GA - #A ACA CTA CAG CGC AGG 1584 Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - ATT GAA GAA GAG CAG AAA AGC AAG AGG AAA GG - #G CAC GAA TAT ACA AAT 1632 Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - ATT AAG TAT TCT CTA GCG GAC CAG ACG AGT GG - #A GAT CAG AGC CCT CTC 1680 Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - CCG CCT TGT ACT CCA ACG CCA CCC TGT GCA GA - #A ATG AGA GAA GAC AGT 1728 Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - GCT AGA GTC TAT GAA AAC GTG GGC CTG ATG CA - #A CAG CAG AAA AGT TTC 1776 Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - AGA TGA - # - # - # 1782 Arg - - - - (2) INFORMATION FOR SEQ ID NO:26: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 593 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:26: - - Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Lys 20 - # 25 - # 30 - - Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Ala Tyr Tyr Asp 50 - # 55 - # 60 - - Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Glu Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - Lys Gly Lys His Gly Ser Phe Leu Val Lys Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - Gln Tyr His Phe Arg Thr Trp Pro Ala His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - Ile Met Asp Ala Gly Pro Val Val Val His Cy - #s Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - Arg - - - - (2) INFORMATION FOR SEQ ID NO:27: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1782 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1779 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:27: - - ATG ACA TCG CGG AGA TGG TTT CAC CCA AAT AT - #C ACT GGT GTG GAG GCA 48 Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - GAA AAC CTA CTG TTG ACA AGA GGA GTT GAT GG - #C AGT TTT TTG GCA AAG 96 Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Lys 20 - # 25 - # 30 - - CCT AGT AAA AGT AAC CCT GGA GAC TTC ACA CT - #T TCC GTT AGA AGA AAT 144 Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - GGA GCT GTC ACC CAC ATC AAG ATT CAG AAC AC - #T GGT GAT TAC TAT GAC 192 Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Asp Tyr Tyr Asp 50 - # 55 - # 60 - - CTG TAT GGA GGG GAG AAA TTT GCC ACT TTG GC - #T GCG TTG GTC CAG TAT 240 Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Ala Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - TAC ATG GAA CAT CAC GGG CAA TTA AAA GAG AA - #G AAT GGA GAT GTC ATT 288 Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - GAG CTT AAA TAT CCT CTG AAC TGT GCA GAT CC - #T ACC TCT GAA AGG TGG 336 Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - TTT CAT GGA CAT CTC TCT GGG AAA GAA GCA GA - #G AAA TTA TTA ACT GAA 384 Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - AAA GGA AAA CAT GGT AGT TTT CTT GTA AAA GA - #G AGC CAG AGC CAC CCT 432 Lys Gly Lys His Gly Ser Phe Leu Val Lys Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - GGA GAT TTT GTT CTT TCT GTG CGC ACT GGT GA - #T GAC AAA GGG GAG AGC 480 Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - AAT GAC GGC AAG TCT AAA GTG ACC CAT GTT AT - #G ATT CGC TGT CAG GAA 528 Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - CTG AAA TAC GAC GTT GGT GGA GGA GAA CGG TT - #T GAT TCT TTG ACA GAT 576 Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190
- - CTT GTG GAA CAT TAT AAG AAG AAT CCT ATG GT - #G GAA ACA TTG GGT ACA 624 Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - GTA CTA CAA CTC AAG CAG CCC CTT AAC ACG AC - #T CGT ATA AAT GCT GCT 672 Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - GAA ATA GAA AGC AGA GTT CGA GAA CTA AGC AA - #A TTA GCT GAG ACC ACA 720 Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - GAT AAA GTC AAA CAA GGC TTT TGG GAA GAA TT - #T GAG ACA CTA CAA CAA 768 Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - CAG GAG TGC AAA CTT CTC TAC AGC CGA AAA GA - #G GGT CAA AGG CAA GAA 816 Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - AAC AAA AAC AAA AAT AGA TAT AAA AAC ATC CT - #G CCC TTT GAT CAT ACC 864 Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - AGG GTT GTC CTA CAC GAT GGT GAT CCC AAT GA - #G CCT GTT TCA GAT TAC 912 Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - ATC AAT GCA AAT ATC ATC ATG CCT GAA TTT GA - #A ACC AAG TGC AAC AAT 960 Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - TCA AAG CCC AAA AAG AGT TAC ATT GCC ACA CA - #A GGC TGC CTG CAA AAC 1008 Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - ACG GTG AAT GAC TTT TGG CGG ATG GTG TTC CA - #A GAA AAC TCC CGA GTG 1056 Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - ATT GTC ATG ACA ACG AAA GAA GTG GAG AGA GG - #A AAG AGT AAA TGT GTC 1104 Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - AAA TAC TGG CCT GAT GAG TAT GCT CTA AAA GA - #A TAT GGC GTC ATG CGT 1152 Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - GTT AGG AAC GTC AAA GAA AGC GCC GCT CAT GA - #C TAT ACG CTA AGA GAA 1200 Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - CTT AAA CTT TCA AAG GTT GGA CAA GGG AAT AC - #G GAG AGA ACG GTC TGG 1248 Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - CAA TAC CAC TTT CGG ACC TGG CCG GAC CAC GG - #C GTG CCC AGC GAC CCT 1296 Gln Tyr His Phe Arg Thr Trp Pro Asp His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - GGG GGC GTG CTG GAC TTC CTG GAG GAG GTG CA - #C CAT AAG CAG GAG AGC 1344 Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - ATC ATG GAT GCA GGG CCG GTC GTG GTG CAC TC - #G AGT GCT GGA ATT GGC 1392 Ile Met Asp Ala Gly Pro Val Val Val His Se - #r Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - CGG ACA GGG ACG TTC ATT GTG ATT GAT ATT CT - #T ATT GAC ATC ATC AGA 1440 Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - GAG AAA GGT GTT GAC TGC GAT ATT GAC GTT CC - #C AAA ACC ATC CAG ATG 1488 Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - GTG CGG TCT CAG AGG TCA GGG ATG GTC CAG AC - #A GAA GCA CAG TAC CGA 1536 Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - TTT ATC TAT ATG GCG GTC CAG CAT TAT ATT GA - #A ACA CTA CAG CGC AGG 1584 Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - ATT GAA GAA GAG CAG AAA AGC AAG AGG AAA GG - #G CAC GAA TAT ACA AAT 1632 Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - ATT AAG TAT TCT CTA GCG GAC CAG ACG AGT GG - #A GAT CAG AGC CCT CTC 1680 Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - CCG CCT TGT ACT CCA ACG CCA CCC TGT GCA GA - #A ATG AGA GAA GAC AGT 1728 Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - GCT AGA GTC TAT GAA AAC GTG GGC CTG ATG CA - #A CAG CAG AAA AGT TTC 1776 Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - AGA TGA - # - # - # 1782 Arg - - - - (2) INFORMATION FOR SEQ ID NO:28: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 593 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:28: - - Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Lys 20 - # 25 - # 30 - - Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Asp Tyr Tyr Asp 50 - # 55 - # 60 - - Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Ala Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - Lys Gly Lys His Gly Ser Phe Leu Val Lys Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - Gln Tyr His Phe Arg Thr Trp Pro Asp His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - Ile Met Asp Ala Gly Pro Val Val Val His Se - #r Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - Arg - - - - (2) INFORMATION FOR SEQ ID NO:29: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1782 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1779 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:29: - - ATG ACA TCG CGG AGA TGG TTT CAC CCA AAT AT - #C ACT GGT GTG GAG GCA 48 Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - GAA AAC CTA CTG TTG ACA AGA GGA GTT GAT GG - #C AGT TTT TTG GCA AAG 96 Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Lys 20 - # 25 - # 30 - - CCT AGT AAA AGT AAC CCT GGA GAC TTC ACA CT - #T TCC GTT AGA AGA AAT 144 Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - GGA GCT GTC ACC CAC ATC AAG ATT CAG AAC AC - #T GGT GAT TAC TAT GAC 192 Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Asp Tyr Tyr Asp 50 - # 55 - # 60 - - CTG TAT GGA GGG GAG AAA TTT GCC ACT TTG GC - #T GCG TTG GTC CAG TAT 240 Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Ala Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - TAC ATG GAA CAT CAC GGG CAA TTA AAA GAG AA - #G AAT GGA GAT GTC ATT 288 Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - GAG CTT AAA TAT CCT CTG AAC TGT GCA GAT CC - #T ACC TCT GAA AGG TGG 336 Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - TTT CAT GGA CAT CTC TCT GGG AAA GAA GCA GA - #G AAA TTA TTA ACT GAA 384 Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - AAA GGA AAA CAT GGT AGT TTT CTT GTA AAA GA - #G AGC CAG AGC CAC CCT 432 Lys Gly Lys His Gly Ser Phe Leu Val Lys Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - GGA GAT TTT GTT CTT TCT GTG CGC ACT GGT GA - #T GAC AAA GGG GAG AGC 480 Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - AAT GAC GGC AAG TCT AAA GTG ACC CAT GTT AT - #G ATT CGC TGT CAG
GAA 528 Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - CTG AAA TAC GAC GTT GGT GGA GGA GAA CGG TT - #T GAT TCT TTG ACA GAT 576 Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - CTT GTG GAA CAT TAT AAG AAG AAT CCT ATG GT - #G GAA ACA TTG GGT ACA 624 Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - GTA CTA CAA CTC AAG CAG CCC CTT AAC ACG AC - #T CGT ATA AAT GCT GCT 672 Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - GAA ATA GAA AGC AGA GTT CGA GAA CTA AGC AA - #A TTA GCT GAG ACC ACA 720 Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - GAT AAA GTC AAA CAA GGC TTT TGG GAA GAA TT - #T GAG ACA CTA CAA CAA 768 Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - CAG GAG TGC AAA CTT CTC TAC AGC CGA AAA GA - #G GGT CAA AGG CAA GAA 816 Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - AAC AAA AAC AAA AAT AGA TAT AAA AAC ATC CT - #G CCC TTT GAT CAT ACC 864 Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - AGG GTT GTC CTA CAC GAT GGT GAT CCC AAT GA - #G CCT GTT TCA GAT TAC 912 Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - ATC AAT GCA AAT ATC ATC ATG CCT GAA TTT GA - #A ACC AAG TGC AAC AAT 960 Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - TCA AAG CCC AAA AAG AGT TAC ATT GCC ACA CA - #A GGC TGC CTG CAA AAC 1008 Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - ACG GTG AAT GAC TTT TGG CGG ATG GTG TTC CA - #A GAA AAC TCC CGA GTG 1056 Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - ATT GTC ATG ACA ACG AAA GAA GTG GAG AGA GG - #A AAG AGT AAA TGT GTC 1104 Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - AAA TAC TGG CCT GAT GAG TAT GCT CTA AAA GA - #A TAT GGC GTC ATG CGT 1152 Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - GTT AGG AAC GTC AAA GAA AGC GCC GCT CAT GA - #C TAT ACG CTA AGA GAA 1200 Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - CTT AAA CTT TCA AAG GTT GGA CAA GGG AAT AC - #G GAG AGA ACG GTC TGG 1248 Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - CAA TAC CAC TTT CGG ACC TGG CCG GCC CAC GG - #C GTG CCC AGC GAC CCT 1296 Gln Tyr His Phe Arg Thr Trp Pro Ala His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - GGG GGC GTG CTG GAC TTC CTG GAG GAG GTG CA - #C CAT AAG CAG GAG AGC 1344 Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - ATC ATG GAT GCA GGG CCG GTC GTG GTG CAC TG - #C AGT GCT GGA ATT GGC 1392 Ile Met Asp Ala Gly Pro Val Val Val His Cy - #s Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - CGG ACA GGG ACG TTC ATT GTG ATT GAT ATT CT - #T ATT GAC ATC ATC AGA 1440 Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - GAG AAA GGT GTT GAC TGC GAT ATT GAC GTT CC - #C AAA ACC ATC CAG ATG 1488 Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - GTG CGG TCT CAG AGG TCA GGG ATG GTC CAG AC - #A GAA GCA CAG TAC CGA 1536 Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - TTT ATC TAT ATG GCG GTC CAG CAT TAT ATT GA - #A ACA CTA CAG CGC AGG 1584 Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - ATT GAA GAA GAG CAG AAA AGC AAG AGG AAA GG - #G CAC GAA TAT ACA AAT 1632 Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - ATT AAG TAT TCT CTA GCG GAC CAG ACG AGT GG - #A GAT CAG AGC CCT CTC 1680 Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - CCG CCT TGT ACT CCA ACG CCA CCC TGT GCA GA - #A ATG AGA GAA GAC AGT 1728 Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - GCT AGA GTC TAT GAA AAC GTG GGC CTG ATG CA - #A CAG CAG AAA AGT TTC 1776 Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - AGA TGA - # - # - # 1782 Arg - - - - (2) INFORMATION FOR SEQ ID NO:30: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 593 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:30: - - Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Lys 20 - # 25 - # 30 - - Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Asp Tyr Tyr Asp 50 - # 55 - # 60 - - Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Ala Leu Val Gln Tyr 65 - # 70 - # 75 - # 80 - - Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - Lys Gly Lys His Gly Ser Phe Leu Val Lys Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Trp 405 - # 410 - # 415 - - Gln Tyr His Phe Arg Thr Trp Pro Ala His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - Ile Met Asp Ala Gly Pro Val Val Val His Cy - #s Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr Leu Gln Arg Arg 515 - # 520 - # 525 - - Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gl - #y His Glu Tyr Thr Asn 530 - # 535 - # 540 - - Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gl - #y Asp Gln Ser Pro Leu 545 5 - #50 5 - #55 5 - #60 - - Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Gl - #u Met Arg Glu Asp Ser 565 - # 570 - # 575 - - Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gl - #n Gln Gln Lys Ser Phe 580 - # 585 - # 590 - - Arg - - - - (2) INFORMATION FOR SEQ ID NO:31: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1788 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1785 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:31: - - ATG GTG AGG TGG TTT CAC CGA GAC CTC AGT GG - #G CTG GAT GCA GAG ACC 48 Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - CTG CTC AAG GGC CGA GGT GTC CAC GGT AGC TT - #C CTG GCT CGG CCC AGT 96 Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Arg Pro Ser 20 - # 25 - # 30 - - CGC AAG AAC CAG GGT GAC TTC TCG CTC TCC GT - #C AGG GTG GGG GAT CAG 144 Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - GTG ACC CAT ATT CGG ATC CAG AAC TCA GGG GC - #T TTC TAT GAC CTG TAT 192 Val Thr His Ile Arg Ile Gln Asn Ser Gly Al - #a Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - GGA GGG GAG AAG TTT GCG ACT CTG ACA GAG CT - #G GTG GAG TAC TAC ACT 240 Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - CAG CAG CAG GGT GTG GTG CAG GAC CGC GAC GG - #C ACC ATC ATC CAC CTC 288 Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - AAG TAC CCG CTG AAC TGC TCC GAT CCC ACT AG - #T GAG AGG TGG TAC CAT 336 Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - GGC CAC ATG TCT GGC GGG CAG GCA GAG ACG CT - #G CTG CAG GCC AAG GGC 384 Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - GAG CCC TGG ACG TTT CTT GTG CGT GAG AGC CT - #C AGC CAG CCT GGA GAC 432 Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Le - #u Ser Gln Pro Gly Asp
130 - # 135 - # 140 - - TTC GTG CTT TCT GTG CTC AGT GAC CAG CCC AA - #G GCT GGC CCA GGC TCC 480 Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - CCG CTC AGG GTC ACC CAC ATC AAG GTC ATG TG - #C GAG GGT GGA CGC TAC 528 Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - ACA GTG GGT GGT TTG GAG ACC TTC GAC AGC CT - #C ACG GAC CTG GTG GAG 576 Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - CAT TTC AAG AAG ACG GGG ATT GAG GAG GCC TC - #A GGC GCC TTT GTC TAC 624 His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - CTG CGG CAG CCG TAC TAT GCC ACG AGG GTG AA - #T GCG GCT GAC ATT GAG 672 Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - AAC CGA GTG TTG GAA CTG AAC AAG AAG CAG GA - #G TCC GAG GAT ACA GCC 720 Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - AAG GCT GGC TTC TGG GAG GAG TTT GAG AGT TT - #G CAG AAG CAG GAG GTG 768 Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - AAG AAC TTG CAC CAG CGT CTG GAA GGG CAA CG - #G CCA GAG AAC AAG GGC 816 Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - AAG AAC CGC TAC AAG AAC ATT CTC CCC TTT GA - #C CAC AGC CGA GTG ATC 864 Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - CTG CAG GGA CGG GAC AGT AAC ATC CCC GGG TC - #C GAC TAC ATC AAT GCC 912 Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - AAC TAC ATC AAG AAC CAG CTG CTA GGC CCT GA - #T GAG AAC GCT AAG ACC 960 Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - TAC ATC GCC AGC CAG GGC TGT CTG GAG GCC AC - #G GTC AAT GAC TTC TGG 1008 Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - CAG ATG GCG TGG CAG GAG AAC AGC CGT GTC AT - #C GTC ATG ACC ACC CGA 1056 Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - GAG GTG GAG AAA GGC CGG AAC AAA TGC GTC CC - #A TAC TGG CCC GAG GTG 1104 Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - GGC ATG CAG CGT GCT TAT GGG CCC TAC TCT GT - #G ACC AAC TGC GGG GAG 1152 Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - CAT GAC ACA ACC GAA TAC AAA CTC CGT ACC TT - #A CAG GTC TCC CCG CTG 1200 His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - GAC AAT GGA GAC CTG ATT CGG GAG ATC TGG CA - #T TAC CAG TAC CTG AGC 1248 Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - TGG CCC GCC CAT GGG GTC CCC AGT GAG CCT GG - #G GGT GTC CTC AGC TTC 1296 Trp Pro Ala His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - CTG GAC CAG ATC AAC CAG CGG CAG GAA AGT CT - #G CCT CAC GCA GGG CCC 1344 Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - ATC ATC GTG CAC TGC AGC GCC GGC ATC GGC CG - #C ACA GGC ACC ATC ATT 1392 Ile Ile Val His Cys Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - GTC ATC GAC ATG CTC ATG GAG AAC ATC TCC AC - #C AAG GGC CTG GAC TGT 1440 Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - GAC ATT GAC ATC CAG AAG ACC ATC CAG ATG GT - #G CGG GCG CAG CGC TCG 1488 Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - GGC ATG GTG CAG ACG GAG GCG CAG TAC AAG TT - #C ATC TAC GTG GCC ATC 1536 Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - GCC CAG TTC ATT GAA ACC ACT AAG AAG AAG CT - #G GAG GTC CTG CAG TCG 1584 Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - CAG AAG GGC CAG GAG TCG GAG TAC GGG AAC AT - #C ACC TAT CCC CCA GCC 1632 Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - ATG AAG AAT GCC CAT GCC AAG GCC TCC CGC AC - #C TCG TCC AAA CAC AAG 1680 Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - GAG GAT GTG TAT GAG AAC CTG CAC ACT AAG AA - #C AAG AGG GAG GAG AAA 1728 Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - GTG AAG AAG CAG CGG TCA GCA GAC AAG GAG AA - #G AGC AAG GGT TCC CTC 1776 Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - AAG AGG AAG TGA - # - # - # 1788 Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:32: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 595 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:32: - - Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Arg Pro Ser 20 - # 25 - # 30 - - Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - Val Thr His Ile Arg Ile Gln Asn Ser Gly Al - #a Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - Trp Pro Ala His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - Ile Ile Val His Cys Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:33: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1788 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1785 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:33: - - ATG GTG AGG TGG TTT CAC CGA GAC CTC AGT GG - #G CTG GAT GCA GAG ACC 48 Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - CTG CTC AAG GGC CGA GGT GTC CAC GGT AGC TT - #C CTG GCT CGG CCC AGT 96 Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Arg Pro Ser 20 - # 25 - # 30 - - CGC AAG AAC CAG GGT GAC TTC TCG CTC TCC GT - #C AGG GTG GGG GAT CAG 144 Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - GTG ACC CAT ATT CGG ATC CAG AAC TCA GGG GC - #T TTC TAT GAC CTG TAT 192 Val Thr His Ile Arg Ile Gln Asn Ser Gly Al - #a Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - GGA GGG GAG AAG TTT GCG ACT CTG ACA GAG CT - #G GTG GAG TAC TAC ACT 240 Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - CAG CAG CAG GGT GTG GTG CAG GAC CGC GAC GG - #C ACC ATC ATC CAC CTC 288 Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - AAG TAC CCG CTG AAC TGC TCC GAT CCC ACT AG - #T GAG AGG TGG TAC CAT 336 Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His
100 - # 105 - # 110 - - GGC CAC ATG TCT GGC GGG CAG GCA GAG ACG CT - #G CTG CAG GCC AAG GGC 384 Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - GAG CCC TGG ACG TTT CTT GTG CGT GAG AGC CT - #C AGC CAG CCT GGA GAC 432 Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - TTC GTG CTT TCT GTG CTC AGT GAC CAG CCC AA - #G GCT GGC CCA GGC TCC 480 Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - CCG CTC AGG GTC ACC CAC ATC AAG GTC ATG TG - #C GAG GGT GGA CGC TAC 528 Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - ACA GTG GGT GGT TTG GAG ACC TTC GAC AGC CT - #C ACG GAC CTG GTG GAG 576 Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - CAT TTC AAG AAG ACG GGG ATT GAG GAG GCC TC - #A GGC GCC TTT GTC TAC 624 His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - CTG CGG CAG CCG TAC TAT GCC ACG AGG GTG AA - #T GCG GCT GAC ATT GAG 672 Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - AAC CGA GTG TTG GAA CTG AAC AAG AAG CAG GA - #G TCC GAG GAT ACA GCC 720 Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - AAG GCT GGC TTC TGG GAG GAG TTT GAG AGT TT - #G CAG AAG CAG GAG GTG 768 Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - AAG AAC TTG CAC CAG CGT CTG GAA GGG CAA CG - #G CCA GAG AAC AAG GGC 816 Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - AAG AAC CGC TAC AAG AAC ATT CTC CCC TTT GA - #C CAC AGC CGA GTG ATC 864 Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - CTG CAG GGA CGG GAC AGT AAC ATC CCC GGG TC - #C GAC TAC ATC AAT GCC 912 Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - AAC TAC ATC AAG AAC CAG CTG CTA GGC CCT GA - #T GAG AAC GCT AAG ACC 960 Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - TAC ATC GCC AGC CAG GGC TGT CTG GAG GCC AC - #G GTC AAT GAC TTC TGG 1008 Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - CAG ATG GCG TGG CAG GAG AAC AGC CGT GTC AT - #C GTC ATG ACC ACC CGA 1056 Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - GAG GTG GAG AAA GGC CGG AAC AAA TGC GTC CC - #A TAC TGG CCC GAG GTG 1104 Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - GGC ATG CAG CGT GCT TAT GGG CCC TAC TCT GT - #G ACC AAC TGC GGG GAG 1152 Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - CAT GAC ACA ACC GAA TAC AAA CTC CGT ACC TT - #A CAG GTC TCC CCG CTG 1200 His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - GAC AAT GGA GAC CTG ATT CGG GAG ATC TGG CA - #T TAC CAG TAC CTG AGC 1248 Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - TGG CCC GAC CAT GGG GTC CCC AGT GAG CCT GG - #G GGT GTC CTC AGC TTC 1296 Trp Pro Asp His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - CTG GAC CAG ATC AAC CAG CGG CAG GAA AGT CT - #G CCT CAC GCA GGG CCC 1344 Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - ATC ATC GTG CAC TCC AGC GCC GGC ATC GGC CG - #C ACA GGC ACC ATC ATT 1392 Ile Ile Val His Ser Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - GTC ATC GAC ATG CTC ATG GAG AAC ATC TCC AC - #C AAG GGC CTG GAC TGT 1440 Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - GAC ATT GAC ATC CAG AAG ACC ATC CAG ATG GT - #G CGG GCG CAG CGC TCG 1488 Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - GGC ATG GTG CAG ACG GAG GCG CAG TAC AAG TT - #C ATC TAC GTG GCC ATC 1536 Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - GCC CAG TTC ATT GAA ACC ACT AAG AAG AAG CT - #G GAG GTC CTG CAG TCG 1584 Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - CAG AAG GGC CAG GAG TCG GAG TAC GGG AAC AT - #C ACC TAT CCC CCA GCC 1632 Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - ATG AAG AAT GCC CAT GCC AAG GCC TCC CGC AC - #C TCG TCC AAA CAC AAG 1680 Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - GAG GAT GTG TAT GAG AAC CTG CAC ACT AAG AA - #C AAG AGG GAG GAG AAA 1728 Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - GTG AAG AAG CAG CGG TCA GCA GAC AAG GAG AA - #G AGC AAG GGT TCC CTC 1776 Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - AAG AGG AAG TGA - # - # - # 1788 Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:34: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 595 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:34: - - Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Arg Pro Ser 20 - # 25 - # 30 - - Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - Val Thr His Ile Arg Ile Gln Asn Ser Gly Al - #a Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - Trp Pro Asp His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - Ile Ile Val His Ser Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:35: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1788 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1785 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:35: - - ATG GTG AGG TGG TTT CAC CGA GAC CTC AGT GG - #G CTG GAT GCA GAG ACC 48 Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - CTG CTC AAG GGC CGA GGT GTC CAC GGT AGC TT - #C CTG GCT CGG CCC AGT 96 Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Arg Pro Ser 20 - # 25 - # 30 - - CGC AAG AAC CAG GGT GAC TTC TCG CTC TCC GT - #C AGG GTG GGG GAT CAG 144 Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - GTG ACC CAT ATT CGG ATC CAG AAC TCA GGG GA - #T TTC TAT GAC CTG TAT 192 Val Thr His Ile Arg Ile Gln Asn Ser Gly As - #p Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - GGA GGG GAG AAG TTT GCG ACT CTG ACA GCG CT - #G GTG GAG TAC TAC ACT 240 Gly Gly Glu Lys Phe Ala Thr Leu Thr Ala Le - #u Val Glu Tyr Tyr Thr
65 - # 70 - # 75 - # 80 - - CAG CAG CAG GGT GTG GTG CAG GAC CGC GAC GG - #C ACC ATC ATC CAC CTC 288 Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - AAG TAC CCG CTG AAC TGC TCC GAT CCC ACT AG - #T GAG AGG TGG TAC CAT 336 Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - GGC CAC ATG TCT GGC GGG CAG GCA GAG ACG CT - #G CTG CAG GCC AAG GGC 384 Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - GAG CCC TGG ACG TTT CTT GTG CGT GAG AGC CT - #C AGC CAG CCT GGA GAC 432 Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - TTC GTG CTT TCT GTG CTC AGT GAC CAG CCC AA - #G GCT GGC CCA GGC TCC 480 Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - CCG CTC AGG GTC ACC CAC ATC AAG GTC ATG TG - #C GAG GGT GGA CGC TAC 528 Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - ACA GTG GGT GGT TTG GAG ACC TTC GAC AGC CT - #C ACG GAC CTG GTG GAG 576 Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - CAT TTC AAG AAG ACG GGG ATT GAG GAG GCC TC - #A GGC GCC TTT GTC TAC 624 His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - CTG CGG CAG CCG TAC TAT GCC ACG AGG GTG AA - #T GCG GCT GAC ATT GAG 672 Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - AAC CGA GTG TTG GAA CTG AAC AAG AAG CAG GA - #G TCC GAG GAT ACA GCC 720 Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - AAG GCT GGC TTC TGG GAG GAG TTT GAG AGT TT - #G CAG AAG CAG GAG GTG 768 Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - AAG AAC TTG CAC CAG CGT CTG GAA GGG CAA CG - #G CCA GAG AAC AAG GGC 816 Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - AAG AAC CGC TAC AAG AAC ATT CTC CCC TTT GA - #C CAC AGC CGA GTG ATC 864 Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - CTG CAG GGA CGG GAC AGT AAC ATC CCC GGG TC - #C GAC TAC ATC AAT GCC 912 Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - AAC TAC ATC AAG AAC CAG CTG CTA GGC CCT GA - #T GAG AAC GCT AAG ACC 960 Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - TAC ATC GCC AGC CAG GGC TGT CTG GAG GCC AC - #G GTC AAT GAC TTC TGG 1008 Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - CAG ATG GCG TGG CAG GAG AAC AGC CGT GTC AT - #C GTC ATG ACC ACC CGA 1056 Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - GAG GTG GAG AAA GGC CGG AAC AAA TGC GTC CC - #A TAC TGG CCC GAG GTG 1104 Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - GGC ATG CAG CGT GCT TAT GGG CCC TAC TCT GT - #G ACC AAC TGC GGG GAG 1152 Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - CAT GAC ACA ACC GAA TAC AAA CTC CGT ACC TT - #A CAG GTC TCC CCG CTG 1200 His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - GAC AAT GGA GAC CTG ATT CGG GAG ATC TGG CA - #T TAC CAG TAC CTG AGC 1248 Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - TGG CCC GAC CAT GGG GTC CCC AGT GAG CCT GG - #G GGT GTC CTC AGC TTC 1296 Trp Pro Asp His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - CTG GAC CAG ATC AAC CAG CGG CAG GAA AGT CT - #G CCT CAC GCA GGG CCC 1344 Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - ATC ATC GTG CAC TCC AGC GCC GGC ATC GGC CG - #C ACA GGC ACC ATC ATT 1392 Ile Ile Val His Ser Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - GTC ATC GAC ATG CTC ATG GAG AAC ATC TCC AC - #C AAG GGC CTG GAC TGT 1440 Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - GAC ATT GAC ATC CAG AAG ACC ATC CAG ATG GT - #G CGG GCG CAG CGC TCG 1488 Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - GGC ATG GTG CAG ACG GAG GCG CAG TAC AAG TT - #C ATC TAC GTG GCC ATC 1536 Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - GCC CAG TTC ATT GAA ACC ACT AAG AAG AAG CT - #G GAG GTC CTG CAG TCG 1584 Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - CAG AAG GGC CAG GAG TCG GAG TAC GGG AAC AT - #C ACC TAT CCC CCA GCC 1632 Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - ATG AAG AAT GCC CAT GCC AAG GCC TCC CGC AC - #C TCG TCC AAA CAC AAG 1680 Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - GAG GAT GTG TAT GAG AAC CTG CAC ACT AAG AA - #C AAG AGG GAG GAG AAA 1728 Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - GTG AAG AAG CAG CGG TCA GCA GAC AAG GAG AA - #G AGC AAG GGT TCC CTC 1776 Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - AAG AGG AAG TGA - # - # - # 1788 Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:36: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 595 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:36: - - Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Arg Pro Ser 20 - # 25 - # 30 - - Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - Val Thr His Ile Arg Ile Gln Asn Ser Gly As - #p Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - Gly Gly Glu Lys Phe Ala Thr Leu Thr Ala Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - Trp Pro Asp His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - Ile Ile Val His Ser Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:37: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1788 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1785 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:37: - - ATG GTG AGG TGG TTT CAC CGA GAC CTC AGT GG - #G CTG GAT GCA GAG ACC 48 Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - CTG CTC AAG GGC CGA GGT GTC CAC GGT AGC TT - #C CTG GCT CGG CCC AGT 96 Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Arg Pro Ser 20 - # 25 - # 30 - - CGC AAG AAC CAG GGT GAC TTC TCG CTC TCC GT - #C AGG GTG GGG GAT CAG 144 Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln
35 - # 40 - # 45 - - GTG ACC CAT ATT CGG ATC CAG AAC TCA GGG GA - #T TTC TAT GAC CTG TAT 192 Val Thr His Ile Arg Ile Gln Asn Ser Gly As - #p Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - GGA GGG GAG AAG TTT GCG ACT CTG ACA GCG CT - #G GTG GAG TAC TAC ACT 240 Gly Gly Glu Lys Phe Ala Thr Leu Thr Ala Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - CAG CAG CAG GGT GTG GTG CAG GAC CGC GAC GG - #C ACC ATC ATC CAC CTC 288 Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - AAG TAC CCG CTG AAC TGC TCC GAT CCC ACT AG - #T GAG AGG TGG TAC CAT 336 Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - GGC CAC ATG TCT GGC GGG CAG GCA GAG ACG CT - #G CTG CAG GCC AAG GGC 384 Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - GAG CCC TGG ACG TTT CTT GTG CGT GAG AGC CT - #C AGC CAG CCT GGA GAC 432 Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - TTC GTG CTT TCT GTG CTC AGT GAC CAG CCC AA - #G GCT GGC CCA GGC TCC 480 Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - CCG CTC AGG GTC ACC CAC ATC AAG GTC ATG TG - #C GAG GGT GGA CGC TAC 528 Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - ACA GTG GGT GGT TTG GAG ACC TTC GAC AGC CT - #C ACG GAC CTG GTG GAG 576 Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - CAT TTC AAG AAG ACG GGG ATT GAG GAG GCC TC - #A GGC GCC TTT GTC TAC 624 His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - CTG CGG CAG CCG TAC TAT GCC ACG AGG GTG AA - #T GCG GCT GAC ATT GAG 672 Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - AAC CGA GTG TTG GAA CTG AAC AAG AAG CAG GA - #G TCC GAG GAT ACA GCC 720 Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - AAG GCT GGC TTC TGG GAG GAG TTT GAG AGT TT - #G CAG AAG CAG GAG GTG 768 Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - AAG AAC TTG CAC CAG CGT CTG GAA GGG CAA CG - #G CCA GAG AAC AAG GGC 816 Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - AAG AAC CGC TAC AAG AAC ATT CTC CCC TTT GA - #C CAC AGC CGA GTG ATC 864 Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - CTG CAG GGA CGG GAC AGT AAC ATC CCC GGG TC - #C GAC TAC ATC AAT GCC 912 Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - AAC TAC ATC AAG AAC CAG CTG CTA GGC CCT GA - #T GAG AAC GCT AAG ACC 960 Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - TAC ATC GCC AGC CAG GGC TGT CTG GAG GCC AC - #G GTC AAT GAC TTC TGG 1008 Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - CAG ATG GCG TGG CAG GAG AAC AGC CGT GTC AT - #C GTC ATG ACC ACC CGA 1056 Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - GAG GTG GAG AAA GGC CGG AAC AAA TGC GTC CC - #A TAC TGG CCC GAG GTG 1104 Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - GGC ATG CAG CGT GCT TAT GGG CCC TAC TCT GT - #G ACC AAC TGC GGG GAG 1152 Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - CAT GAC ACA ACC GAA TAC AAA CTC CGT ACC TT - #A CAG GTC TCC CCG CTG 1200 His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - GAC AAT GGA GAC CTG ATT CGG GAG ATC TGG CA - #T TAC CAG TAC CTG AGC 1248 Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - TGG CCC GCC CAT GGG GTC CCC AGT GAG CCT GG - #G GGT GTC CTC AGC TTC 1296 Trp Pro Ala His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - CTG GAC CAG ATC AAC CAG CGG CAG GAA AGT CT - #G CCT CAC GCA GGG CCC 1344 Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - ATC ATC GTG CAC TGC AGC GCC GGC ATC GGC CG - #C ACA GGC ACC ATC ATT 1392 Ile Ile Val His Cys Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - GTC ATC GAC ATG CTC ATG GAG AAC ATC TCC AC - #C AAG GGC CTG GAC TGT 1440 Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - GAC ATT GAC ATC CAG AAG ACC ATC CAG ATG GT - #G CGG GCG CAG CGC TCG 1488 Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - GGC ATG GTG CAG ACG GAG GCG CAG TAC AAG TT - #C ATC TAC GTG GCC ATC 1536 Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - GCC CAG TTC ATT GAA ACC ACT AAG AAG AAG CT - #G GAG GTC CTG CAG TCG 1584 Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - CAG AAG GGC CAG GAG TCG GAG TAC GGG AAC AT - #C ACC TAT CCC CCA GCC 1632 Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - ATG AAG AAT GCC CAT GCC AAG GCC TCC CGC AC - #C TCG TCC AAA CAC AAG 1680 Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - GAG GAT GTG TAT GAG AAC CTG CAC ACT AAG AA - #C AAG AGG GAG GAG AAA 1728 Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - GTG AAG AAG CAG CGG TCA GCA GAC AAG GAG AA - #G AGC AAG GGT TCC CTC 1776 Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - AAG AGG AAG TGA - # - # - # 1788 Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:38: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 595 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:38: - - Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Arg Pro Ser 20 - # 25 - # 30 - - Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - Val Thr His Ile Arg Ile Gln Asn Ser Gly As - #p Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - Gly Gly Glu Lys Phe Ala Thr Leu Thr Ala Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - Trp Pro Ala His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - Ile Ile Val His Cys Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:39: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1788 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1785 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:39: - - ATG GTG AGG TGG TTT CAC CGA GAC CTC AGT GG - #G CTG GAT GCA GAG ACC 48 Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr
1 5 - # 10 - # 15 - - CTG CTC AAG GGC CGA GGT GTC CAC GGT AGC TT - #C CTG GCT AAG CCC AGT 96 Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Lys Pro Ser 20 - # 25 - # 30 - - CGC AAG AAC CAG GGT GAC TTC TCG CTC TCC GT - #C AGG GTG GGG GAT CAG 144 Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - GTG ACC CAT ATT CGG ATC CAG AAC TCA GGG GC - #T TTC TAT GAC CTG TAT 192 Val Thr His Ile Arg Ile Gln Asn Ser Gly Al - #a Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - GGA GGG GAG AAG TTT GCG ACT CTG ACA GAG CT - #G GTG GAG TAC TAC ACT 240 Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - CAG CAG CAG GGT GTG GTG CAG GAC CGC GAC GG - #C ACC ATC ATC CAC CTC 288 Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - AAG TAC CCG CTG AAC TGC TCC GAT CCC ACT AG - #T GAG AGG TGG TAC CAT 336 Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - GGC CAC ATG TCT GGC GGG CAG GCA GAG ACG CT - #G CTG CAG GCC AAG GGC 384 Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - GAG CCC TGG ACG TTT CTT GTG AAG GAG AGC CT - #C AGC CAG CCT GGA GAC 432 Glu Pro Trp Thr Phe Leu Val Lys Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - TTC GTG CTT TCT GTG CTC AGT GAC CAG CCC AA - #G GCT GGC CCA GGC TCC 480 Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - CCG CTC AGG GTC ACC CAC ATC AAG GTC ATG TG - #C GAG GGT GGA CGC TAC 528 Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - ACA GTG GGT GGT TTG GAG ACC TTC GAC AGC CT - #C ACG GAC CTG GTG GAG 576 Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - CAT TTC AAG AAG ACG GGG ATT GAG GAG GCC TC - #A GGC GCC TTT GTC TAC 624 His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - CTG CGG CAG CCG TAC TAT GCC ACG AGG GTG AA - #T GCG GCT GAC ATT GAG 672 Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - AAC CGA GTG TTG GAA CTG AAC AAG AAG CAG GA - #G TCC GAG GAT ACA GCC 720 Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - AAG GCT GGC TTC TGG GAG GAG TTT GAG AGT TT - #G CAG AAG CAG GAG GTG 768 Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - AAG AAC TTG CAC CAG CGT CTG GAA GGG CAA CG - #G CCA GAG AAC AAG GGC 816 Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - AAG AAC CGC TAC AAG AAC ATT CTC CCC TTT GA - #C CAC AGC CGA GTG ATC 864 Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - CTG CAG GGA CGG GAC AGT AAC ATC CCC GGG TC - #C GAC TAC ATC AAT GCC 912 Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - AAC TAC ATC AAG AAC CAG CTG CTA GGC CCT GA - #T GAG AAC GCT AAG ACC 960 Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - TAC ATC GCC AGC CAG GGC TGT CTG GAG GCC AC - #G GTC AAT GAC TTC TGG 1008 Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - CAG ATG GCG TGG CAG GAG AAC AGC CGT GTC AT - #C GTC ATG ACC ACC CGA 1056 Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - GAG GTG GAG AAA GGC CGG AAC AAA TGC GTC CC - #A TAC TGG CCC GAG GTG 1104 Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - GGC ATG CAG CGT GCT TAT GGG CCC TAC TCT GT - #G ACC AAC TGC GGG GAG 1152 Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - CAT GAC ACA ACC GAA TAC AAA CTC CGT ACC TT - #A CAG GTC TCC CCG CTG 1200 His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - GAC AAT GGA GAC CTG ATT CGG GAG ATC TGG CA - #T TAC CAG TAC CTG AGC 1248 Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - TGG CCC GAC CAT GGG GTC CCC AGT GAG CCT GG - #G GGT GTC CTC AGC TTC 1296 Trp Pro Asp His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - CTG GAC CAG ATC AAC CAG CGG CAG GAA AGT CT - #G CCT CAC GCA GGG CCC 1344 Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - ATC ATC GTG CAC TGC AGC GCC GGC ATC GGC CG - #C ACA GGC ACC ATC ATT 1392 Ile Ile Val His Cys Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - GTC ATC GAC ATG CTC ATG GAG AAC ATC TCC AC - #C AAG GGC CTG GAC TGT 1440 Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - GAC ATT GAC ATC CAG AAG ACC ATC CAG ATG GT - #G CGG GCG CAG CGC TCG 1488 Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - GGC ATG GTG CAG ACG GAG GCG CAG TAC AAG TT - #C ATC TAC GTG GCC ATC 1536 Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - GCC CAG TTC ATT GAA ACC ACT AAG AAG AAG CT - #G GAG GTC CTG CAG TCG 1584 Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - CAG AAG GGC CAG GAG TCG GAG TAC GGG AAC AT - #C ACC TAT CCC CCA GCC 1632 Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - ATG AAG AAT GCC CAT GCC AAG GCC TCC CGC AC - #C TCG TCC AAA CAC AAG 1680 Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - GAG GAT GTG TAT GAG AAC CTG CAC ACT AAG AA - #C AAG AGG GAG GAG AAA 1728 Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - GTG AAG AAG CAG CGG TCA GCA GAC AAG GAG AA - #G AGC AAG GGT TCC CTC 1776 Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - AAG AGG AAG TGA - # - # - # 1788 Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:40: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 595 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:40: - - Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Lys Pro Ser 20 - # 25 - # 30 - - Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - Val Thr His Ile Arg Ile Gln Asn Ser Gly Al - #a Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - Glu Pro Trp Thr Phe Leu Val Lys Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - Trp Pro Asp His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - Ile Ile Val His Cys Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:41: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1788 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single
(D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1785 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:41: - - ATG GTG AGG TGG TTT CAC CGA GAC CTC AGT GG - #G CTG GAT GCA GAG ACC 48 Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - CTG CTC AAG GGC CGA GGT GTC CAC GGT AGC TT - #C CTG GCT AAG CCC AGT 96 Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Lys Pro Ser 20 - # 25 - # 30 - - CGC AAG AAC CAG GGT GAC TTC TCG CTC TCC GT - #C AGG GTG GGG GAT CAG 144 Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - GTG ACC CAT ATT CGG ATC CAG AAC TCA GGG GA - #T TTC TAT GAC CTG TAT 192 Val Thr His Ile Arg Ile Gln Asn Ser Gly As - #p Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - GGA GGG GAG AAG TTT GCG ACT CTG ACA GCG CT - #G GTG GAG TAC TAC ACT 240 Gly Gly Glu Lys Phe Ala Thr Leu Thr Ala Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - CAG CAG CAG GGT GTG GTG CAG GAC CGC GAC GG - #C ACC ATC ATC CAC CTC 288 Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - AAG TAC CCG CTG AAC TGC TCC GAT CCC ACT AG - #T GAG AGG TGG TAC CAT 336 Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - GGC CAC ATG TCT GGC GGG CAG GCA GAG ACG CT - #G CTG CAG GCC AAG GGC 384 Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - GAG CCC TGG ACG TTT CTT GTG AAG GAG AGC CT - #C AGC CAG CCT GGA GAC 432 Glu Pro Trp Thr Phe Leu Val Lys Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - TTC GTG CTT TCT GTG CTC AGT GAC CAG CCC AA - #G GCT GGC CCA GGC TCC 480 Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - CCG CTC AGG GTC ACC CAC ATC AAG GTC ATG TG - #C GAG GGT GGA CGC TAC 528 Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - ACA GTG GGT GGT TTG GAG ACC TTC GAC AGC CT - #C ACG GAC CTG GTG GAG 576 Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - CAT TTC AAG AAG ACG GGG ATT GAG GAG GCC TC - #A GGC GCC TTT GTC TAC 624 His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - CTG CGG CAG CCG TAC TAT GCC ACG AGG GTG AA - #T GCG GCT GAC ATT GAG 672 Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - AAC CGA GTG TTG GAA CTG AAC AAG AAG CAG GA - #G TCC GAG GAT ACA GCC 720 Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - AAG GCT GGC TTC TGG GAG GAG TTT GAG AGT TT - #G CAG AAG CAG GAG GTG 768 Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - AAG AAC TTG CAC CAG CGT CTG GAA GGG CAA CG - #G CCA GAG AAC AAG GGC 816 Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - AAG AAC CGC TAC AAG AAC ATT CTC CCC TTT GA - #C CAC AGC CGA GTG ATC 864 Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - CTG CAG GGA CGG GAC AGT AAC ATC CCC GGG TC - #C GAC TAC ATC AAT GCC 912 Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - AAC TAC ATC AAG AAC CAG CTG CTA GGC CCT GA - #T GAG AAC GCT AAG ACC 960 Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - TAC ATC GCC AGC CAG GGC TGT CTG GAG GCC AC - #G GTC AAT GAC TTC TGG 1008 Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - CAG ATG GCG TGG CAG GAG AAC AGC CGT GTC AT - #C GTC ATG ACC ACC CGA 1056 Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - GAG GTG GAG AAA GGC CGG AAC AAA TGC GTC CC - #A TAC TGG CCC GAG GTG 1104 Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - GGC ATG CAG CGT GCT TAT GGG CCC TAC TCT GT - #G ACC AAC TGC GGG GAG 1152 Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - CAT GAC ACA ACC GAA TAC AAA CTC CGT ACC TT - #A CAG GTC TCC CCG CTG 1200 His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - GAC AAT GGA GAC CTG ATT CGG GAG ATC TGG CA - #T TAC CAG TAC CTG AGC 1248 Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - TGG CCC GAC CAT GGG GTC CCC AGT GAG CCT GG - #G GGT GTC CTC AGC TTC 1296 Trp Pro Asp His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - CTG GAC CAG ATC AAC CAG CGG CAG GAA AGT CT - #G CCT CAC GCA GGG CCC 1344 Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - ATC ATC GTG CAC TGC AGC GCC GGC ATC GGC CG - #C ACA GGC ACC ATC ATT 1392 Ile Ile Val His Cys Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - GTC ATC GAC ATG CTC ATG GAG AAC ATC TCC AC - #C AAG GGC CTG GAC TGT 1440 Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - GAC ATT GAC ATC CAG AAG ACC ATC CAG ATG GT - #G CGG GCG CAG CGC TCG 1488 Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - GGC ATG GTG CAG ACG GAG GCG CAG TAC AAG TT - #C ATC TAC GTG GCC ATC 1536 Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - GCC CAG TTC ATT GAA ACC ACT AAG AAG AAG CT - #G GAG GTC CTG CAG TCG 1584 Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - CAG AAG GGC CAG GAG TCG GAG TAC GGG AAC AT - #C ACC TAT CCC CCA GCC 1632 Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - ATG AAG AAT GCC CAT GCC AAG GCC TCC CGC AC - #C TCG TCC AAA CAC AAG 1680 Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - GAG GAT GTG TAT GAG AAC CTG CAC ACT AAG AA - #C AAG AGG GAG GAG AAA 1728 Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - GTG AAG AAG CAG CGG TCA GCA GAC AAG GAG AA - #G AGC AAG GGT TCC CTC 1776 Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - AAG AGG AAG TGA - # - # - # 1788 Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:42: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 595 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:42: - - Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Lys Pro Ser 20 - # 25 - # 30 - - Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - Val Thr His Ile Arg Ile Gln Asn Ser Gly As - #p Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - Gly Gly Glu Lys Phe Ala Thr Leu Thr Ala Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - Glu Pro Trp Thr Phe Leu Val Lys Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - Trp Pro Asp His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - Ile Ile Val His Cys Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu
580 - # 585 - # 590 - - Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:43: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1788 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1785 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:43: - - ATG GTG AGG TGG TTT CAC CGA GAC CTC AGT GG - #G CTG GAT GCA GAG ACC 48 Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - CTG CTC AAG GGC CGA GGT GTC CAC GGT AGC TT - #C CTG GCT AAG CCC AGT 96 Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Lys Pro Ser 20 - # 25 - # 30 - - CGC AAG AAC CAG GGT GAC TTC TCG CTC TCC GT - #C AGG GTG GGG GAT CAG 144 Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - GTG ACC CAT ATT CGG ATC CAG AAC TCA GGG GC - #T TTC TAT GAC CTG TAT 192 Val Thr His Ile Arg Ile Gln Asn Ser Gly Al - #a Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - GGA GGG GAG AAG TTT GCG ACT CTG ACA GAG CT - #G GTG GAG TAC TAC ACT 240 Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - CAG CAG CAG GGT GTG GTG CAG GAC CGC GAC GG - #C ACC ATC ATC CAC CTC 288 Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - AAG TAC CCG CTG AAC TGC TCC GAT CCC ACT AG - #T GAG AGG TGG TAC CAT 336 Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - GGC CAC ATG TCT GGC GGG CAG GCA GAG ACG CT - #G CTG CAG GCC AAG GGC 384 Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - GAG CCC TGG ACG TTT CTT GTG AAG GAG AGC CT - #C AGC CAG CCT GGA GAC 432 Glu Pro Trp Thr Phe Leu Val Lys Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - TTC GTG CTT TCT GTG CTC AGT GAC CAG CCC AA - #G GCT GGC CCA GGC TCC 480 Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - CCG CTC AGG GTC ACC CAC ATC AAG GTC ATG TG - #C GAG GGT GGA CGC TAC 528 Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - ACA GTG GGT GGT TTG GAG ACC TTC GAC AGC CT - #C ACG GAC CTG GTG GAG 576 Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - CAT TTC AAG AAG ACG GGG ATT GAG GAG GCC TC - #A GGC GCC TTT GTC TAC 624 His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - CTG CGG CAG CCG TAC TAT GCC ACG AGG GTG AA - #T GCG GCT GAC ATT GAG 672 Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - AAC CGA GTG TTG GAA CTG AAC AAG AAG CAG GA - #G TCC GAG GAT ACA GCC 720 Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - AAG GCT GGC TTC TGG GAG GAG TTT GAG AGT TT - #G CAG AAG CAG GAG GTG 768 Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - AAG AAC TTG CAC CAG CGT CTG GAA GGG CAA CG - #G CCA GAG AAC AAG GGC 816 Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - AAG AAC CGC TAC AAG AAC ATT CTC CCC TTT GA - #C CAC AGC CGA GTG ATC 864 Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - CTG CAG GGA CGG GAC AGT AAC ATC CCC GGG TC - #C GAC TAC ATC AAT GCC 912 Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - AAC TAC ATC AAG AAC CAG CTG CTA GGC CCT GA - #T GAG AAC GCT AAG ACC 960 Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - TAC ATC GCC AGC CAG GGC TGT CTG GAG GCC AC - #G GTC AAT GAC TTC TGG 1008 Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - CAG ATG GCG TGG CAG GAG AAC AGC CGT GTC AT - #C GTC ATG ACC ACC CGA 1056 Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - GAG GTG GAG AAA GGC CGG AAC AAA TGC GTC CC - #A TAC TGG CCC GAG GTG 1104 Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - GGC ATG CAG CGT GCT TAT GGG CCC TAC TCT GT - #G ACC AAC TGC GGG GAG 1152 Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - CAT GAC ACA ACC GAA TAC AAA CTC CGT ACC TT - #A CAG GTC TCC CCG CTG 1200 His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - GAC AAT GGA GAC CTG ATT CGG GAG ATC TGG CA - #T TAC CAG TAC CTG AGC 1248 Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - TGG CCC GAC CAT GGG GTC CCC AGT GAG CCT GG - #G GGT GTC CTC AGC TTC 1296 Trp Pro Asp His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - CTG GAC CAG ATC AAC CAG CGG CAG GAA AGT CT - #G CCT CAC GCA GGG CCC 1344 Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - ATC ATC GTG CAC TCC AGC GCC GGC ATC GGC CG - #C ACA GGC ACC ATC ATT 1392 Ile Ile Val His Ser Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - GTC ATC GAC ATG CTC ATG GAG AAC ATC TCC AC - #C AAG GGC CTG GAC TGT 1440 Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - GAC ATT GAC ATC CAG AAG ACC ATC CAG ATG GT - #G CGG GCG CAG CGC TCG 1488 Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - GGC ATG GTG CAG ACG GAG GCG CAG TAC AAG TT - #C ATC TAC GTG GCC ATC 1536 Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - GCC CAG TTC ATT GAA ACC ACT AAG AAG AAG CT - #G GAG GTC CTG CAG TCG 1584 Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - CAG AAG GGC CAG GAG TCG GAG TAC GGG AAC AT - #C ACC TAT CCC CCA GCC 1632 Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - ATG AAG AAT GCC CAT GCC AAG GCC TCC CGC AC - #C TCG TCC AAA CAC AAG 1680 Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - GAG GAT GTG TAT GAG AAC CTG CAC ACT AAG AA - #C AAG AGG GAG GAG AAA 1728 Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - GTG AAG AAG CAG CGG TCA GCA GAC AAG GAG AA - #G AGC AAG GGT TCC CTC 1776 Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - AAG AGG AAG TGA - # - # - # 1788 Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:44: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 595 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:44: - - Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Lys Pro Ser 20 - # 25 - # 30 - - Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - Val Thr His Ile Arg Ile Gln Asn Ser Gly Al - #a Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - Glu Pro Trp Thr Phe Leu Val Lys Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - Trp Pro Asp His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - Ile Ile Val His Ser Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala
530 - # 535 - # 540 - - Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:45: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1788 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1785 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:45: - - ATG GTG AGG TGG TTT CAC CGA GAC CTC AGT GG - #G CTG GAT GCA GAG ACC 48 Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - CTG CTC AAG GGC CGA GGT GTC CAC GGT AGC TT - #C CTG GCT AAG CCC AGT 96 Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Lys Pro Ser 20 - # 25 - # 30 - - CGC AAG AAC CAG GGT GAC TTC TCG CTC TCC GT - #C AGG GTG GGG GAT CAG 144 Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - GTG ACC CAT ATT CGG ATC CAG AAC TCA GGG GC - #T TTC TAT GAC CTG TAT 192 Val Thr His Ile Arg Ile Gln Asn Ser Gly Al - #a Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - GGA GGG GAG AAG TTT GCG ACT CTG ACA GAG CT - #G GTG GAG TAC TAC ACT 240 Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - CAG CAG CAG GGT GTG GTG CAG GAC CGC GAC GG - #C ACC ATC ATC CAC CTC 288 Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - AAG TAC CCG CTG AAC TGC TCC GAT CCC ACT AG - #T GAG AGG TGG TAC CAT 336 Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - GGC CAC ATG TCT GGC GGG CAG GCA GAG ACG CT - #G CTG CAG GCC AAG GGC 384 Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - GAG CCC TGG ACG TTT CTT GTG AAG GAG AGC CT - #C AGC CAG CCT GGA GAC 432 Glu Pro Trp Thr Phe Leu Val Lys Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - TTC GTG CTT TCT GTG CTC AGT GAC CAG CCC AA - #G GCT GGC CCA GGC TCC 480 Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - CCG CTC AGG GTC ACC CAC ATC AAG GTC ATG TG - #C GAG GGT GGA CGC TAC 528 Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - ACA GTG GGT GGT TTG GAG ACC TTC GAC AGC CT - #C ACG GAC CTG GTG GAG 576 Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - CAT TTC AAG AAG ACG GGG ATT GAG GAG GCC TC - #A GGC GCC TTT GTC TAC 624 His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - CTG CGG CAG CCG TAC TAT GCC ACG AGG GTG AA - #T GCG GCT GAC ATT GAG 672 Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - AAC CGA GTG TTG GAA CTG AAC AAG AAG CAG GA - #G TCC GAG GAT ACA GCC 720 Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - AAG GCT GGC TTC TGG GAG GAG TTT GAG AGT TT - #G CAG AAG CAG GAG GTG 768 Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - AAG AAC TTG CAC CAG CGT CTG GAA GGG CAA CG - #G CCA GAG AAC AAG GGC 816 Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - AAG AAC CGC TAC AAG AAC ATT CTC CCC TTT GA - #C CAC AGC CGA GTG ATC 864 Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - CTG CAG GGA CGG GAC AGT AAC ATC CCC GGG TC - #C GAC TAC ATC AAT GCC 912 Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - AAC TAC ATC AAG AAC CAG CTG CTA GGC CCT GA - #T GAG AAC GCT AAG ACC 960 Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - TAC ATC GCC AGC CAG GGC TGT CTG GAG GCC AC - #G GTC AAT GAC TTC TGG 1008 Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - CAG ATG GCG TGG CAG GAG AAC AGC CGT GTC AT - #C GTC ATG ACC ACC CGA 1056 Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - GAG GTG GAG AAA GGC CGG AAC AAA TGC GTC CC - #A TAC TGG CCC GAG GTG 1104 Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - GGC ATG CAG CGT GCT TAT GGG CCC TAC TCT GT - #G ACC AAC TGC GGG GAG 1152 Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - CAT GAC ACA ACC GAA TAC AAA CTC CGT ACC TT - #A CAG GTC TCC CCG CTG 1200 His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - GAC AAT GGA GAC CTG ATT CGG GAG ATC TGG CA - #T TAC CAG TAC CTG AGC 1248 Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - TGG CCC GCC CAT GGG GTC CCC AGT GAG CCT GG - #G GGT GTC CTC AGC TTC 1296 Trp Pro Ala His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - CTG GAC CAG ATC AAC CAG CGG CAG GAA AGT CT - #G CCT CAC GCA GGG CCC 1344 Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - ATC ATC GTG CAC TGC AGC GCC GGC ATC GGC CG - #C ACA GGC ACC ATC ATT 1392 Ile Ile Val His Cys Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - GTC ATC GAC ATG CTC ATG GAG AAC ATC TCC AC - #C AAG GGC CTG GAC TGT 1440 Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - GAC ATT GAC ATC CAG AAG ACC ATC CAG ATG GT - #G CGG GCG CAG CGC TCG 1488 Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - GGC ATG GTG CAG ACG GAG GCG CAG TAC AAG TT - #C ATC TAC GTG GCC ATC 1536 Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - GCC CAG TTC ATT GAA ACC ACT AAG AAG AAG CT - #G GAG GTC CTG CAG TCG 1584 Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - CAG AAG GGC CAG GAG TCG GAG TAC GGG AAC AT - #C ACC TAT CCC CCA GCC 1632 Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - ATG AAG AAT GCC CAT GCC AAG GCC TCC CGC AC - #C TCG TCC AAA CAC AAG 1680 Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - GAG GAT GTG TAT GAG AAC CTG CAC ACT AAG AA - #C AAG AGG GAG GAG AAA 1728 Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - GTG AAG AAG CAG CGG TCA GCA GAC AAG GAG AA - #G AGC AAG GGT TCC CTC 1776 Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - AAG AGG AAG TGA - # - # - # 1788 Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:46: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 595 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:46: - - Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Lys Pro Ser 20 - # 25 - # 30 - - Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - Val Thr His Ile Arg Ile Gln Asn Ser Gly Al - #a Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - Glu Pro Trp Thr Phe Leu Val Lys Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - Trp Pro Ala His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - Ile Ile Val His Cys Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80
- - Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:47: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1788 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1785 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:47: - - ATG GTG AGG TGG TTT CAC CGA GAC CTC AGT GG - #G CTG GAT GCA GAG ACC 48 Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - CTG CTC AAG GGC CGA GGT GTC CAC GGT AGC TT - #C CTG GCT AAG CCC AGT 96 Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Lys Pro Ser 20 - # 25 - # 30 - - CGC AAG AAC CAG GGT GAC TTC TCG CTC TCC GT - #C AGG GTG GGG GAT CAG 144 Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - GTG ACC CAT ATT CGG ATC CAG AAC TCA GGG GA - #T TTC TAT GAC CTG TAT 192 Val Thr His Ile Arg Ile Gln Asn Ser Gly As - #p Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - GGA GGG GAG AAG TTT GCG ACT CTG ACA GCG CT - #G GTG GAG TAC TAC ACT 240 Gly Gly Glu Lys Phe Ala Thr Leu Thr Ala Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - CAG CAG CAG GGT GTG GTG CAG GAC CGC GAC GG - #C ACC ATC ATC CAC CTC 288 Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - AAG TAC CCG CTG AAC TGC TCC GAT CCC ACT AG - #T GAG AGG TGG TAC CAT 336 Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - GGC CAC ATG TCT GGC GGG CAG GCA GAG ACG CT - #G CTG CAG GCC AAG GGC 384 Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - GAG CCC TGG ACG TTT CTT GTG AAG GAG AGC CT - #C AGC CAG CCT GGA GAC 432 Glu Pro Trp Thr Phe Leu Val Lys Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - TTC GTG CTT TCT GTG CTC AGT GAC CAG CCC AA - #G GCT GGC CCA GGC TCC 480 Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - CCG CTC AGG GTC ACC CAC ATC AAG GTC ATG TG - #C GAG GGT GGA CGC TAC 528 Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - ACA GTG GGT GGT TTG GAG ACC TTC GAC AGC CT - #C ACG GAC CTG GTG GAG 576 Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - CAT TTC AAG AAG ACG GGG ATT GAG GAG GCC TC - #A GGC GCC TTT GTC TAC 624 His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - CTG CGG CAG CCG TAC TAT GCC ACG AGG GTG AA - #T GCG GCT GAC ATT GAG 672 Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - AAC CGA GTG TTG GAA CTG AAC AAG AAG CAG GA - #G TCC GAG GAT ACA GCC 720 Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - AAG GCT GGC TTC TGG GAG GAG TTT GAG AGT TT - #G CAG AAG CAG GAG GTG 768 Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - AAG AAC TTG CAC CAG CGT CTG GAA GGG CAA CG - #G CCA GAG AAC AAG GGC 816 Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - AAG AAC CGC TAC AAG AAC ATT CTC CCC TTT GA - #C CAC AGC CGA GTG ATC 864 Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - CTG CAG GGA CGG GAC AGT AAC ATC CCC GGG TC - #C GAC TAC ATC AAT GCC 912 Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - AAC TAC ATC AAG AAC CAG CTG CTA GGC CCT GA - #T GAG AAC GCT AAG ACC 960 Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - TAC ATC GCC AGC CAG GGC TGT CTG GAG GCC AC - #G GTC AAT GAC TTC TGG 1008 Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - CAG ATG GCG TGG CAG GAG AAC AGC CGT GTC AT - #C GTC ATG ACC ACC CGA 1056 Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - GAG GTG GAG AAA GGC CGG AAC AAA TGC GTC CC - #A TAC TGG CCC GAG GTG 1104 Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - GGC ATG CAG CGT GCT TAT GGG CCC TAC TCT GT - #G ACC AAC TGC GGG GAG 1152 Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - CAT GAC ACA ACC GAA TAC AAA CTC CGT ACC TT - #A CAG GTC TCC CCG CTG 1200 His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - GAC AAT GGA GAC CTG ATT CGG GAG ATC TGG CA - #T TAC CAG TAC CTG AGC 1248 Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - TGG CCC GAC CAT GGG GTC CCC AGT GAG CCT GG - #G GGT GTC CTC AGC TTC 1296 Trp Pro Asp His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - CTG GAC CAG ATC AAC CAG CGG CAG GAA AGT CT - #G CCT CAC GCA GGG CCC 1344 Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - ATC ATC GTG CAC TCC AGC GCC GGC ATC GGC CG - #C ACA GGC ACC ATC ATT 1392 Ile Ile Val His Ser Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - GTC ATC GAC ATG CTC ATG GAG AAC ATC TCC AC - #C AAG GGC CTG GAC TGT 1440 Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - GAC ATT GAC ATC CAG AAG ACC ATC CAG ATG GT - #G CGG GCG CAG CGC TCG 1488 Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - GGC ATG GTG CAG ACG GAG GCG CAG TAC AAG TT - #C ATC TAC GTG GCC ATC 1536 Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - GCC CAG TTC ATT GAA ACC ACT AAG AAG AAG CT - #G GAG GTC CTG CAG TCG 1584 Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - CAG AAG GGC CAG GAG TCG GAG TAC GGG AAC AT - #C ACC TAT CCC CCA GCC 1632 Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - ATG AAG AAT GCC CAT GCC AAG GCC TCC CGC AC - #C TCG TCC AAA CAC AAG 1680 Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - GAG GAT GTG TAT GAG AAC CTG CAC ACT AAG AA - #C AAG AGG GAG GAG AAA 1728 Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - GTG AAG AAG CAG CGG TCA GCA GAC AAG GAG AA - #G AGC AAG GGT TCC CTC 1776 Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - AAG AGG AAG TGA - # - # - # 1788 Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:48: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 595 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:48: - - Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Lys Pro Ser 20 - # 25 - # 30 - - Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - Val Thr His Ile Arg Ile Gln Asn Ser Gly As - #p Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - Gly Gly Glu Lys Phe Ala Thr Leu Thr Ala Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - Glu Pro Trp Thr Phe Leu Val Lys Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - Trp Pro Asp His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe
420 - # 425 - # 430 - - Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - Ile Ile Val His Ser Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:49: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1788 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1785 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:49: - - ATG GTG AGG TGG TTT CAC CGA GAC CTC AGT GG - #G CTG GAT GCA GAG ACC 48 Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - CTG CTC AAG GGC CGA GGT GTC CAC GGT AGC TT - #C CTG GCT AAG CCC AGT 96 Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Lys Pro Ser 20 - # 25 - # 30 - - CGC AAG AAC CAG GGT GAC TTC TCG CTC TCC GT - #C AGG GTG GGG GAT CAG 144 Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - GTG ACC CAT ATT CGG ATC CAG AAC TCA GGG GA - #T TTC TAT GAC CTG TAT 192 Val Thr His Ile Arg Ile Gln Asn Ser Gly As - #p Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - GGA GGG GAG AAG TTT GCG ACT CTG ACA GCG CT - #G GTG GAG TAC TAC ACT 240 Gly Gly Glu Lys Phe Ala Thr Leu Thr Ala Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - CAG CAG CAG GGT GTG GTG CAG GAC CGC GAC GG - #C ACC ATC ATC CAC CTC 288 Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - AAG TAC CCG CTG AAC TGC TCC GAT CCC ACT AG - #T GAG AGG TGG TAC CAT 336 Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - GGC CAC ATG TCT GGC GGG CAG GCA GAG ACG CT - #G CTG CAG GCC AAG GGC 384 Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - GAG CCC TGG ACG TTT CTT GTG AAG GAG AGC CT - #C AGC CAG CCT GGA GAC 432 Glu Pro Trp Thr Phe Leu Val Lys Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - TTC GTG CTT TCT GTG CTC AGT GAC CAG CCC AA - #G GCT GGC CCA GGC TCC 480 Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - CCG CTC AGG GTC ACC CAC ATC AAG GTC ATG TG - #C GAG GGT GGA CGC TAC 528 Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - ACA GTG GGT GGT TTG GAG ACC TTC GAC AGC CT - #C ACG GAC CTG GTG GAG 576 Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - CAT TTC AAG AAG ACG GGG ATT GAG GAG GCC TC - #A GGC GCC TTT GTC TAC 624 His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - CTG CGG CAG CCG TAC TAT GCC ACG AGG GTG AA - #T GCG GCT GAC ATT GAG 672 Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - AAC CGA GTG TTG GAA CTG AAC AAG AAG CAG GA - #G TCC GAG GAT ACA GCC 720 Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - AAG GCT GGC TTC TGG GAG GAG TTT GAG AGT TT - #G CAG AAG CAG GAG GTG 768 Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - AAG AAC TTG CAC CAG CGT CTG GAA GGG CAA CG - #G CCA GAG AAC AAG GGC 816 Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - AAG AAC CGC TAC AAG AAC ATT CTC CCC TTT GA - #C CAC AGC CGA GTG ATC 864 Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - CTG CAG GGA CGG GAC AGT AAC ATC CCC GGG TC - #C GAC TAC ATC AAT GCC 912 Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - AAC TAC ATC AAG AAC CAG CTG CTA GGC CCT GA - #T GAG AAC GCT AAG ACC 960 Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - TAC ATC GCC AGC CAG GGC TGT CTG GAG GCC AC - #G GTC AAT GAC TTC TGG 1008 Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - CAG ATG GCG TGG CAG GAG AAC AGC CGT GTC AT - #C GTC ATG ACC ACC CGA 1056 Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - GAG GTG GAG AAA GGC CGG AAC AAA TGC GTC CC - #A TAC TGG CCC GAG GTG 1104 Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - GGC ATG CAG CGT GCT TAT GGG CCC TAC TCT GT - #G ACC AAC TGC GGG GAG 1152 Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - CAT GAC ACA ACC GAA TAC AAA CTC CGT ACC TT - #A CAG GTC TCC CCG CTG 1200 His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - GAC AAT GGA GAC CTG ATT CGG GAG ATC TGG CA - #T TAC CAG TAC CTG AGC 1248 Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - TGG CCC GCC CAT GGG GTC CCC AGT GAG CCT GG - #G GGT GTC CTC AGC TTC 1296 Trp Pro Ala His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - CTG GAC CAG ATC AAC CAG CGG CAG GAA AGT CT - #G CCT CAC GCA GGG CCC 1344 Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - ATC ATC GTG CAC TGC AGC GCC GGC ATC GGC CG - #C ACA GGC ACC ATC ATT 1392 Ile Ile Val His Cys Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - GTC ATC GAC ATG CTC ATG GAG AAC ATC TCC AC - #C AAG GGC CTG GAC TGT 1440 Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - GAC ATT GAC ATC CAG AAG ACC ATC CAG ATG GT - #G CGG GCG CAG CGC TCG 1488 Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - GGC ATG GTG CAG ACG GAG GCG CAG TAC AAG TT - #C ATC TAC GTG GCC ATC 1536 Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - GCC CAG TTC ATT GAA ACC ACT AAG AAG AAG CT - #G GAG GTC CTG CAG TCG 1584 Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - CAG AAG GGC CAG GAG TCG GAG TAC GGG AAC AT - #C ACC TAT CCC CCA GCC 1632 Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - ATG AAG AAT GCC CAT GCC AAG GCC TCC CGC AC - #C TCG TCC AAA CAC AAG 1680 Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - GAG GAT GTG TAT GAG AAC CTG CAC ACT AAG AA - #C AAG AGG GAG GAG AAA 1728 Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - GTG AAG AAG CAG CGG TCA GCA GAC AAG GAG AA - #G AGC AAG GGT TCC CTC 1776 Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - AAG AGG AAG TGA - # - # - # 1788 Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:50: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 595 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:50: - - Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Lys Pro Ser 20 - # 25 - # 30 - - Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - Val Thr His Ile Arg Ile Gln Asn Ser Gly As - #p Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - Gly Gly Glu Lys Phe Ala Thr Leu Thr Ala Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - Glu Pro Trp Thr Phe Leu Val Lys Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu
370 - # 375 - # 380 - - His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - Trp Pro Ala His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - Ile Ile Val His Cys Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:51: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:51: - - GGTCATAGTA AGCACTGTTC - # - # - # 20 - - - - (2) INFORMATION FOR SEQ ID NO:52: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:52: - - CGGAATTCAA CATGACATCG CGGAG - # - # 25 - - - - (2) INFORMATION FOR SEQ ID NO:53: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:53: - - GAACACTGGT GCTTACTATG ACC - # - # 23 - - - - (2) INFORMATION FOR SEQ ID NO:54: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:54: - - ATTAACCCTC ACTAAAG - # - # - # 17 - - - - (2) INFORMATION FOR SEQ ID NO:55: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:55: - - CTGGACCAAC GCAGCCAAAG T - # - # - #21 - - - - (2) INFORMATION FOR SEQ ID NO:56: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino - #acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:56: - - Cys Ala Cys Thr Thr Thr Gly Gly Cys Thr Gl - #y Cys Gly Thr Thr Gly 1 5 - # 10 - # 15 - - Gly Thr Cys Cys Ala Gly 20 - - - - (2) INFORMATION FOR SEQ ID NO:57: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:57: - - CACGCCGTGG GCCGGCCAG - # - # - # 19 - - - - (2) INFORMATION FOR SEQ ID NO:58: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:58: - - CTGGCCGGCC CACGGCGTG - # - # - # 19 - - - - (2) INFORMATION FOR SEQ ID NO:59: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1788 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1785 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:59: - - ATG GTG AGG TGG TTT CAC CGA GAC CTC AGT GG - #G CTG GAT GCA GAG ACC 48 Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - CTG CTC AAG GGC CGA GGT GTC CAC GGT AGC TT - #C CTG GCT CGG CCC AGT 96 Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Arg Pro Ser 20 - # 25 - # 30 - - CGC AAG AAC CAG GGT GAC TTC TCG CTC TCC GT - #C AGG GTG GGG GAT CAG 144 Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - GTG ACC CAT ATT CGG ATC CAG AAC TCA GGG GC - #T TTC TAT GAC CTG TAT 192 Val Thr His Ile Arg Ile Gln Asn Ser Gly Al - #a Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - GGA GGG GAG AAG TTT GCG ACT CTG ACA GAG CT - #G GTG GAG TAC TAC ACT 240 Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - CAG CAG CAG GGT GTG GTG CAG GAC CGC GAC GG - #C ACC ATC ATC CAC CTC 288 Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - AAG TAC CCG CTG AAC TGC TCC GAT CCC ACT AG - #T GAG AGG TGG TAC CAT 336 Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - GGC CAC ATG TCT GGC GGG CAG GCA GAG ACG CT - #G CTG CAG GCC AAG GGC 384 Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - GAG CCC TGG ACG TTT CTT GTG CGT GAG AGC CT - #C AGC CAG CCT GGA GAC 432 Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - TTC GTG CTT TCT GTG CTC AGT GAC CAG CCC AA - #G GCT GGC CCA GGC TCC 480 Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - CCG CTC AGG GTC ACC CAC ATC AAG GTC ATG TG - #C GAG GGT GGA CGC TAC 528 Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - ACA GTG GGT GGT TTG GAG ACC TTC GAC AGC CT - #C ACG GAC CTG GTG GAG 576 Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - CAT TTC AAG AAG ACG GGG ATT GAG GAG GCC TC - #A GGC GCC TTT GTC TAC 624 His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - CTG CGG CAG CCG TAC TAT GCC ACG AGG GTG AA - #T GCG GCT GAC ATT GAG 672 Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - AAC CGA GTG TTG GAA CTG AAC AAG AAG CAG GA - #G TCC GAG GAT ACA GCC 720 Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - AAG GCT GGC TTC TGG GAG GAG TTT GAG AGT TT - #G CAG AAG CAG GAG GTG 768 Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - AAG AAC TTG CAC CAG CGT CTG GAA GGG CAA CG - #G CCA GAG AAC AAG GGC 816 Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - AAG AAC CGC TAC AAG AAC ATT CTC CCC TTT GA - #C CAC AGC CGA GTG ATC 864 Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - CTG CAG GGA CGG GAC AGT AAC ATC CCC GGG TC - #C GAC TAC ATC AAT GCC 912 Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - AAC TAC ATC AAG AAC CAG CTG CTA GGC CCT GA - #T GAG AAC GCT AAG ACC 960 Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - TAC ATC GCC AGC CAG GGC TGT CTG GAG GCC AC - #G GTC AAT GAC TTC TGG 1008 Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - CAG ATG GCG TGG CAG GAG AAC AGC CGT GTC AT - #C GTC ATG ACC ACC CGA 1056 Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - GAG GTG GAG AAA GGC CGG AAC AAA TGC GTC CC - #A TAC TGG CCC GAG GTG 1104 Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - GGC ATG CAG CGT GCT TAT GGG CCC TAC TCT GT - #G ACC AAC TGC GGG GAG 1152 Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - CAT GAC ACA ACC GAA TAC AAA CTC CGT ACC TT - #A CAG GTC TCC CCG CTG 1200 His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - GAC AAT GGA GAC CTG ATT CGG GAG ATC TGG CA - #T TAC CAG TAC CTG AGC 1248 Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - TGG CCC GAC CAT GGG GTC CCC AGT GAG CCT GG - #G GGT GTC CTC AGC TTC 1296 Trp Pro Asp His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - CTG GAC CAG ATC AAC CAG CGG CAG GAA AGT CT - #G CCT CAC GCA GGG CCC 1344 Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - ATC ATC GTG CAC TGC AGC GCC GGC ATC GGC CG - #C ACA GGC ACC ATC ATT 1392 Ile Ile Val His Cys Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - GTC ATC GAC ATG CTC ATG GAG AAC ATC TCC AC - #C AAG GGC CTG GAC TGT 1440 Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - GAC ATT GAC ATC CAG AAG ACC ATC CAG ATG GT - #G CGG GCG CAG CGC TCG 1488 Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - GGC ATG GTG CAG ACG GAG GCG CAG TAC AAG TT - #C ATC TAC GTG GCC ATC 1536 Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - GCC CAG TTC ATT GAA ACC ACT AAG AAG AAG CT - #G GAG GTC CTG CAG TCG 1584 Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser
515 - # 520 - # 525 - - CAG AAG GGC CAG GAG TCG GAG TAC GGG AAC AT - #C ACC TAT CCC CCA GCC 1632 Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - ATG AAG AAT GCC CAT GCC AAG GCC TCC CGC AC - #C TCG TCC AAA CAC AAG 1680 Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - GAG GAT GTG TAT GAG AAC CTG CAC ACT AAG AA - #C AAG AGG GAG GAG AAA 1728 Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - GTG AAG AAG CAG CGG TCA GCA GAC AAG GAG AA - #G AGC AAG GGT TCC CTC 1776 Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - AAG AGG AAG TGA - # - # - # 1788 Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:60: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 595 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:60: - - Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Arg Pro Ser 20 - # 25 - # 30 - - Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - Val Thr His Ile Arg Ile Gln Asn Ser Gly Al - #a Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - Trp Pro Asp His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - Ile Ile Val His Cys Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:61: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1788 base - #pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..1785 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:61: - - ATG GTG AGG TGG TTT CAC CGA GAC CTC AGT GG - #G CTG GAT GCA GAG ACC 48 Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - CTG CTC AAG GGC CGA GGT GTC CAC GGT AGC TT - #C CTG GCT CGG CCC AGT 96 Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Arg Pro Ser 20 - # 25 - # 30 - - CGC AAG AAC CAG GGT GAC TTC TCG CTC TCC GT - #C AGG GTG GGG GAT CAG 144 Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - GTG ACC CAT ATT CGG ATC CAG AAC TCA GGG GA - #T TTC TAT GAC CTG TAT 192 Val Thr His Ile Arg Ile Gln Asn Ser Gly As - #p Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - GGA GGG GAG AAG TTT GCG ACT CTG ACA GCG CT - #G GTG GAG TAC TAC ACT 240 Gly Gly Glu Lys Phe Ala Thr Leu Thr Ala Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - CAG CAG CAG GGT GTG GTG CAG GAC CGC GAC GG - #C ACC ATC ATC CAC CTC 288 Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - AAG TAC CCG CTG AAC TGC TCC GAT CCC ACT AG - #T GAG AGG TGG TAC CAT 336 Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - GGC CAC ATG TCT GGC GGG CAG GCA GAG ACG CT - #G CTG CAG GCC AAG GGC 384 Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - GAG CCC TGG ACG TTT CTT GTG CGT GAG AGC CT - #C AGC CAG CCT GGA GAC 432 Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - TTC GTG CTT TCT GTG CTC AGT GAC CAG CCC AA - #G GCT GGC CCA GGC TCC 480 Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - CCG CTC AGG GTC ACC CAC ATC AAG GTC ATG TG - #C GAG GGT GGA CGC TAC 528 Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - ACA GTG GGT GGT TTG GAG ACC TTC GAC AGC CT - #C ACG GAC CTG GTG GAG 576 Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - CAT TTC AAG AAG ACG GGG ATT GAG GAG GCC TC - #A GGC GCC TTT GTC TAC 624 His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - CTG CGG CAG CCG TAC TAT GCC ACG AGG GTG AA - #T GCG GCT GAC ATT GAG 672 Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - AAC CGA GTG TTG GAA CTG AAC AAG AAG CAG GA - #G TCC GAG GAT ACA GCC 720 Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - AAG GCT GGC TTC TGG GAG GAG TTT GAG AGT TT - #G CAG AAG CAG GAG GTG 768 Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - AAG AAC TTG CAC CAG CGT CTG GAA GGG CAA CG - #G CCA GAG AAC AAG GGC 816 Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - AAG AAC CGC TAC AAG AAC ATT CTC CCC TTT GA - #C CAC AGC CGA GTG ATC 864 Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - CTG CAG GGA CGG GAC AGT AAC ATC CCC GGG TC - #C GAC TAC ATC AAT GCC 912 Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - AAC TAC ATC AAG AAC CAG CTG CTA GGC CCT GA - #T GAG AAC GCT AAG ACC 960 Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - TAC ATC GCC AGC CAG GGC TGT CTG GAG GCC AC - #G GTC AAT GAC TTC TGG 1008 Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - CAG ATG GCG TGG CAG GAG AAC AGC CGT GTC AT - #C GTC ATG ACC ACC CGA 1056 Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - GAG GTG GAG AAA GGC CGG AAC AAA TGC GTC CC - #A TAC TGG CCC GAG GTG 1104 Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - GGC ATG CAG CGT GCT TAT GGG CCC TAC TCT GT - #G ACC AAC TGC GGG GAG 1152 Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - CAT GAC ACA ACC GAA TAC AAA CTC CGT ACC TT - #A CAG GTC TCC CCG CTG 1200 His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - GAC AAT GGA GAC CTG ATT CGG GAG ATC TGG CA - #T TAC CAG TAC CTG AGC 1248 Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - TGG CCC GAC CAT GGG GTC CCC AGT GAG CCT GG - #G GGT GTC CTC AGC TTC 1296 Trp Pro Asp His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - CTG GAC CAG ATC AAC CAG CGG CAG GAA AGT CT - #G CCT CAC GCA GGG CCC 1344 Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - ATC ATC GTG CAC TGC AGC GCC GGC ATC GGC CG - #C ACA GGC ACC ATC ATT 1392 Ile Ile Val His Cys Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - GTC ATC GAC ATG CTC ATG GAG AAC ATC TCC AC - #C AAG GGC CTG GAC TGT 1440 Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - GAC ATT GAC ATC CAG AAG ACC ATC CAG ATG GT - #G CGG GCG CAG CGC TCG 1488 Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser
485 - # 490 - # 495 - - GGC ATG GTG CAG ACG GAG GCG CAG TAC AAG TT - #C ATC TAC GTG GCC ATC 1536 Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - GCC CAG TTC ATT GAA ACC ACT AAG AAG AAG CT - #G GAG GTC CTG CAG TCG 1584 Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - CAG AAG GGC CAG GAG TCG GAG TAC GGG AAC AT - #C ACC TAT CCC CCA GCC 1632 Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - ATG AAG AAT GCC CAT GCC AAG GCC TCC CGC AC - #C TCG TCC AAA CAC AAG 1680 Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - GAG GAT GTG TAT GAG AAC CTG CAC ACT AAG AA - #C AAG AGG GAG GAG AAA 1728 Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - GTG AAG AAG CAG CGG TCA GCA GAC AAG GAG AA - #G AGC AAG GGT TCC CTC 1776 Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - AAG AGG AAG TGA - # - # - # 1788 Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:62: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 595 amino - #acids (B) TYPE: amino acid (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:62: - - Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Arg Pro Ser 20 - # 25 - # 30 - - Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - Val Thr His Ile Arg Ile Gln Asn Ser Gly As - #p Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - Gly Gly Glu Lys Phe Ala Thr Leu Thr Ala Le - #u Val Glu Tyr Tyr Thr 65 - # 70 - # 75 - # 80 - - Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270 - - Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - Trp Pro Asp His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - Ile Ile Val His Cys Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Le - #u Glu Val Leu Gln Ser 515 - # 520 - # 525 - - Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Il - #e Thr Tyr Pro Pro Ala 530 - # 535 - # 540 - - Met Lys Asn Ala His Ala Lys Ala Ser Arg Th - #r Ser Ser Lys His Lys 545 5 - #50 5 - #55 5 - #60 - - Glu Asp Val Tyr Glu Asn Leu His Thr Lys As - #n Lys Arg Glu Glu Lys 565 - # 570 - # 575 - - Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Ly - #s Ser Lys Gly Ser Leu 580 - # 585 - # 590 - - Lys Arg Lys 595 - - - - (2) INFORMATION FOR SEQ ID NO:63: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 524 amino - #acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: peptide - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:63: - - Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Arg 20 - # 25 - # 30 - - Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Asp Tyr Tyr Asp 50 - # 55 - # 60 - - Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Glu Leu Val Gln Tyr 65 - #70 - #75 - #80 - - Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pr - #o Thr Ser Glu Arg Trp 100 - # 105 - # 110 - - Phe His Gly His Leu Ser Gly Lys Glu Ala Gl - #u Lys Leu Leu Thr Glu 115 - # 120 - # 125 - - Lys Gly Lys His Gly Ser Phe Leu Val Arg Gl - #u Ser Gln Ser His Pro 130 - # 135 - # 140 - - Gly Asp Phe Val Leu Ser Val Arg Thr Gly As - #p Asp Lys Gly Glu Ser 145 1 - #50 1 - #55 1 - #60 - - Asn Asp Gly Lys Ser Lys Val Thr His Val Me - #t Ile Arg Cys Gln Glu 165 - # 170 - # 175 - - Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Ph - #e Asp Ser Leu Thr Asp 180 - # 185 - # 190 - - Leu Val Glu His Tyr Lys Lys Asn Pro Met Va - #l Glu Thr Leu Gly Thr 195 - # 200 - # 205 - - Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Th - #r Arg Ile Asn Ala Ala 210 - # 215 - # 220 - - Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Ly - #s Leu Ala Glu Thr Thr 225 2 - #30 2 - #35 2 - #40 - - Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Ph - #e Glu Thr Leu Gln Gln 245 - # 250 - # 255 - - Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Gl - #u Gly Gln Arg Gln Glu 260 - # 265 - # 270 - - Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Le - #u Pro Phe Asp His Thr 275 - # 280 - # 285 - - Arg Val Val Leu His Asp Gly Asp Pro Asn Gl - #u Pro Val Ser Asp Tyr 290 - # 295 - # 300 - - Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Gl - #u Thr Lys Cys Asn Asn 305 3 - #10 3 - #15 3 - #20 - - Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gl - #n Gly Cys Leu Gln Asn 325 - # 330 - # 335 - - Thr Val Asn Asp Phe Trp Arg Met Val Phe Gl - #n Glu Asn Ser Arg Val 340 - # 345 - # 350 - - Ile Val Met Thr Thr Lys Glu Val Glu Arg Gl - #y Lys Ser Lys Cys Val 355 - # 360 - # 365 - - Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Gl - #u Tyr Gly Val Met Arg 370 - # 375 - # 380 - - Val Arg Asn Val Lys Glu Ser Ala Ala His As - #p Tyr Thr Leu Arg Glu 385 3 - #90 3 - #95 4 - #00 - - Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Th - #r Glu Arg Thr Val Met 405 - # 410 - # 415 - - Gln Tyr His Phe Arg Thr Trp Pro Asp His Gl - #y Val Pro Ser Asp Pro 420 - # 425 - # 430 - - Gly Gly Val Leu Asp Phe Leu Glu Glu Val Hi - #s His Lys Gln Glu Ser 435 - # 440 - # 445 - - Ile Met Asp Ala Gly Pro Val Val Val His Cy - #s Ser Ala Gly Ile Gly 450 - # 455 - # 460 - - Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Le - #u Ile Asp Ile Ile Arg 465 4 - #70 4 - #75 4 - #80 - - Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pr - #o Lys Thr Ile Gln Met 485 - # 490 - # 495 - - Val Arg Ser Gln Arg Ser Gly Met Val Gln Th - #r Glu Ala Gln Tyr Arg 500 - # 505 - # 510 - - Phe Ile Tyr Met Ala Val Gln His Tyr Ile Gl - #u Thr 515 - # 520 - - - - (2) INFORMATION FOR SEQ ID NO:64: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 518 amino - #acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: peptide - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:64: - - Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Arg Pro Ser 20 - # 25 - # 30 - - Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - Val Thr His Ile Arg Ile Gln Asn Ser Gly As - #p Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Le - #u Val Glu Tyr Tyr Thr 65 - #70 - #75 - #80 - - Gln Gln Gln Gly Val Leu Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Se - #r Glu Arg Trp Tyr His 100 - # 105 - # 110 - - Gly His Met Ser Gly Gly Gln Ala Glu Thr Le - #u Leu Gln Ala Lys Gly 115 - # 120 - # 125 - - Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Le - #u Ser Gln Pro Gly Asp 130 - # 135 - # 140 - - Phe Val Leu Ser Val Leu Ser Asp Gln Pro Ly - #s Ala Gly Pro Gly Ser 145 1 - #50 1 - #55 1 - #60 - - Pro Leu Arg Val Thr His Ile Lys Val Met Cy - #s Glu Gly Gly Arg Tyr 165 - # 170 - # 175 - - Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Le - #u Thr Asp Leu Val Glu 180 - # 185 - # 190 - - His Phe Lys Lys Thr Gly Ile Glu Glu Ala Se - #r Gly Ala Phe Val Tyr 195 - # 200 - # 205 - - Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val As - #n Ala Ala Asp Ile Glu 210 - # 215 - # 220 - - Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Gl - #u Ser Glu Asp Thr Ala 225 2 - #30 2 - #35 2 - #40 - - Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Le - #u Gln Lys Gln Glu Val 245 - # 250 - # 255 - - Lys Asn Leu His Gln Arg Leu Glu Gly Gln Ar - #g Pro Glu Asn Lys Gly 260 - # 265 - # 270
- - Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe As - #p His Ser Arg Val Ile 275 - # 280 - # 285 - - Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Se - #r Asp Tyr Ile Asn Ala 290 - # 295 - # 300 - - Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro As - #p Glu Asn Ala Lys Thr 305 3 - #10 3 - #15 3 - #20 - - Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Th - #r Val Asn Asp Phe Trp 325 - # 330 - # 335 - - Gln Met Ala Trp Gln Glu Asn Ser Arg Val Il - #e Val Met Thr Thr Arg 340 - # 345 - # 350 - - Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pr - #o Tyr Trp Pro Glu Val 355 - # 360 - # 365 - - Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Va - #l Thr Asn Cys Gly Glu 370 - # 375 - # 380 - - His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Le - #u Gln Val Ser Pro Leu 385 3 - #90 3 - #95 4 - #00 - - Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp Hi - #s Tyr Gln Tyr Leu Ser 405 - # 410 - # 415 - - Trp Pro Asp His Gly Val Pro Ser Glu Pro Gl - #y Gly Val Leu Ser Phe 420 - # 425 - # 430 - - Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Le - #u Pro His Ala Gly Pro 435 - # 440 - # 445 - - Ile Ile Val His Cys Ser Ala Gly Ile Gly Ar - #g Thr Gly Thr Ile Ile 450 - # 455 - # 460 - - Val Ile Asp Met Leu Met Glu Asn Ile Ser Th - #r Lys Gly Leu Asp Cys 465 4 - #70 4 - #75 4 - #80 - - Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Va - #l Arg Ala Gln Arg Ser 485 - # 490 - # 495 - - Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Ph - #e Ile Tyr Val Ala Ile 500 - # 505 - # 510 - - Ala Gln Phe Ile Glu Thr 515 - - - - (2) INFORMATION FOR SEQ ID NO:65: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 491 amino - #acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: peptide - - (ix) FEATURE: (A) NAME/KEY: Modified-sit - #e (B) LOCATION: 292 (D) OTHER INFORMATION: - #/product= "158 amino acid insert in the PTO - #domain" - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:65: - - Met Ser Ser Arg Arg Trp Phe His Pro Thr Il - #e Ser Gly Ile Glu Ala 1 5 - # 10 - # 15 - - Glu Lys Leu Leu Gln Glu Gln Gly Phe Asp Gl - #y Ser Phe Leu Ala Arg 20 - # 25 - # 30 - - Leu Ser Ser Ser Asn Pro Gly Ala Phe Thr Le - #u Ser Val Arg Arg Gly 35 - # 40 - # 45 - - Asn Glu Val Thr His Ile Lys Ile Gln Asn As - #n Gly Asp Phe Phe Asp 50 - # 55 - # 60 - - Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Pr - #o Glu Leu Val Gln Tyr 65 - #70 - #75 - #80 - - Tyr Met Glu Asn Gly Glu Leu Lys Glu Lys As - #n Gly Ile Ala Ile Glu 85 - # 90 - # 95 - - Leu Lys Gln Pro Leu Ile Cys Ala Glu Pro Th - #r Thr Glu Arg Trp Phe 100 - # 105 - # 110 - - His Gly Asn Leu Ser Gly Lys Glu Ala Glu Ly - #s Leu Ile Leu Glu Arg 115 - # 120 - # 125 - - Gly Lys Asn Gly Ser Phe Leu Val Arg Glu Se - #r Gln Ser Lys Pro Gly 130 - # 135 - # 140 - - Asp Phe Val Leu Ser Val Arg Thr Asp Asp Ly - #s Val Thr His Val Met 145 1 - #50 1 - #55 1 - #60 - - Ile Arg Trp Gln Asp Lys Lys Tyr Asp Val Gl - #y Gly Gly Glu Ser Phe 165 - # 170 - # 175 - - Gly Thr Leu Ser Glu Leu Ile Asp His Tyr Ly - #s Arg Asn Pro Met Val 180 - # 185 - # 190 - - Glu Thr Cys Gly Thr Val Val His Leu Arg Gl - #n Pro Phe Asn Ala Thr 195 - # 200 - # 205 - - Arg Ile Thr Ala Ala Gly Ile Asn Ala Arg Va - #l Glu Gln Leu Val Lys 210 - # 215 - # 220 - - Gly Gly Phe Trp Glu Glu Phe Glu Ser Leu Gl - #n Gln Asp Ser Arg Asp 225 2 - #30 2 - #35 2 - #40 - - Thr Phe Ser Arg Asn Glu Gly Tyr Lys Gln Gl - #u Asn Arg Leu Lys Asn 245 - # 250 - # 255 - - Arg Tyr Arg Asn Ile Leu Pro Tyr Asp His Th - #r Arg Val Lys Leu Leu 260 - # 265 - # 270 - - Asp Val Glu His Ser Val Ala Gly Ala Glu Ty - #r Ile Asn Ala Asn Tyr 275 - # 280 - # 285 - - Ile Arg Leu Xaa Gly Cys Leu Leu Thr Gln Gl - #n Val Asn Thr Val Thr 290 - # 295 - # 300 - - Asp Phe Trp Asn Met Val Trp Gln Glu Asn Th - #r Arg Val Ile Val Met 305 3 - #10 3 - #15 3 - #20 - - Thr Thr Lys Glu Tyr Glu Arg Gly Lys Glu Ly - #s Cys Ala Arg Tyr Trp 325 - # 330 - # 335 - - Pro Asp Glu Gly Arg Ser Glu Gln Phe Gly Hi - #s Ala Arg Ile Gln Cys 340 - # 345 - # 350 - - Val Ser Glu Asn Ser Thr Ser Asp Tyr Thr Le - #u Arg Glu Phe Leu Val 355 - # 360 - # 365 - - Ser Trp Arg Asp Gln Pro Ala Arg Arg Ile Ph - #e His Tyr His Phe Gln 370 - # 375 - # 380 - - Val Trp Pro Asp His Gly Val Pro Ala Asp Pr - #o Gly Cys Val Leu Asn 385 3 - #90 3 - #95 4 - #00 - - Phe Leu Gln Asp Val Asn Thr Arg Gln Ser Hi - #s Leu Ala Gln Ala Gly 405 - # 410 - # 415 - - Glu Lys Pro Gly Pro Ile Cys Val His Cys Se - #r Ala Gly Ile Gly Arg 420 - # 425 - # 430 - - Thr Gly Thr Phe Ile Val Ile Asp Met Ile Le - #u Asp Gln Ile Val Arg 435 - # 440 - # 445 - - Asn Gly Leu Asp Thr Glu Ile Asp Ile Gln Ar - #g Thr Ile Gln Met Val 450 - # 455 - # 460 - - Arg Ser Gln Arg Ser Gly Leu Val Gln Thr Gl - #u Ala Gln Tyr Lys Phe 465 4 - #70 4 - #75 4 - #80 - - Val Tyr Tyr Ala Val Gln His Tyr Ile Gln Th - #r 485 - # 490 - - - - (2) INFORMATION FOR SEQ ID NO:66: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 104 amino - #acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: peptide - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:66: - - Met Thr Ser Arg Arg Trp Phe His Pro Asn Il - #e Thr Gly Val Glu Ala 1 5 - # 10 - # 15 - - Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gl - #y Ser Phe Leu Ala Arg 20 - # 25 - # 30 - - Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Le - #u Ser Val Arg Arg Asn 35 - # 40 - # 45 - - Gly Ala Val Thr His Ile Lys Ile Gln Asn Th - #r Gly Asp Tyr Tyr Asp 50 - # 55 - # 60 - - Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Al - #a Glu Leu Val Gln Tyr 65 - #70 - #75 - #80 - - Tyr Met Glu His His Gly Gln Leu Lys Glu Ly - #s Asn Gly Asp Val Ile 85 - # 90 - # 95 - - Glu Leu Lys Tyr Pro Leu Asn Cys 100 - - - - (2) INFORMATION FOR SEQ ID NO:67: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 102 amino - #acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: peptide - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:67: - - Met Val Arg Trp Phe His Arg Asp Leu Ser Gl - #y Leu Asp Ala Glu Thr 1 5 - # 10 - # 15 - - Leu Leu Lys Gly Arg Gly Val His Gly Ser Ph - #e Leu Ala Arg Pro Ser 20 - # 25 - # 30 - - Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Va - #l Arg Val Gly Asp Gln 35 - # 40 - # 45 - - Val Thr His Ile Arg Ile Gln Asn Ser Gly As - #p Phe Tyr Asp Leu Tyr 50 - # 55 - # 60 - - Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Le - #u Val Glu Tyr Tyr Thr 65 - #70 - #75 - #80 - - Gln Gln Gln Gly Val Val Gln Asp Arg Asp Gl - #y Thr Ile Ile His Leu 85 - # 90 - # 95 - - Lys Tyr Pro Leu Ile Cys 100 - - - - (2) INFORMATION FOR SEQ ID NO:68: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 103 amino - #acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: peptide - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:68: - - Met Ser Ser Arg Arg Trp Phe His Pro Thr Il - #e Ser Gly Ile Glu Ala 1 5 - # 10 - # 15 - - Glu Lys Leu Leu Gln Glu Gln Gly Phe Asp Gl - #y Ser Phe Leu Ala Arg 20 - # 25 - # 30 - - Leu Ser Ser Ser Asn Pro Gly Ala Phe Thr Le - #u Ser Val Arg Arg Gly 35 - # 40 - # 45 - - Asn Glu Val Thr His Ile Lys Ile Gln Asn As - #n Gly Asp Phe Phe Asp 50 - # 55 - # 60 - - Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Pr - #o Glu Leu Val Gln Tyr 65 - #70 - #75 - #80 - - Tyr Met Glu Asn Gly Glu Leu Lys Glu Lys As - #n Gly Gln Ala Ile Glu 85 - # 90 - # 95 - - Leu Lys Gln Pro Leu Ile Cys 100 - - - - (2) INFORMATION FOR SEQ ID NO:69: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 amino - #acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: peptide - - (ix) FEATURE: (A) NAME/KEY: Modified-sit - #e (B) LOCATION: 4 (D) OTHER INFORMATION: - #/product= "phosphorylated" - - (ix) FEATURE: (A) NAME/KEY: Modified-sit - #e (B) LOCATION: 28 (D) OTHER INFORMATION: - #/product= "Phosphorylated" - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:69: - - Asp Ile Thr Tyr Ala Asp Leu Asn Leu Pro Ly - #s Gly Lys Lys Pro Ala 1 5 - # 10 - # 15 - - Pro Gln Ala Ala Glu Pro Asn Asn His Thr Gl - #u Tyr Ala Ser Ile Gln 20 - # 25 - # 30 - - Thr Ser - - - - (2) INFORMATION FOR SEQ ID NO:70: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 amino - #acids (B) TYPE: amino acid (C) STRANDEDNESS: (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: peptide - - (ix) FEATURE: (A) NAME/KEY: Modified-sit - #e (B) LOCATION: 5 (D) OTHER INFORMATION: - #/note= "5 = any amino acid" - - (ix) FEATURE: (A) NAME/KEY: Modified-sit - #e (B) LOCATION: 8 (D) OTHER INFORMATION: - #/note= "8 = any amino acid" - - (ix) FEATURE: (A) NAME/KEY: Modified-sit - #e (B) LOCATION: 9 (D) OTHER INFORMATION: - #/note= "9 = any amino acid" - - (ix) FEATURE: (A) NAME/KEY: Modified-sit - #e (B) LOCATION: 11 (D) OTHER INFORMATION: - #/note= "11 can be serine or threonine" - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:70: - - Ile Val His Cys Xaa Ala Gly Xaa Xaa Arg Xa - #a Gly 1 5 - # 10 __________________________________________________________________________