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United States Patent | 6,121,010 |
Vallee ,   et al. | September 19, 2000 |
A method for the treatment of alcohol abuse using daidzin and compounds analogous to daidzin is disclosed. Also disclosed is a method for screening compounds having antidipsotropic activity.
Inventors: | Vallee; Bert L. (Boston, MA); Keung; Wing-Ming (Wayland, MA) |
Assignee: | The Endowment for Research in Human Biology (Boston, MA) |
Appl. No.: | 310614 |
Filed: | May 12, 1999 |
Current U.S. Class: | 435/26; 435/25; 514/415; 514/456; 514/654 |
Intern'l Class: | C12Q 001/32; C12Q 001/26; A61K 031/405; A61K 031/135; A61K 031/35 |
Field of Search: | 435/26,25 514/415,654,456 |
5204369 | Apr., 1993 | Vallee et al. | 514/456. |
5624910 | Apr., 1997 | Vallee et al. | 514/27. |
Foreign Patent Documents | |||
WO 93/00896 | Jan., 1993 | WO. |
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TABLE I ______________________________________ ALDH-2 ETOH Intake No. R- K.sub.i .alpha.K.sub.i Suppression, % ______________________________________ 1 H- (daidzein) 9.2 180 32 2 Glc- (daidzin) 0.042 0.65 64 3 HOOC(CH.sub.2).sub.5 -- 0.009 0.15 70 4 HOOC(CH.sub.2).sub.6 -- 0.009 0.14 69 5 HOOC(CH.sub.2).sub.9 -- 0.004 0.05 84 6 HOOC(CH.sub.2).sub.10 -- 0.003 0.04 86 7 CH.sub.3 CH.sub.2 -- 0.035 0.56 nd 8. 1,3-dioxane-ethyl- 32 9. Br(CH.sub.2).sub.4 29 10. Br(CH.sub.2).sub.6 -- 0.003 0.07 14 11. (CH.sub.3 CH.sub.2).sub.3 N.sup.+ (CH.sub.2).sub.6 -- 0.005 0.08 nd 12. NH.sub.2 (CH.sub.2).sub.4 -- 18 13. NH.sub.2 (CH.sub.2).sub.6 -- 0.036 0.60 nd 14. Br(CH.sub.2).sub.6 CO-- 0.02 0.26 nd 15. (CH.sub.3 CH.sub.2).sub.3 N.sup.+ (CH.sub.2).sub.2 -- 0.08 1.6 nd 16. ClCH.sub.2 CO-- 1.06 10.6 nd 17. BrCH.sub.2 CO-- 1.8 20 nd 18. (CH.sub.3).sub.2 N(CH.sub.2).sub.3 CO-- 1.75 24 nd 19. HOCH.sub.2 (OH)CHCH.sub.2 -- 17 20. Puerarine 15 440 0 21. Chrysin 35 110 0 22. 7,8-Dihydroxyflavone 35 270 0 ______________________________________