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United States Patent | 6,096,745 |
Poindexter ,   et al. | August 1, 2000 |
A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of heteroaryl derivatives of imidazolone compounds of Formula 1. ##STR1## As antagonists of NPY-induced feeding behavior, these compounds and known analogs are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.
Inventors: | Poindexter; Graham S. (Old Saybrook, CT); Gillman; Kevin (Madison, CT) |
Assignee: | Bristol-Myers Squibb Co. (Princeton, NJ) |
Appl. No.: | 261658 |
Filed: | March 3, 1999 |
Current U.S. Class: | 514/252.05; 514/252.1; 514/256; 514/341; 514/380; 544/333; 544/405; 546/274.1; 546/274.4; 548/260; 548/312.4; 548/314.7; 548/315.1; 548/315.7 |
Intern'l Class: | A61K 031/416.6; C07D 233/70; C07D 239/24; C07D 241/10 |
Field of Search: | 544/333,405 546/274.1,274.4 548/260,312.4,315.7,315.1,314.7,351.1,351.7 514/252,256,341,380 |
3894008 | Jul., 1975 | Irvine | 546/274. |
Gehlert, et al., "Neuropeptide Y Receptor Antagonists in Obesity," Expert Opinion on Investigational Drugs, vol. 6, No. 12, Dec. 1997, pp. 1827-1838 . |