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United States Patent | 6,087,336 |
Edwards ,   et al. | July 11, 2000 |
The invention concerns pharmaceutically useful peptide derivatives of the formula (I): P--R.sup.1 --R.sup.2 --R.sup.3 --R.sup.4, in which P, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 have the various meanings defined herein, and their pharmaceutically acceptable salts, and pharmaceutical compositions containing them. The novel peptide derivatives are of value in treating MHC class II dependent T-cell mediated autoimmune or inflammatory diseases, such as rheumatoid arthritis. The invention further concerns processes for the manufacture of the novel peptide derivatives and the use of the compounds in medical treatment.
Inventors: | Edwards; Philip Neil (Macclesfield, GB); Luke; Richard William Arthur (Macclesfield, GB); Cotton; Ronald (Macclesfield, GB) |
Assignee: | Zeneca Limited (Macclesfield, GB) |
Appl. No.: | 125517 |
Filed: | August 20, 1998 |
PCT Filed: | February 18, 1997 |
PCT NO: | PCT/GB97/00438 |
371 Date: | August 20, 1998 |
102(e) Date: | August 20, 1998 |
PCT PUB.NO.: | WO97/31023 |
PCT PUB. Date: | August 28, 1997 |
Feb 23, 1996[GB] | 9603855 | |
Oct 05, 1996[GB] | 9620819 |
Current U.S. Class: | 514/14; 514/15; 514/16; 530/327; 530/328; 530/332 |
Intern'l Class: | A61K 038/08; A61K 038/10; C07K 007/06; C07K 007/08 |
Field of Search: | 514/14,15,16,17 530/327,328,329,332 |
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5166136 | Nov., 1992 | Ward et al. | 514/15. |
5223485 | Jun., 1993 | Kawai et al. | 514/16. |
5331089 | Jul., 1994 | Curtis et al. | 530/317. |
5719296 | Feb., 1998 | Acton, III et al. | 548/550. |
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______________________________________ Concentration Volume of Volume of of peptide(.mu. stock polymer stock peptide g/ml) solution (.mu.l) solution (.mu.l) ______________________________________ 50 1000 1000 40 1000 800 30 1000 600 20 1000 400 10 1000 200 5 1000 100 0 1000 0 ______________________________________
__________________________________________________________________________ # SEQUENCE LISTING - (1) GENERAL INFORMATION: - (iii) NUMBER OF SEQUENCES: 62 - (2) INFORMATION FOR SEQ ID NO: 1: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" /note= "[(S)-2 - #-((R)-3-amino-2-oxopyrrolidin-1-yl)propanoyl]- Ala-piperidi - #ne-4-car #1: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Lys Val Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 2: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-(6-oxo-1,7-diazaspiro[4.4]non-7-yl) propanoyl]- #-Ala-piperidine-4-ca #2: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Lys Val Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 3: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:4 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"Ala-piperidine-4-carboxamide" #3: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Lys Ala Xaa Ala Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 4: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Ile" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala-4-aminophenylace #4: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Arg Thr Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 5: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Arg" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala-piperidine-4-car #5: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Ala Val Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 6: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Arg" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala-4-aminophenylace #6: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Ala Thr Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 7: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala-4-aminophenylace #7: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Arg Val Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 8: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Gly-4-aminophenylace #8: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Arg Ala Arg Val Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 9: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala-piperidine-4-car #9: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ile Ala Arg Val Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 10: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala-4-aminophenylace #10: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Arg Ala His Val Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 11: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala-piperidine-4-car #11: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Asn Arg Val Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 12: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide
(B) LOCATION:4 (D) OTHER INFORMATION:/pro - #duct= "OTHER"/note= "[(S)-2 - #-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"Ala-piperidine-4-carboxamide" #12: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Arg Ala Xaa Ala Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 13: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Gly-3-aminopropylami #13: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Arg Ala Ala Thr Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 14: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Gly-3-aminopropylgua #14: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Arg Ala Ala Thr Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 15: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Gly-NHethyl" #15: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Arg Ala Arg Thr Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 16: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-3-guanidinoAla" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala-4-aminophenylace #16: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Ala Thr Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 17: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-3-(tetramethylguanidino)Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala-4-aminophenylace #17: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Ala Thr Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 18: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Arg" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Gly-4-(2-aminoethyl) #18: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Ala Thr Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 19: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Arg" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Gly-piperazin-4-yl.C #19: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Ala Thr Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 20: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Arg" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Gly-4-aminophenethyl #20: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Ala Thr Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 21: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala-4-aminophenylace #21: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Arg Thr Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 22: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-[NH-NH-CO]-4-aminoph #22: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Arg Ala Arg Thr Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 23: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-NH-NH-CONH2" #23: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Arg Ala Arg Thr Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 24: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Ala"
- (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:4 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"Ala-4-aminophenylacetamide" #24: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Arg Ala Xaa Arg Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 25: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"3-(2-cyanobenzo[b]thiophen-5-yl)propanoyl-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:4 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"Ala-4-aminophenylacetamide" #25: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Arg Ala Xaa Arg Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 26: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Arg" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:4 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"Ala-4-aminophenylacetamide" #26: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Xaa Arg Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 27: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Arg" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:4 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"Ala-4-aminophenylacetamide" #27: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ile Ala Xaa Arg Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 28: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Ile" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:4 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Leu" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"Ala-4-aminophenylacetamide" #28: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Arg Ala Xaa Arg Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 29: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:4 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[((R)-3-amino-2-oxopyrrolidin-1-yl)acetyl]-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"Ala-4-aminophenylacetamide" #29: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Arg Ala Xaa Ala Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 30: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Arg" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:4 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"Ala-4-aminophenylacetamide" #30: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Xaa Ala Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 31: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-tetramethylhomoArg-" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala-4-aminophenylace #31: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Ala Thr Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 32: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Arg" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala-(4-aminophenyl.C #32: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Ala Thr Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 33: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Arg" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala-4-aminophenylace methyl ester" #33: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Ala Thr Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 34: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Arg" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala-4-aminophenyl ac #34: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Ala Thr Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 35: - (i) SEQUENCE CHARACTERISTICS:
#acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Arg" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala-4-aminophenylace #35: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Ala Thr Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 36: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Dpr" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala-4-aminophenylace #36: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Ala Thr Xaa 1 5 - (2) INFORMATION FOR SEQ ID NO: 37: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 5 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide #37: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Ala Ala Ala Lys Val 1 5 - (2) INFORMATION FOR SEQ ID NO: 38: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 5 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide #38: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Ala Lys Ala Ala Val 1 5 - (2) INFORMATION FOR SEQ ID NO: 39: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 5 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide #39: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Ala Ala Ala Arg Val 1 5 - (2) INFORMATION FOR SEQ ID NO: 40: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 5 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide #40: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Ala Arg Ala Ala Val 1 5 - (2) INFORMATION FOR SEQ ID NO: 41: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 5 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide #41: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Ala Lys Ala Lys Val 1 5 - (2) INFORMATION FOR SEQ ID NO: 42: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 5 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide #42: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Ala Arg Ala Arg Val 1 5 - (2) INFORMATION FOR SEQ ID NO: 43: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 5 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide #43: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Ala Arg Ala Lys Val 1 5 - (2) INFORMATION FOR SEQ ID NO: 44: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 5 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide #44: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Ala Lys Ala Arg Val 1 5 - (2) INFORMATION FOR SEQ ID NO: 45: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 5 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide #45: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Ile Ala Ala Arg Thr 1 5 - (2) INFORMATION FOR SEQ ID NO: 46: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 5 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide #46: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Arg Ala Ala Ala Val 1 5 - (2) INFORMATION FOR SEQ ID NO: 47: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 5 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide #47: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Arg Ala Ala Ala Thr 1 5 - (2) INFORMATION FOR SEQ ID NO: 48: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 5 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide #48: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Ala Ala Ala Arg Thr 1 5 - (2) INFORMATION FOR SEQ ID NO: 49: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 5 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide #49: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Ala Arg Ala Arg Thr 1 5 - (2) INFORMATION FOR SEQ ID NO: 50: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 5 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide #50: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Ala Ile Ala Arg Val 1 5 - (2) INFORMATION FOR SEQ ID NO: 51: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 5 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide #51: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Ala Arg Ala His Val 1 5 - (2) INFORMATION FOR SEQ ID NO: 52: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 5 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide #52: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Ala Arg Ala Ala Thr 1 5 - (2) INFORMATION FOR SEQ ID NO: 53: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 5 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide #53: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Ala Ala Asn Arg Val 1 5 - (2) INFORMATION FOR SEQ ID NO: 54: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 5 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"3-guanidinoAla"ote= #54: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Ala Thr 1 5 - (2) INFORMATION FOR SEQ ID NO: 55: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 5 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"3-(tetramethylguanidino)Ala" #55: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Ala Thr 1 5 - (2) INFORMATION FOR SEQ ID NO: 56: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 4 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:4 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"cyclohexylAla"note= #56: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Tyr Ala Ala Xaa - (2) INFORMATION FOR SEQ ID NO: 57:
- (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 4 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide #57: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Tyr Ala Ala Phe 1 - (2) INFORMATION FOR SEQ ID NO: 58: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 4 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide #58: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Ala Phe Phe Phe 1 - (2) INFORMATION FOR SEQ ID NO: 59: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 4 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide #59: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Ala Ala Ala Phe 1 - (2) INFORMATION FOR SEQ ID NO: 60: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 15 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"biotinyl-2-aminohexanoyl" #60: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Pro Lys Tyr Val Lys Gln Asn Thr Leu Ly - #s Leu Ala Thr Gly # 15 - (2) INFORMATION FOR SEQ ID NO: 61: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 14 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide #61: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Le - #u Ala Thr Gly # 10 - (2) INFORMATION FOR SEQ ID NO: 62: - (i) SEQUENCE CHARACTERISTICS: #acids (A) LENGTH: 6 amino (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - (ii) MOLECULE TYPE: peptide - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:1 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"5-Phenylpentanoyl-Lys-" - (ix) FEATURE: (A) NAME/KEY: Peptide (B) LOCATION:6 (D) OTHER INFORMATION:/pro - #duct= "OTHER" #"[(S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl) propanoyl]- #-Ala-4-aminophenylace #62: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - Xaa Ala Ala Ala Thr Xaa 1 5 __________________________________________________________________________