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| United States Patent |
6,080,388
|
|
Gers-Barlag
, et al.
|
June 27, 2000
|
Cosmetic and dermatological sunscreen formulations containing triazine
derivatives and alkane carboxylic acids
Abstract
Light protection active ingredient combinations of tris(2-ethylhexyl)
4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)trisbenzoate and branched
and/or unbranched alkanecarboxylic acids having chain lengths of from 10
to 24 carbon atoms, at least 10% of these alkanecarboxylic acids being in
protonated form.
| Inventors:
|
Gers-Barlag; Heinrich (Hamburg, DE);
Kropke; Rainer (Hamburg, DE)
|
| Assignee:
|
Beiersdorf AG (Hamburg, DE)
|
| Appl. No.:
|
101115 |
| Filed:
|
January 25, 1999 |
| PCT Filed:
|
January 6, 1997
|
| PCT NO:
|
PCT/EP97/00029
|
| 371 Date:
|
January 25, 1999
|
| 102(e) Date:
|
January 25, 1999
|
| PCT PUB.NO.:
|
WO97/25020 |
| PCT PUB. Date:
|
July 17, 1997 |
Foreign Application Priority Data
| Jan 13, 1996[DE] | 196 01 104 |
| Current U.S. Class: |
424/60; 424/59; 424/400; 424/401 |
| Intern'l Class: |
A61K 007/44; A61K 007/42; A61K 007/00 |
| Field of Search: |
424/59,60,400,401
|
References Cited
| Foreign Patent Documents |
| 154303 | Sep., 1985 | EP.
| |
| 685224 | Dec., 1995 | EP.
| |
Primary Examiner: Dodson; Shelley A.
Attorney, Agent or Firm: Norris, McLaughlin & Marcus, P.A.
Claims
We claim:
1. A cosmetic or dermatologic composition comprising an amount effective to
protect skin against the damaging effects of UV light of a combination of:
a) tris (2-ethylhexyl) 4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)
trisbenzoate; and
b) one or more branched alkanecarboxylic acids having chain lengths from 10
to 24 carbon atoms, at least 10% of said alkanecarboxylic acids being in
protonated form.
2. A cosmetic or dermatologic composition according to claim 1, which
further comprises a salicylic acid derivative selected from the group
consisting of 4-isopropylbenzyl salicylate, 2-ethylhexyl salicylate, octyl
salicylate, homomenthyl salicylate and mixtures thereof.
3. A cosmetic or dermatologic composition according to claim 1, which
comprises tris (2-ethylhexyl) 4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)
trisbenzoate in an amount ranging from 0.1-10.0% by weight based on the
total weight of the composition.
4. A cosmetic or dermatologic composition according to claim 3, which
comprises tris (2-ethylhexyl) 4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)
trisbenzoate in an amount ranging from 0.5-6.0% by weight based on the
total weight of the composition.
5. A cosmetic or dermatologic composition according to claim 1, which
comprises one or more branched alkanecarboxylic acids having chain lengths
from 10 to 24 carbon atoms in an amount ranging from 0.1-10.0% by weight
based on the total weight of the composition.
6. A cosmetic or dermatologic composition according to claim 5, which
comprises one or more branched alkanecarboxylic acids having chain lengths
from 10 to 24 carbon atoms in an amount ranging from 0.5-6.0% by weight
based on the total weight of the composition.
7. A cosmetic or dermatologic composition according to claim 1, which
comprises:
a) tris (2-ethylhexyl) 4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)
trisbenzoate; and
b) one or more branched alkanecarboxylic acids having chain lengths from 10
to 24 carbon atoms;
in a weight ratio of a):b) ranging from 1:10 to 10:1.
8. A cosmetic or dermatologic composition according to claim 7, wherein the
ratio of a):b) ranges from 1:4 to 4:1.
9. A method of protecting skin from the damaging effects of UV light
comprising applying thereto a cosmetic or dermatologic composition
comprising an amount effective to protect skin against the damaging
effects of UV light of a combination of:
a) tris (2-ethylhexyl) 4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)
trisbenzoate; and
b) one or more branched alkanecarboxylic acids having chain lengths from 10
to 24 carbon atoms, at least 10% of said alkanecarboxylic acids being in
protonated form.
10. The method according to claim 9, wherein said cosmetic or dermatologic
composition further comprises a salicylic acid derivative selected from
the group consisting of 4-isopropylbenzyl salicylate, 2-ethylhexyl
salicylate, octyl salicylate, homomenthyl salicylate and mixtures thereof.
11. The method according to claim 9, wherein said cosmetic or dermatologic
composition comprises tris (2-ethylhexyl)
4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino) trisbenzoate in an amount
ranging from 0.1-10.0% by weight based on the total weight of the
composition.
12. The method according to claim 11, wherein said cosmetic or dermatologic
composition comprises tris (2-ethylhexyl)
4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino) trisbenzoate in an amount
ranging from 0.5-6.0% by weight based on the total weight of the
composition.
13. The method according to claim 9, wherein said cosmetic or dermatologic
composition comprises one or more branched alkanecarboxylic acids having
chain lengths from 10 to 24 carbon atoms in an amount ranging from
0.1-10.0% by weight based on the total weight of the composition.
14. The method according to claim 13, wherein said cosmetic or dermatologic
composition comprises one or more branched alkanecarboxylic acids having
chain lengths from 10 to 24 carbon atoms in an amount ranging from
0.5-6.0% by weight based on the total weight of the composition.
15. The method according to claim 9, wherein said cosmetic or dermatologic
composition comprises:
a) tris (2-ethylhexyl) 4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)
trisbenzoate; and
b) one or more branched alkanecarboxylic acids having chain lengths from 10
to 24 carbon atoms;
in a weight ratio of a):b) ranging from 1:10 to 10:1.
16. The method according to claim 15, wherein in said cosmetic or
dermatologic composition the ratio of a):b) ranges from 1:4 to 4:1.
Description
The present invention relates to cosmetic and dermatological light
protection formulations, in particular skin care cosmetic and
dermatological light protection formulations.
The damaging effect of the ultraviolet part of solar radiation on the skin
is generally known. While rays having a wavelength of less than 290 nm
(the UVC region) are absorbed by the ozone layer in the Earth's
atmosphere, rays in the region between 290 nm and 320 nm, the UVB range,
cause erythema, simple sunburn or even burns of varying severity.
The narrower region around 308 nm is stated as the erythema activity
maximum of sunlight.
Numerous compounds are known for protecting against UVB radiation; these
are usually derivatives of 3-benzylidenecamphor, 4-aminobenzoic acid,
cinnamic acid, salicylic acid, benzophenone and also
2-phenylbenzimidazole.
For the region between about 320 nm and about 400 nm, the UVA region, it is
also important to have available filter substances, since the rays of that
region can also cause damage. Thus, it has been found that UVA radiation
leads to damage of the elastic and collagenic fibres of connective tissue,
causing premature ageing of the skin, and that it is to be regarded as a
cause of numerous phototoxic and photoallergic reactions. The damaging
effect of UVB radiation can be intensified by UVA radiation.
However, UV radiation can also lead to photochemical reactions, in which
case the photochemical reaction products intervene in the skin's
metabolism.
Such photochemical reaction products are predominantly free-radical
compounds, for example hydroxyl radicals. Undefined free-radical
photo-products which are formed in the skin itself can also display
uncontrolled secondary reactions because of their high reactivity.
However, singlet oxygen, a non-radical excited state of the oxygen
molecule, can also be formed during UV irradiation, as can short-lived
epoxides and many others. Singlet oxygen, for example, differs from the
normal triplet oxygen (free-radical ground state) by its increased
reactivity. However, excited, reactive (free-radical) triplet states of
the oxygen molecule also exist.
UV radiation is also a type of ionizing radiation. There is therefore the
risk that UV exposure may also produce ionic species, which then, for
their part, are capable of oxidative intervention in the bio-chemical
processes.
An advantageous UVB filter is tris(2-ethylhexyl)
4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)trisbenzoate, synonym:
2,4,6-tris[anilino(p-carbo-2'-ethyl-1'-hexyloxy)]-1,3,5-triazine.
##STR1##
This UVB filter substance is marketed by BASF Aktiengesellschaft under the
trade name UVINUL.RTM. T 150 and is distinguished by good UV absorption
properties.
The main disadvantage of this UVB filter is poor solubility in lipids.
Known solvents for this UVB filter can dissolve a maximum of about 15% by
weight of this filter, corresponding to about 1-1.5% by weight of
dissolved, and thus active, UV filter substance.
It was therefore surprising, and could not have been foreseen by the person
skilled in the art, that light protection active ingredient combinations
of tris(2-ethylhexyl)
4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)trisbenzoate and branched
and/or unbranched alkanecarboxylic acids having chain lengths of from 10
to 24 carbon atoms, at least 10% of these alkanecarboxylic acids being in
protonated form, overcome the disadvantages of the prior art.
The invention also relates in particular to the use of branched and/or
unbranched alkanecarboxylic acids having chain lengths of from 10 to 24
carbon atoms, at least 10% of these alkanecarboxylic acids being in
protonated form, as solvents, solubility promoters or solubilizers for
tris(2-ethylhexyl)
4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)trisbenzoate, in particular
for the use in light protection formulations.
A prerequisite for the suitability of the active ingredient combinations
according to the invention for the purposes according to the invention is
of course the cosmetic and dermatological acceptability of the base
substances.
According to the invention, it is possible to double the use amounts of
tris(2-ethylhexyl)
4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)trisbenzoate in cosmetic or
dermatological formulations compared with the prior art.
In addition, it was surprising that the addition of the alkanecarboxylic
acids according to the invention has a stabilizing effect on solutions of
tris(2-ethylhexyl)
4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)trisbenzoate, since the latter
substance not only displays poor solubility, but also readily crystallizes
out again from its solution. The invention thus also relates to a process
for the stabilization of solutions of tris(2-ethylhexyl)
4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)trisbenzoate which is
characterized in that an effective content of alkanecarboxylic acids
according to the invention is added to such solutions.
Particular preference is given to those combinations which comprise, as
alkanecarboxylic acids, palmitic acid and/or stearic acid and/or
isostearic acid and/or eicosanoic acid.
The total amount of tris(2-ethylhexyl)
4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)trisbenzoate in the finished
cosmetic or dermatological formulations is advantageously chosen from the
range from 0.1-10.0% by weight, preferably 0.5-6.0% by weight, based on
the total weight of the formulations.
The total amount of one or more alkanecarboxylic acids according to the
invention in the finished cosmetic or dermatological preparations is
advantageously chosen from the range from 0.1-10% by weight, preferably
0.5-6.0% by weight, based on the total weight of the formulations.
It is advantageous to choose weight ratios of tris(2-ethylhexyl)
4,4',4"-(1,3,5-triazine-2,4,6-tri-yltriimino)trisbenzoate and one or more
alkanecarboxylic acids according to the invention from the range from 1:10
to 10:1, preferably 1:4 to 4:1.
Cosmetic and dermatological formulations according to the invention also
advantageously comprise inorganic pigments consisting of metal oxides
and/or other metal compounds which are sparingly soluble or insoluble in
water, in particular the oxides of titanium (TiO.sub.2), zinc (ZnO), iron
(for example Fe.sub.2 O.sub.3), zirconium (ZrO.sub.2), silicon
(SiO.sub.2), manganese (for example MnO), aluminium (Al.sub.2 O.sub.3) or
cerium (for example Ce.sub.2 O.sub.3), mixed oxides of the corresponding
metals and mixtures of such oxides. The pigments are particularly
preferably those based on TiO.sub.2.
It is particularly advantageous for the purposes of the present invention,
although not absolutely necessary, if the inorganic pigments are present
in hydrophobic form, i.e. they have been surface-treated to repel water.
This surface treatment can comprise providing the pigments with a thin
hydrophobic layer by processes known per se.
Such a process comprises, for example, producing the hydrophobic surface
layer by a reaction according to
nTiO.sub.2 +m(RO).sub.3 Si--R'.fwdarw.nTiO.sub.2 (surface).
n and m here are stoichiometric parameters to be employed as desired and R
and R' are the desired organic radicals. Hydrophobicized pigments prepared
analogously to DE-A 33 14 742, for example, are advantageous.
Advantageous TiO.sub.2 pigments are obtainable, for example, under the
trade names MT 100 T from TAYCA.
The cosmetic and/or dermatological light protection formulations according
to the invention can have the customary composition and can be used for
cosmetic and/or dermatological light protection, and furthermore for the
treatment, care and cleansing of the skin and/or hair and as a make-up
product in decorative cosmetics.
For use, the cosmetic and dermatological formulations according to the
invention are applied to the skin and/or hair in an adequate amount in the
manner customary for cosmetics.
Particularly preferred cosmetic and dermatological formulations are those
which are present in the form of a sunscreen composition. These can
advantageously additionally comprise at least one further UVA filter
and/or at least one further UVB filter and/or at least one inorganic
pigment, preferably an inorganic micropigment.
The cosmetic and dermatological formulations according to the invention can
comprise cosmetic auxiliaries such as are usually used in such
formulations, for example preservatives, bactericides, perfumes,
antifoams, dyes, pigments which have a colouring action, thickeners,
moisturizers and/or humectants, fats, oils, waxes or other customary
constituents of a cosmetic or dermatological formulation, such as
alcohols, polyols, polymers, foam stabilizers, electrolytes, organic
solvents or silicone derivatives.
An additional content of antioxidants is generally preferred. According to
the invention favourable antioxidants which can be used are all the
antioxidants which are suitable or customary for cosmetic and/or
dermatological uses.
The antioxidants are advantageously chosen from the group consisting of
amino acids (for example glycine, histidine, tyrosine, tryptophan) and
derivatives thereof, imidazoles (for example urocanic acid) and
derivatives thereof, peptides, such as D,L-carnosine, D-carnosine,
L-carnosine and derivatives thereof (for example anserine), carotenoids,
carotenes (for example .alpha.-carotene, .beta.-carotene, lycopene) and
derivatives thereof, chlorogenic acid and derivatives thereof, lipoic acid
and derivatives thereof (for example dihydrolipoic acid), aurothioglucose,
propylthiouracil and other thiols (for example thioredoxin, glutathione,
cysteine, cystine, cystamine and the glycosyl, N-acetyl, methyl, ethyl,
propyl, amyl, butyl and lauryl, palmitoyl, oleyl, .gamma.-linoleyl,
cholesteryl and glyceryl esters thereof) and salts thereof, dilauryl
thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and
derivatives thereof (esters, ethers, peptides, lipids, nucleotides,
nucleosides and salts) and sulphoximine compounds (for example
buthionine-sulphoximines, homocysteine-sulphoximine, buthionine sulphones,
penta-, hexa- and heptathionine-sulphoximine) in very low tolerated doses
(for example pmol to .mu.mol/kg), and furthermore (metal) chelating agents
(for example .alpha.-hydroxy-fatty acids, palmitic acid, phytic acid,
lactoferrin), .alpha.-hydroxy acids (for example citric acid, lactic acid,
malic acid), humic acid, bile acid, bile extracts, bilirubin, biliverdin,
EDTA, EGTA and derivatives thereof, unsaturated fatty acids and
derivatives thereof (for example .gamma.-linolenic acid, linoleic acid,
oleic acid), folic acid and derivatives thereof, furfurylidenesorbitol and
derivatives thereof, ubiquinone and ubiquinol and derivatives thereof,
vitamin C and derivatives (for example ascorbyl palmitate, Mg ascorbyl
phosphate, ascorbyl acetate), tocopherols and derivatives (for example
vitamin E acetate), vitamin A and derivatives (vitamin A palmitate) and
coniferyl benzoate of benzoin resin, rutic acid and derivatives thereof,
.alpha.-glycosylrutin, ferulic acid, furfurylideneglucitol, carnosine,
butylated hydroxytoluene, butylated hydroxyanisole, nordihydroguaiac resin
acid, nordihydroguaiaretic acid, trihydroxybutyrophenone, uric acid and
derivatives thereof, mannose and derivatives thereof, zinc and derivatives
thereof (for example ZnO, ZnSO.sub.4), selenium and derivatives thereof
(for example selenium methionine), stilbenes and derivatives thereof (for
example stilbene oxide, trans-stilbene oxide) and the derivatives of these
active ingredients mentioned which are suitable according to the invention
(salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and
lipids).
The amount of the abovementioned antioxidants (one or more compounds) in
the formulations is preferably from 0.001 to 30% by weight, particularly
preferably 0.05-20% by weight, in particular 1-10% by weight, based on the
total weight of the formulation.
If vitamin E and/or derivatives thereof is or are the antioxidant or
antioxidants, it is advantageous to choose the respective concentrations
thereof from the range 0.001-10% by weight, based on the total weight of
the formulation.
If vitamin A or vitamin A derivatives or carotenes or derivatives thereof
is or are the antioxidant or antioxidants, it is advantageous to choose
the respective concentrations thereof from the range 0.001-10% by weight,
based on the total weight of the formulation.
The lipid phase can advantageously be chosen from the following group of
substances:
mineral oils, mineral waxes
oils, such as triglycerides of capric or of caprylic acid, but preferably
castor oil;
fats, waxes and other natural and synthetic fatty substances, preferably
esters of fatty acids with alcohols of low C number, for example with
isopropanol, propylene glycol or glycerol, or esters of fatty alcohols
with alkanoic acids of low C number or with fatty acids;
alkyl benzoates;
silicone oils, such as dimethylpolysiloxanes, diethylpolysiloxanes,
diphenylpolysiloxanes and mixed forms thereof.
If appropriate, the aqueous phase of the formulations according to the
invention advantageously comprises
alcohols, diols or polyols of low C number and ethers thereof, preferably
ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol,
ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl,
monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl
ether and analogous products, furthermore alcohols of low C number, for
example ethanol, isopropanol, 1,2-propanediol and glycerol, and, in
particular, one or more thickeners, which can advantageously be chosen
from the group consisting of silicon dioxide, aluminium silicates,
polysaccharides and derivatives thereof, for example hyaluronic acid,
xanthan gum and hydroxypropylmethylcellulose, particularly advantageously
from the group consisting of poly-acrylates, preferably a polyacrylate
from the group consisting of so-called Carbopols, for example Carbopols of
types 980, 981, 1382, 2984 and 5984, in each case individually or in
combination.
The cosmetic or dermatological light protection formulations advantageously
comprise inorganic pigments, in particular micropigments, for example in
amounts of from 0.1% by weight to 30% by weight, preferably in amounts
from 0.5% by weight to 10% by weight, but in particular from 1% by weight
to 6% by weight, based on the total weight of the formulations.
It is advantageous according to the invention to employ, in addition to the
combinations according to the invention oil-soluble UVA filters and/or UVB
filters in the lipid phase and/or water-soluble UVA filters and/or UVB
filters in the aqueous phase.
The light protection formulations according to the invention can
advantageously comprise further substances which absorb UV radiation in
the UVB region, the total amount of filter substances being, for example,
from 0.1% by weight to 30% by weight, preferably 0.5 to 10% by weight, in
particular 1 to 6% by weight, based on the total weight of the
formulations, in order to provide cosmetic formulations which protect the
skin from the entire region of ultraviolet radiation. They can also be
used as sunscreens.
The further UVB filters can be oil-soluble or water-soluble. Advantageous
oil-soluble UVB filter substances are, for example:
3-benzylidenecamphor derivatives, preferably 3-(4-methylbenzylidene)camphor
and 3-benzylidenecamphor;
4-aminobenzoic acid derivatives, preferably 2-ethylhexyl
4-(dimethylamino)benzoate and amyl 4-(dimethylamino)benzoate;
esters of cinnamic acid, preferably 2-ethylhexyl 4-methoxycinnamate and
isopentyl 4-methoxycinnamate;
derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzophenone,
2-hydroxy-4-methoxy-4'-methylbenzophenone and
2,2'-dihydroxy-4-methoxybenzophenone;
esters of benzalmalonic acid, preferably di(2-ethylhexyl)
4-methoxybenzalmalonate.
Advantageous water-soluble UVB filter substances are, for example:
salts of 2-phenylbenzimidazole-5-sulphonic acid, such as its sodium,
potassium or its triethanolammonium salt, and the sulphonic acid itself;
sulphonic acid derivatives of benzophenones, preferably
2-hydroxy-4-methoxybenzophenone-5-sulphonic acid and salts thereof;
sulphonic acid derivatives of 3-benzylidenecamphor, such as, for example,
4-(2-oxo-3-bornylidenemethyl) benzenesulphonic acid,
2-methyl-5-(2-oxo-3-bornylidenemethyl) benzenesulphonic acid and salts
thereof.
The list of further UVB filters mentioned which can be used in combination
with the active ingredient combinations according to the invention is not
of course intended to be limiting.
It may also be advantageous to combine the combinations according to the
invention with further UVA filters which have hitherto customarily been
present in cosmetic formulations. These substances are preferably
derivatives of dibenzoylmethane, in particular
1-(4'-tert-butylphenyl)-3-(4'-methoxyphenyl)propane-1,3-dione and
1-phenyl-3-(4'-isopropylphenyl) propane-1,3-dione. These combinations and
formulations which comprise these combinations are also provided by the
invention. The amounts used for the UVB combination can be employed.
It is furthermore advantageous to combine the active ingredient
combinations according to the invention with further UVA and/or UVB
filters.
It is also particularly advantageous to combine the active ingredient
combinations according to the invention with salicylic acid derivatives,
some known examples of which are likewise able to absorb UV radiation.
Customary UV filters include
##STR2##
The invention also relates to a process for the preparation of the cosmetic
and/or dermatological light protection formulations according to the
invention, which is characterized in that the tris(2-ethylhexyl)
4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)trisbenzoate is suspended and
if desired homogenized, in a manner known per se, in one or more
alkanecarboxylic acids or an oil phase containing alkanecarboxylic acids
with uniform stirring and, if necessary, with warming, combined if
necessary with further lipid components and if necessary with one or more
emulsifiers, after which the oil phase is mixed with the aqueous phase
into which, if necessary, a thickener has been incorporated, and which
preferably is at roughly the same temperature as the oil phase; the
mixture is homogenized if desired and left to cool to room temperature.
After the mixture has cooled to room temperature, it is possible to repeat
homogenization particularly if further volatile constituents are to be
incorporated.
The examples below serve to illustrate the present invention without
limiting it. Unless stated otherwise, all quantities, proportions and
percentages are by weight and based on the total amount or on the total
weight of the formulations.
EXAMPLE 1
______________________________________
% by weight
______________________________________
Glyceryl stearate SE 3.50
Stearic acid 1.80
Glycerol 3.00
Cetearyl alcohol 0.50
Sodium hydroxide (45%)
0.20
Preservative q.s.
Perfume q.s.
Water, demin. ad 100.0
Octyldodecanol 7.0
Caprylyl ether 8.0
Uvinul T150 3.0
Cetearyl isononanoate 6.0
Carbomer 0.20
______________________________________
EXAMPLE 2
______________________________________
Glyceryl stearate 2.50
Isostearic acid 3.50
Glycerol 3.00
Cetearyl alcohol 1.50
Sodium hydroxide (45%) 0.13
Octyldodecanol 7.0
Capric/caprylic 5.0
triglyceride
Cetearyl isononanoate 6.0
Uvinul T150 5.0
Carbomer 0.2
Preservative q.s.
Perfume q.s.
Water, demin. ad 100.0
______________________________________
EXAMPLE 3
______________________________________
Glyceryl stearate SE 3.50
Palmitic acid 3.50
Butylene glycol 5.00
Cetearyl alcohol 3.00
Sodium hydroxide (45%) 0.35
Preservative q.s.
Perfume q.s.
Water, demin. ad 100.0
C.sub.12 -C.sub.15 alkyl benzoate
10.0
Uvinul T150 4.0
Cetearyl isononanoate 6.0
Carbomer 0.20
______________________________________
EXAMPLE 4
______________________________________
Glyceryl stearate SE 4.00
Stearic acid 2.00
C.sub.12 -C.sub.15 -alkyl benzoate
5.00
Capric/caprylic 5.00
triglyceride
Octyldodecanol 5.00
Butylene glycol 5.00
Cetearyl alcohol 0.50
Carbomer 0.20
Butylmethoxydibenzoyl- 2.00
methane
Methylbenzylidene- 4.00
camphor
Uvinul T150 1.00
Octyl salicylate 2.00
Tocopheryl acetate 1.00
Furfurylidenesorbitol 0.50
Cyclomethicone 2.00
Na.sub.3 HEDTA 1.00
Sodium hydroxide (45%) 0.25
Preservative q.s.
Perfume q.s.
Water, demin. ad 100.0
______________________________________
EXAMPLE 5
______________________________________
Glyceryl stearate SE 4.00
Stearic acid 2.00
C.sub.12 -C.sub.15 -alkyl benzoate
5.00
Capric/caprylic 5.00
triglyceride
Octyldodecanol 5.00
Glycerol 5.00
Cetearyl alcohol 0.50
Carbomer 0.20
Butylmethoxydibenzoyl- 2.00
methane
Methylbenzylidene- 4.00
camphor
Uvinul T150 1.50
Octyl salicylate 3.00
Tocopheryl acetate 1.00
Furfurylidenesorbitol 0.50
Cyclomethicone 2.00
Na.sub.3 HEDTA 1.00
Sodium hydroxide (45%) 0.25
Preservative q.s.
Perfume q.s.
Water, demin. ad 100.0
______________________________________
EXAMPLE 6
______________________________________
Glyceryl stearate SE 4.00
Stearic acid 2.00
C.sub.12 -C.sub.15 -alkyl benzoate
5.00
Capric/caprylic 5.00
triglyceride
Octyldodecanol 5.00
Butylene glycol 5.00
Cetearyl alcohol 0.50
Carbomer 0.20
Butylmethoxydibenzoyl- 2.00
methane
Methylbenzylidene- 4.00
camphor
Uvinul T150 1.50
Octyl salicylate 4.00
Tocopheryl acetate 1.00
Furfurylidenesorbitol 0.50
Cyclomethicone 2.00
Na.sub.3 HEDTA 1.00
Sodium hydroxide (45%) 0.25
Preservative q.s.
Perfume q.s.
Water, demin. ad 100.0
______________________________________
EXAMPLE 7
______________________________________
Glyceryl stearate SE 4.00
Stearic acid 2.00
C.sub.12 -C.sub.15 -alkyl benzoate
5.00
Mineral oil 5.00
Octyldodecanol 5.00
Glycerol 5.00
Cetearyl alcohol 0.50
Carbomer 0.20
Butylmethoxydibenzoyl- 2.00
methane
Methylbenzylidene- 4.00
camphor
Uvinul T150 1.50
Octyl salicylate 5.00
Tocopheryl acetate 1.00
Furfurylidenesorbitol 0.50
Cyclomethicone 2.00
Na.sub.3 HEDTA 1.00
Sodium hydroxide (45%) 0.25
Preservative q.s.
Perfume q.s.
Water, demin. ad 100.0
______________________________________
EXAMPLE 8
______________________________________
Glyceryl stearate SE 4.00
Stearic acid 2.00
C.sub.12 -C.sub.15 -alkyl benzoate
5.00
Capric/caprylic 5.00
triglyceride
Octyldodecanol 5.00
Butylene glycol 5.00
Cetearyl alcohol 0.50
Carbomer 0.20
Butylmethoxydibenzoyl- 2.00
methane
Methylbenzylidene- 4.00
camphor
Uvinul T150 2.00
Octyl salicylate 5.00
Tocopheryl acetate 1.00
Furfurylidenesorbitol 0.50
Cyclomethicone 2.00
Na.sub.3 HEDTA 1.00
Sodium hydroxide (45%) 0.25
Preservative q.s.
Perfume q.s.
Water, demin. ad 100.0
______________________________________
EXAMPLE 9
______________________________________
Glyceryl stearate SE 4.00
Stearic acid 2.00
C.sub.12 -C.sub.15 -alkyl benzoate
5.00
Capric/caprylic 5.00
triglyceride
Octyldodecanol 5.00
Butylene glycol 5.00
Cetearyl alcohol 0.50
Carbomer 0.20
Butylmethoxydibenzoyl- 2.00
methane
Methylbenzylidene- 4.00
camphor
Uvinul T150 2.00
Octyl salicylate 5.00
Homomenthyl salicylate 5.00
Tocopheryl acetate 1.00
Furfurylidenesorbitol 0.50
Cyclomethicone 2.00
Na.sub.3 HEDTA 1.00
Sodium hydroxide (45%) 0.25
Preservative q.s.
Perfume q.s.
Water, demin. ad 100.0
______________________________________
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