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United States Patent | 6,057,286 |
Harrison ,   et al. | May 2, 2000 |
The invention provides for use of selective inhibitors of GSK3 for treatment of diseases that are mediated by GSK3 activity, including non-insulin dependent diabetes mellitus (NIDDM) and Alzheimer's disease. Also described are methods of identifying inhibitors of GSK3 activity. The selective GSK3 inhibitor can be a peptide, peptoid, small organic molecule, or polynucleotide.
Inventors: | Harrison; Stephen D. (Berkeley, CA); Ring; David B. (Palo Alto, CA) |
Assignee: | Chiron Corporation (Emeryville, CA) |
Appl. No.: | 832567 |
Filed: | April 2, 1997 |
Intern'l Class: | A61K 031/00 |
Field of Search: | 514/1,3,2 435/194 530/350,300 |
5252333 | Oct., 1993 | Horrobin | 424/422. |
Foreign Patent Documents | |||
WO 97/41854 | Nov., 1997 | WO. |
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__________________________________________________________________________ # SEQUENCE LISTING - - - - (1) GENERAL INFORMATION: - - (iii) NUMBER OF SEQUENCES: 2 - - - - (2) INFORMATION FOR SEQ ID NO:1: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 amino - #acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: peptide - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1: - - Ser Gly Ser Gly Lys Arg Arg Glu Ile Leu Se - #r Arg Arg Pro Ser Tyr 1 5 - # 10 - # 15 - - Arg - - - - (2) INFORMATION FOR SEQ ID NO:2: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 5 amino - #acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: peptide - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2: - - Ser Xaa Xaa Xaa Ser 1 5 __________________________________________________________________________