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United States Patent | 6,034,101 |
Gupta ,   et al. | March 7, 2000 |
A dosage form and a method are disclosed and claimed for administering a drug in a sustained and constantly ascending rate per unit time to provide an intended therapeutic effect while concomitantly lessening the development of unwanted effects.
Inventors: | Gupta; Suneel K. (Sunnyvale, CA); Guinta; Diane R. (Palo Alto, CA); Christopher; Carol A. (Belmont, CA); Saks; Samuel R. (Hillsborough, CA) |
Assignee: | ALZA Corporation (Palo Alto, CA) |
Appl. No.: | 910593 |
Filed: | July 31, 1997 |
Intern'l Class: | A61K 031/42; A61K 031/135; A61K 031/445 |
Field of Search: | 514/317,376,654,964 |
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______________________________________ Ascending Profile Range Time TID Concentration (Fraction of TID Concentration) (h) (ng/MI) Low High ______________________________________ 1.5 4.8 (peak) 0.75 0.90 3.0 3.8 1.07 1.37 4.0 2.8 (trough) 1.32 2.29 5.5 6.5 (peak) 0.80 1.20 7.0 4.8 1.42 1.81 8.0 3.6 (trough) 2.17 2.50 9.5 7.0 (peak) 1.10 1.23 11.0 5.2 1.00 1.38 12.0 3.9 0.97 1.54 15.0 1.7 1.00 1.94 ______________________________________