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United States Patent | 6,020,000 |
Wong ,   et al. | February 1, 2000 |
The present invention is directed to an active agent dosage form that is useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a matrix that has an insoluble material circumscribing a portion of the surface of the matrix. The invention is also directed to a method of making the active agent dosage form.
Inventors: | Wong; Patrick S.-L. (Palo Alto, CA); Edgren; David Emil (El Granada, CA); Dong; Liang C. (Sunnyvale, CA); Ferrari; Vincent Joseph (Foster City, CA) |
Assignee: | ALZA Corporatiton (Palo Alto, CA) |
Appl. No.: | 149042 |
Filed: | September 8, 1998 |
Current U.S. Class: | 424/472; 424/463; 424/464; 424/467; 424/468; 424/474; 424/484; 424/486; 424/488 |
Intern'l Class: | A61K 009/24; A61K 009/48 |
Field of Search: | 424/463,464,468,472,467,484,486,474 |
4803076 | Feb., 1989 | Ranade | 424/438. |
5422123 | Jun., 1995 | Conte et al. | 424/479. |
5464633 | Nov., 1995 | Conte et al. | 424/480. |
5487901 | Jan., 1996 | Conte et al. | 424/472. |
5626874 | May., 1997 | Conte et al. | 424/464. |
5650169 | Jul., 1997 | Conte et al. | 424/472. |
5667804 | Sep., 1997 | Wong et al. | 424/472. |
5738874 | Apr., 1998 | Conte et al. | 424/472. |
5780057 | Jul., 1998 | Conte et al. | 424/468. |
Foreign Patent Documents | |||
WO 99/18938 | Apr., 1999 | WO. | |
WO 99/21551 | May., 1999 | WO. |
Robert Langer et al., "Polymers for the Controlled Release of Macromolecules: Kinetics, Applications and External Control," AIChE Symposium Series, No. 206, vol. 77, 1981, pp. 10-20. Dean S.T. Hsieh et al., "Zero-Order Controlled-Release Polymer Matrices for Micro- and Macromolecules," Journal of Pharmaceutical Sciences, vol. 72, No. 1, Jan. 1983, pp. 17-22. Robert H. Zimmer, M.D., Ph.D., "How to Develop Drug Products Using the Geomatrix Technology," JAGO Pharma AG, Apr. 1997. |