Back to EveryPatent.com
United States Patent | 6,011,178 |
Werbitzky ,   et al. | January 4, 2000 |
2-Amino-4,5,3',4'-tetramethoxybenzophenone of the formula: ##STR1## is prepared by mononitration of 3,3',4,4'-tetramethyoxybenzophenone using nitric acid in the presence of acetic acid, and subsequent reduction of the nitro group. The compound is an intermediate in the synthesis of active ingredients against rheumatoid arthritis.
Inventors: | Werbitzky; Oleg (Visp, CH); Brieden; Walter (Brig-Glis, CH); Heinzmann; Etienne (Visperterminen, CH) |
Assignee: | Lonza, Ltd. (Gampel/Valais, CH) |
Appl. No.: | 266741 |
Filed: | March 12, 1999 |
Mar 13, 1998[CH] | 0610/98 |
Current U.S. Class: | 564/328; 564/321; 564/329; 564/416; 568/306; 568/314; 568/332; 568/333 |
Intern'l Class: | C07C 217/84; C07C 217/90 |
Field of Search: | 568/306,319,322,332,333,312,314,315 564/416,321,328,329 |
5650410 | Jul., 1997 | Sohda et al. | 514/233. |
Foreign Patent Documents | |||
06328859 | May., 1993 | JP. | |
WO 97-09984 | Mar., 1997 | WO. |
Lawson et al, J.Chem.Soc., vol. 125, p. 626, 1924. Harrison et al, Compendium of Organic Synthetic Methods, p. 266, 1971. March, Advanced Organic Chemistry, third edition, p. 486, 1985. Munchhof et al., Journal Of Organic Chemistry, vol. 60, No 23, (Nov. 3, 1995), pp. 7086 and 7087, (Munchhof et al.). Upton et al., Journal Of Pharmacy and Pharmacology, vol. 50, No. 5, May, 1998, pp. 476 yo 482, (Upton et al.). |