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United States Patent | 5,780,638 |
Kraus ,   et al. | July 14, 1998 |
5-Hydroxymethylthiazole is prepared in an improved manner by reducing 5-formylthiazole using a borane compound. Particularly advantageous in this case is the use of 5-formylthiazole which has been obtained by reaction of a 2-halomalonaldehyde compound with thioformamide in the presence of less than 5% by weight of water (based on the reaction mixture).
Inventors: | Kraus; Helmut (Odenthal, DE); Fiege; Helmut (Leverkusen, DE) |
Assignee: | Bayer Aktiengesellschaft (Leverkusen, DE) |
Appl. No.: | 762625 |
Filed: | December 9, 1996 |
Dec 18, 1995[DE] | 195 47 076.1 |
Current U.S. Class: | 548/203; 548/200 |
Intern'l Class: | C07D 277/24 |
Field of Search: | 548/203,200 |
Foreign Patent Documents | |||
0486948 | May., 1992 | EP. |
Kerdesky,Synthetic Communication, 25(17), 2639, 1995. Lancaster Catalog pp. 190-191, 1995. Potts Comprehensive Heterocyclic Chemistry, vol. 6, p. 295, 1984. von H. Erlenmeyer, et al., 245. Zur Kenntnis des .alpha.›Thiazolyl-(5)!-pyrrolidins, Helv. Chim.Acts., 29, (1946). van S. Fallab, 27, Uber Thiazolyl-(5)-carbinol, Helv. Chim. Acts., 35, 215, (1952). |