Back to EveryPatent.com
United States Patent | 5,759,518 |
Schmitt-Willich ,   et al. | June 2, 1998 |
The invention relates to new metal complexes of dendrimeric macromolecules that contain 8 to 64 ions of an element of atomic numbers 21-129, 39, 42-44, or 57-83 and a polymeric, complexing ligand of formula I A--(X).sub.b (I) in which A, X and b have different meanings, agents that contain these compounds as well as the use of the latter in diagnosis. The invention further relates to a process for the production of the complexes and agents.
Inventors: | Schmitt-Willich; Heribert (Berlin, DE); Platzek; Johannes (Berlin, DE); Muhler; Andreas (Berlin, DE); Frenzel; Thomas (Berlin, DE) |
Assignee: | Schering Aktiengesellschaft (Berlin, DE) |
Appl. No.: | 663233 |
Filed: | October 3, 1996 |
PCT Filed: | December 2, 1994 |
PCT NO: | PCT/EP94/04016 |
371 Date: | October 3, 1996 |
102(e) Date: | October 3, 1996 |
PCT PUB.NO.: | WO95/17451 |
PCT PUB. Date: | June 29, 1995 |
Dec 22, 1993[DE] | 43 44 460.1 |
Current U.S. Class: | 424/9.36; 424/1.65; 424/9.364; 424/9.365; 424/9.42; 534/10; 534/14; 534/15; 534/16 |
Intern'l Class: | A61B 005/055; A61K 051/04; A61K 049/04; C07F 005/00 |
Field of Search: | 424/1.65,9.322,9.34,9.341,9.36,9.364,9.365,9.4,9.42 534/10,14,15,16 540/465,460 |
4587329 | May., 1986 | Tomalia et al. | 528/363. |
5135737 | Aug., 1992 | Keana | 424/9. |
5281704 | Jan., 1994 | Love et al. | 540/465. |
5364613 | Nov., 1994 | Sieving et al. | 424/9. |
5364614 | Nov., 1994 | Platzek et al. | 424/9. |
5405601 | Apr., 1995 | Dunn et al. | 424/9. |
5446145 | Aug., 1995 | Love et al. | 540/465. |
5449761 | Sep., 1995 | Belinka, Jr. et al. | 534/10. |
5517993 | May., 1996 | Unger et al. | 128/653. |
5527524 | Jun., 1996 | Tomalia et al. | 424/1. |
5556968 | Sep., 1996 | Carvalho et al. | 540/460. |
5593660 | Jan., 1997 | Krause et al. | 424/9. |
5650136 | Jul., 1997 | Platzek et al. | 424/9. |