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| United States Patent |
5,753,241
|
|
Ribier, deceased
, et al.
|
May 19, 1998
|
Transparent nanoemulsion less than 100 NM based on fluid non-ionic
amphiphilic lipids and use in cosmetic or in dermopharmaceuticals
Abstract
An oil-in-water nanoemulsion in which the oil globules have a mean size of
less than 100 nm and which contains an amphiphilic lipid component
containing at least one non-ionic amphiphilic lipid which is liquid at an
ambient temperature of less than 45.degree. C. The nanoemulsion can be
used in the fields of cosmetics and dermopharmaceuticals. The nanoemulsion
is stable on storage, can contain significant amounts of oil while
retaining good transparency, and can contain heat-sensitive active agents.
| Inventors:
|
Ribier, deceased; Alain (late of Paris, FR);
Simonnet; Jean-Thierry (Paris, FR);
Legret; Sylvie (Chatillon, FR)
|
| Assignee:
|
L'Oreal (Paris, FR)
|
| Appl. No.:
|
607353 |
| Filed:
|
February 26, 1996 |
Foreign Application Priority Data
| Current U.S. Class: |
424/401; 424/78.03; 424/450; 424/525; 424/776; 514/552; 514/873; 514/938; 516/56; 516/63; 516/74; 516/99 |
| Intern'l Class: |
A61K 006/00; A61K 031/74; A01N 037/02 |
| Field of Search: |
424/195.1,520-525,401,450,78.03
514/552,937,938,873
252/304,312,314
|
References Cited
| Foreign Patent Documents |
| 0 334 777 A1 | Sep., 1989 | EP.
| |
| 0 490 053 A1 | Jun., 1992 | EP.
| |
| 0 516 508 A1 | Dec., 1992 | EP.
| |
| 0 572 080 A1 | Dec., 1993 | EP.
| |
Other References
French Search Report Dated Dec. 11, 1995.
|
Primary Examiner: Saucier; Sandra E.
Attorney, Agent or Firm: Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
Claims
What is claimed:
1. An oil-in-water nanoemulsion comprising water, oil globules having a
mean size of less than 100 nm dispersed in an aqueous phase and an
amphiphilic lipid component situated at the oil/aqueous phase interface
wherein the amphiphilic lipid component comprises at least one non-ionic
amphiphilic lipid which is liquid at a temperature of less than 45.degree.
C. and wherein the ratio by weight of the amount of oil to the amount of
amphiphilic lipid component is from 3 to 10.
2. The nanoemulsion according to claim 1, wherein the non-ionic amphiphilic
lipid is an ester or a mixture of esters of at least one polyol, selected
from the group consisting of polyethylene glycol containing from 1 to 60
ethylene oxide units, sorbitan, glycerol containing from 2 to 30 ethylene
oxide units and polyglycerol containing from 2 to 15 glycerol units, with
at least one fatty acid containing at least one saturated or unsaturated,
linear or branched, C.sub.8 -C.sub.22 alkyl chain.
3. The nanoemulsion according to claim 1 wherein the ratio by weight of the
amount of oil to the amount of amphiphilic lipid component is from 3 to 6.
4. The nanoemulsion according to claim 1 wherein the amphiphilic lipid
component further comprises at least one ionic amphiphilic lipid.
5. The nanoemulsion according to claim 4, wherein the at least one ionic
amphiphilic lipid is selected from the group consisting of neutralized
anionic lipids, amphoteric ionic lipids and alkylsulphonic derivatives.
6. The nanoemulsion according to claim 4 wherein the at least one ionic
amphiphilic lipid is selected from the group consisting of:
alkaline salts of dicetyl and dimyristyl phosphate;
alkaline salts of cholesterol sulphate;
alkaline salts of cholesterol phosphate;
salts of amino acids containing fatty groups;
sodium salts of phosphatidic acid;
phospholipids; and
alkylsulphonic derivatives of formula:
##STR2##
in which R represents C.sub.16 -C.sub.22 alkyl radicals, taken as a
mixture or separately, and M is an alkali metal.
7. The nanoemulsion according to claim 4 wherein the ionic amphiphilic
lipid is present in concentrations ranging from 2 to 10% by weight with
respect to the total weight of the amphiphilic lipid component.
8. The nanoemulsion according to claim 1 wherein the proportion of oil is
from 5 to 30% by weight with respect to the total weight of the
nanoemulsion.
9. The nanoemulsion according to claim 1 wherein the oil is selected from
the group consisting of:
animal or vegetable oils formed by esters of fatty acids and of polyols
vegetable or animal oils of formula R.sub.9 COOR.sub.10, in which R.sub.9
represents the residue of a higher fatty acid containing from 7 to 19
carbon atoms and R.sub.10 represents a branched hydrocarbon chain
containing from 3 to 20 carbon atoms;
natural or synthetic essential oils;
hydrocarbons;
halogenated hydrocarbons;
esters of an inorganic acid and of an alcohol;
ethers and polyethers; and
silicones, as a mixture with at least one of the oils defined above.
10. The nanoemulsion according to claim 1 further comprising an additive
that improves transparency.
11. The nanoemulsion according to claim 10, wherein the additive is a lower
alcohol or glycol.
12. The nanoemulsion according to claim 11 wherein the additive is present
in concentrations ranging from 5 to 30% by weight with respect to the
total weight of the nanoemulsion.
13. The nanoemulsion according to claim 12, said nanoemulsion containing a
lower alcohol in a concentration ranging from 5 to 20% by weight with
respect to the total weight of the emulsion.
14. The nanoemulsion according to claim 12, said nanoemulsion containing a
glycol in concentrations ranging from 2 to 15% by weight with respect to
the total weight of the emulsion.
15. The nanoemulsion according to claim 11, said nanoemulsion comprising at
least 15% by weight of said lower alcohol with respect to the total weight
of the composition.
16. The nanoemulsion according to claim 1 further comprising a
water-soluble or liposoluble cosmetic or dermopharmaceutical active agent.
17. The nanoemulsion according to claim 1, further comprising an additive
selected from the group consisting of gelling agents, preservatives and
fragrances.
18. The nanoemulsion according to claim 1 wherein the oil globules have a
mean size ranging from 30 to 75 nm.
19. The nanoemulsion according to claim 1 wherein the oil globules have a
mean size ranging from 40 to 60 nm.
20. The nanoemulsion according to claim 1, wherein said nanoemulsion has a
transparency, determined by the transmittance coefficient, measured at a
wavelength of 600 nm, ranging from 30 to 90%.
21. A composition for topical use comprising the nanoemulsion according to
claim 1.
22. A process for the treatment of the skin and/or of the scalp, comprising
applying a nanoemulsion according to claim 1 to the skin and/or the scalp.
23. A process for the preparation of the nanoemulsion as defined in claim
1, comprising mixing an aqueous phase and an oily phase together with
stirring at a temperature of less than 45.degree. C. to form a mixture and
then carrying out high-pressure homogenization at a pressure greater than
10.sup.8 Pa on said mixture.
24. The process according to claim 23, wherein the pressure is from
12.times.10.sup.7 to 18.times.10.sup.7 Pa.
Description
SUMMARY OF THE INVENTION
The present invention relates to an oil-in-water nanoemulsion which is
preferably transparent and in which the oil globules have a mean size of
less than 100 nm. The invention nanoemulsion further preferably comprises
an amphiphilic lipid component based on at least one non-ionic amphiphilic
lipid which is liquid at temperatures less than 45.degree. C. The
invention nanoemulsion is useful for the topical application of, in
particular, cosmetics, skin conditioners, and dermopharmaceuticals.
BACKGROUND OF THE INVENTION
Oil-in-water emulsions are well-known in the field of cosmetics,
dermopharmaceuticals, etc., in particular for the preparation of cosmetic
products such as lotions, tonics, serums or toilet waters. Transparent
microemulsions are also known. Microemulsions are not, strictly speaking,
emulsions; these are transparent solutions of micelles, that is to say
that the oil present is dissolved therein by virtue of the joint presence
of surfactants and of cosurfactants and by virtue, generally, of a high
proportion of these surfactants and cosurfactants. The extremely small
size of the particles, which is the cause of their transparency, arises
from this "solubilization". The disadvantages of these microemulsions,
however, are related to their high proportion of surfactants, leading to
intolerances and resulting in a sticky feel during application to the
skin. Thus, EP-A-572,080 describes microemulsions containing an oil, a
fragrance and a mixture of surfactant and of cosurfactant, the proportion
of oil and of mixture of surfactant and cosurfactant being between 0.85
and 2.5.
Nanoemulsions comprising oil globules having a mean size of less than 100
nm have already been used in order to obtain transparent compositions
having an appearance similar to water and resulting, after application to
the skin, in a feel similar to that of a cream or milk. These
nanoemulsions, in contrast to microemulsions, are true emulsions where the
oil globules are dispersed in an aqueous phase, the surfactants being
situated at the oil/aqueous phase interface. The transparency of these
emulsions arises from the small size of the oily globules, which small
size is obtained by virtue of passing through a high- pressure
homogenizer.
Nanoemulsions comprising an amphiphilic lipid phase composed of
phosphoglycerides, water and oil are known. These emulsions have the
disadvantage of being unstable on storage at conventional storage
temperatures, namely between 0.degree. and 45.degree. C. They result in
yellow compositions and produce a rancid smell which develops after a few
days of storage. They are described in EP 406 162.
Nanoemulsions comprising the combination of a long-chain fatty alcohol
and/or of a long-chain fatty acid and of a soap type surfactant of a
long-chain fatty acid forming a gel, the phase transition temperature of
which is greater than 60.degree. C., are also known. These emulsions are
prepared at temperatures greater than 70.degree. C. which limit the use of
heat-sensitive active principles in such compositions. They are described,
for example, in EP-A-615,741.
The inventors have unexpectedly discovered new nanoemulsions exhibiting all
the advantages of known nanoemulsions without their disadvantages nor the
disadvantages of microemulsions. The invention nanoemulsions have oil
globules whose mean size is less than 100 nm, and they are stable on
storage between 0.degree. and 45.degree. C. for at least two months. The
nanoemulsions in accordance with the invention are preferably prepared at
temperatures between 20.degree. and 450.degree. C. and are compatible with
heat-sensitive active principles. They can contain significant amounts of
oil, while retaining good transparency properties. They can particularly
contain significant amounts of fragrance and can improve their
persistence. They also promote penetration of the active principles into
the surface layers of the skin.
DETAILED DESCRIPTION OF THE INVENTION
The subject of the present invention is an oil-in-water nanoemulsion having
oil globules, the mean size of which is less than 100 nm, and comprising
an amphiphilic lipid component, characterized in that the amphiphilic
lipid component comprises at least one non-ionic amphiphilic lipid which
is liquid at a temperature of less than 45.degree. C. and that the ratio
by weight of the amount of oil to the amount of amphiphilic lipid
component varies from 2 to 10. The invention nanoemulsions are
water-containing nanoemulsions.
The amphiphilic non-ionic lipids of the invention are preferably chosen
from esters or mixtures of esters of at least one polyol, preferably
chosen from polyethylene glycol containing from 1 to 60 ethylene oxide
units, sorbitan, glycerol containing from 2 to 30 ethylene oxide units or
polyglycerols containing from 2 to 15 glycerol units, with at least one
fatty acid containing at least one saturated or unsaturated, linear or
branched, C.sub.8 -C.sub.22 alkyl chain.
Mention may be made, by way of example, of
the isostearate of polyethylene glycol with a molecular weight of 400, sold
under the name PEG 400 isostearate by the company Unichema;
diglyceryl isostearate, sold by the company Solvay;
glyceryl laurate containing 2 glycerol units, sold by the company Solvay;
sorbitan oleate, sold under the name Span 80 by the company ICI;
sorbitan isostearate, sold under the name Nikkol SI 10R by the company
Nikko;
.alpha.-butylglucoside cocoate or .alpha.-butylglucoside caprate, marketed
by the company ULICE.
The ratio by weight of the amount of oil contained in the emulsion in
accordance with the invention to the amount of amphiphilic lipid component
(oil/lipid) preferably varies from 3 to 6, but may be as high as 10 and
includes 2, 3, 4, 5, 6, 7, 8, and 9 and all values and subranges
therebetween.
A specific form of the nanoemulsion in accordance with the invention is
characterized in that the amphiphilic lipid component additionally contain
one or a number of ionic amphiphilic lipids.
Ionic amphiphilic lipids which may be used in the nanoemulsions of the
invention include, and are preferably chosen from the group formed by
neutralized anionic lipids, amphoteric ionic lipids or alkylsulphonic
derivatives.
They are more preferably chosen from the group formed by:
alkaline salts of dicetyl and dimyristyl phosphate;
alkaline salts of cholesterol sulphate;
alkaline salts of cholesterol phosphate;
amino acids containing fatty groups, such as mono- and disodium
acylglutamates;
sodium salts of phosphatidic acid;
phospholipids;
alkylsulphonic derivatives of formula:
##STR1##
in which R represents a C.sub.16 -C.sub.22 alkyl radical, in particular
C.sub.16 H.sub.33 and C.sub.18 H.sub.37 radicals, taken as a mixture or
separately, and M is an alkali metal, such as sodium.
The ionic amphiphilic lipids are present in the nanoemulsions of the
invention in concentrations preferably ranging from 2 to 10% by weight and
more preferably from 5 to 10% by weight with respect to the total weight
of the amphiphilic lipid component.
The nanoemulsions in accordance with the invention contain an amount of oil
preferably ranging from 5 to 30% by weight with respect to the total
weight of the emulsion.
Oils which can be used in the emulsions of the invention include, and are
preferentially chosen from, the group formed by:
animal or vegetable oils formed by esters of fatty acids and of polyols, in
particular liquid triglycerides, for example sunflower, maize, soybean,
gourd, grape seed, sesame and hazelnut oils, fish oils or caprylic/capric
triglyceride, or vegetable or animal oils of formula R.sub.9 COOR.sub.10,
in which R.sub.9 represents the residue of a higher fatty acid containing
from 7 to 19 carbon atoms and R.sub.10 represents a branched hydrocarbon
chain containing from 3 to 20 carbon atoms, for example purcellin oil;
natural or synthetic essential oils such as, for example, oils of
eucalyptus, of lavandin, of lavender, of vetiver, of Litsea cubeba, of
lemon, of santal, of rosemary, of camomile, of savory, of nutmeg, of
cinnamon, of hyssop, of caraway, of orange, of geranium, of cade and of
bergamot;
hydrocarbons, such as hexadecane and liquid paraffin;
halogenated hydrocarbons, in particular fluorocarbons, such as
fluoroamines, for example perfluorotributylamine, fluorinated
hydrocarbons, for example perfluorodecahydronaphthalene, fluoroesters and
fluoroethers;
esters of an inorganic acid and of an alcohol;
ethers and polyethers;
silicones, as a mixture with at least one of the oils defined above, for
example decamethylcyclopentasiloxane or dodecamethylcyclohexasiloxane.
The emulsions in accordance with the present invention can contain
additives, in order to improve the transparency of the formulation. These
additives are preferably chosen from the group formed by:
lower C.sub.1 -C.sub.8 alcohols, such as ethanol,
glycols, such as glycerol, propylene glycol, 1,3-butylene glycol,
dipropylene glycol or polyethylene glycols containing from 4 to 16
ethylene oxide units and preferably from 8 to 12.
Additives, such as those mentioned above, are present in the emulsions of
the invention in concentrations preferably ranging from 5 to 30% by weight
with respect to the total weight of the emulsion. The alcohols are
preferably used at concentrations ranging from 5 to 20% by weight. The
glycols are preferably used as concentrations ranging from 2 to 15% by
weight.
In addition, the use of the alcohols as defined above, at concentrations
greater than or equal to 15% by weight, make it possible to obtain
preservative-free emulsions.
The emulsions of the invention can contain water-soluble or liposoluble
active principles (agents) having a cosmetic, dermopharmaceutical, etc.
activity. The liposoluble active principles are generally thought to be
confined in the oily globules of the emulsion, whereas the water-soluble
active principles are thought to be confined in the aqueous phase of the
emulsion. Mention may be made, as examples of active principles, of
vitamins, such as vitamin E and its derivatives, provitamins, such as
panthenol, humectants, sunscreens, etc.
The nanoemulsions in accordance with the invention can also contain
adjuvants used for the formulation of the nanoemulsion in the form of a
lotion, serum, cream or milk, such as gelling agents, preservatives and
fragrances. Mention may be made, among the gelling agents which can be
used, of cellulose derivatives, such as hydroxypropyl methyl cellulose,
fatty alcohols such as stearyl, cetyl and behenyl alcohols, alga
derivatives such as satiagum, natural gums such as gum tragacanth and
synthetic polymers such as the mixtures of polycarboxyvinyl acids marketed
under the name Carbopol by the company Goodrich and the mixture of Na
acrylate/acrylamide copolymers marketed under the name Hostacerin PN 73 by
the company Hoechst.
The oil globules of the nanoemulsions of the invention preferably have a
mean size ranging from 30 to 75 nm and more preferentially from 40 to 60
nm. They can be as large as less than 100 nm and include 5, 10, 15, 20,
25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, and 95 nm and all
values and subranges therebetween. The size of the globules makes it
possible to promote penetration of the active principles into the surface
layers of the skin (carrier effect).
The nanoemulsions according to the invention are preferably colorless or
possibly slightly bluish and exhibit a transparency, determined by the
transmittance coefficient, measured at a wavelength of 600 nm,
preferentially ranging from 30 to 90% and more particularly from 50 to
80%.
The nanoemulsions of the invention can be obtained by a process,
characterized in that the aqueous phase and the oily phase are mixed, with
vigorous stirring, at an ambient temperature of less than 45.degree. C.
followed by high-pressure homogenization at a pressure greater than
10.sup.8 Pa and preferably ranging from 12.times.10.sup.7 to
18.times.10.sup.7 Pa. Such a process makes it possible to produce, at
ambient temperature, nanoemulsions which are compatible with
heat-sensitive active compounds and which can contain significant amounts
of oils and in particular fragrances which contain fatty substances,
without denaturing them.
Further subjects of the invention are a composition for topical use such as
a cosmetic or dermopharmaceutical composition, characterized in that it is
composed of an emulsion as defined above, and the use of the same on the
skin, hair, eyes, face, etc.
A further subject of the invention is the use of the nanoemulsions as
defined above as the basis for care and/or make-up products for the skin
and/or the face and/or the scalp, such as lotions, serums, milks, creams
or toilet waters.
Finally, the invention also relates to a non-therapeutic process for caring
for the skin or for the scalp, characterized in that a nanoemulsion as
defined above is applied to the skin or to the scalp.
The following examples will make it possible to understand the invention
better without, however, having a limiting nature.
EXAMPLES
For the following Examples 1 to 7, the following procedure is used:
the amphiphilic lipids are homogenized with the oils and the lipophilic
active principles and adjuvants at a temperature of 45.degree. C. in a
first phase A;
the hydrophilic active principles and adjuvants are dissolved at a
temperature of 20.degree. to 30.degree. C. in a second phase B;
then, the phases A and B are mixed using a turbine homogenizer and then
homogenization is carried out using a high-pressure homogenizer of the
Soavi-Niro type at a pressure of 1500 bars, over 7 passages, the
temperature of the product being maintained below 35.degree. C.
In the case of Example 7, the gelling agent is added in a phase C which is
mixed with the phases A and B using a turbine homogenizer.
Example 1
Vitamin-Containing Care Water
First Phase
______________________________________
PEG-400 isostearate, sold by the company
4.5%
Unichema
Disodium salt of N-stearoyl-L-glutamic acid,
0.5%
marketed under the name Acylglutamate
HS21 by the Company Ajinomoto (ionic
amphiphilic lipid)
Jojoba oil 6%
Mixture of sunflower, hybrid sunflower,
6%
musk rose and blackcurrant seed oils
Cyclomethicone 7%
Vitamin E acetate 1%
Copherol F1300, marketed by Henkel
0.2%
Stabilized vitamin A palmitate
0.1%
Non-denatured absolute ethanol
15%
______________________________________
Second Phase
______________________________________
Demineralized water 54.7%
Glycerol 5%
______________________________________
An emulsion is obtained in which the size of the oil globules is 63 nm with
a transparency, determined by the transmittance coefficient at 600 nm,
equal to 40%.
Example 2
Care Fluid
First Phase
______________________________________
PEG-400 isostearate, sold by the company
4.5%
Unichema
Disodium salt of N-stearoyl-L-glutamic acid,
0.5%
marketed under the name Acylglutamate
HS21 by the Company Ajinomoto (ionic
amphiphilic lipid)
Jojoba oil 5%
Avocado oil 5%
Volatile silicone 9%
Cetyl alcohol 1%
Vitamin E acetate 1%
Copherol F1300 0.2%
Stabilized vitamin A palmitate
0.1%
Non-denatured absolute ethanol
15%
______________________________________
Second Phase
______________________________________
Glycerol 5%
Demineralized water q.s. for
100%
______________________________________
A thick transparent emulsion is obtained in which the size of the globules
is 53 nm and the transparency 60%.
Example 3
Fluid Eyeliner
First Phase
______________________________________
PEG-400 isostearate, sold by the company Unichema
4.5%
Disodium salt of N-stearoyl-L-glutamic acid,
0.5%
marketed under the name Acylglutamate
HS21 by the Company Ajinomoto (ionic
amphiphilic lipid)
Jojoba oil 5%
Light liquid petrolatum 4%
Avacado oil 4%
Volatile silicone 6%
Vitamin E acetate 1%
Copherol F1300 0.2%
______________________________________
Second Phase
______________________________________
Glycerol 5%
Polyethylene glycol containing 8 ethylene
10%
oxide units
Demineralized water q.s. for
100%
______________________________________
An opalescent emulsion is obtained in which the size of the globules is 65
nm and the transparency 42%.
Example 4
Body Care Fluid
First Phase
______________________________________
PEG-400 isostearate, sold by the company Unichema
4.5%
Disodium salt of N-stearoyl-L-glutamic acid,
0.5%
marketed under the name Acylglutamate
HS21 by the company Ajinomoto (ionic
amphiphilic lipid)
Light liquid petrolatum 7%
Avocado oil 7%
Volatile silicone 6%
Vitamin E acetate 1%
Non-denatured absolute ethanol
15%
______________________________________
Second Phase
______________________________________
Glycerol 5%
Demineralized water q.s. for
100%
______________________________________
A particularly fluid fluid is obtained in which the size of the globules is
of the order of 50 nm and the transparency 60%.
Example 5
Moisturizing Fluid
First Phase
______________________________________
.alpha.-Butylglucoside cocoate, marketed by ULICE
4.5%
Disodium salt of N-stearoyl-L-glutamic acid,
0.5%
marketed under the name Acylglutamate
HS21 by the Company Ajinomoto (ionic
amphiphilic lipid)
Jojoba oil 5%
Avocado oil 5%
Volatile silicone 6%
Stearyl heptanoate/stearyl caprylate
2%
Vitamin E acetate 1%
Non-denatured absolute ethanol
15%
______________________________________
Second Phase
______________________________________
Glycerol 6%
Sodium hyaluronate 0.10%
Demineralized water q.s. for
100%
______________________________________
A transparent emulsion is obtained in which the size of the globules is 52
nm and the transparency 58%.
Example 6
Scented Fluid
First Phase
______________________________________
PEG-400 isostearate, sold by the company Unichema
4.5%
Disodium salt of N-stearoyl-L-glutamic acid,
0.5%
marketed under the name Acylglutamate
HS21 by the Company Ajinomoto (ionic
amphiphilic lipid)
Jojoba oil 4%
Mixture of sunflower, hybrid sunflower,
4%
musk rose and blackcurrant seed oils
Volatile silicone 6%
Fragrance 6%
Non-denatured absolute ethanol
15%
______________________________________
Second Phase
______________________________________
Demineralized water 54.7%
Glycerol 5%
Demineralized water q.s. for
100%
______________________________________
A scented lotion of high persistence is obtained in which the size of the
oil globules is 50 nm with a transparency equal to 54%.
Example 7
Scented Balm
First Phase
______________________________________
.alpha.-Butylglucoside cocoate, marketed by ULICE
4.5%
Disodium salt of N-stearoyl-L-glutamic acid,
0.5%
marketed under the name Acylglutamate
HS21 by the Company Ajinomoto (ionic
amphiphilic lipid)
Mixture of sunflower, hybrid sunflower,
7%
musk rose and blackcurrant seed oils
Light liquid petrolatum 7%
Volatile silicone 6%
Fragrance 1.5%
Vitamin E acetate 0.5%
Non-denatured absolute ethanol
15%
______________________________________
Second Phase
______________________________________
Glycerol 5%
Sterile demineralized water q.s. for
100%
______________________________________
Third Phase
______________________________________
Hydroxypropyl cellulose, marketed under
0.4%
the name Methocel E 4 M QG by the company Dow Chemical
Sterile demineralized water 15%
______________________________________
A smooth non-sticky balm is obtained in which the size of the globules is
54 nm and the transparency 53%.
In addition to the specific examples of various components of the invention
nanoemulsions given above, those compounds and compositions meeting the
functional requirements of the invention components listed in Volumes 1
and 2 of the International Cosmetic Ingredient Dictionary, 6th Ed., 1995,
J. A. Wenninger, et al, Eds., published by the Cosmetic, Toiletry and
Fragrance Association, incorporated herein by reference, are also to be
included. Moreover, each invention component may be a mixture of
acceptable compounds or compositions.
This application is based on French Patent Application 95-02268, filed Feb.
27, 1995, incorporated herein by reference.
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