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United States Patent | 5,721,258 |
Schwarz ,   et al. | February 24, 1998 |
The NMDA-antagonistic effect of flupirtine permits the preparation of medicaments for the treatment of cerebral ischemia, neurodegenerative disorders, traumatic brain and bone marrow damage, and other illnesses.
Inventors: | Schwarz; Michael (Essen, DE); Pergande; Gabriela (Offenbach, DE); Engel; Jurgen (Alzenau, DE); Nickel; Bernd (Muhltal, DE); Ulrich; Heinz (Niedernberg, DE); Szelenyi; Stefan (Schwaig, DE) |
Assignee: | Asta Medica Aktiengesellschaft (Dresden, DE) |
Appl. No.: | 602742 |
Filed: | April 19, 1996 |
PCT Filed: | August 10, 1994 |
PCT NO: | PCT/EP94/02649 |
371 Date: | April 19, 1996 |
102(e) Date: | April 19, 1996 |
PCT PUB.NO.: | WO95/05175 |
PCT PUB. Date: | February 23, 1995 |
Aug 17, 1993[DE] | 4327516.8 |
Current U.S. Class: | 514/352 |
Intern'l Class: | A61K 031/44 |
Field of Search: | 514/352 |
5162346 | Nov., 1992 | Lobisch et al. | 514/356. |
Foreign Patent Documents | |||
199 951 | Dec., 1986 | EP. | |
467 164 | Jan., 1992 | EP. | |
33 37 593 | May., 1984 | DE. | |
2 084 138 | Apr., 1982 | GB. |
Schwarz et al: "N-Methyl-D-Aspartate (NMDA)-Mediated Muscle Relaxant Action of Flupirtine in Rat", Neuroreport, vol. 5, No. 15, Oct. 1994, pp. 1981-1984. Friedel, et al: "Flupirtine", Drugs, vol. 45, NO. 4, Apr. 1993, pp. 548-569. Seaman, et al: "Flupirtine", Curr. Probl. Epilepsy, vol. 4, 1986, pp. 135-145. Sheridan, et al: "Pilot Stody of Flupirtine in Refractory Seizures," Neurology, vol. 36, 1986, p. 85. |