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United States Patent | 5,677,340 |
Yu ,   et al. | October 14, 1997 |
Methods for visibly reducing a skin wrinkle and for reversing the effect of aging on human facial skin involving comprising topically applying to the wrinkle and/or affected facial skin gluconic acid or gluconolactone.
Inventors: | Yu; Ruey J. (Ambler, PA); Van Scott; Eugene J. (Abington, PA) |
Assignee: | Tristrata Technology, Inc. (Wilmington, DE) |
Appl. No.: | 468077 |
Filed: | June 6, 1995 |
Current U.S. Class: | 514/557; 514/844; 514/847; 514/873 |
Intern'l Class: | A61K 031/19; A61K 007/48 |
Field of Search: | 514/557,574,844,847,873,941 |
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4246261 | Jan., 1981 | Van Scott et al. | 424/240. |
4287214 | Sep., 1981 | Van Scott et al. | 424/346. |
4363815 | Dec., 1982 | Yu et al. | 424/274. |
4380549 | Apr., 1983 | Van Scott et al. | 424/317. |
4518789 | May., 1985 | Yu et al. | 560/105. |
4612331 | Sep., 1986 | Barnett et al. | 514/558. |
4929722 | May., 1990 | Partain et al. | 536/20. |
4983382 | Jan., 1991 | Wilmott et al. | 424/62. |
5021451 | Jun., 1991 | McLane et al. | 514/460. |
5091171 | Feb., 1992 | Yu et al. | 424/642. |
5093109 | Mar., 1992 | Mausner | 424/63. |
5108751 | Apr., 1992 | Hagan et al. | 424/401. |
5153230 | Oct., 1992 | Jeffery | 514/847. |
5389677 | Feb., 1995 | Yu et al. | 514/557. |
5470880 | Nov., 1995 | Yu et al. | 514/574. |
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__________________________________________________________________________ DEGREE OF IMPROVEMENT __________________________________________________________________________ None Mild Moderate Substantial Complete) (0) (1+) (2+) (3+) (4+) __________________________________________________________________________ Thickness Highly Detectable Readily Barely Normal elevated reduction apparent elevated thickness reduction Texture Visibly Palpably Uneven but Slightly Visibly and rough rough not rough uneven palpably smooth __________________________________________________________________________
__________________________________________________________________________ DEGREE OF IMPROVEMENT __________________________________________________________________________ None Mild Moderate Substantial Complete) (0) (1+) (2+) (3+) (4+) __________________________________________________________________________ THICKNESS Highly Detectable Readily Barely Normal elevated reduction apparent elevated thickness reduction TEXTURE Visibly Palpably Uneven but Slightly Visibly and rough rough not rough uneven palpably smooth COLOR Intense Red Dark Pink Light Pink Normal Skin Red Color __________________________________________________________________________
______________________________________ Topical Effects on Psoriasis of Antipsoriatic Compositions Therapeutic Compositions* Effectiveness ______________________________________ Hydrocortisone 2.5% alone 1+ With lactic acid 2+ With glycolic acid 2+ With ethyl pyruvate 2+ With methyl pyruvate 2+ With benzilic acid 2+ With pyruvic acid 2+ With methyllactic acid 2+ Hydrocortisone 17-valerate 0.2% alone 2+ With lactic acid 3+ With glycolic acid 3+ With benzilic acid 3+ With ethyl pyruvate 3+ With methyl pyruvate 3+ With gluconolactone 3+ With pyruvic acid 3+ Betamethasone dipropionate 0.05% alone 3+ With lactic acid 4+ With glycolic acid 4+ With ethyl pyruvate 4+ With methyl pyruvate 4+ With mandelic acid 4+ With benzilic acid 4+ Clobetasol propionate 0.05% alone 3+ With lactic acid 4+ With glycolic acid 4+ With ethyl pyruvate 4+ With methyl pyruvate 4+ With methyllactic acid 4+ With mandelic acid 4+ With tropic acid 4+ With benzilic acid 4+ ______________________________________ *Except the "alone" preparations, all others were amphoteric or pseudoamphoteric compositions containing 0.2 to 2M alpha hydroxyacids or related compounds.