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United States Patent | 5,663,198 |
Reul ,   et al. | September 2, 1997 |
Drug formulations comprising coated, very sparingly water-soluble drugs for inhalational pharmaceutical forms, and process for their preparation. Drug formulations comprising micronized particles of very sparingly water-soluble drugs which are coated with a natural, physiologically acceptable ampholytic surfactant soluble in water to give a micellar/colloidal solution, and a process for the preparation of these drug formulations, are described. When placed in an appropriate final container and after the addition of a chlorine-free, partially fluorinated propellant gas liquefiable under pressure, these formulations are suitable for inhalation.
Inventors: | Reul; Bernhard (Konigstein, DE); Petri; Walter (Wiesbaden, DE) |
Assignee: | Hoechst Aktiengesellschaft (Frankfurt am Main, DE) |
Appl. No.: | 274343 |
Filed: | July 13, 1994 |
Jul 15, 1993[DE] | 43 23 636.7 |
Current U.S. Class: | 514/471; 424/45; 424/46; 424/490; 424/491; 424/494; 424/496; 424/497; 424/499; 424/500 |
Intern'l Class: | A61K 031/34 |
Field of Search: | 424/45,46,490,491,494,496,497,499,500 514/471 |
5230884 | Jul., 1993 | Evans et al. | 424/45. |
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