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United States Patent |
5,662,921
|
Fein
,   et al.
|
September 2, 1997
|
Therapeutic uses of emu oil
Abstract
Emu oil is therapeutically used in methods for lowering cholesterol,
triglycerides and low density lipoproteins and increasing high density
lipoproteins; preventing and treating allergies; preventing scarring;
treating headaches; preventing nose bleeds; treating and preventing cold
and flu symptoms; and relieving discomfort associated with menstruation.
Additionally, emu oil acts as an effective chemical buffer in combination
with glycolic acid.
Inventors:
|
Fein; Elaine (Scarsdale, NY);
Caputo; John (Westport, CT);
Nagal; Ann Karrey (Mamaroneck, NY);
Nagal; Karrey-Lynn (Mamaroneck, NY)
|
Assignee:
|
Elf Resources, Inc. (New Rochelle, NY)
|
Appl. No.:
|
476300 |
Filed:
|
June 7, 1995 |
Current U.S. Class: |
424/436; 424/434; 424/435; 424/451; 424/464; 424/489; 424/522; 514/937 |
Intern'l Class: |
A61K 035/12 |
Field of Search: |
424/401,522,434,435,436,451,464,489
514/937
|
References Cited
U.S. Patent Documents
5431924 | Jul., 1995 | Ghosh et al. | 424/522.
|
Primary Examiner: Venkat; Jyothsna
Attorney, Agent or Firm: Jordan and Hamburg
Parent Case Text
This is a division of application Ser. No. 08/344,269, filed Nov. 23, 1994,
now U.S. Pat. No. 5,472,713.
Claims
What is claimed is:
1. A method of lowering cholesterol and triglycerides comprising
administering an amount of emu oil effective for lowering cholesterol and
triglycerides.
2. The method of claim 1, wherein the effective amount of emu oil is 2-10
milliliters.
3. The method of claim 1, wherein the mode of administration is selected
from the group consisting of oral, parenteral, enteral, rectal and
systemic.
4. A method of lowering cholesterol and triglycerides comprising
administering 2-10 milliliters of emu oil per day.
Description
BACKGROUND OF THE INVENTION
The present invention relates to uses of emu oil for preventing and
treating a variety of ailments.
Emu oil has been used in Australia as an Aboriginal liniment, the oil being
rendered from the bird's fat. The oil is used in cosmetics and
cosmetic-related items, including wrinkle-retarding emollients, cosmetic
bases and moisturizers for the face and body. It was traditionally used by
the Aborigines for treating burns and as a remedy for arthritis and sports
injuries. In Australian pharmacies, emu oil is sold as a liniment and a
lubricant. Additionally, emu oil is used as a massage oil.
According to one publication, emu oil alone has been unable to reduce
inflammation, even though the Aboriginal tribes of Australia have been
using emu oil for arthritis. Instead, PCT/AU91/00517, International
Publication No. WO 92/08470 found it necessary to add a miscible diluent,
such as isopropyl alcohol, amyl alcohol or acetate, ethyl, methyl or
isopropylsalicylate, t-tree oil, eucalyptus oil, cineole, or the like, to
emu oil to achieve an anti-inflammatory effect.
An important use of emu oil provided by the present invention is for
lowering cholesterol for treating high cholesterol conditions. The primary
constituents of emu oil are fatty acids. Others have utilized fatty acids
for lowering cholesterol and/or for treating high cholesterol conditions.
U.S. Pat. No. 3,849,554 to Winitz uses a defined diet to reduce blood serum
cholesterol. The diet includes amino acids, vitamins, minerals, essential
fatty acids, including linoleic, linolenic and arachidonic, and
carbohydrates, including glucose, maltose, and polysaccharides of glucose.
Winitz finds its diet works to reduce blood serum cholesterol principally
by controlling the type of carbohydrate in the diet. For example, Winitz
finds an increase in cholesterol where sucrose is used.
DiTullio, U.S. Pat. No. 3,969,508,refers to lowering the concentration of
plasma triglycerides using a hypolipidemic composition to produce
hypolipidemic activity in hyperlipidemic subjects. The active ingredient
used is 4-(2-thenoyl)-2,3-dichlorophenoxy acetic acid. DeTullio finds, as
a result of its method, that plasma cholesterol concentrations are not
significantly effected and there is no significant effect on free fatty
acids.
U.S. Pat. No. 4,472,432 to Iwamura refers to using alpha and beta
unsaturated fatty acids from clams to improve lipid metabolism.
Specifically, it provides a prophylaxis and remedy of hyperlipidemia and
lipotropic effect and prophylaxis of hyterosclerosis arteriosclerosis.
Iwamura refers to using 2-octadecenoic acid to decrease total cholesterol,
triglyceride and blood serum and total lipid amount in addition to
decreasing cholesterol and triglyceride in the liver.
Revici, U.S. Pat. No. 4,513,008 refers to a method of inactivating an
enveloped virus, such as herpes, using at least a C.sub.20-24 linear
polyunsaturated acid.
U.S. Pat. No. 4,603,142 to Burger refers to using d-.alpha.-tocotrienol in
a method for lowering cholesterol. According to Burger, its key
ingredient, d-.alpha.-tocotrienol, is found in high-protein barley flour
sad lemon grass oil. Additionally, according to Burger,
d-.alpha.-tocotrienol inhibits cholesterol biosynthesis.
Ward, U.S. Pat. No. 4,678,808, refers to intravenous emulsions of omega-3
fatty acid esters for supplying essential fatty acids. The omega-3-fatty
acid ester of Ward is derived from marine oil. Ward refers to using
omega-3-fatty acid esters for treating thrombotic diseases.
U.S. Pat. No. 4,851,437 to Revici refers to using tung oil for treating
arteriosclerosis.
Beyer, U.S. Pat. Nos. 4,920,123 sad 5,110,817, refer to a method for
controlling and/or lowering serum triglyceride and/or serum cholesterol
levels in mammals. In its method, Beyer uses pyrazinoylguanidines.
U.S. Pat. No. 4,999,380 to Berger refers to a process of treating
lipoprotein disorders associated with cholesterol metabolism using a lipid
from the black currant seed to increase high density lipoproteins (HDLs)
sad decrease low density lipoproteins. (LDLs).
Wakabayashi, U.S. Pat. No. 5,034,414, refers to using fish oil fatty acids
as an antithrombotic and an antiartherosclerotic.
U.S. Pat. No. 5,277,910 to Hidvegi refers to a process for preparing a
pharmaceutical composition for selectively lowering the blood-lipid level.
The composition includes saponins from alfalfa.
Mattson, U.S. Pat. No. 4,034,083 and Reissue No. 33,885, refer to
compositions for inhibiting the absorption of cholesterol. The composition
includes polyesters which act as fat substitutes and are not absorbable or
digestible. According to Mattson, the polyesters interfere with the body's
absorption of cholesterol. Accordingly, Mattson uses its compositions to
treat hypercholesterolemia (high blood cholesterol). Mattson uses fatty
acids to make its polyesters.
Jandacek, U.S. Pat. No. 4,005,195 and Reissue No. 33,996, refer to
compositions for treating hypercholesterolemia. The compositions referred
to in Jandacek include liquid polyol fatty acid polyesters with anti-anal
leakage agents. According to Jandacek, the polyesters interfere with the
body's absorption of cholesterol. The anti-anal leakage agents are
anti-laxative agents, such as a C.sub.12 or higher saturated fatty acid,
for example, cocoa butter, palm oil, etc.
SUMMARY OF THE INVENTION
The present invention is directed to new uses for emu oil. It has been
discovered that administration of emu oil on a regular basis results in
lowering cholesterol, triglyceride and low density liproproteins (LDL's)
and increasing levels of high density lipoproteins (HDL's). Additionally,
regular use of emu oil results in improving the rate of growth and
condition of nails, preventing and treating allergies, preventing nose
bleeds, and preventing and treating headaches (especially migraine
headaches). Additionally, emu oil can be used to prevent scarring when
applied to a newly received cut or burn. It also diminishes old scars.
Stretch marks, such as those acquired during pregnancy, can be prevented by
application of emu oil. Additionally, application of emu oil diminishes or
completely erases existing stretch marks.
Emu oil can be administered as necessary for treating cold and flu
symptoms, including sore throats and nasal congestion. In the same manner
emu oil can be taken as a remedy for the ailments related to menstruation.
Finally, emu oil can be used as a chemical buffer.
It is an object of the present invention to provide methods for the
above-described uses of emu oil.
If is a further object of the present invention to provide modes of
administration of emu oil for obtaining the benefits described above.
The above and other objects, features and advantages of the present
invention will be described herein by a detailed description thereof.
DETAILED DESCRIPTION OF THE INVENTION
Emu oil is obtained from a large, approximately five feat tail, flightless
bird of Australia known as an emu, Dromideius novaehollandiae. Emus are
farmed for their meat, which is low in cholesterol and fat. The oil
rendered from the emu is actually a semi-solid fat (i.e., fat and oil
mixture) at room temperature, but will herein be referred to as an oil.
The fat and oil mixture is stripped from the carcass of the emu and can be
melted to further liquify the oil. Emu oil obtained in this manner is
yellow and is olfactorially offensive. It is possible, through refining
processes, to remove the yellow color from the oil and reduce its odor.
PCT/AU91/00517 refers to removing the yellow color from emu oil by
exposing it to sunlight, page 8, and by subjecting it to chemical
oxidation by mixing it with benzoyl peroxide in an organic solvent, page
9.
In PCT/AU91/00517 it was found that the remarkable anti-inflammatory
effects of the emu oil composition, when mixed with a miscible diluent,
disappeared upon removal of the yellow components of the emu oil.
Accordingly, PCT/AU91/00517 is directed to using specifically the yellow
component of the emu oil along with a miscible diluent. However, the
present inventors have found upon refining emu oil to remove the yellow
color and reduce its odor, there is no difference in the constituents of
the oil, besides its impurities being removed, and the refined oil can be
used according to the present invention. Accordingly, for the uses of emu
oil in accordance with the present invention either the raw yellow oil or
a refined oil can be used.
One type of refined emu oil is manufactured under the trademark KALAYA OIL
and can be obtained from New World Technology, Inc. P.O. Box 7580
Greenwich, Conn., 06836-7580. Material Safety Data Sheet Information on
such a refined oil are as follows:
______________________________________
IDENTIFICATION
______________________________________
Product Name EMU OIL
UN Number None Allocated
Dangerous Goods Class
None Allocated
Subsidiary Risk None Allocated
Hazchem Code None Allocated
Poisons Schedule Not Scheduled
______________________________________
TABLE 1
______________________________________
PHYSICAL PROPERTIES
Description:
At 20.degree. C. it is a semi-solid white mass, at
600.degree. C. a practically clear yellow, colored
liquid. Very slight odor.
Boiling Point:
>150.degree. C.
Refractive Index:
1.4642
Vapor Pressure:
Not available
Acid Value: 0.45
Specific Gravity:
0.9458 g/mL
Saponification
187.09
Value:
Flashpoint: >140.degree. C.
Peroxide Value:
1.475
Solubility in Water:
insoluble Iodine Value:
70.97
Water Content:
<0.1% w/w Ester Value: 186.64
______________________________________
TABLE 2
______________________________________
Constituents (Fatty Acids)
Mean Content (%)
______________________________________
C14: 0 myristic 0.2
C16: 0 palmitic 30.7
C16: 1 palmitoleic
4.2
C18: 0 stearic 10.7
C18: 1 oleic 46.3
C18: 1 elaidic 0.7
C18: 2 linoleic 6.5
C18: 3 (9, 12, 15) linolenic
0.1
______________________________________
______________________________________
HEALTH HAZARD INFORMATION
HEALTH EFFECTS
Emu Oil is an edible oil.
INGESTION Emu Oil is non-irritant.
EYES Emu Oil is non-irritant to mucous
membranes.
SKIN Emu Oil at room temperature is non-
irritant to most skin types.
INHALATION Emu Oil at room temperature does not
present an inhalation hazard.
INGESTION Since Emu Oil is edible, ingestion
should not cause problems.
INHALATION Not considered as harmful.
PRECAUTIONS FOR USE
EXPOSURE LIMITS
Not considered hazardous.
There are no known Threshold Limited
Values (TLV) for Emu Oil.
VENTILATION Precautions are not usually required.
PERSONAL Personal protection is not required.
PROTECTION
FLAMMABILITY Not considered combustible under 140.degree. C.
SAFE HANDLING INFORMATION
STORAGE & Emu Oil is an edible oil and should not
TRANSPORT pose problems with transportation or
storage. However, it should not be stored
or transported with toxic chemicals,
flammable gases, explosives, oxidizing
agents and spontaneously combustible
substances. Store in a cool area and keep
containers closed to avoid contamination
from impurities.
SPILLS AND Contain using sand or earth and use as an
DISPOSAL absorbent (sand, sawdust, vermiculite)
where appropriate. Collect and seal in
properly labelled containers for disposal.
Wash area down with excess water. Waste
material may be incinerated under
controlled conditions where permitted.
Refer to local Waste Management
Authority Regulations for other approved
methods.
FIRE/EXPLOSION
Remove containers from path of fire.
HAZARD Heating can cause expansion and rupture
of containers. Keep containers cool with
water spray.
EXTINGUISHING
Carbon dioxide, dry chemical powder,
MEDIA BCF or alcohol stable foam.
______________________________________
Analysis by Dr. R. B. Longmore, BSc, MSc, PhD (manchr) of the refined oil
by gas chromatograph yielded the following information:
TABLE 3
______________________________________
FAME Analysis, relative fatty acid content
Identity
Name Mean content (%) std. dev
______________________________________
C14: 0 myristic 0.7 0.0 (3)
C16: 0 palmitic 26.7 0.2
C16: 1 palmitoleic
5.4 0.1 (3)
C18: 0 stearic 11.3 0.3
C18: 1 oleic 46.1 0.8
C18: 1 elaidic 1.7 one sample detection
C18: 2 linoleic 8.4 0.2
C18: 3 (9, 12, 15)
0.6 0.0 (1)
linolenic
______________________________________
Note: actual results:
sample 1: C18: 1 = 46.7%, 0.0% elaidic.
sample 2: C18: 1 = 45.6, 1.75% elaidic.
When elaidic not quantified it may be integrated in C18: 1 oleic peak.
Further analysis, by ORLON Laboratories Pry. Ltd. on Dec. 21, 1993, of
physical properties of the refined Emu Oil yielded the following
information:
TABLE 4
______________________________________
TEST RESULT
______________________________________
Weight per mL @ 20.degree. C.
0.9216 g/mL
Refractive Index @ 20.degree. C.
1.460
Acid Value 0.40
Saponification Value 189.84
Iodine Value 65.83
Peroxide Value 2.83
Ester Value 189.44
Water Content Nil Detected
P-Anisidine Value 2.75
Totox Value 8.41
______________________________________
An independent study on the composition of refined emu oil vs. chicken oil
was conducted in Aug. 1993 by Mr. Donald A. Swift. The results of his
analysis are reproduced below:
STATEMENT OF ANALYSIS
Date of Report: 27 Aug. 1993
Sample: Refined emu oil
Description: Colorless semisolid oil; odorless; melts to clear oil
TABLE 5
______________________________________
FAME Analysis, relative fatty acid content
Identity
Name Mean Content (%)
STD Dev
______________________________________
C14: 0 Myristic 0.0 0.0
C16: 0 Palmitic 22.0 0.12
C16: 1 Palmitoleic 1.3 0.12
C18: 0 Stearic 6.8 0.44
C18: 1 Oleic 62.4 1.5
C18: 1 Elaidic 0.44 0.88
C18: 2 Linoleic 6.9 0.41
C18: 3 (9, 12, 15) Linolenic
0.0 0.0
______________________________________
STATEMENT OF ANALYSIS
Date of Report: 20 Aug. 1993
Sample: Chicken Oil
Description: Straw-colored semisolid oil; characteristic odor; melts to
clear oil
TABLE 6
______________________________________
FAME Analysis, relative fatty acid content
Identity
Name Mean Content (%)
STD Dev
______________________________________
C14: 0 Myristic 0.8 0.0 (1)
C16: 0 Palmitic 14.2 1.2
C16: 1 Palmitoleic 3.3 0.38
C18: 0 Stearic 3.6 0.52
C18: 1 Oleic 66.6 1.9
C18: 1 Elaidic 1.6 0.01
C18: 2 Linoleic 9.3 0.28
C18: 3 (9, 12, 15) Linolenic
0.9 0.
______________________________________
FATTY ACID ANALYSIS OF EMU SUBCUTANEOUS AND INTESTINAL FAT SAMPLE
PREPARATION
Samples of fat from the freezer were cut in sections, and slices cut
through the sections to provide representative samples of the fat. The
slices were placed in a beaker and microwaved at the lowest setting to
melt the fat, with the fat temperature not exceeding 110.degree. C.
One drop of each sample of fat was then placed in a sample tube with 2
drops of T.A.M.H. and 200 .mu.L of toluene. The tube was then shaken,
rotated for one hour and then placed into the freezer to await G.C.
analysis.
G.C. PARAMETERS
Column Type: HP Ultra
Carrier Gas: H.sub.2 at 80 KPa
Column Length: 25 meters
Column Diameter: 0.2 mm
Initial Temperature: 195.degree. C. for 18 minutes, then
Temperature Rise of 15.degree. C./minute to the,
Final Temperature of 310.degree. C. for 1 minute
TABLE 7
______________________________________
Subcutaneous Fat Subcutaneous
Fatty (#185) Intestinal Fat(#78)
Fat(NT #5)
Acid 1 2 Mean 3 4 Mean 5 6 Mean
______________________________________
14:1 trace trace trace
trace
trace
trace
trace
trace
trace
14:0 0.5 0.5 0.5 0.4 0.5 0.4 0.3 0.3 0.3
16:1 2.7 2.6 2.6 3.8 3.9 3.8 4.3 4.3 4.3
16:0 22.0 21.9 22.0 22.9 23.8 23.4 19.6 19.7 19.6
18:2 16.3 16.4 16.4 10.0 9.9 10.0 5.8 5.8 5.8
18:3 0.7 0.6 0.6 0.5 0.4 0.4 0.2 0.2 0.2
18:1(9)
44.3 43.9 44.1 47.9 47.6 47.8 56.7 56.6 56.6
18:1(7)
1.8 2.0 1.9 2.9 2.5 2.7 2.5 2.4 2.4
18:1 0.3 0.4 0.4 0.4 0.3 0.4 0.2 0.1 0.2
(trans)
18:0 10.4 10.5 10.4 10.2 10.0 10.1 10.0 10.0 10.0
20:1 0.4 0.4 0.4 0.04 0.4 0.4 0.4 0.4 0.4
Other 0.6 0.8 0.7 0.6 0.7 0.6 0 0.2 0.2
______________________________________
NOTE:
18:2 and 18:3 percentages were obtained from a small injection of sample
(0.2 .mu.L) whilst all other results were from a large injection.
Sample 1,2,3,4 were of white appearance, solid at room temperature whilst
samples 5,6 were of yellow appearance and partially liquid at room
temperature.
Additionally, international application PCT/AU91/00517 includes a mass
spectral analysis of emu oil and other products in its Table 5. This table
is reproduced below as TABLE 8.
TABLE 8
__________________________________________________________________________
GLC - Mass Spectral Analysis of Emu Oil and Other Products (as % of
Total)
Identification
no. (batch)
135
136
137
138
157
158*
159'
181
203
202
__________________________________________________________________________
Palmitic
24.1
26.0
31.1
28.2
27.3
32.0
26.5
27.5
13.2
5.6
(C16:0)
Palmitoleic
ND ND ND ND ND ND ND 4.0
<1.0
ND
(C16:1)
Stearic
10.7
11.6
9.0
10.5
9.9
11.3
9.2
8.4
2.7
1.4
(C18:0)
Oleic 59.9
58.1
55.2
56.6
43.7
39.8
44.2
54.2
62.4
59.9
(C18:1)
Linoleic
5.3
4.3
4.7
4.7
7.4
6.8
8.1
5.9
20.1
23.8
(C18:2)
a-Linolenic
ND ND ND ND 11.7
10.1
11.9
ND 1.7
9.1
(C18:3)
g-Linolenic
ND ND ND ND ND ND ND ND ND ND
(C18:3)
__________________________________________________________________________
* -- Sediment after cooling EO 157 to 10.degree. C.
' -- Supernatant after cooling EO 157 to 10.degree. C.
202 -- Canola Brand polyunsaturated cooking oil
ND -- Not detectable
" -- A commercial preparation of EO diluted with peanut oil (4.1 v/v)
International Application PCT/AU91/00517 also includes a comparison of the
fatty acid composition of free range chicken and emu fats in its Table 6.
This table is reproduced below as TABLE 9:
TABLE 9
______________________________________
Comparison of Fatty Acid Composition of Free Range
Chicken and Emu Fats (Data generated after methoxide
hydrolysis and GLC expressed as %).
Number
Fatty Acid Carbons Unsaturation
Emu Chicken
______________________________________
Myristic C14 0 0.32 1.25
Palmitic C16 0 21.27
22.03
Palmitoleic C16 1 5.57 6.85
Stearic C18 0 7.81 5.94
Oleic C18 1 54.52
48.37
Linoleic C18 2 7.24 12.06
Linolenic C18 3 0.41 0.86
Arachidic C20 0 0.37 0.51
Arachidonic C20 4 <0.2 <0.2
Total poly- 7.65 12.92
unsaturated Fatty
Acids present
______________________________________
The inventors have found emu oil can be ingested at least once a day for
lowering cholesterol and increasing rate of nail growth and condition,
e.g., durability of nails. The precise amount of emu oil ingested depends
upon several factors including the requirements of the patient and the age
and weight of the patient. Though emu oil should be taken daily for
obtaining these therapeutic effects, the exact amount of the dosage is not
critical, for example, some patients may benefit most from administration
of from between two and ten milliliters of the emu oil. Others may find
between three and seven milliliters of emu oil beneficial. Still others
may ingest between four and six milliliters of emu oil. A preferable dose
for adults is one teaspoon of emu oil per day.
Information regarding the use of fatty acids and certain natural oils for
lowering cholesterol and treating conditions related to cholesterol
metabolism, including, but not limited to, dosages of fatty acids and fat
emulsions and forms of administration, are known to those with skill in
the art as illustrated by the United States Patents Incorporated herein by
reference. The following United States patents are incorporated herein by
reference: Winitz 3,849,554; DiTullio 3,969,508; Iwamura 4,472,432; Revici
4,513,008; Burger 4,603,142; Ward 4,678,808; Revici 4,851,437,
Beyer4,920,123 and 5,110,817; Berger 4,999,380; Wakabayashi 5,034,414;
Hidvegi 5,277,910; Mattson 4,034,083, reissue number 33,885 and Jandacek
4,005,195, reissue number 33,996, regarding the information referred to in
the preceding sentence and the subject matter encompassed by these
patents.
Examples 1 and 2 illustrates the cholesterol lowering effects of daily
ingestion of emu oil. As can be seen from Examples 1 and 2, emu oil is
effective for lowering blood serum cholesterol. The patients in both
Examples 1 and 2 have found the effectiveness of emu oil is greatest when
it is taken on a regular basis and that the effectiveness of the emu oil
for lowering cholesterol diminishes when emu oil is not taken on a regular
basis.
Example 1--Mature human female aged 38 years ingests approximately 5 drops
or one teaspoon of emu oil per day: Prior to this patient's ingestion of
emu oil, testing on Jan. 6, 1993 yielded the following results:
______________________________________
Total cholesterol 272 mg/dl
LDL 193 mg/dl
HDL 58 mg/dl
Triglycerides 103 mg/dl
______________________________________
Subsequent to ingestion of emu oil, testing yielded the following results:
Testing on Feb. 19, 1994, when patient was taking approximately one
teaspoon of emu oil per day, but not on a regular basis:
______________________________________
Total cholesterol 231 mg/dl
HDL 43 mg/dl
Chol./HDL 5 mg/dl
LDL 171 mg/dl
Triglycerides 87 mg/dl
______________________________________
Testing on May 26, 1994, when patient was taking approximately one teaspoon
of emu oil per day on a more regular basis:
______________________________________
Total cholesterol 210 mg/dl
LDL 132 mg/dl
HDL 66 mg/dl
Triglycerides 58 mg/dl
______________________________________
Example 2 Mature human female aged 60 years ingests 7 to 10 drops of emu
oil per day, approximately one teaspoonful. Patient has previously taken
Mevocore for lowering her cholesterol and has suffered side effects,
including hair loss. Patient does not suffer from side effects from
ingesting emu oil and her hair has been restored.
Prior to this patient's ingestion of emu oil, testing on Jul. 27, 1993
yielded the following results:
______________________________________
Total cholesterol 292 mg/dl
HDL 40 mg/dl
Chol./HDL 7.3
LDL 205 mg/dl
Triglycerides 233 mg/dl
______________________________________
Subsequent to ingestion of emu oil of approximately one teaspoon per day,
testing on Feb. 2, 1994 yielded the following results:
______________________________________
Total cholesterol 264 mg/dl
HDL 38 mg/dl
Chol./HDL 7
LDL 179 mg/dl
Triglycerides 239 mg/dl
______________________________________
Example 3--For the prevention and treatment of allergies, a mature human
female aged 60 years, has, for a time period of between six months and one
year, coated the inside of her nostrils with the emu oil. As a result, the
seasonal allergies she usually suffers have been alleviated.
Examples 4 and 5 illustrate the use of emu oil for preventing scarring.
Example 4--A mature human male suffered a deep elongated cut and applied
the emu oil to the cut, the expected scar did not result.
Example 5--An immature human male aged 13 years impaled his finger on a
fish hook. Upon removal of the fish hook emu oil was applied and the
expected scar did not result.
Example 6 illustrates the use of emu oil for alleviating headaches. When
using emu oil for treating a headache, the emu oil should be applied to
the forehead and temples.
Example 6--A mature human female having a severe migraine headache applied
emu oil to her temples. As a result of applying the emu oil, the patient's
migraine was alleviated. Normally, this patient would have to go to her
doctor to receive a shot to alleviate her migraine.
Example 7 illustrates the use of emu oil for preventing nose bleeds,
especially chronic nosebleeds. Emu oil can be used to prevent nose bleeds
by application of a coating of emu oil inside the nostrils.
Example 7--Emu oil was applied to the inside of the nostrils of an immature
human male who normally has chronic nose bleeds. As a result of using the
emu oil, on a dally basis, the usual nose bleeds did not occur. Examples 8
and 9 illustrate the use of emu oil for preventing and treating cold and
flu symptoms.
Example 8--A mature human female, aged 60, who normally suffers from bad
colds and the flu on a constant basis and who was always on antibiotics,
applied emu oil on a regular basis inside her nostrils and ingested
approximately one teaspoon per day of emu oil and was able to
substantially prevent contraction of a cold or flu. Additionally, when the
patient did suffer from congestion, additional application inside her
nostrils alleviated her congestion. Further, when the patient did suffer a
sore throat, application of emu oil on the back of her tongue alleviated
her sore throat.
Example 9--On Aug. 23 and 24, 1994 a mature human female, aged 27 years,
was able to relieve her sore throat by placing approximately one quarter
of a teaspoon of emu oil on her tongue, near the back of her tongue. On
Aug. 25, 1994 this patient no longer had a sore throat.
Example 10 illustrates the effectiveness of emu oil for treating
premenstrual syndrome (PMS).
Example 10--A mature human female aged 38 ingesting emu oil on a regular
basis of approximately one teaspoon per day no longer suffers from PMS and
is relieved of suffering during her menstrual period. The patient also has
a shortened menstrual period. The patient's usual symptoms of PMS and
ailments during her menstrual period include stomach cramps, backaches,
headaches and painful swelling, all of which the patient no longer
suffers.
Emu oil can be used as a chemical buffer. Application of glycolic acid in
skin treatments normally causes redness and irritation. The present
inventors combined glycolic acid with emu oil, which operated as a buffer,
such that the normal redness and irritation experienced upon application
of glycolic acid were absent. Example 11 is illustrative of the use of emu
oil as a chemical buffer.
Example 11--Combined 7% emu oil with 10% glycolic acid in a 2 oz. jar.
Use of the preparation of Example 11 did not cause redness and irritation.
Normally, it is not possible to use a-preparation containing 10% glycolic
acid due to the high level of irritation which results. However, in
Example 11, emu oil acts as a chemical buffer to enable use of a
preparation containing glycolic acid.
The present invention includes any known means of administration for
administering emu oil. Generally known topical, systemic, enteral, rectal,
parenteral and oral means of administration for administering emu oil are
included in the present invention. Included as modes of administration are
ingestion of emu oil by spoon, dropper or gelatin capsule, including time
release capsules, directly into the patient's mouth or added to the
patient's food. In accordance with the present invention, the patient may
ingest an emulsion of emu oil. Accordingly, oral administration of emu oil
may be in the form of tablets, capsules, emulsions, suspension, powders,
etc., without limitation. Additionally, topical applications of the emu
oil are beneficial for preventing and treating scars, preventing and
treating headaches (especially migraine headaches), preventing and
treating allergies and preventing and treating nose bleeds. Systemic
administration may include subcutaneous or intramuscular injections of emu
oil alone or in conjunction with a neutral vehicle. For parenteral
administration, sterile solutions or emulsions are preferred.
The inventors do not know exactly how emu oil operates to achieve the
benefits described above. However, it is hypothesized the effectiveness of
emu oil in the Examples outlined above results from it being readily
absorbed by the body and operating at a cellular level.
Having described the invention it will be appreciated that the present
invention is not limited to that described above and that various changes
and modifications can be effected therein by one of ordinary skill in the
art without departing from the scope or spirit of the invention as defined
by the appended claims.
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