Back to EveryPatent.com
United States Patent | 5,656,620 |
Ismail | August 12, 1997 |
Treatment and prophylaxis of pain involves administration of vitamin E combined with salicylic acid in a pharmaceutically acceptable carrier or adjuvant.
Inventors: | Ismail; Roshdy (Seibengebirgs-Apotheke Siebengebirgsallee 2, D-5000 Koln 41, DE) |
Appl. No.: | 475100 |
Filed: | June 7, 1995 |
Jan 28, 1984[DE] | 34 02 938.1 | |
Feb 07, 1984[DE] | 34 07 025.7 | |
Feb 15, 1984[DE] | 34 05 239.9 | |
Jun 04, 1984[DE] | 34 20 738.4 |
Current U.S. Class: | 514/161; 514/458 |
Intern'l Class: | A61K 031/62; A61K 031/355 |
Field of Search: | 514/161,458 |
3149037 | Sep., 1964 | Aiello et al. | |
3208907 | Sep., 1965 | Delarue | 167/65. |
3436459 | Apr., 1969 | Klaui. | |
4199576 | Apr., 1980 | Reller | 424/230. |
4241054 | Dec., 1980 | Volpenhein et al. | |
4284630 | Aug., 1981 | Yu et al. | |
4307717 | Dec., 1981 | Hymes et al. | |
4386072 | May., 1983 | Horrobin et al. | |
4412986 | Nov., 1983 | Kawata et al. | |
4542026 | Sep., 1985 | Rios. | |
4627850 | Dec., 1986 | Deters et al. | |
4684524 | Aug., 1987 | Eckenoff et al. | |
4751241 | Jun., 1988 | Motoyama et al. | |
4879275 | Nov., 1989 | Ninaskanian et al. | |
5153001 | Oct., 1992 | Ismail. |
Steiner, M., "Effect of Alpha-Tocopherol Administration on Platelet Function in Man", Division of Hematologic Research, The Memorial Hospital, Pawtucket, RI and Brown University, Providence, RI, pp. 73-77 (1983). Cuzzocrea et al., "Veranderungen der Blutviskositat nach Vitamin E-gabe beim Kaninchen", Boll Soc Ital Biol Sper 59(5):679-85 (1983), pp. 1-7. Williams et al., "Nephrotic Syndrome after the Application of Mercury Ointment", The Lancet, Original Articles, Sep. 1958, pp. 602-604. Haeger, K., "Long-time Treatment of Intermittent Claudication with Vitamin E", The American Journal of Clinical Nutrition, 27 Oct. 1974, pp. 1179-1181. Wilson et al., "Clinical Trial of Alpha-Tocopherol in the Prophylaxis of Thrombo-Embolism", The Lancet, Original Articles, Mar. 6, 1954, pp. 486-488. Toone, W.M., "Effects of Vitamin E: Good and Bad", The New England Journal of Medicine, Nov. 1, 1973, pp. 979-980. L.J. Machlin, "Vitamin E -A Comprehensive Treatise" (1980), pp. 578-583 and 586-595. Sakharchuk et al., Chem. Abstract 101,48378(k) (1984). Reynolds, E. F., "Martindale The Extra Pharmacopoeia", 28th edition, published 1982 by The Pharmaceutical Press (London) pp. 242 and 1663. |