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United States Patent | 5,643,789 |
Ducheyne ,   et al. | July 1, 1997 |
Novel non-crystalline, porous bioactive glass and ceramic materials that permit the in vitro formation of bone tissue when exposed to a tissue culture medium and inoculated with cells are disclosed. The present invention also discloses methods of treating bioactive glass materials to control pH so that when the glass is exposed to a tissue culture medium and then inoculated with cells, bone tissue growth occurs in vitro. The glass material disclosed is preferably formed from SiO.sub.2, CaO, Na.sub.2 O and P.sub.2 O.sub.5 and the porous, non-crystalline structure is most preferably created by melting the constituents, cooling and pulverizing the resulting glass, and then forming and hot pressing the powder. The glass of the present invention may be formed to produce templates that are useful for various indications, as well as granules that may be formed into a paste.
Inventors: | Ducheyne; Paul (Rosemont, PA); El-Ghannam; Ahmed (Philadelphia, PA); Shapiro; Irving (Philadelphia, PA) |
Assignee: | Trustees of the University of Pennslyvania (Philadelphia, PA) |
Appl. No.: | 278579 |
Filed: | July 21, 1994 |
Current U.S. Class: | 435/402; 424/422; 435/1.1; 435/325; 435/378 |
Intern'l Class: | C12N 005/08; C12N 005/00; A61F 002/28 |
Field of Search: | 435/240.1,240.2,240.21,240.23,240.243 424/422 |
4608199 | Aug., 1986 | Caplan et al. | 530/414. |
4609551 | Sep., 1986 | Caplan et al. | 424/95. |
4620327 | Nov., 1986 | Caplan et al. | 632/10. |
5204106 | Apr., 1993 | Schepers et al. | 424/423. |
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