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United States Patent | 5,622,819 |
Herman | April 22, 1997 |
The present invention comprises a novel culture method and device in which living cells or subcellular biocatalysts are immobilized by the opposition of a centrifugal force field and a liquid flow field. The immobilized cells or biocatalysts are ordered into a three-dimensional array of particles, the density of which is determined by the particle size, shape, intrinsic density and by the selection of combinations of parameters such as liquid flow rate and angular velocity of rotation.
Inventors: | Herman; Heath H. (Tucker, GA) |
Assignee: | Kinetic Biosystems, Inc. (Tucker, GA) |
Appl. No.: | 412289 |
Filed: | March 28, 1995 |
Current U.S. Class: | 435/4; 435/29; 435/243 |
Intern'l Class: | C12Q 001/00; C12Q 001/02; C12N 001/00 |
Field of Search: | 435/240.25,240.46,243,284,286,813,4,29 210/150,610 |
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Foreign Patent Documents | |||
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