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| United States Patent |
5,614,201
|
|
Slavtcheff
, et al.
|
March 25, 1997
|
Cosmetic composition for treatment of pimples and redness
Abstract
A cosmetic composition is provided which includes at least one keratolytic
agent and a combination of water-soluble and water-insoluble
anti-irritancy agents in a pharmaceutically acceptable carrier. Most
effective is a combination of a C.sub.7 -C.sub.30 .beta.-hydroxy
carboxylic acids such as salicylic acid with a C.sub.1 -C.sub.2
.alpha.-hydroxy carboxylic acid such as glycolic or lactic acids. The
water-soluble anti-irritancy agent is preferably a salt of glycyrrhizinic
acid. The water-insoluble anti-irritancy agent is preferably a-bisabolol,
azulene or combinations thereof. Other performance components may include
a C.sub.1 -C.sub.10 alkyl lactate and an antimicrobial agent such as a
zinc or aluminum salt.
| Inventors:
|
Slavtcheff; Craig S. (Cheshire, CT);
Barrow; Stephen R. (Trumbull, CT);
Kanga; Vispi D. (Shelton, CT);
Cheney; Michael C. (Fairfield, CT);
Znaiden; Alexander (Trumbull, CT)
|
| Assignee:
|
Chesebrough-Pond's USA Co., Division of Conopco, Inc. (Greenwich, CT)
|
| Appl. No.:
|
417417 |
| Filed:
|
April 5, 1995 |
| Current U.S. Class: |
424/401; 424/744; 424/DIG.5; 514/557; 514/783; 514/844; 514/845; 514/846; 514/847; 514/859 |
| Intern'l Class: |
A61K 007/00; A61K 035/78; A61K 031/19 |
| Field of Search: |
424/401,195,195.1,65,67,68
514/783,844,845,846,847,859
|
References Cited
U.S. Patent Documents
| 3920835 | Nov., 1975 | Van Scott et al. | 424/311.
|
| 3984470 | Oct., 1976 | Binon et al. | 424/316.
|
| 3988470 | Oct., 1976 | Van Scott et al. | 424/283.
|
| 4021572 | May., 1977 | Van Scott et al. | 424/317.
|
| 4105782 | Aug., 1978 | Yu et al. | 424/283.
|
| 4105783 | Aug., 1978 | Yu et al. | 424/283.
|
| 4536399 | Aug., 1985 | Flynn et al. | 514/63.
|
| 4540567 | Sep., 1985 | Oneto et al. | 424/45.
|
| 4545990 | Oct., 1985 | Le Foyer de Costil et al. | 514/557.
|
| 4608370 | Aug., 1986 | Aronsohn | 514/159.
|
| 4613592 | Sep., 1986 | Benzoni | 514/63.
|
| 4772592 | Sep., 1986 | Benzoni | 514/63.
|
| 4880621 | Nov., 1989 | Grollier et al. | 424/74.
|
| 4933177 | Jun., 1990 | Grollier et al. | 424/74.
|
| 4961927 | Oct., 1990 | Kogure | 424/94.
|
| 5057502 | Oct., 1991 | Walsh | 514/54.
|
| 5091171 | Feb., 1992 | Yu et al. | 424/642.
|
| 5482710 | Jan., 1996 | Slavtcheff et al. | 424/195.
|
| Foreign Patent Documents |
| 0508324 | Oct., 1992 | EP.
| |
| 2130486 | Jun., 1984 | GB.
| |
Other References
International Search Report Dec. 12, 1994.
H. Fey & I. Otte "Worterbuch Der Kosmetik"--p. 29 1985.
|
Primary Examiner: Dodson; Shelley A.
Attorney, Agent or Firm: Honig; Milton L.
Parent Case Text
This is a Divisional application of Ser. No. 08/099,876, filed Jul. 30,
1993, now U.S. Pat. No. 5,482,710.
Claims
What is claimed is:
1. A cosmetic composition in an effective amount for treatment of pimples,
blemishes and redness comprising:
(i) from about 0.1 to about 10% of at least one keratolytic agent each
selected from the group consisting of C.sub.7 -C.sub.30 .beta.-hydroxy
carboxylic acids and their salts, C.sub.1 -C.sub.25 .alpha.-hydroxy
carboxylic acids and their salts and mixtures thereof,
(ii) from about 0.0001 to about 5% by weight each of an anti-irritancy
agent combination which includes:
(a) a water-soluble anti-irritancy material which is a C.sub.20 -C.sub.100
saponin; and
(b) a water-insoluble anti-irritancy agent selected from the group
consisting of C.sub.7 -C.sub.30 polycyclic polyenes, C.sub.15 -C.sub.40
triterpenes and mixtures thereof, the water-soluble and water-insoluble
anti-irritancy agents being present in a relative weight ratio from about
20:1 to 1:20;
(iii) from about 1 to about 99.9% by weight of a cosmetically acceptable
carrier; and
(iv) from about 0.1 to about 5% of a zinc or aluminum salt.
2. A composition according to claim 1 wherein the zinc salt is selected
from the group consisting of zinc sulphate, zinc chloride, zinc
phenolsulphonate and combinations thereof.
3. A cosmetic composition according to claim 1 wherein the at least one
keratolytic agent comprises from about 0.1 to about 10% by weight of a
C.sub.7 to C.sub.30 .beta.-hydroxy carboxylic acid and also from about 0.1
to about 10% by weight of a C.sub.1 -C.sub.25 .alpha.-hydroxy carboxylic
acid.
4. A composition according to claim 3 wherein the C.sub.7 -C.sub.30
.beta.-hydroxy carboxylic acid is salicylic acid and the C.sub.1 -C.sub.25
.alpha.-hydroxy carboxylic acid is selected from the group consisting of
glycolic acid, lactic acid, 2-hydroxy octanoic acid and combinations
thereof.
5. A composition according to claim 1 wherein the composition further
comprises from about 0.01 to about 5% by weight of C.sub.1 -C.sub.10 alkyl
lactate.
6. A composition according to claim 1 wherein the water-soluble
anti-irritancy agent is diglycyrrhizinic acid and salts thereof.
7. A composition according to claim 6 wherein the water-insoluble
anti-irritancy agent is selected from the group consisting of dipotassium
glycyrrihizinate and ammonium glycyrrihizinate.
8. A composition according to claim 1 wherein the water-insoluble
anti-irritancy agent is selected from the group consisting of
.alpha.-bisabolol, azulene and combinations thereof.
9. A composition according to claim 1 further comprising from about 0.1 to
about 5% by weight of aloe extract.
10. A composition according to claim 1 wherein the .beta.-hydroxy
carboxylic acids are selected from salicylic acid.
Description
BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention concerns a cosmetic composition that when applied to the
skin, especially the face, is effective against pimples and redness.
2. The Related Aft
Pimples and reddened skin areas are of great concern to both juveniles and
adults. These skin problems can arise either from disease conditions or as
a result of skin changes associated with aging or hormonal changes.
Disease conditions include those of dry skin, ichthyosis, eczema, palmar
and plantar hyperkeratoses, dandruff, acne and warts. Skin changes
associated with aging may include such symptoms as age spots, wrinkling
and related aging changes.
U.S. Pat. Nos. 4,105,782, 4,105,783, 4,021,572, 3,879,537, 3,920,835,
3,984,470 and U.S. Pat. No. 3,988,470, all to Van Scott and Yu, report on
the use of .alpha.-hydroxyacids for the treatment of diseased skin. These
patents especially focus upon lower molecular weight .alpha.-hydroxyacids
such as lactic and glycolic acids. Ammonium salts were found to be more
effective than the free acid, and both of the aforementioned forms were
said to be substantially better than the alkali metal salts. A problem
with this technology is that when the .alpha.-hydroxyacids are present at
levels sufficient to be effective, they cause a stinging sensation and
even redness on the skin. Indeed, the art considers the stinging and
redness as a sign of effective performance. Consumers, of course, would
prefer performance without side effects.
More recently, U.S. Pat. No. 5,091,171 (Yu et al) disclosed the use of
.alpha.-hydroxyacids for treatment of non-disease conditions.
A rich source of literature is available that describes treatment of ache
vulgaris. For instance, U.S. Pat. No. 4,536,399 (Flynn et al) reports the
combination of benzoyl peroxide or salicylic acid with fumed silica
intended to treat oily skin. Benzoyl peroxide based anti-acne compositions
with irritation suppressants are described in U.S. Pat. No. 4,545,990 (Le
Foyer de Costil et al). U.S. Pat. No. 4,608,370 (Aronsohn) reports removal
of at least some blemishes and the imparting of a useful, healthy
complexion with a composition of salicylic acid, resorcinol, lactic acid
and ethyl alcohol. Other acne treatments are reported in U.S. Pat. No.
4,613,592 and U.S. Pat. No. 4,772,592, both to Benzoyl. These treatments
utilize C.sub.1 -C.sub.4 alkyl lactates as the active ingredient in a
water-in-oil emulsion.
A slightly different approach is found in U.S. Pat. No. 5,057,502 (Walsh)
which utilizes Juniper extract materials to thin heavy oily, greasy
secretions from the skin. Co-actives are reported to be vitamin A, aloe
vera and camomile extract. Pulverized flowers are reported in the skin
treatments of U.S. Pat. No. 4,880,621 and U.S. Pat. No. 4,933,177, both to
Grollier et al. Even though the many aforementioned treatments may be
effective, consumers are not satisfied with either the speed of
performance or results from these formulations.
Accordingly, it is an object of the present invention to provide a cosmetic
composition that can eliminate pimples, blemishes and redness within a
short period after application.
It is another object of the present invention to provide a cosmetic
composition for the treatment of pimples, blemishes and redness which
avoids any undesirable side effects such as stinging and heightened skin
color.
These and other objects of the present invention will become more readily
apparent from consideration of the following summary, detailed description
and examples which follow.
SUMMARY OF THE INVENTION
A cosmetic composition is provided that includes:
(i) from about 0.1 to about 10% of at least one keratolytic agent each
selected from the group consisting of C.sub.7 -C.sub.30 .beta.-hydroxy
carboxylic acids and their salts, C.sub.1 -C.sub.25 .alpha.-hydroxy
carboxylic acids and their salts and mixtures thereof.
(ii) from about 0.0001 to about 5% by weight each of an anti-irritancy
agent combination which includes:
(a) a water-soluble anti-irritancy material which is a C.sub.20 -C.sub.100
saponin; and
(b) a water-insoluble anti-irritancy agent selected from the group
consisting of C.sub.7 -C.sub.30 polycyclic polyenes, C.sub.15 -C.sub.40
triterpenes and mixtures thereof, the water-soluble and water-insoluble
anti-irritancy agents being present in a relative weight ratio from about
20:1 to 1:20; and
(iii) from about 1 to about 99.9% by weight of a pharmaceutically
acceptable carrier.
Particularly suitable as the .alpha.-hydroxy carboxylic acids are glycolic,
lactic and 2-hydroxyoctanoic acids as well as their alkali metal and
ammonium salts. The preferred .beta.-hydroxy carboxylic acid is salicylic
acid and its alkali metal and ammonium salts. Especially useful is a
combination of .alpha.- and .beta.-hydroxy carboxylic acids.
Glycyrrhizinic acid and salts thereof, especially the dipotassium and
ammonium salts, are the preferred water-soluble anti-irritancy agents
.alpha.-Bisabolol and azulene are the preferred water-insoluble
anti-irritancy agents.
DETAILED DESCRIPTION
Now there has been found a cosmetic composition formulated with at least
one keratolytic agent which is either a .alpha.-hydroxy or .beta.-hydroxy
carboxylic acid and a combination of two types of anti-irritancy agent.
This composition rapidly reduces the size of blemishes and reduces overall
redness. Stinging sensations often associated with hydroxy carboxylic
acids are no longer a problem with the combination of actives.
Accordingly, a first critical component of compositions according to the
present invention is that of a keratolytic agent. Under the class of
keratolytic agents there are two categories useful for the present
invention.
The first category is represented by C.sub.7 -C.sub.30 .beta.-hydroxy
carboxylic acids and their salts. Illustrative of this category is
salicylic acid as well as the alkalimetal and ammonium salts thereof.
Suitable amounts of salicylic acid or salt forms may range from about 0.1
to about 10%, preferably between about 0.8 and about 2.5%, optimally
between about 1 and 1.5% by weight.
The second category of keratolytic agent is represented by C.sub.1
-C.sub.25 .alpha.-hydroxy carboxylic acids of Formula I having the
structure:
##STR1##
wherein R and R.sup.1 are H, F, Cl, Br, alkyl, aralkyl or aryl groups of
saturated or unsaturated, isomeric or nonisomeric, straight or branched
chain, having 1 to 25 carbon atoms, or cyclic form having 5 or 6 ring
members, and in addition, R and R.sup.1 may carry OH, CHO, COOH and alkoxy
groups having 1 to 9 carbon atoms, the .alpha.-hydroxyacid existing as a
free acid or lactone form, or in salt form with an organic amine base or
an inorganic alkali, and as stereoisomers, and D, and DL forms when R and
R.sup.1 are not identical.
Illustrative of this group of materials are 2-hydroxyethanoic acid
(glycolic acid); 2-hydroxypropanoic acid (lactic acid); 2-methyl
2-hydroxypropanoic acid (methyllactic acid); 2-hydroxybutanoic acid;
2-hydroxypentanoic acid; 2-hydroxyhexanoic acid; 2-hydroxyheptanoic acid;
2-hydroxyoctanoic acid; 2-hydroxynonanoic acid; 2-hydroxydecanoic acid;
2-hydroxyundecanoic acid; 2-hydroxydodecanoic acid (.beta.-hydroxylauric
acid); 2-hydroxytetradecanoic acid (.alpha.-hydroxymyristic acid);
2-hydroxyhexadecanoic acid (.alpha.-hydroxypalmitic acid);
2-hydroxyoctadecanoic acid (.alpha.-hydroxystearic acid);
2-hydroxyeicosanoic acid (.alpha.-hydroxyarachidonic acid); 2-phenyl
2-hydroxyethanoic acid (mandelic acid); 2,2-diphenyl 2-hydroxyethanoic
acid (benzilic acid); 3-phenyl 2-hydroxypropanoic aid (phenyllactic acid);
2-phenyl 2-methyl 2-hydroxyethanoic acid (atrolactic acid);
2-(4'-hydroxyphenyl) 2-hydroxyethanoic acid; 2-(4'-chlorophenyl
2-hydroxyethanoic acid; 2-(3'-hydroxy-4'-methoxyphenyl) 2-hydroxyethanoic
acid; 2-(4"-hydroxy-3'-methoxyphenyl) 2-hydroxyethanoic acid;
3-(2-hydroxyphenyl) 2-hydroxypropanoic acid; 3-(4'-hydroxyphenyl)
2-hydroxypropanoic acid; and 2-(3",4'-dihydroxyphenyl) 2-hydroxyethanoic
acid.
Most preferred of this group of materials are glycolic acid, lactic acid
and 2-hydroxyoctanoic acid and salts thereof. The salts may be selected
from alkalimetal, ammonium and C.sub.1 -C.sub.20 alkyl or alkanol ammonium
counterions. Levels of .alpha.-hydroxyalkanoic acids may range from about
0.1 to about 10%, preferably between about 0.2 and 1%, optimally between
about 0.4 and 0.5% by weight.
In a particularly preferred embodiment, there will be present a mixture of
both a .beta.-hydroxy carboxylic acid and an .alpha.-hydroxy carboxylic
acid. For instance, the optimum combination is a mixture of salicylic acid
and glycolic acid in a relative weight ratio from about 20:1 to about
1:20, preferably from about 10:1 to 1:1, optimally from about 3:1 to about
2:1.
Compositions of the present invention can include a variety of
anti-irritancy agents. These are either water-soluble or water-insoluble
(i.e. oil-soluble). The water-soluble anti-irritancy agents should be
C.sub.20 -C.sub.100 saponins, primary examples of which are glycyrrhizinic
acid, especially the alkalimetal and ammonium salts. The water-insoluble
anti-irritancy agents should be selected from C.sub.7 -C.sub.30 polycyclic
polyenes, C.sub.15 -C.sub.40 triterpenes and mixtures thereof.
Representative of the polyenes is azulene (synthetically derived or
extracted from yarrow). Representative of the triterpenes is
.alpha.-bisabolol (synthetically derived or extracted from chamomile).
Each of these can be present at levels ranging from about 0.0001 to about
5%, preferably from about 0.001 to about 1%, optimally from about 0.01 to
about 0.5% by weight. Most especially preferred is dipotassium
glycyrrhizinate. Amounts of this material may range from about 0.001 to
about 3%, preferably from about 0.1 to about 0.5%, optimally between about
0.15 and 0.2% by weight.
In a preferred embodiment, the cosmetic composition of the present
invention will include a combination of dipotassium glycyrrhizinate and
.alpha.-bisabolol. These will be present in a weight ratio of about 20:1
to 1:20, preferably between about 5:1 and 1:5, optionally between about
3:1 and about 1:3 by weight.
A still further component of compositions according to the present
invention may be C.sub.1 -C.sub.10 alkyl lactates. Most preferred is ethyl
lactate which may be present in amounts ranging from about 0.01 to about
5%, preferably between about 0.5 and 3%. optimally between about 1.5 and
2.5% by weight.
A variety of herbal extracts may be included as components of the
composition. These extracts may include those of thyme, rosemary, myrrh,
bitter orange, coltsfoot and sage. Each of these may range in an amount
anywhere from about 0.00001 to about 2%, preferably between about 0.01 and
about 0.5% by weight.
Compositions of the invention preferably also contain aloe extract to
assist with skin adhesion. Aloe extract levels may range from about 0.01
to about 5%, preferably from about 0.05 to 1%, optimally between 0.1 and
0.75% by weight.
Antimicrobial agents may also be useful in compositions of the present
invention. Typically the antimicrobial agent may be material such as
triclosan tricarbanilide, tea tree oil, farnesol, farnesol acetate,
hexachlorophene, C.sub.4 -C.sub.20 quaternary ammonium salts such as
benzolconjure chloride and a variety of zinc or aluminum salts. Typically
the zinc or aluminum salts are compounds such as zinc pyridinethione, zinc
sulphate, zinc chloride, zinc phenolsulphonale, aluminum chloride,
aluminum sulphate and aluminum chlorhydrate. Amounts of the antimicrobial
agent may range from about 0.1 to about 5%, preferably from about 0.2 to
about 1%, optimally about 0.3% by weight.
Compositions of the present invention may either be aqueous or anhydrous.
Preferably the compositions are aqueous. Water will then be present in
amounts which may range from about 5 to about 90%, preferably from about
30 to about 55%, optimally between about 35 and 45% by weight.
Besides water, relatively volatile solvents may also be incorporated within
compositions of the present invention. Most preferred are monohydric
C.sub.1 -C.sub.3 alkanols. These include ethyl alcohol, methyl alcohol and
isopropyl alcohol. The amount of monohydric alkanol may range from about 5
to about 50%, preferably from about 15 to about 40%, optimally between
about 25 to 35% by weight.
Emollient materials in the form of silicone oils and synthetic esters may
be Incorporated into compositions of the present invention. Amounts of the
emollients may range anywhere from about 0.1 to about 30%, preferably
between about 1 and 20% by weight.
Silicone oils may be divided into the volatile and non-volatile variety.
The term "volatile" as used herein refers to those materials which have a
measurable vapor pressure at ambient temperature. Volatile silicone oils
are preferably chosen from cyclic or linear polydimethylsiloxanes
containing from about 3 to about 9, preferably from about 4 to about 5,
silicon atoms.
Linear volatile silicone materials generally have viscosities less than
about 5 centistokes at 25.degree. C. while cyclic materials typically have
viscosities of less than about 10 centistokes.
Nonvolatile silicone oils useful as an emollient material include polyalkyl
siloxanes, polyalkylaryl siloxanes and polyether siloxane copolymers. The
essentially non-volatile polyalkyl siloxanes useful herein include, for
example, polydimethyl siloxanes with viscosities of from about 5 to about
100,000 centistokes at 25.degree. C. Among the preferred non-volatile
emollients useful in the present compositions are the polydimethyl
siloxanes having viscosities from about 10 to about 400 centistokes at
25.degree. C.
Among the ester emollients are:
(1) Alkenyl esters of fatty acids having 10 to 20 carbon atoms. Examples
thereof include oleyl myristate, oleyl stearate, and oleyl oleate.
(2) Ether-esters such as fatty acid esters of ethoxylated fatty alcohols.
(3) Polyhydric alcohol esters. Ethylene glycol mono and di-fatty acid
esters, diethylene glycol mono- and di-fatty acid esters, polyethylene
glycol (200-6000) mono- and di-fatty acid esters, propylene glycol mono-
and di-fatty acid esters, polypropylene glycol 2000 monooleate,
polypropylene glycol 2000 monostearate, ethoxylated propylene glycol
monostearate, glyceryl mono- and di-fatty acid esters, polyglycerol
poly-fatty esters, ethoxylated glyceryl monostearate, 1,3-butylene glycol
monostearate, 1,3-butylene glycol distearate, polyoxyethylene polyol fatty
acid ester, sorbitan fatty acid esters, and polyoxyethylene sorbitan fatty
acid esters are satisfactory polyhydric alcohol esters.
(4) Wax esters such as beeswax, spermaceti, myristyl myristate, stearyl
stearate.
(5) Sterols esters, of which cholesterol fatty acid esters are examples
thereof.
Most preferred from the foregoing list of esters are PEG-40 hydrogenated
castor oil (available as Cremophore RH40.RTM.) and PPG-10-cetyl ether
(available as Procetyl-10.RTM.).
Humectants of the polyhydric alcohol-type may also be included in the
compositions of this invention. The humectant aids in increasing the
effectiveness of the emolient, reduces scaling, stimulates removal of
built-up scale and improves skin feel. Typical polyhydric alcohols include
glycerol, polyalkylene glycols and more preferably alkylene polyols and
their derivatives, including propylene glycol, dipropylene glycol,
polypropylene glycol, polyethylene glycol and derivatives thereof,
sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1,3-butylene glycol,
1,2,6-hexanetriol, ethoxylated glycerol, propoxylated glycerol and
mixtures thereof. For best results the humectant is preferably propylene
glycol. The amount of humectant may range anywhere from 0.5 to 30%,
preferably between 1 and 15% by weight of the composition.
Thickeners/viscosifiers in amounts up to about 5% by weight of the
composition may also be included. As known to those skilled in the art,
the precise amount of thickeners can vary depending upon the consistency
and thickness of the composition which is desired. Exemplary thickeners
are xanthan gum, sodium carboxymethyl cellulose, hydroxyalkyl and alkyl
celluloses (particularly hydroxypropyl cellulose), and cross-linked
acrylic acid polymers such as those said by B. F. Goodrich under the
Carbopol trademark.
Collectively the water, solvents, silicones, esters, humectants and/or
thickeners are viewed as pharmaceutically acceptable carriers for the
keratolytic and anti-irritancy agents. Total amount of carrier will range
from about 1 to 99.9%, preferably from about 80 to 99% by weight.
Cosmetic compositions of the present invention may be in any form. These
forms may include lotions, creams, sticks, roll-on formulations, mousses,
aerosol sprays, pad-applied formulations, and overnight facial masks.
A particularly preferred embodiment of the present invention is that the
actives be incorporated into a quick-drying gel or paste that forms a
peelable facial mask. A film-forming and an adhesion promoting polymer are
necessary in this product form. Polyvinyl alcohol can serve as the
film-forming polymer. Preferably the polyvinyl alcohol will be present as
a low and high molecular weight species. The former will have a number
average molecular weight ranging from about 15,000 to 27,000. The higher
polyvinyl alcohol material will have a number average molecular weight
ranging from about 44,000 to 65,000. These materials are available from
the Air Products Company under the trademark, Airvol 205S.RTM. and Airvol
523.RTM.. Amounts of total polyvinyl alcohol will range from about 2 to
about 40%, preferably from about 10 to about 20%, optimally between about
10 and 15% by weight. The ratio of low to high molecular weight may range
from about 1:20 to 20: 1, preferably from about 1:10 to 1: 1, optimally
from about 1:5 to 1:3, respectively.
As the adhesion promoting polymer, it is preferable to employ a hydrophobic
acrylate or methacrylate polymer. Especially useful is Pemulen TR2.RTM.
from the B. F. Goodrich Company. The CTFA name is acrylates/C.sub.10
-C.sub.30 alkyl acrylate cross-polymer. The adhesion-promoting polymer
will be present in amounts from about 0. 1 to about 20%, preferably from
about 0.5 to about 5%, more preferably from about 1 to about 2% by weight.
The following examples will more fully illustrate select embodiments of
this invention. All parts, percentages and proportions referred to herein
and in the appended claims are by weight unless otherwise indicated.
EXAMPLE 1
Illustrative formulas for a water-rinseable, skin cleanser and toner are
listed below.
______________________________________
INGRE- Formula (Weight %)
DIENT 1 2 3 4 5
______________________________________
Carbopol
30.0 30.0 30.0 30.0 30.0
934 .RTM. (2%
aqueous
solution)
Poly- 18.0 18.0 18.0 18.0 18.0
alphaole-
fin (3.8 cst)
Glycerin
4.0 4.0 4.0 4.0 4.0
Stearyl 3.0 3.0 3.0 3.0 3.0
alcohol
Borax 2.5 2.5 2.5 2.5 2.5
Ceteareth-
2.0 2.0 2.0 2.0 2.0
20
Benzyl 1.5 1.5 1.5 1.5 1.5
alcohol
Salicylic
1.5 1.5 1.5 1.0 1.0
acid
Glycolic
1.0 1.0 1.0 1.5 1.5
acid
Di- 0.5 0.5 0.5 0.5 0.5
ammonium
glycyrrhi-
zinate
.alpha.-Bisabolol
0.1 -- 0.1 0.4 --
Azulene -- 0.1 0.1 -- 0.4
Methyl- 0.2 0.2 0.2 0.2 0.2
paraben
Propyl- 0.1 0.1 0.1 0.1 0.1
paraben
Disodium
0.1 0.1 0.1 0.1 0.1
EDTA
Water Balance Balance Balance
Balance
Balance
______________________________________
EXAMPLE 2
Illustrative cream formulas according to the present invention are
described below.
______________________________________
INGRE- Formula (Weight %)
DIENT 6 7 8 9 10
______________________________________
Silicone Oil
32.0 32.0 32.0 20.0 15.0
Q2-3225C
Ethanol 10.0 10.0 10.0 10.0 10.0
Isopro- 12.0 5.0 5.0 5.0 5.0
panol
Diisopropyl
5.0 8.5 8.5 8.5 8.5
myristate
Sorbitan
2.5 2.5 2.5 2.5 2.5
trioleate
Zinc phen-
0.5 0.5 0.5 0.5 0.5
olsulfonate
Salicylic
1.0 0.8 0.5 0.5 0.5
acid
Ammonium
0.5 0.5 -- -- --
lactate
Ammonium
-- -- 0.5 0.5 0.5
glycolate
t-Butyl 0.3 0.3 -- -- --
lactate
Ethyl -- -- 0.3 0.3 0.3
lactate
Disodium
0.5 0.5 0.5 0.5 0.3
glycyrrhi-
zinate
.alpha.-Bisabolol
0.3 0.3 0.3 0.3 0.5
DMDM 0.2 0.2 0.2 0.2 0.2
Hydantoin
Fragrance
0.1 0.1 0.1 0.1 0.1
Water Balance Balance Balance
Balance
Balance
______________________________________
EXAMPLE 3
Illustrative anhydrous stick formulas according to the present invention
are described below.
______________________________________
Formula (Weight %)
INGREDIENT 11 12 13
______________________________________
Cyclomethicone 40.3 40.7 40.7
Stearyl alcohol 30.0 30.0 30.0
Hydrogenated castor oil
20.0 20.0 20.0
Talc 5.0 5.0 5.0
PEG-8-Distearate 2.0 2.0 2.0
Salicylic acid 1.5 1.5 1.5
Glycolic acid 0.8 0.4 0.4
Dipotassium glycyrrhizinate
0.3 0.3 0.2
.alpha.-Bisabolol 0.1 0.1 0.2
______________________________________
EXAMPLE 4
Illustrative aqueous stick formulas according to the present invention are
described below.
______________________________________
Formula (Weight %)
INGREDIENT 14 15 16
______________________________________
Water 39.7 40.3 40.8
Propylene glycol 40.0 40.0 40.0
Sodium stearate 10.0 10.0 10.0
Poloxamer 1307 .RTM.
8.0 8.0 8.0
Sodium Salicylate 2.0 1.5 1.0
Dipotassium glycyrrhizinate
0.2 0.2 0.2
.alpha.-Bisabolol 0.1 -- --
______________________________________
EXAMPLE 5
Illustrative anhydrous ointment formulas according to the present invention
are described below.
______________________________________
Formula (Weight %)
INGREDIENT 17 18 19
______________________________________
Zinc Oxide 38.1 38.3 38.2
Cod liver oil 25.0 25.0 25.0
Lanolin 15.0 15.0 15.0
Petrolatum 10.0 10.0 10.0
Talc 9.5 9.5 9.5
Salicylic acid 2.0 2.0 1.0
Glycolic acid -- -- 1.0
Dipotassium glycyrrhizinate
0.2 0.2 0.2
.alpha.-Bisabolol 0.1 -- --
Azulene 0.1 -- 0.1
______________________________________
EXAMPLE 6
A series of illustrative overnight facial masks according to the present
invention and their clinical performance are described below. Each formula
is a combination of an aqueous (A), alcoholic (B) and oily (C) phase.
______________________________________
IN- FORMULA (Weight %)
GREDIENT 20 21 22 23 24 25
______________________________________
Water 43.000 42.000 39.000
39.000
40.500
40.500
Zinc sulfate
0.300 0.300 0.300 0.300 0.300 0.300
Polyvinyl
2.500 2.800 2.800 2.800 2.800 2.800
alcohol
(PVA-205)
Polyvinyl
9.000 9.500 9.500 9.500 10.000
10.000
alcohol
(PVA-523)
Polyethylene
0.050 0.100 0.100 0.100 0.100 0.100
glycol-20000
Aloe extract,
0.750 0.750 0.750 0.750 0.750 0.750
40.times.
Propylene
4.000 4.000 4.000 4.000 4.000 4.000
glycol
Propylene
1.500 1.000 1.000 1.000 1.000 1.000
glycol-4
Dipotassium
-- 0.100 0.250 0.250 0.150 0.150
glycyrrizinate
______________________________________
______________________________________
INGRE- FORMULA (Weight %)
DIENT* 20 21 22 23 24 25
______________________________________
Alcohol 28.850 29.450 32.300
33.100
30.020
27.770
SD-40
Salicylic acid
1.300 1.300 1.300 0.500 0.750 1.500
Glycolic acid
0.200 0.200 0.200 0.200 0.400 0.400
Ethyl lactate
1.000 1.000 1.000 1.000 1.500 3.000
Myrrh HS 0.500 0.500 0.500 0.500 0.500 0.500
Rosemary HS
0.500 0.500 0.500 0.500 0.500 0.500
Coltsfoot HS
0.500 0.500 0.500 0.500 0.500 0.500
Sage HS 0.500 0.500 0.500 0.500 0.500 0.500
Bitter orange
0.500 0.500 0.500 0.500 0.500 0.500
HS
Yarrow HS
0.500 0.500 0.500 0.500 0.500 0.500
Pemulen 1.350 1.300 0.500 0.500 0.500 0.500
TS-2 .RTM.
Phos- -- -- 1.300 1.300 1.300 1.300
pholipid
PTC .RTM.
______________________________________
*HS indicates a 2% by weight dry extract in propylene glycol.
__________________________________________________________________________
FORMULA (Weight %)
INGREDIENT 20 21 22 23 24 25
__________________________________________________________________________
Cremopore RH40 .RTM.
1.600
1.600
1.600
1.600
1.600
1.600
Procetyl-10 .RTM.
0.800
0.800
0.800
0.800
0.800
0.800
.alpha.-Bisabolol, natural
0.500
0.500
0.500
0.500
0.500
0.500
Vitamin E acetate
0.200
0.200
0.200
0.200
0.400
0.400
Vitamin E linoleate
-- -- -- -- -- 0.100
Vitamin A palmitate
0.050
0.050
0.050
0.050
0.050
0.050
Tea tree oil
0.050
0.050
0.050
0.050
0.080
0.080
% Reduction in average
-7 -18 -17 -3 -28 -34
blemish size overnight
__________________________________________________________________________
The clinical studies were conducted with from 7 to 13 panelists. Average
percentage size change of blemishes were determined after overnight
treatment. The results, as listed in the table above, demonstrate the
effectiveness of including dipotassium glycyrrhizinate (DPG) into the mask
product. Formula 21 containing 0.1% dipotassium glycyrrhizinate exhibited
an 18% reduction in average blemish size compared to the 7% of Formula 20,
wherein DPG was absent. The effectiveness of salicylic acid was also
demonstrated by comparison of Formula 22 (1.3% salicylic acid) exhibiting
a 17% blemish size reduction by contrast with Formula 23 (0.5% salicylic
acid) with only a 3% blemish size reduction.
The foregoing description and examples illustrate selected embodiments of
the present Invention. In light thereof, various modifications will be
suggested to one skilled in the art, all of which are within the spirit
and purview of this invention.
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