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United States Patent | 5,603,956 |
Mateescu ,   et al. | February 18, 1997 |
The present application is concerned with a solid slow release pharmaceutical dosage unit. More specifically, the invention is directed to a tablet form prepared by direct compression of cross-linked amylose (CLA) having a definite cross-linking degree, .alpha.-amylase and a pharmaceutical agent. The presence of the cross-linked amylose allows a sustained release of the drug, while the .alpha.-amylase permits the modulation of the release time. In other words, the release time of the drug is function of the amount of .alpha.-amylase in the tablet. The amount of .alpha.-amylase is defined in terms of Enzyme Units.
Inventors: | Mateescu; Mircea A. (Verdun, CA); Dumoulin; Yves (Ste-Julie, CA); Cartilier; Louis (Beaconsfield, CA); Lenaerts; Vincent (Argenteuil, CA) |
Assignee: | Labopharm Inc. (Ste-Therese, CA) |
Appl. No.: | 261228 |
Filed: | June 16, 1994 |
Current U.S. Class: | 424/488; 424/94.1 |
Intern'l Class: | A61K 047/36 |
Field of Search: | 424/488,94.1 |
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