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United States Patent | 5,603,945 |
Isobe ,   et al. | February 18, 1997 |
A preparation or a pet food comprising an edible carboxylic acid, edible hydroxycarboxylic acid such as fumaric acid or a salt thereof is administered or fed to a pet. The content of the edible organic acid or a salt thereof is, in terms of the edible organic acid, about 0.1 to 99.9% by weight for the preparation such as a solid preparation and about 0.01 to 10% by weight for the pet food such as a dry food. The dose of the edible organic acid or a salt thereof is, in terms of the edible organic acid, about 5 to 500 mg/day/kg of body weight. The preparation and pet food have an improved palatability and safety in comparison with a conventional urine-acidifying agent, thus the administration or feeding of said preparation or pet food prevent or treat urinary calculosis in a pet even in a small amount.
Inventors: | Isobe; Yoshio (Suginami-ku, JP); Ito; Toshio (Suita, JP); Kogure; Norio (Bunkyo-ku, JP); Narita; Hideaki (Suginami-ku, JP); Hanazawa; Norio (Minato-ku, JP); Kanayama; Kiichi (Ebina, JP) |
Assignee: | Takeda Chemical Industries, Ltd. (Osaka, JP) |
Appl. No.: | 197591 |
Filed: | February 17, 1994 |
Feb 19, 1993[JP] | 5-054944 |
Current U.S. Class: | 424/442; 424/439 |
Intern'l Class: | A23K 001/165; A23K 001/17 |
Field of Search: | 424/439,442 426/805 514/557,784 |
4362710 | Dec., 1982 | Watanabe | 424/14. |
4412986 | Nov., 1983 | Kawata et al. | 424/80. |
4424234 | Jan., 1984 | Alderson et al. | 424/317. |
G. F. Taton et al., "Evaluation of ammonium chloride as a urinary acidifier in the cat", JAVMA, vol. 184, No. 4, Feb. 15, 1984, pp. 433-436. L. D. Lewis et al., "Feline urologic syndrome: causes and clinical management", Veterinary Medicine, Companion Animals/Cats, Mar. 1984, pp. 323-337. K. C. Bov ee et al., "Recurrence of Feline Urethal Obstruction", JAVMA, vol. 174, No. 1, Jan. 1, 1979, pp. 93-96. W. E. Lloyd et al., "Effects of orally administered ammonium chloride and methionine on feline urinary acidity", Veterinary Medicine, Companion Animals / Cats, Jun. 1984, pp. 773-778. L. J. Rich et al., "Feline Urethral Obstruction: Mineral Aspects", Am. J. Vet. Res., vol. 29, No. 11, pp. 2149-2156, Nov. 1968. D. R. Finco et al., "Characterization and Treatment of Water, Electrolyte, and Acid-Base Imbalances of Induced Urethral Obstruction in the Cat", Am. J. Vet. Res., vol. 38, No. 6, pp. 823-830, Jun. 1977. G. F. Taton et al., "Urinary acidification in the prevention and treatment of feline struvite urolithiasis", JAVMA, vol. 184, No. 4, Feb. 15, 1984, pp. 437-443. J. S. Reif et al., "Feline Urethral Obstruction: A Case-Control Study", JAVMA, vol. 170, No. 11, Jun. 1, 1977, pp. 1320-1324. C. F. Burrows et al., "Characterization and Treatment of Acid-Base and Renal Defects Due to Urethral Obstruction in Cats", Javma, vol. 172, No. 7, Apr. 1, 1978, pp. 801-805. Y. Maede et al., "Methionine-Induced Hemolytic Anema with Methemoglobinemia and Heinz Body Formation in Erythrocytes in Cats", vol. 38, pp. 568-571, 1985. J. R. Burns et al., "Solubility product of magnesium ammonium phosphate hexahydrate at various temperatures", pp. 426-428. C. A. Osborne et al., "Feline Cystitis, Urethitis, Urethral Obstructional Syndrome", Part I, Etiopathogenesis and Clinical Manifestations, Modern Veterinary Practice, Mar. 1978, pp. 173-180. C. A. Osborne et al., "Feline Cystitis, Urethitis, Urethral Obstructional Syndrome", Part II, Therapy of Disorders of the Upper and Lower Urinary Tract, May 1978, pp. 349-357. J. L. Parks, "Complications of Urogenital Tract Surgery", pp. 391-394. J. E. Brown et al., "Ammonium Chloride/Methionine Toxicity in Kittens", Feline Pratice --Toxicology, vol. 14, No. 2, Mar.-Apr. 1984, pp. 16-19. D. F. Senior et al., "Effectiveness of Ammonium Chloride as a Urinary Acidifier in Cats Fed a Popular Brand of Canned Cat Food", Feline Practice, Nov.-Dec. 1986, vol. 16, No. 6, pp. 24-27. C. A. Osborne, et al., "Feline Cystitis, Urethritis, Urethral Obstruction Syndrome, Adverse Drug Reactions; Client Education", Sep. 1978, pp. 668-673. C. A. Osborne et al., "Feline Cystitis, Urethritis, Urethral Obstruction Syndrome, Prophylaxis", Jul. 1978, pp. 513-519. |
TABLE 1 __________________________________________________________________________ Specific gravity Protein Blood pCO.sub.2 Blood HCO.sub.3.sup.- Urine pH of urine in urine Blood pH (mm Hg) (m mol/liter) __________________________________________________________________________ Normal values 6.5 or 1.020 7.10 40 8 to 15 less to 1.040 to 7.35 Before 8.5 >1.010 +++ 7.195 43.8 16.9 administration 1st day 7.0 >1.030 +++ -- -- -- 4th day 6.5 >1.030 +++ -- -- -- 7th day 6.5 >1.030 + 7.136 36.3 12.2 10th day 6.5 >1.030 +/- -- -- -- 13th day 6.5 >1.030 + 7.129 33.9 11.2 17th day 6.5 >1.030 +/- -- -- -- 27th day 6.0 >1.030 - 7.166 38.2 13.8 __________________________________________________________________________
TABLE 2 __________________________________________________________________________ Specific gravity Protein Blood pCO.sub.2 Blood HCO.sub.3.sup.- Urine pH of urine in urine Blood pH (mm Hg) (m mol/liter) __________________________________________________________________________ Normal values 7.0 or 1.018 -- 7.10 40 8 to 15 less to 1.045 to 7.35 Before 7.0 1.015 +++ -- -- -- administration 1st day 7.0 >1.025 +++ -- -- -- 12th day 6.0 >1.025 ++ -- -- -- 15th day 6.0 >1.015 + -- -- -- 25th day 6.0 >1.010 - -- -- -- 39th day 6.0 >1.010 - -- -- -- 48th day 6.0 >1.030 - 7.286 40.4 19.2 60th day 5.0 >1.010 - 7.381 29.0 17.2 68th day 6.5 >1.015 - -- -- -- 74th day 6.5 >1.010 - 7.166 38.2 13.8 __________________________________________________________________________