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| United States Patent |
5,571,535
|
|
Flowers
, et al.
|
November 5, 1996
|
Treatment of topical infections
Abstract
A composition and method for use in treating topical Herpes Simplex 1
infections of the skin, in which the composition comprises a mixture of at
least 0.5% by weight of the following ingredients: an alkali metal
carbonate; an alkali metal phosphate; and an alkali metal hypochlorite, in
a pharmaceutically acceptable topical carrier in the form of a powder, a
cream, or a lotion, and the method comprises applying such compositions to
the skin at the site of the infection.
| Inventors:
|
Flowers; Marianne (4372 37th St., San Diego, CA 92105-1003);
Tavares; Basilio (4372 37th St., San Diego, CA 92105-1003)
|
| Appl. No.:
|
620145 |
| Filed:
|
November 30, 1990 |
| Current U.S. Class: |
424/489; 424/78.07; 424/401; 424/715; 424/722; 424/744; 514/887; 514/937 |
| Intern'l Class: |
A61K 009/06; A61K 009/10 |
| Field of Search: |
424/489,401,78.07,715,722,195.1
514/937,887
|
References Cited
U.S. Patent Documents
| 4369180 | Jan., 1983 | Mihalovits | 426/195.
|
Other References
Gennaro. (1985). Remington's Pharmaceutical Sciences, Mack Pub., p. 811.
Berkow et al., The Merck Manual, 15 Edition pp. 2267-2270 & 2327-2328
(1987).
Budavari et al. (1989). The Merck Index, Merck and Co., Inc.
|
Primary Examiner: Bawa; Raj
Attorney, Agent or Firm: Knobbe, Martens, Olson & Bear
Parent Case Text
CROSS REFERENCE TO RELATED APPLICATION
This is a continuation-in-part of U.S. patent application Ser. No.
07/389,689, filed Aug. 3, 1989, now abandoned.
Claims
What is claimed is:
1. A composition packaged for treatment of topical herpes simplex 1
infections of the skin, comprising a mixture of at least 0.5% by weight of
the following ingredients: an alkali metal carbonate; an alkali metal
phosphate; and an alkali metal hypochlorite, in a pharmaceutically
acceptable topical carrier in the form of a powder, a cream, or a lotion,
together with sufficient corn starch to provide blending consistency.
2. A composition packaged for treatment of topical herpes simplex 1
infections of the skin, comprising a mixture of at least 0.5% by weight of
the following ingredients: an alkali metal carbonate; an alkali metal
phosphate; and an alkali metal hypochlorite, in a pharmaceutically
acceptable topical carrier comprising aloe lotion.
3. A method for topical treatment of cold sores caused by Herpes simplex I
infections of the skin, comprising applying a composition comprising a
mixture of at least 0.5% by weight of each of the following ingredients:
an alkali metal carbonate; an alkali metal phosphate; and an alkali metal
hypochlorite, in a pharmaceutically acceptable carrier to the site of the
infection.
4. The method of claim 3, wherein said infection is herpes simplex I.
5. The method of claim 3, wherein the composition is applied in the form of
a drying paste.
6. The method of claim 3, wherein the infection is ringworm.
7. The method of claim 3, wherein the alkali metal carbonate comprises a
mixture of calcium carbonate and sodium carbonate.
8. The method of claim 3, wherein the ingredients are present in the
following weight ratios:
Calcium carbonate 5-10 parts
Sodium carbonate 5-10 parts
Sodium phosphate (anhydrous) 5-10 parts
Calcium hypochlorite 6-12 parts.
9. The method of claim 3, wherein the ingredients are present in the
following weight ratios:
Calcium carbonate about 7 parts
Sodium carbonate about 7 parts
Sodium phosphate (anhydrous) about 7 parts
Calcium hypochlorite about 8 parts.
10. The method of claim 3, wherein said excipient comprises sufficient corn
starch to provide blending consistency.
11. The method of claim 3, wherein said excipient comprises aloe lotion.
Description
BACKGROUND OF THE INVENTION
The present invention relates to a method and composition for treatment of
topical bacterial, vital, and fungal infections. It is particularly useful
in treatment of cold sores, fever blisters, and other symptoms of herpes
simplex I virus infection, as well as other topical infections such as
impetigo and ringworm.
There are many people who suffer occasionally or chronically from herpes
simplex I, the common cold sore. Cold sores can appear on the lips, around
the rim of the mouth, in nostrils, around the rim of the nostrils, and on
the upper lip between the nose and the mouth.
A cold sore usually goes through a cycle. The onset is characterized by
stinging, vexing, burning, an itching sensation, and swelling and
rubification of the skin tissues in the afflicted area. Next comes the
development of blisters and continued swelling. Blisters may break and
weep.
Finally the blisters begin to shrink and dry, followed by a scab covering.
The scab covering is unsightly, as is the entire cold sore process, and
even during the scab phase there are often onsets of burning, stinging,
and itching. The course of the infection from onset to disappearance is
usually about three weeks.
Needless to say, no one wants a cold sore. For those with high profile
professions, such as sales personnel, entertainers, actors, and models,
the affliction is more than a mere embarrassment; it can mean loss of
work. Makeup can cover the problem only partially.
The present invention addresses this problem by providing a method and
composition for treating and eliminating the effects of this viral
infection. The composition used is an antiviral and antibacterial
material.
SUMMARY OF THE INVENTION
The compositions of the present invention may advantageously comprise a
mixture of at least 0.5% by weight of each of the following ingredients:
an alkali metal carbonate, preferably sodium carbonate or calcium
carbonate; an alkali metal phosphate such as sodium phosphate or calcium
phosphate; and an alkali metal hypochlorite such as calcium hypochlorite.
The balance up to 100% of the composition can be made up of
pharmaceutically acceptable diluents, carriers, and excipients, such as
corn starch, aloe vera lotion, silica, polysorbates, glycerine, alcohol,
water, and the like. The composition may be in the form of a dry powder, a
lotion, cream, paste, or ointment. In a preferred embodiment, the alkali
metal carbonate comprises a mixture of calcium carbonate and sodium
carbonate, most preferably in approximately equimolar amounts.
The method of the present invention requires applying the composition
described herein to the site of a topical infection of the skin or mucous
membranes, such as the site of a cold sore, impetigo, herpes eruption,
ringworm, and the like. The composition is preferably applied as a paste
or other spreadable composition having sufficient viscosity to remain
localized on the affected area. The liquid vehicle used with the active
ingredients is preferably volatile, so that it can evaporate and leave a
dry composition on the skin. This dry composition is believed to exert a
drawing effect on the affected area, with therapeutic results.
DETAILED DESCRIPTION OF THE INVENTION
The present invention includes a blending of ingredients; active, inactive,
cleaning agents and carrier; where said ingredients can provide a
treatment or cure for those suffering from symptoms of herpes simplex I,
other topical herpes or viral infections, common cold sores and fever
blisters, ringworm, impetigo, and other viral, fungal, and bacterial
infections of the skin.
The compositions of the present invention may advantageously comprise a
mixture of at least 0.5% by weight of each of the following ingredients:
an alkali. metal carbonate, preferably sodium carbonate or calcium
carbonate; an alkali metal phosphate such as sodium phosphate or calcium
phosphate; and an alkali metal hypochlorite such as calcium hypochlorite.
The balance up to 100% of the composition can be made up of
pharmaceutically acceptable diluents, carriers, and excipients, such as
corn starch, aloe vera lotion, silica, polysorbates, glycerine, alcohol,
water, and the like. The composition may be in the form of a dry powder, a
lotion, cream, paste, or ointment. In a preferred embodiment, the alkali
metal carbonate comprises a mixture of calcium carbonate and sodium
carbonate, most preferably in approximately equimolar amounts.
In one embodiment. of the invention, the active ingredients of the
composition are present in the following weight ratios:
Calcium carbonate 5-10 parts
Sodium carbonate 5-10 parts
Sodium phosphate (anhydrous) 5-10 parts
Calcium hypochlorite 6-12 parts
In another embodiment of the invention, the active ingredients are present
in the following weight ratios:
Calcium carbonate about 7 parts
Sodium carbonate about 7 parts
Sodium phosphate (anhydrous) about 7 parts
Calcium hypochlorite about 8 parts
In still another embodiment, the composition is a wettable powder with the
following composition of active ingredients:
Calcium carbonate (CACO.sub.3)1.4%
Sodium carbonate (Na.sub.2 CO.sub.3)1.4%
Sodium phosphate (Na.sub.2 HPO.sub.4)1.4% (anhydrous)
Calcium hypochlorite (Chlorinol)8%
The remainder of this particular formulation may be a dry, wettable
excipient, such as corn starch, modified food starch, fumed silica, and
the like.
In any of the compositions, the formulation can also comprise inert
ingredients such as corn starch, for blending consistency and control of
dosage strength, and blending ingredients, such as aloe lotion, for
texture, color, and aroma, in such proportions as desired.
In the practice of the present invention, the dry formulation described
above in the Summary of the Invention is combined with water and is
applied to the site of the of the infection as a paste. The formulation
acts as a cleaning drawing agent as said paste dries. Most importantly,
the combination of ingredients effectively kills or renders harmless any
active virus of the herpes simplex strain. When applied to a suspected
cold sore patch the compound will first clean the area, second draw the
fluids of the weeping lesions or watery blisters into the paste and
finally the antiseptic qualities of the compound will kill all viruses and
bacteria present.
The result is the cold sore is immediately relieved of the vexing pain,
stinging and burning sensations common with cold sores. Not only is the
pain and discomfort eliminated quickly, but the cold sore itself and the
colony of virus which caused the eruption in the first place is
eradicated. The sufferer will have the pain vanquished and the cold sore
will not erupt later with the unsightly weeping lesions and later scabs.
Cold sores will quickly disappear as soon as the application of the remedy
is made and they will not reoccur.
By using the compound of the invention, a user can eliminate the initial
discomfort and unsightliness of the usual three week period onset,
eruption and final healing of a cold sore.
The purpose of the invention is to provide a home remedy which is simple to
use and effective against herpes simplex I, the common cold sore, and the
other indications mentioned above. The composition should not be taken
internally.
The present invention solves the problem of herpes simplex I, cold sores,
quickly and permanently. In one preferred embodiment, the ingredients
remain dry and ready for use until water is added to form a light paste.
When applied, the chemicals first clean the area, next they begin killing
of the virus causing the irritation. As the paste dries, it has a drawing
effect. This drawing effect will pull the fluid of the weeping lesion into
the paste. The most contagious stage is blunted because the fluid
containing the virus is pulled into the paste and killed.
At any stage, the compound will be effective against cold sores. Almost
instant relief from the horrendous cold sore is achieved. Repeat or
continued applications are not necessary as the virus causing the
inflammation is killed, leaving the natural body action to take over and
return the affected cells to normal.
Persons who have chronic cold sores will hail the compound of the instant
invention as a wonder cure.
Although certain preferred embodiments are described, it will be apparent
that various modifications, changes, different excipients, and the like
can be readily made without departing from the spirit of the invention.
Thus, it is intended that the scope of the present invention be measured
by the appended claims and their reasonable equivalents.
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