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United States Patent | 5,565,478 |
Kohn ,   et al. | October 15, 1996 |
The present invention provides compositions and methods for the treatment of cancer in a subject wherein compounds of formula I defined herein in combination with paclitaxel or other modified taxane analogs provide enhanced anticancer effects over the effects achieved with the individual compounds.
Inventors: | Kohn; Elise C. (Olney, MD); Reed; Eddie (Germantown, MD); Liotta; Lance A. (Potomac, MD) |
Assignee: | The United States of America as represented by the Department of Health (Washington, DC) |
Appl. No.: | 212612 |
Filed: | March 14, 1994 |
Current U.S. Class: | 514/359; 514/8; 514/383; 514/393; 514/399; 514/449 |
Intern'l Class: | A61K 031/41; A61K 031/415; A61K 031/335 |
Field of Search: | 514/359,396,449,399,255,383,8 |
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4235871 | Nov., 1980 | Papahadjopoulos et al. | 424/19. |
4501728 | Feb., 1985 | Geho et al. | 424/38. |
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