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United States Patent | 5,556,996 |
Beard ,   et al. | September 17, 1996 |
Compounds of the formula ##STR1## wherein all the symbols in the formula are as defined in the specification, have retinoid-like activity.
Inventors: | Beard; Richard L. (Santa Ana Heights, CA); Chandraratna; Roshantha A. (Missio Viejo, CA) |
Assignee: | Allergan (Waco, TX) |
Appl. No.: | 366174 |
Filed: | December 29, 1994 |
Current U.S. Class: | 549/407; 549/404; 549/408; 549/409 |
Intern'l Class: | C07D 311/04; C07D 311/58 |
Field of Search: | 549/407,408,409,404 |
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______________________________________ ##STR4## Formula 3 Compound # R.sub.8 ______________________________________ 1 CH.sub.3 CH.sub.2 2 H ______________________________________
TABLE 1 ______________________________________ Compound # IC.sub.80 conc (nmols) ______________________________________ 1 >300 2 73 ______________________________________