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United States Patent | 5,306,562 |
Barany | April 26, 1994 |
The preparation and properties of xanthenylamide handles for use in peptide synthesis is disclosed. The compounds, omega-(9-(9-fluorenylmethyloxycarbonyl)aminoxanthan-2-oxy)alkanoic acid derivatives, are used as peptide handles in the solid-phase synthesis of peptide amides.
Inventors: | Barany; George (Falcon Heights, MN) |
Assignee: | Regents of the University of Minnesota (Minneapolis, MN) |
Appl. No.: | 884653 |
Filed: | May 15, 1992 |
Current U.S. Class: | 428/402; 435/DIG.42; 525/132; 526/72; 548/364.4; 548/371.1; 549/394 |
Intern'l Class: | B32B 005/16; C08F 008/00; C08F 002/00; C07D 231/00 |
Field of Search: | 549/394 548/364,358 526/72 525/132 428/402 |
Foreign Patent Documents | |||
19697A/90 | May., 1990 | IT. |
Albericio, F. et al., J. Organ. Chem. 55:3730-3743 (1990). P. Sieber, Tetrahedron Letters 28:2107-2110 (1987). Barany et al., Int. J. Peptide Protein Res. 30:703-739 (1987). Caciagli, V. et al., Proceeding of the European Peptide Symposium (Sep. 1990), Abstract P97. European Search Report for EP 91307876.2. Patrick et al., Chemical Abstracts 79:78525a (Oct. 1, 1973). Capuano et al., Chemical Abstracts 76:85648j (Apr. 10, 1972). Bender et al., Chemical Abstracts 99:88276A (Sep. 5, 1983). |