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United States Patent | 5,274,090 |
Zhang ,   et al. | December 28, 1993 |
Disclosed is a metalloporphyrin-ligand complex which includes (a) a meso-tetraphenylporphyrin, (b) a crown ether rigidly attached to the meso-tetraphenylporphyrin by covalent attachment on one side of the porphyrin to two diagonally opposing phenyl groups, (c) a metal bound to the pyrrole nitrogens of the porphyrin, (d) a bridge covalently linking two diagonally opposing phenyl groups on the other side of the porphyrin, effective to hinder .mu.-oxo diner formation, and (e) a ligand having (i) a primary amine which is held noncovalently by the crown ether and (ii) a metal-coordinating atom which is coordinately bound to the metal. In another aspect, the invention includes a water-soluble oxygen carrier. The oxygen carrier includes a meso-.alpha.,.alpha.,.alpha.,.alpha.-tetrakis(o-propanoylamino)phenylporph yrin, in which the 3-carbons of the propanoyl groups are each covalently bound to a quaternary amine, and iron or cobalt is bound to the pyrrole nitrogens of the porphyrin. The oxygen carrier also includes a ligand L for protecting the open face of the porphyrin from .mu.-oxo dimer formation.
Inventors: | Zhang; Xumu (Mountain View, CA); Uffelman; Erich S. (Menlo Park, CA); Collman; James P. (Stanford, CA) |
Assignee: | The Board of Trustees of the Leland Stanford Junior University (Stanford, CA) |
Appl. No.: | 973030 |
Filed: | November 9, 1992 |
Current U.S. Class: | 540/145; 540/452; 540/454 |
Intern'l Class: | C07D 481/29; C01B 013/00; C01B 031/18 |
Field of Search: | 540/145 |
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Foreign Patent Documents | |||
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0439387A2 | Jan., 1991 | EP | 55/16. |
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