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United States Patent | 5,246,869 |
Potter ,   et al. | September 21, 1993 |
The objective of the present invention is a method for determining two or more radioactively labeled ligands simultaneously in the same sample. According to the invention the ligands are determined with proximity assay so that for determining said ligands support materials with different scintillation characteristics are employed, each said support material having attached onto it molecules specifically binding one of said ligands. The support material consists totally or partially of scintillator.
Inventors: | Potter; Colin (Headington, GB2); Warner; Gerald (Headington, GB2); Oikari; Timo (Turku, FI) |
Assignee: | Wallac Oy (Turku, FI) |
Appl. No.: | 761836 |
Filed: | September 23, 1991 |
PCT Filed: | March 21, 1990 |
PCT NO: | PCT/FI90/00073 |
371 Date: | September 23, 1991 |
102(e) Date: | September 23, 1991 |
PCT PUB.NO.: | WO90/11524 |
PCT PUB. Date: | October 4, 1990 |
Mar 22, 1989[FI] | 891354 |
Current U.S. Class: | 436/518; 252/301.17; 436/524; 436/528; 436/534; 436/804 |
Intern'l Class: | G01N 033/543 |
Field of Search: | 252/301.17 435/973,7.1 436/518,524,528,527,804,534 |
4016250 | Apr., 1977 | Saxena | 436/804. |
4568649 | Feb., 1986 | Bertoglio et al. | 436/534. |
George T. Reynolds, "Solid and Liquid Scintillation Counters", Nucleonics, vol. 10, No. 7, pp. 46-53, (1952). "Latest Developments in Scintillation Counting", Nucleonics, vol. 10, No. 3, pp. 32-41, (1952). Bosworth et al., "Scintillation Proximity Assay," Nature, vol. 341, pp. 167-168, (1989). |