Back to EveryPatent.com
United States Patent | 5,227,394 |
Plate ,   et al. | July 13, 1993 |
The invention relates to pyrazole derivative having formula I ##STR1## wherein R.sub.1 is ##STR2## and R.sub.2 is hydrogen, or R.sub.1 is wherein n is 1 or 2 and R.sub.2 is hydrogen or halogen; and R.sub.3 is bromine or iodine; or a pharmaceutically acceptable salt thereof. The compounds of this invention have muscarinic properties and can be used for the treatment of cognition disorders, for analgesia, and afore the treatment of cholinergic deficiencies.
Inventors: | Plate; Ralf (Oss, NL); Rae; Duncan R. (Lanark, GB6) |
Assignee: | Akzo N.V. (Arnhem, NL) |
Appl. No.: | 919806 |
Filed: | July 27, 1992 |
Jul 26, 1991[EP] | 91.306.870.6 |
Current U.S. Class: | 514/406; 514/305; 514/341; 546/133; 546/275.4; 548/364.7 |
Intern'l Class: | A61K 031/415; A61K 031/435; C07D 401/04; C07D 487/08 |
Field of Search: | 546/133,279 548/364.7 514/406,305,341 |
Foreign Patent Documents | |||
0239309 | Sep., 1987 | EP. | |
0307141 | Mar., 1989 | EP. | |
0316718 | May., 1989 | EP. | |
0296721 | Apr., 1990 | EP. | |
0384288 | Aug., 1990 | EP. | |
0402056 | Dec., 1990 | EP. | |
0427390 | May., 1991 | EP. |
M. Ferles et al., "Reaction of a 1-pyridyl-1,3-butanediones and 1,3-dipridyl-1,3-propanediones", Collect. Czech. Chem. Commun., vol. 46, No. 5, pp. 1167-1172, Prague, Czech., (1981). C. W. Thornber, "Isoterism and Molecular Modification in Drug Design", Chem. Soc. Rev., vol. 18, pp. 563-580, 1979. |