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United States Patent | 5,145,871 |
Cavazza | September 8, 1992 |
The use is described of acetyl D-carnitine and its pharmacologically acceptable salts in the therapeutic treatment of glaucoma. The medicament may be administered orally or parenterally or be applied as a collyrium containing approximately 1-10% w/v of acetyl D-carnitine.
Inventors: | Cavazza; Claudio (Rome, IT) |
Assignee: | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (Rome, IT) |
Appl. No.: | 442702 |
Filed: | November 28, 1989 |
Dec 01, 1988[IT] | 48614 A/88 |
Current U.S. Class: | 514/546; 514/913 |
Intern'l Class: | A61K 031/22 |
Field of Search: | 514/546,913 |
4724230 | Feb., 1988 | Cone, Jr. | 514/728. |
Int. J. Tiss. Reac., vol. 6, No. 2, 1984, Bioscience Ediprint Inc., Z. Farinella et al.: "Effects of carnitine and acetylcarnitine isomers on mitochondrial respiration", pp. 141-143, see summary Relevant To Claim No. 1,3-8. Dialog Information Services, File 5, (Biosis), Accession No.: 0019195970, L. Scorolli et al.: "Evaluation of effects of L acetylcarnitine on some functional parameters in a senile glaucomatous patient", & Ann Ottalmol Clin Ocul 114 (9),1988, 927-934, see the whole abstract. Relevant To Claim NO. 1,3-8. Journal of Pharmaceutical Sciences, vol. 69, No. 9, Sep. 1980, American Pharmaceutical Association, K. W. Reed et al.: "Acetylcarnitine and cholinergic receptors", pp. 1065-1068, see p. 1066: Experimental Relevant To Claim No. 1,3-8. The Merck Manual of Diagnosis and Therapy, 1987, 15th edition, edited by R. Berkow et al., Merck Sharp & Dohme Research Laboratories, (Rahway, N.J. U.S.), pp. 2234-2240, chapter 224: "Glaucoma" see pp. 2236-2237 Relevant To Claim No. 1,3-8. |