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United States Patent | 5,132,414 |
Rosowsky ,   et al. | July 21, 1992 |
Compounds having the structure ##STR1## in which R is alkyl, aryl, or aralkyl, A is hydrogen or a water-soluble cation, B is hydrogen, fluorine, or azido, the bond is saturated when B is fluorine or azido and is saturated or unsaturated when B is hydrogen, and D is a purine or pyrimidine base are effective inhibitors of retrovirus replication.
Inventors: | Rosowsky; Andre (Needham, MA); Ruprecht; Ruth M. (Boston, MA) |
Assignee: | Dana-Farber Cancer Institute, Inc. (Boston, MA) |
Appl. No.: | 521748 |
Filed: | May 10, 1990 |
Current U.S. Class: | 536/26.7; 536/26.8; 536/27.14; 536/28.2 |
Intern'l Class: | C07H 019/00 |
Field of Search: | 536/27,28,29,23 514/45,120 |
3817982 | Jun., 1974 | Verheyden et al. | 536/23. |
4386081 | May., 1983 | Helgstrand et al. | 514/120. |
Foreign Patent Documents | |||
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0355031 | Aug., 1989 | EP. |
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