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United States Patent | 5,108,758 |
Allwood ,   et al. | April 28, 1992 |
Delayed release compositions comprising an active compound and glassy amylose. A variety of different types of active compound may be employed in the compositions. The compositions are particularly adapted for achieving the selective release of medicaments into the colon.
Inventors: | Allwood; Michael C. (Fulbourn, GB2); Archer; David B. (Little Melton, GB2); Ring; Stephen G. (Hethersett, GB2) |
Assignee: | National Research Development Corporation (London, GB2) |
Appl. No.: | 438488 |
Filed: | December 19, 1989 |
PCT Filed: | May 25, 1989 |
PCT NO: | PCT/GB89/00581 |
371 Date: | December 19, 1989 |
102(e) Date: | December 19, 1989 |
PCT PUB.NO.: | WO89/11269 |
PCT PUB. Date: | November 30, 1989 |
May 26, 1988[GB] | 8812490 |
Current U.S. Class: | 424/468; 424/479; 424/488; 424/489; 424/493; 424/499; 536/102 |
Intern'l Class: | A61K 009/22; A61K 009/36; C08B 031/00 |
Field of Search: | 424/468,489,490,493,499,418,409,488,479,4,7.1 427/3 536/102 |
3499962 | Mar., 1970 | Wurzburg | 424/35. |
4695467 | Sep., 1987 | Uemura et al. | 424/502. |
4755397 | Jul., 1988 | Eden et al. | 427/213. |
Foreign Patent Documents | |||
0118240 | Sep., 1984 | EP. | |
1072795 | Jun., 1967 | GB. | |
28900419 | Jan., 1989 | WO. |
Ring, S. G. et al., "Static and Dynamic Light Scattering Studies of Amylose Solutions", Macromolecules, 1985m 18, pp. 182-188. J. Med. Chem. (1984), 27, 261-266, Friend & Chang. Science (1986), 233, 1081-1084, Saffran et al. Food Chemistry (1988), 28, 97-109, Ring et al. Englyst & Cummings, "Cereals in a European Context", Ed. Morton, First European Conference on Food Science and Technology, Ellis Harwood, Chichester, England (1987), p. 221. J. Am. Pharm. Assoc. (1959), 48, 244, Wagner et al. Langlois & Wagner, "Production and Use of Amylose" in Starch Chemistry & Technology, vol. II, Eds. R. L. Whistler and E. F. Paschall, Academic Press (1965), p. 451. "Work on Oral Insulin", article in Diabetes for the News (1987), published by Amec Laboratories Ltd., Bucks. J. Sci. Food Agric. (1986), 37, 699-706, Englyst & MacFarlane. J. Appl. Bacteriol. (1986), 60, 195-201, Englyst & MacFarlane. |