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United States Patent | 5,047,963 |
Kosaka | September 10, 1991 |
A particle suspension is irradiated with a laser beam, and side-scattered light from a single particle irradiated in an irradiating zone is detected as one or a plurality of particle signals. The degree of complexity of the particle nucleus is determined by extracting high-frequency signal components contained in the particle signal, and the degree of symmetry of the particle nucleus is determined by extracting the magnitude of a difference between this single particle signal and a signal obtained by flipping over the particle signal in terms of time. The degrees of complexity and symmetry of the particle nucleus serve as data for particle analysis.
Inventors: | Kosaka; Tokihiro (Hyogo, JP) |
Assignee: | TOA Medical Electronics Co., Ltd. (Kobe, JP) |
Appl. No.: | 401983 |
Filed: | September 1, 1989 |
Sep 30, 1988[JP] | 63-246539 |
Current U.S. Class: | 702/128; 356/336; 356/339 |
Intern'l Class: | G06F 015/42; G01N 015/02 |
Field of Search: | 364/555,497,498 73/865.5 250/574 356/336,338,339 |
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4732479 | Mar., 1988 | Tanaka et al. | 356/336. |
4735504 | Apr., 1988 | Tycko | 356/343. |
4827144 | May., 1989 | Zaitsu et al. | 250/574. |
4830494 | May., 1989 | Ishikawa et al. | 250/574. |
4987539 | Jan., 1991 | Moore et al. | 364/555. |
Foreign Patent Documents | |||
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An Article from Review of Scientific Instruments, vol. 55, No. 9 dated Sep., 1984, pp. 1375-1400 entitled, "Flow Cytometry". An Article entitled, "Applications of Flow Cytometry in Clinical Diagnosis", from TRAC: Trends in Analytical Chemistry, vol. 3, No. 4, published 4/1984. Article from the Journal of Histochemistry and Cytochemistry, vol. 27, pp. 321-324, published 1979 entitled, "A Multidimensional Slit-Scan Flow System". |