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United States Patent | 5,008,262 |
Swedo ,   et al. | April 16, 1991 |
The instant invention is drawn to the use of clomipramine for treating trichotillomania and onchyphagia.
Inventors: | Swedo; Susan E. (Lorton, VA); Rapoport; Judith L. (Washington, DC); Leonard; Henrietta L. (Washington, DC) |
Assignee: | The United States of America as represented by the Department of Health (Washington, DC) |
Appl. No.: | 207617 |
Filed: | April 19, 1988 |
Current U.S. Class: | 514/217; 514/219; 514/563 |
Intern'l Class: | A61K 031/395 |
Field of Search: | 514/219,217 |
4596799 | Jun., 1986 | Wasley | 514/219. |
4710504 | Dec., 1987 | Baldwin | 514/219. |
4761411 | Aug., 1988 | Glamkowski et al. | 514/219. |
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TABLE I ______________________________________ Pt. Baseline CMI DMI No. Age Treatment score** score score ______________________________________ 1 24 yr. Librium, 20 0 -- desaryl, Behavioral modification 2 23 yr. Behavioral 20 10 -- modification, Relaxation 3 25 yr. Aversion therapy 11 7 14 Hypnosis 4 16 yr. Psychotherapy 23 21 7* 5 23 yr. Elavil 20 14 16 Centrex Behavioral modification Psychotherapy 6 23 yr. Tofranil 18 0 18 Xanax Psychotherapy 7 21 yr. Behavioral 15 12 14 modification Psychotherapy 8 8 yr. Xanax 17 14 19 Psychotherapy Inpatient therapy ______________________________________ All scores shown are total trichotillomania score. * = subsequently relapsed and responded to CMI with score = 5